Book Hotels in Depew, NY

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Top Depew hotels

Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
2761 Long Road Grand Island NY
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $92 total per night from Oct 27 to Oct 28
$92 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"The rooms were clean when we just arrived i.e., on day1 of our stay. But it went downhill after that. They weren’t cleaned on day2, which we were still ok with. But it wasn’t done on day3 too, in spite of us specially putting in a request at the front desk for housekeeping. When we complained about ..."

Reviewed on Sep 27, 2026

Opens in a new windowHoliday Inn Express Grand Island - Niagara Falls by IHG
Comfort Inn & Suites Niagara Falls Blvd USA

Comfort Inn & Suites Niagara Falls Blvd USA

2.5 out of 5
6115 Niagara Falls Blvd Niagara Falls NY
Fully refundable
$85 nightly
The price is $97 total per night from Oct 26 to Oct 27
$97 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The toilet did not work randomly and they weren’t real helpful. We finally said we wanted another room so they would work on it."

Reviewed on Sep 26, 2026

Opens in a new windowComfort Inn & Suites Niagara Falls Blvd USA
La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst

3 out of 5
145 Innkeepers Lane Buffalo NY
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $118 total per night from Oct 26 to Oct 27
$118 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Only complaint was that there was no decaf coffee and seating was awkward. The booth benches were low compared to the tables and there weren’t many tables with just chairs."

Reviewed on Sep 26, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Buffalo Amherst
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Sep 28 to Sep 29
$106 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"This was one of the cheapest hotels I could find considering the situation we were in. The room was clean, comfortable, there was coffee in the room, beds were super comfy, overall a great stay!"

Reviewed on Sep 26, 2026

Opens in a new windowBuffalo Airport Hotel
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $95 total per night from Sep 28 to Sep 29
$95 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
Opens in a new windowM Hotel Buffalo
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $147 total per night from Oct 1 to Oct 2
$147 total
Oct 1 - Oct 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Opens in a new windowGarden Place Hotel
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Fully refundable
$83 nightly
The price is $95 total per night from Oct 25 to Oct 26
$95 total
Oct 25 - Oct 26
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free self parking, and a free airport shuttle. Traveling on business? Take advantage ...
Opens in a new windowSleep Inn & Suites Buffalo Airport
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
$152 nightly
The price is $178 total per night from Oct 25 to Oct 26
$178 total
Oct 25 - Oct 26
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Opens in a new windowHyatt Regency Buffalo / Hotel and Conference Center
Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown

3 out of 5
125 High St Buffalo NY
$158 nightly
The price is $184 total per night from Sep 28 to Sep 29
$184 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features a 24-hour gym and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and airport ...
Opens in a new windowWyndham Garden Buffalo Downtown
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Depew Hotel & Travel Guide\n

If you're thinking of exploring the Buffalo area and are looking for a place to stay in Depew, Travelocity offers an exciting assortment to decide between. Inside the resourceful booking pages, the modern traveler will find 50 flexible accommodation options within a 6-mile (10-kilometer) distance of Depew's center.

Visitors searching for a hotel in the heart of Depew should plan to stay at Pink Fountain Motor Inn.

9 miles (14 kilometers) from the town center of Depew, you will find the The Mansion On Delaware Ave. Alternatively, the Lofts on Pearl is positioned 9 miles (14 kilometers) away. Other possible Travelocity-listed hotels are the Hampton Inn & Suites Buffalo Downtown and the Hotel @ The Lafayette.

After you have seen Depew, put aside some time to investigate the other natural and cultural attractions of the Niagara Falls - Western New York area. Get to know Niagara Falls - Western New York's art galleries and theaters. You should also make the time to admire its lakes. Wise visitors in this part of United States of America will enjoy ice skating and guided nature walks.

8 miles (12 kilometers) to the west of Depew, you can reach Downtown Buffalo, home to Greater Buffalo Sports Hall of Fame and Old Erie County Hall. Some of our recommended Downtown Buffalo hotels and accommodations include the Embassy Suites Buffalo and Hyatt Regency Buffalo / Hotel and Conference Center. 9 miles (15 kilometers) to the northwest of Depew, you can also stay at Amherst, home to the Homewood Suites by Hilton Buffalo/Amherst and Residence Inn Buffalo Amherst. Should you choose to stay in Amherst, set aside some time to explore the Boulevard Mall and Lasertron.

Simply because you and your traveling partners are taking a break from your usual habits, who says you can't enjoy your passion for a day of sports. You can find First Niagara Center 9 miles (14 kilometers) to the west of Depew. Sleep right in the thick of the sporting action at the Holiday Inn Buffalo-Downtown or the Holiday Inn Express & Suites Buffalo Downtown.

For travelers flying through Buffalo Niagara International Airport, you may like to book some accommodation at Staybridge Suites Buffalo-Airport, or Hilton Garden Inn Buffalo Airport, each of which are conveniently located nearby.

Frequently asked questions

What are the top kid-friendly hotels in Depew?
Family vacations are where treasured memories are made, but it's no secret that traveling with young ones can be stressful. These kid-friendly Depew hotels come with perks that aim to keep adventurers of all ages relaxed and happy: Firemans Park Quarters will help make your adventure the best one yet. It features a range of conveniences geared toward families, such as a playground and pet-friendly facilities. Quiet suburban home 10 minutes from airport/25 min from Niagara Falls is another great choice. After a fun day of exploring Depew, come home to your comfy room and amenities like pet-friendly facilities and internet access.
Where can I find cheap hotels in Depew?
At Travelocity you'll find really nice hotels in Depew at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Depew rather than in Depew. We may find you even better rates, too.
How do I find the best Depew hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Depew then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Depew?
The cheapest hotel in Depew is $92. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Depew?
There are 880 hotels in Depew on Travelocity.
What are the best hotels in Depew?
Depew has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Depew for you!
When is the best time to visit Depew?
If you want the joy of a fun-filled trip in peak season, visit Depew during June, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Depew?
Based on historic data is usually the cheapest month to visit Depew. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Depew?
There are multiple hotels in Depew that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Depew. We have plenty of kid-friendly hotels in Depew to choose from on Travelocity!
Why book a hotel in Depew through Travelocity?
Because we have the top hotels in Depew! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Depew on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Depew hotel reviews by fellow wanderers

Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

4 out of 5
Posted 10 hours ago
Travelocity Verified Review
"We enjoyed our stay very much! The elevator by main desk actually closed or tried to a couple times almost like sensor was not reading a person there and pretty quick needs to be looked at slammed my arm a couple times. Everyone was very helpful. The breakfast was wonderful all in all a great trip!"
A verified traveler stayed at Holiday Inn Express Grand Island - Niagara Falls by IHG
Holiday Inn Express Grand Island - Niagara Falls by IHG

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