Book Hotels in Depew, NY

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Top Depew hotels

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $178 total per night from Aug 16 to Aug 17
$178 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"I don’t have any complaints at all. Was a great stay ."

Reviewed on Aug 2, 2026

Opens in a new windowHyatt Regency Buffalo / Hotel and Conference Center
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Fully refundable
$116 nightly
The price is $136 total per night from Aug 10 to Aug 11
$136 total
Aug 10 - Aug 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free self parking, and a free airport shuttle. Traveling on business? Take advantage ...
"Clean, cozy, comfortable, and a great price! I would absolutely recommend especially if you are flying in or out of the Buffalo Airport. We ended up getting very delayed and landing in NY at 4am. The shuttle was still running. Staff was very New York ;), but still super helpful and accommodating. ..."

Reviewed on Aug 2, 2026

Opens in a new windowSleep Inn & Suites Buffalo Airport
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $126 total per night from Aug 3 to Aug 4
$126 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"El cuarto limpio , cama cómoda , la única situación fue con el personal de registro que fue rudo y no tienen la disposición de ayudar , había desayuno no eran tantas cosas pero lo que había era rico y fresco"

Reviewed on Aug 1, 2026

Opens in a new windowGarden Place Hotel
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $109 total per night from Aug 5 to Aug 6
$109 total
Aug 5 - Aug 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Opens in a new windowBuffalo Airport Hotel
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $122 total per night from Aug 3 to Aug 4
$122 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
Opens in a new windowM Hotel Buffalo
Comfort Inn University

Comfort Inn University

2.5 out of 5
1 Flint Rd Buffalo NY
Fully refundable
$112 nightly
The price is $127 total per night from Aug 30 to Aug 31
$127 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Opens in a new windowComfort Inn University
Fairbridge Inn Express Buffalo Airport Williamsville

Fairbridge Inn Express Buffalo Airport Williamsville

2 out of 5
7200 Transit Road Buffalo NY
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $85 total per night from Aug 3 to Aug 4
$85 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. There's luggage storage and multilingual staff can provide around-the-clock ...
Opens in a new windowFairbridge Inn Express Buffalo Airport Williamsville
Days Inn & Suites by Wyndham Niagara Falls/Buffalo

Days Inn & Suites by Wyndham Niagara Falls/Buffalo

2.5 out of 5
2821 Niagara Falls Blvd Niagara Falls NY
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $139 total per night from Aug 3 to Aug 4
$139 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
Opens in a new windowDays Inn & Suites by Wyndham Niagara Falls/Buffalo
La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst

3 out of 5
145 Innkeepers Lane Buffalo NY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $138 total per night from Aug 30 to Aug 31
$138 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham Buffalo Amherst
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Depew Hotel & Travel Guide\n

If you're thinking of exploring the Buffalo area and are looking for a place to stay in Depew, Travelocity offers an exciting assortment to decide between. Inside the resourceful booking pages, the modern traveler will find 50 flexible accommodation options within a 6-mile (10-kilometer) distance of Depew's center.

Visitors searching for a hotel in the heart of Depew should plan to stay at Pink Fountain Motor Inn.

9 miles (14 kilometers) from the town center of Depew, you will find the The Mansion On Delaware Ave. Alternatively, the Lofts on Pearl is positioned 9 miles (14 kilometers) away. Other possible Travelocity-listed hotels are the Hampton Inn & Suites Buffalo Downtown and the Hotel @ The Lafayette.

After you have seen Depew, put aside some time to investigate the other natural and cultural attractions of the Niagara Falls - Western New York area. Get to know Niagara Falls - Western New York's art galleries and theaters. You should also make the time to admire its lakes. Wise visitors in this part of United States of America will enjoy ice skating and guided nature walks.

8 miles (12 kilometers) to the west of Depew, you can reach Downtown Buffalo, home to Greater Buffalo Sports Hall of Fame and Old Erie County Hall. Some of our recommended Downtown Buffalo hotels and accommodations include the Embassy Suites Buffalo and Hyatt Regency Buffalo / Hotel and Conference Center. 9 miles (15 kilometers) to the northwest of Depew, you can also stay at Amherst, home to the Homewood Suites by Hilton Buffalo/Amherst and Residence Inn Buffalo Amherst. Should you choose to stay in Amherst, set aside some time to explore the Boulevard Mall and Lasertron.

Simply because you and your traveling partners are taking a break from your usual habits, who says you can't enjoy your passion for a day of sports. You can find First Niagara Center 9 miles (14 kilometers) to the west of Depew. Sleep right in the thick of the sporting action at the Holiday Inn Buffalo-Downtown or the Holiday Inn Express & Suites Buffalo Downtown.

For travelers flying through Buffalo Niagara International Airport, you may like to book some accommodation at Staybridge Suites Buffalo-Airport, or Hilton Garden Inn Buffalo Airport, each of which are conveniently located nearby.

Frequently asked questions

What are the top kid-friendly hotels in Depew?
Family vacations are where treasured memories are made, but it's no secret that traveling with young ones can be stressful. These kid-friendly Depew hotels come with perks that aim to keep adventurers of all ages relaxed and happy: Firemans Park Quarters will help make your adventure the best one yet. It features a range of conveniences geared toward families, such as a playground and pet-friendly facilities. Quiet suburban home 10 minutes from airport/25 min from Niagara Falls is another great choice. After a fun day of exploring Depew, come home to your comfy room and amenities like pet-friendly facilities and internet access.
Where can I find cheap hotels in Depew?
At Travelocity you'll find really nice hotels in Depew at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Depew rather than in Depew. We may find you even better rates, too.
How do I find the best Depew hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Depew then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Depew?
The cheapest hotel in Depew is $85. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Depew?
There are 895 hotels in Depew on Travelocity.
What are the best hotels in Depew?
Depew has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Depew for you!
When is the best time to visit Depew?
If you want the joy of a fun-filled trip in peak season, visit Depew during June, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Depew?
Based on historic data is usually the cheapest month to visit Depew. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Depew?
There are multiple hotels in Depew that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Depew. We have plenty of kid-friendly hotels in Depew to choose from on Travelocity!
Why book a hotel in Depew through Travelocity?
Because we have the top hotels in Depew! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Depew on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Depew hotel reviews by fellow wanderers

Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

5 out of 5
Posted 8 hours ago
Travelocity Verified Review
"Clean, cozy, comfortable, and a great price! I would absolutely recommend especially if you are flying in or out of the Buffalo Airport. We ended up getting very delayed and landing in NY at 4am. The shuttle was still running. Staff was very New York ;), but still super helpful and accommodating. Breakfast is small, but still wonderful."
A verified traveler stayed at Sleep Inn & Suites Buffalo Airport
Sleep Inn & Suites Buffalo Airport

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