Book Hotels in Depew, NY
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Top Depew hotels
Hampton Inn Buffalo - Amherst, NY
Excellent experience
Reviewed on Nov 12, 2025
Comfort Inn & Suites Niagara Falls Blvd USA
Staff very nice room clean
Reviewed on Nov 13, 2025
La Quinta Inn & Suites by Wyndham Buffalo Amherst
Spacious rooms, good wi-fi, complementary coffee during the day, free parking and breakfast. Convenient location between the airport and Niagara Falls. Mediocre cleaning, noisy neighbors (probably permanent or long time guests).
Reviewed on Nov 10, 2025
Hyatt Regency Buffalo / Hotel and Conference Center
Everything was great although lobby bar not open
Reviewed on Nov 14, 2025
Buffalo Airport Hotel
The location of the hotel and the fact there was a convenient free shuttle to the airport was very helpful. The rooms were fine, clean, albeit older. I had a lamp spark and blow the power in the room so I sat in the dark for 30 min until they could fix. The hotel is fine for a one or two night ...
Reviewed on Nov 10, 2025
Days Inn & Suites by Wyndham Niagara Falls/Buffalo
Fresh food for breakfast and parking was very safe
Reviewed on Nov 14, 2025
Garden Place Hotel
Ok
Reviewed on Nov 10, 2025
DoubleTree by Hilton Hotel Buffalo - Amherst
It was as expected for a family of 4.
Reviewed on Nov 12, 2025
M Hotel Buffalo
Very happy again, nice and helpful staff.
Reviewed on Nov 13, 2025
Depew Hotel & Travel Guide\n
If you're thinking of exploring the Buffalo area and are looking for a place to stay in Depew, Travelocity offers an exciting assortment to decide between. Inside the resourceful booking pages, the modern traveler will find 50 flexible accommodation options within a 6-mile (10-kilometer) distance of Depew's center.
Visitors searching for a hotel in the heart of Depew should plan to stay at Pink Fountain Motor Inn.
9 miles (14 kilometers) from the town center of Depew, you will find the The Mansion On Delaware Ave. Alternatively, the Lofts on Pearl is positioned 9 miles (14 kilometers) away. Other possible Travelocity-listed hotels are the Hampton Inn & Suites Buffalo Downtown and the Hotel @ The Lafayette.
After you have seen Depew, put aside some time to investigate the other natural and cultural attractions of the Niagara Falls - Western New York area. Get to know Niagara Falls - Western New York's art galleries and theaters. You should also make the time to admire its lakes. Wise visitors in this part of United States of America will enjoy ice skating and guided nature walks.
8 miles (12 kilometers) to the west of Depew, you can reach Downtown Buffalo, home to Greater Buffalo Sports Hall of Fame and Old Erie County Hall. Some of our recommended Downtown Buffalo hotels and accommodations include the Embassy Suites Buffalo and Hyatt Regency Buffalo / Hotel and Conference Center. 9 miles (15 kilometers) to the northwest of Depew, you can also stay at Amherst, home to the Homewood Suites by Hilton Buffalo/Amherst and Residence Inn Buffalo Amherst. Should you choose to stay in Amherst, set aside some time to explore the Boulevard Mall and Lasertron.
Simply because you and your traveling partners are taking a break from your usual habits, who says you can't enjoy your passion for a day of sports. You can find First Niagara Center 9 miles (14 kilometers) to the west of Depew. Sleep right in the thick of the sporting action at the Holiday Inn Buffalo-Downtown or the Holiday Inn Express & Suites Buffalo Downtown.
For travelers flying through Buffalo Niagara International Airport, you may like to book some accommodation at Staybridge Suites Buffalo-Airport, or Hilton Garden Inn Buffalo Airport, each of which are conveniently located nearby.
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Days Inn & Suites by Wyndham Niagara Falls/Buffalo
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