Book Hotels in Depew, NY
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Top Depew hotels
Hampton Inn Buffalo - Amherst, NY
Soundproofing is basically non-existent in this hotel. Every time someone moved in the room next door, kids cried, or someone ran down the hall, we heard it loud and clear in our room. Was kept up most of the night by constant noise.
Reviewed on May 10, 2026
Holiday Inn Express Grand Island - Niagara Falls by IHG
Great & clean property. Nice breakfast!
Reviewed on May 9, 2026
La Quinta Inn & Suites by Wyndham Buffalo Amherst
The hotel itself is nice and the front desk employee was courteous. I’m sure if we hadn’t found 3 different large blood stains down the side of the bed and the carpet wasn’t damp we might have better things to say. We’d go again but we’ll inspect the room first before going to sleep.
Reviewed on May 5, 2026
Buffalo Airport Hotel
Very dated, the bathroom door looked water damaged and was splintered. The bathtub was very stained but still clean. My door lock broke and I was unable to access my room for an hour. Having said that, the front desk, cleaning staff and maintenance were very good.
Reviewed on May 9, 2026
Sleep Inn & Suites Buffalo Airport
Was a group on our floor that was partying and yelling a screaming until at least 0330. We had to get up at 0430 for a procedure at the hospital and didn’t get hardly any sleep. Not acceptable. I’m reluctant to stay again if this type of activity is happening.
Reviewed on May 8, 2026
La Quinta Inn by Wyndham Buffalo Airport
Very good location and decent property. The biggest strength is their excellent staff
Reviewed on May 10, 2026
Garden Place Hotel
There was a shortage of chairs in the room. WiFi connected to La Quinta hotel next door(?). No suitcase stand in the room … it was mentioned to staff on the phone and also face to face, with no results.
Reviewed on May 9, 2026
M Hotel Buffalo
Clean room and price is fair
Reviewed on May 7, 2026
Hyatt Regency Buffalo / Hotel and Conference Center
Depew Hotel & Travel Guide\n
If you're thinking of exploring the Buffalo area and are looking for a place to stay in Depew, Travelocity offers an exciting assortment to decide between. Inside the resourceful booking pages, the modern traveler will find 50 flexible accommodation options within a 6-mile (10-kilometer) distance of Depew's center.
Visitors searching for a hotel in the heart of Depew should plan to stay at Pink Fountain Motor Inn.
9 miles (14 kilometers) from the town center of Depew, you will find the The Mansion On Delaware Ave. Alternatively, the Lofts on Pearl is positioned 9 miles (14 kilometers) away. Other possible Travelocity-listed hotels are the Hampton Inn & Suites Buffalo Downtown and the Hotel @ The Lafayette.
After you have seen Depew, put aside some time to investigate the other natural and cultural attractions of the Niagara Falls - Western New York area. Get to know Niagara Falls - Western New York's art galleries and theaters. You should also make the time to admire its lakes. Wise visitors in this part of United States of America will enjoy ice skating and guided nature walks.
8 miles (12 kilometers) to the west of Depew, you can reach Downtown Buffalo, home to Greater Buffalo Sports Hall of Fame and Old Erie County Hall. Some of our recommended Downtown Buffalo hotels and accommodations include the Embassy Suites Buffalo and Hyatt Regency Buffalo / Hotel and Conference Center. 9 miles (15 kilometers) to the northwest of Depew, you can also stay at Amherst, home to the Homewood Suites by Hilton Buffalo/Amherst and Residence Inn Buffalo Amherst. Should you choose to stay in Amherst, set aside some time to explore the Boulevard Mall and Lasertron.
Simply because you and your traveling partners are taking a break from your usual habits, who says you can't enjoy your passion for a day of sports. You can find First Niagara Center 9 miles (14 kilometers) to the west of Depew. Sleep right in the thick of the sporting action at the Holiday Inn Buffalo-Downtown or the Holiday Inn Express & Suites Buffalo Downtown.
For travelers flying through Buffalo Niagara International Airport, you may like to book some accommodation at Staybridge Suites Buffalo-Airport, or Hilton Garden Inn Buffalo Airport, each of which are conveniently located nearby.
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La Quinta Inn by Wyndham Buffalo Airport
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