Explore top 2026 5 Star Hotels in Duck Key
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Duck Key 5 Star hotels

Isla Bella Beach Resort & Spa
"Everything was good. As expected for a resort of this price. Staff are very helpful and friendly (English for some is not too good). The rooms were spacious and met our expectations— beautiful bathroom, shower was excellent. Included a bath tub as well as separate shower. 2 sinks. Very nice robes! ..."
Reviewed on Sep 11, 2026

Sea Glass Cove
Duck Key Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Duck Key to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Duck Key 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Duck Key before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Duck Key hotel reviews by fellow wanderers

Isla Bella Beach Resort & Spa
"Everything was good. As expected for a resort of this price. Staff are very helpful and friendly (English for some is not too good). The rooms were spacious and met our expectations— beautiful bathroom, shower was excellent. Included a bath tub as well as separate shower. 2 sinks. Very nice robes! The bed could have been better. It was comfortable except for the sleeping spot…. It was too soft and sunk in that spot. Time to turn the mattress or get a new one! We had a veranda room, walked right out to one of 5 pools and easy short walk to beach bar and sunset deck, Pools have nice relaxing, fun beach music. Appreciated they gave you free water bottles, metal. Not plastic. They have many water filling stations throughout the resort. Free complimentary bike rentals. Biked over to the old railroad bridge for a 2 mile ride over the water… 2 miles back. Everything was clean and classy. Good for events. Only bad thing was the iguanas; you have to watch them, they are a nuisance but are easily ‘shewed away’. Views of ocean are nice. Right on water. The smell of the washed up sargassum is noticeable. They did a good job of clearing it up. Staff quickly answered our requests for a fan and a small microwave. Would highly recommend this resort if you want to be pampered and relax."
More ways to wander Duck Key
Explore More Ways to Travel with Travelocity
- Sugar Loaf Lodge
- Hotels near Sombrero Beach
- Old Town Key West Hotels
- Resorts in Marathon
- Houseboats in Marathon
- Hotels in Marathon
- Tropical Cottages
- Tranquility Bay Beachfront Hotel and Resort
- Skipjack Resort & Marina
- Rainbow Bend Resort
- Pet Friendly in Marathon
- Kingsail Resort
- Isla Bella Beach Resort & Spa
- Hawks Cay Resort
- Gulf View Waterfront Resort
- Grassy Flats Resort & Beach Club
- Floating Sea Cove Resort & Marina
- Faro Blanco Resort Marathon Florida Keys Curio by Hilton
- Conch Key Fishing Lodge and Marina
- Coconut Cay Resort & Marina
- Budget in Marathon
- Captain Pips Marina & Hideaway
- Knight's Key Suites
- Bonefish Bay Motel
- Beach in Marathon
- Banana Bay Resort & Marina
- Lower Matecumbe Beach Hotels
- Hotels in Long Key
- Lime Tree Bay Resort
- Fiesta Key RV Resort
- Edgewater Lodge
- Hotels in Layton
- Hotels in Key West
- Southernmost Beach Resort and Guesthouses
- Pier House Resort & Spa
- Opal Key Resort & Marina Key West
- Budget in Key West
- Beach in Key West
- All-Inclusive in Key West
- Key West Historic District Hotels
- Resorts in Key Largo
- Hotels in Key Largo
- Marina Del Mar Resort and Marina
- Beach in Key Largo
- Baker's Cay Resort Key Largo Curio Collection by Hilton
- All-Inclusive in Key Largo
- Hotels in Key Colony Beach
- Glunz Ocean Beach Hotel & Resort
- Resorts in Islamorada
- Hotels in Islamorada
- The Islands of Islamorada
- Pines & Palms Resort
- Pet Friendly in Islamorada
- La Siesta Resort & Villas
- La Jolla Resort
- Islander Resort
- Fisher Inn Resort & Marina
- Coconut Cove Resort and Marina
- Chesapeake Beach Resort
- Cheeca Lodge & Spa
- Breezy Palms Resort
- Beach in Islamorada
- Amara Cay Resort
- Hotels near Duval Street
- Pet Friendly in Duck Key
- Hotels near Curry Hammock State Park
- Hotels in Conch Key
- Hotels in Big Pine Key
- Sunshine Key RV Resort & Marina
- 5 Star Hotels in Key West
- 5 Star Hotels in Islamorada
- 5 Star Hotels in Homestead
- 5 Star Hotels in Cudjoe Key
- 4 Star Hotels in Key West
- 4 Star Hotels in Key West Historic District
- 4 Star Hotels in Key Largo
- 4 Star Hotels in Islamorada
- 4 Star Hotels in Bahia Honda Key
- 3 Star Hotels in Windley Key
- 3 Star Hotels in Lower Keys
- 3 Star Hotels in Key West
- 3 Star Hotels in Key Largo
- 3 Star Hotels in Big Pine Key
- 2 Star Hotels in Lower Florida Keys
- 2 Star Hotels in Bahia Honda Key
- 4 Star Hotels in Upper Matecumbe Key
- 4 Star Hotels in Marathon
- Ocean Pointe Suites at Key Largo
- Sugarloaf Key Hotel at KOA Resort





