Explore top 2025 5 Star Hotels in Big Pine Key
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Big Pine Key 5 Star hotels
Isla Bella Beach Resort & Spa
Loved the property for a relaxing getaway. The balcony views are fabulous and photo worthy. Staff was very friendly and helpful and the grounds are beautiful. Only cons.... walls are thin. Our next door neighbors were having a great time and we heard their laughter and conversations when they were ...
Reviewed on Nov 13, 2025
Big Pine Key Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Big Pine Key to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Big Pine Key 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Big Pine Key before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Big Pine Key hotel reviews by fellow wanderers
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
More ways to wander Big Pine Key
Explore More Ways to Travel with Travelocity
- 4 Star Hotels in Marathon
- B&B in No Name Key
- No Name Key Hotels
- Rv Parks in No Name Key
- Villas in No Name Key
- Long Beach Estates Hotels
- 3 Star Hotels in Key Colony Beach
- 3 Star Hotels in Sugarloaf Shores
- Hotels near National Key Deer Refuge Visitor Center
- 3 Star Hotels in Key Largo
- 4 Star Hotels in Key Largo
- 5 Star Hotels in Key Largo
- 5 Star Hotels in Cudjoe Key
- 4 Star Hotels in Melody Key
- Cottages in Ramrod Key
- Extended Stay Hotels in Ramrod Key
- Pet Friendly Hotels in Ramrod Key
- Ramrod Key Hotels
- Vacation Homes in Ramrod Key
- 3 Star Hotels in Conch Key
- No Name Key Hotels
- Apartments in Summerland Key
- B&B in Summerland Key
- Chalets in Summerland Key
- Cottages in Summerland Key
- Country Houses in Summerland Key
- Holiday Park Resorts in Summerland Key
- Adults Only Resorts & in Summerland Key
- All Inclusive Resorts & in Summerland Key
- Cheap Hotels in Summerland Key
- Hotels with Kitchenettes in Summerland Key
- Summerland Key Hotels
- Houseboats in Summerland Key
- Motels in Summerland Key
- Vacation Homes in Summerland Key
- Rv Parks in Summerland Key
- Safari Camps in Summerland Key
- Town Houses in Summerland Key
- Treehouses in Summerland Key
- Villas in Summerland Key
- 3 Star Hotels in Lower Arsnicker Keys
- 3 Star Hotels in Plantation Key
- 5 Star Hotels in Plantation Key
- B&B in Little Torch Key
- Condos in Little Torch Key
- Cottages in Little Torch Key
- All Inclusive Resorts & in Little Torch Key
- Cheap Hotels in Little Torch Key
- Kid Friendly Hotels in Little Torch Key
- Hotels with Kitchenettes in Little Torch Key
- Noble House Hotels in Little Torch Key
- Little Torch Key Hotels
- Motels in Little Torch Key
- Vacation Homes in Little Torch Key
- Rv Parks in Little Torch Key
- Resorts in Little Torch Key
- 2 Star Hotels in Bahia Honda Key
- B&B in Bahia Honda Key
- Resorts in Bahia Honda Key
- Villas in Bahia Honda Key
- 4 Star Hotels in Islamorada
- 5 Star Hotels in Islamorada
- 3 Star Hotels in Rockland Key
- 4 Star Hotels in Rockland Key
- 2 Star Hotels in Boca Chica Key
- 3 Star Hotels in Key West
- 4 Star Hotels in Key West
- 5 Star Hotels in Key West
- Hotels near Blue Hole
- Houseboats in Middle Torch Key
- 4 Star Hotels in Upper Matecumbe Key
- 3 Star Hotels in Key Haven
- 5 Star Hotels in Key Haven
- 2 Star Hotels in Lower Matecumbe Key
- 4 Star Hotels in Lower Matecumbe Key
- 4 Star Hotels in Key West Historic District
- Tropical Bay Estates Hotels
- Hotels near Coupon Bight Aquatic Preserve
- 4 Star Hotels in Duck Key
- 5 Star Hotels in Lower Florida Keys
- 5 Star Hotels in Sunset Key