Explore top 2026 5 Star Hotels in Texas Medical Center

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Top Texas Medical Center 5 Star hotels

The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston

5 out of 5
1600 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$455 nightly
The price is $533 total per night from Jan 22 to Jan 23
$533 total
Jan 22 - Jan 23, 2026
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.6/10 Exceptional! (888 reviews)
Amazing place and excellent customer service

Reviewed on Dec 16, 2025

Opens in a new windowThe Post Oak Hotel at Uptown Houston
ACP Hotel Houston Westchase, MOD Collection by Sonesta

ACP Hotel Houston Westchase, MOD Collection by Sonesta

5 out of 5
6855 W Sam Houston Pkwy S Houston TX
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $90 total per night from Jan 21 to Jan 22
$90 total
Jan 21 - Jan 22, 2026
Total with taxes and fees
This aparthotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
7.8/10 Good! (1,007 reviews)
the room clean and very nice staffs . the hotel very close to a lot restaurant shopping market . quit place and safe .

Reviewed on Dec 20, 2025

Opens in a new windowACP Hotel Houston Westchase, MOD Collection by Sonesta
Four Seasons Hotel Houston

Four Seasons Hotel Houston

5 out of 5
1300 Lamar St Houston TX
Fully refundableReserve now, pay when you stay
$524 nightly
The price is $613 total per night from Dec 30 to Dec 31
$613 total
Dec 30 - Dec 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9/10 Wonderful! (1,000 reviews)
Room was clean

Reviewed on Dec 10, 2025

Opens in a new windowFour Seasons Hotel Houston
JW Marriott Houston Downtown

JW Marriott Houston Downtown

5 out of 5
806 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $231 total per night from Jan 2 to Jan 3
$231 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, express check-in, ...
8.8/10 Excellent! (1,001 reviews)
Clean upscale without doing too much.

Reviewed on Dec 21, 2025

Opens in a new windowJW Marriott Houston Downtown
The St. Regis Houston

The St. Regis Houston

5 out of 5
1919 Briar Oaks Ln Houston TX
Fully refundableReserve now, pay when you stay
$394 nightly
The price is $460 total per night from Jan 4 to Jan 5
$460 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Families will appreciate the onsite laundry facilities and babysitting. ...
9/10 Wonderful! (405 reviews)
Clean room and good service

Reviewed on Nov 10, 2025

Opens in a new windowThe St. Regis Houston
La Colombe d'Or Hotel

La Colombe d'Or Hotel

5 out of 5
3410 Montrose Blvd Houston TX
Fully refundableReserve now, pay when you stay
$433 nightly
The price is $506 total per night from Dec 27 to Dec 28
$506 total
Dec 27 - Dec 28
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.2/10 Wonderful! (147 reviews)
Room was great, staff good. Quiet and clean.

Reviewed on Dec 14, 2025

Opens in a new windowLa Colombe d'Or Hotel
7550 Kirby Dr

7550 Kirby Dr

5 out of 5
7550 Kirby Dr Houston TX
This apartment doesn't skimp on freebies - guests receive free WiFi and free self parking. An outdoor pool and laundry facilities are also provided.
8.2/10 Very Good! (45 reviews)
I enjoyed my stay it was worth it

Reviewed on Aug 3, 2025

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Opens in a new window7550 Kirby Dr
TUSCAN VILLA

TUSCAN VILLA

5 out of 5
3130 S Rice Ave Houston TX
This villa doesn't skimp on freebies - guests receive free WiFi and free self parking. Valet parking, dry cleaning, and luggage storage are also offered.
Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer ...

Reviewed on Jul 14, 2024

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Opens in a new windowTUSCAN VILLA
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Recent Texas Medical Center hotel reviews by fellow wanderers

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Cool hotel wasn’t expensive compared to other hotels "
A verified traveler stayed at Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston

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