Explore top 2025 5 Star Hotels in Texas Medical Center

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Top Texas Medical Center 5 Star hotels

The Post Oak Hotel at Uptown Houston

1600 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$457 nightly

$535 total

Dec 2 - Dec 3

Total with taxes and fees

A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.6/10 Exceptional! (864 reviews)

Beautiful hotel

Reviewed on Nov 10, 2025

ACP Hotel Houston Westchase, MOD Collection by Sonesta

6855 W Sam Houston Pkwy S Houston TX

Fully refundableReserve now, pay when you stay

$72 nightly

$84 total

Nov 30 - Dec 1

Total with taxes and fees

This aparthotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...

7.8/10 Good! (1,003 reviews)

Room very clean and staff take care customers good

Reviewed on Nov 15, 2025

Four Seasons Hotel Houston

1300 Lamar St Houston TX

Fully refundableReserve now, pay when you stay

$584 nightly

$684 total

Nov 21 - Nov 22

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9/10 Wonderful! (1,000 reviews)

Jacob at the front desk was awesome!

Reviewed on Aug 31, 2025

JW Marriott Houston Downtown

806 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$190 nightly

$221 total

Nov 28 - Nov 29

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, express check-in, ...

8.8/10 Excellent! (1,002 reviews)

Good

Reviewed on Nov 17, 2025

The St. Regis Houston

1919 Briar Oaks Ln Houston TX

Fully refundableReserve now, pay when you stay

$375 nightly

$439 total

Dec 14 - Dec 15

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Families will appreciate the onsite laundry facilities and babysitting. ...

9/10 Wonderful! (401 reviews)

Clean room and good service

Reviewed on Nov 10, 2025

La Colombe d'Or Hotel

3410 Montrose Blvd Houston TX

Fully refundableReserve now, pay when you stay

$427 nightly

$500 total

Nov 24 - Nov 25

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (136 reviews)

Very nice

Reviewed on Nov 15, 2025

7550 Kirby Dr

7550 Kirby Dr Houston TX

This apartment doesn't skimp on freebies - guests receive free WiFi and free self parking. An outdoor pool and laundry facilities are also provided.

8.2/10 Very Good! (45 reviews)

I enjoyed my stay it was worth it

Reviewed on Aug 3, 2025

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TUSCAN VILLA

3130 S Rice Ave Houston TX

This villa doesn't skimp on freebies - guests receive free WiFi and free self parking. Valet parking, dry cleaning, and luggage storage are also offered.

Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer ...

Reviewed on Jul 14, 2024

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