Book Hotels in Southeast Minnesota, MN
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Top Southeast Minnesota hotels
Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$107 nightly
The price is $123 total per night from Sep 25 to Sep 26
$123 total
Sep 25 - Sep 26
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"will stay again,"
Reviewed on Sep 21, 2026
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $124 total per night from Sep 27 to Sep 28
$124 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"Everything I get an apartment type room smoking and dog friendly and it’s worth every cent"
Reviewed on Sep 21, 2026
Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $169 total per night from Oct 8 to Oct 9
$169 total
Oct 8 - Oct 9
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Great proximity to Mayo for our appt. Our dinner at Essex wasn’t very good. The waiter was great! But the food was a disappointment compared to the atmosphere. The waiter explained that the chefs were not on duty—only a line cook."
Reviewed on Sep 21, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Sep 27 to Sep 28
$89 total
Sep 27 - Sep 28
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"Helped my daughter stay a little past check out time to finish a phone call remotely to the U of M"
Reviewed on Sep 21, 2026
Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $176 total per night from Oct 10 to Oct 11
$176 total
Oct 10 - Oct 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"There was a very large (by the sound of his bark) dog just down the hall from us. He had been barking for some time before we called the front desk about it. We were told that it is a dog friendly hotel and nothing they could do and she was very short with us. It took about an hour and the poor dog ..."
Reviewed on Sep 19, 2026
Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $82 total per night from Sep 22 to Sep 23
$82 total
Sep 22 - Sep 23
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"Could have stayed one more day, but the food was so gross, it dragged everything else down. Biscuits had green mold and white fuzz growing on them. Coffee was terrible all three days I tried to drink it. Too many grounds were used, by as much as 30-40% guessing on how black and syrupy it was (probably ..."
Reviewed on Sep 20, 2026
Treasure Island Resort & Casino
5734 Sturgeon Lake Road Welch MN
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $94 total per night from Oct 21 to Oct 22
$94 total
Oct 21 - Oct 22
Total with taxes and fees
This hotel features a casino, a full-service spa, and a water park. Bring the family and enjoy the lazy river, children's club, and children's pool. Enjoy the ...
Express Suites Riverport Inn & Suites
900 Bruski Dr Winona MN
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $134 total per night from Sep 22 to Sep 23
$134 total
Sep 22 - Sep 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Sep 26 to Sep 27
$108 total
Sep 26 - Sep 27
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Southeast Minnesota hotels
Red Carpet Inn Rochester
2214 South Broadway Rochester MN
$60 nightly
The price is $69 total per night from Sep 22 to Sep 23
$69 total
Sep 22 - Sep 23
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Southeast Minnesota with star-rating
Check Southeast Minnesota Hotels by Star Rating
4 Star Hotels
8 properties
Recent Southeast Minnesota hotel reviews by fellow wanderers
AmericInn by Wyndham Rochester Near Mayo Clinic
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Helped my daughter stay a little past check out time to finish a phone call remotely to the U of M"
A verified traveler stayed at AmericInn by Wyndham Rochester Near Mayo Clinic
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