Book Hotels in Southeast Minnesota, MN

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Southeast Minnesota hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Fully refundable
$113 nightly
The price is $130 total per night from May 22 to May 23
$130 total
May 22 - May 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
The hotel offers much for a relatively compact area. The room was exceptionally well designed and certainly immaculate. We enjoyed the two meals that we had in the evening because of their convenience and quality. The host and server was exceptional. The garage is a little puzzling, but if you’re ...

Reviewed on May 17, 2026

Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from May 31 to Jun 1
$160 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
The room was clean and comfortable. The location was convenient. The only downside was that staff was vacuuming in the hallway at 8pm. We had to get up early for an event.

Reviewed on May 18, 2026

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$93 nightly
The price is $107 total per night from May 23 to May 24
$107 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Clean, comfortable hotel in a great location. It’s surrounded by bars and restaurants. The parking garage attached to the hotel is not included in the nightly price but when we were there, it was only $16 for the night, not bad.

Reviewed on May 13, 2026

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
Treasure Island Resort & Casino

Treasure Island Resort & Casino

3 out of 5
5734 Sturgeon Lake Road Welch MN
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Jun 10 to Jun 11
$100 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel features a casino, a full-service spa, and a water park. Bring the family and enjoy the lazy river, children's club, and children's pool. Enjoy the ...
Everything was as expected

Reviewed on May 17, 2026

Opens in a new windowTreasure Island Resort & Casino
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from May 23 to May 24
$131 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
Dated property, but well kept. Excellent location and restaurant. Only complaint is the water pressure, found it difficult to wash my hair!

Reviewed on May 17, 2026

Opens in a new windowCenterstone Plaza Hotel Soldiers Field - Mayo Clinic Area
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $113 total per night from Jun 13 to Jun 14
$113 total
Jun 13 - Jun 14
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Goood staff

Reviewed on May 14, 2026

Opens in a new windowSpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from May 22 to May 23
$146 total
May 22 - May 23
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Staff was very friendly. Room was meticulously cleaned. Very easy to get to and from my appointments at the Mayo Clinic from the hotel.

Reviewed on May 18, 2026

Opens in a new windowKahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from May 19 to May 20
$152 total
May 19 - May 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Well, when we pulled in the parking lot, it’s just an absolutely beautiful place really nice. And when I walked inside, I thought a oh boy my husband and I have hit the jackpot. This is absolutely breathtaking. OK the room was nice. It was tiny, but very nice looking the problems I had were. There ...

Reviewed on May 15, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Great for an overnight

Reviewed on May 16, 2026

Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
Don't see what you're looking for?
See all available properties in Southeast Minnesota
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Southeast Minnesota hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Southeast Minnesota hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity