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Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$117 nightly
The price is $134 total per night from Apr 25 to Apr 26
$134 total
Apr 25 - Apr 26
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Nice clean property. Good location
Reviewed on Apr 15, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $167 total per night from Apr 19 to Apr 20
$167 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Our stay at the Aspen was amazing! They were so kind and the rooms were great. Breakfast wasn't too bad and the evening week day meals was a major plus. We will definitely be back again soon!.
Reviewed on Apr 15, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$108 nightly
The price is $124 total per night from May 10 to May 11
$124 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Bar
Reviewed on Apr 14, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from May 8 to May 9
$108 total
May 8 - May 9
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Room was clean and comfortable Staff was friendly and helpful
Reviewed on Apr 13, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Apr 19 to Apr 20
$131 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
Great place
Reviewed on Apr 13, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $144 total per night from May 15 to May 16
$144 total
May 15 - May 16
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
It was a very nice stay!
Reviewed on Apr 15, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $80 total per night from Apr 19 to Apr 20
$80 total
Apr 19 - Apr 20
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Comfortable beds and pillows, bathroom needs a little touch up.
Reviewed on Apr 15, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Apr 20 to Apr 21
$108 total
Apr 20 - Apr 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
The eggs seemed undercooked but options were good. The pool was great. Beds in the room were uncomfortable. Wish the tv had the option to have Netflix etc. overall was a decent hotel for the price.
Reviewed on Apr 14, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Apr 17 to Apr 18
$152 total
Apr 17 - Apr 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
They couldn’t find our reservation because it was booked by Expedia. The same thing happened the last time we stayed in this hotel. It took .45 minutes for them to search for our prepaid reservation.
Reviewed on Apr 16, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
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Recent Byron hotel reviews by fellow wanderers

Kahler Inn and Suites - Mayo Clinic Area
3 out of 5
Posted 12 hours ago
Travelocity Verified Review
"They couldn’t find our reservation because it was booked by Expedia. The same thing happened the last time we stayed in this hotel. It took .45 minutes for them to search for our prepaid reservation. "
A verified traveler stayed at Kahler Inn and Suites - Mayo Clinic Area
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