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Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$121 nightly
The price is $139 total per night from Apr 3 to Apr 4
$139 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Easy airport shuttle. Cleanest hotel ever stayed in.
Reviewed on Mar 16, 2026

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $79 total per night from Mar 29 to Mar 30
$79 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
Overall great!
Reviewed on Mar 15, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $175 total per night from Mar 18 to Mar 19
$175 total
Mar 18 - Mar 19
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Great amenities
Reviewed on Mar 13, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
$95 nightly
The price is $109 total per night from Apr 4 to Apr 5
$109 total
Apr 4 - Apr 5
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Good hotels
Reviewed on Mar 15, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
$94 nightly
The price is $108 total per night from Apr 3 to Apr 4
$108 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Pros: affordable, staff willing to help and breakfast Cons: bathroom flooring buckling, no pool towels (asked for some but out), hot tub was warm but not working and stains on the furniture.
Reviewed on Mar 11, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Mar 18 to Mar 19
$146 total
Mar 18 - Mar 19
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Very friendly staff, clean & quiet rooms, nice pool and hot tub. The location makes it easy for us to get to where we need to go. No complaints.
Reviewed on Mar 16, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
$79 nightly
The price is $91 total per night from Mar 18 to Mar 19
$91 total
Mar 18 - Mar 19
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
Rooms were clean. Amenities were nice. Breakfast was delicious.
Reviewed on Mar 17, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Mar 22 to Mar 23
$84 total
Mar 22 - Mar 23
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
The property is severly run down. Needs an update soon or you will start losing patrons.
Reviewed on Mar 14, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Apr 10 to Apr 11
$151 total
Apr 10 - Apr 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Yes
Reviewed on Mar 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
42 properties
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Recent Byron hotel reviews by fellow wanderers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Rooms were clean. Amenities were nice. Breakfast was delicious."
A verified traveler stayed at Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
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