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Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$113 nightly
The price is $130 total per night from May 22 to May 23
$130 total
May 22 - May 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Parking was expensive but otherwise it was fine
Reviewed on May 15, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from May 31 to Jun 1
$160 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Good
Reviewed on May 13, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$93 nightly
The price is $107 total per night from May 23 to May 24
$107 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Clean, comfortable hotel in a great location. It’s surrounded by bars and restaurants. The parking garage attached to the hotel is not included in the nightly price but when we were there, it was only $16 for the night, not bad.
Reviewed on May 13, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from May 23 to May 24
$131 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
Always a great place to stay at.
Reviewed on May 15, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
$94 nightly
The price is $108 total per night from May 23 to May 24
$108 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Goood staff
Reviewed on May 14, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from May 21 to May 22
$146 total
May 21 - May 22
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Was a good visit
Reviewed on May 15, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from May 21 to May 22
$108 total
May 21 - May 22
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
Everyone there is so ice and so helpful. As if they really cared and wanted you there. Love that there were so many ways to get to wherever you parked that it’s never far walk..the breakfast was good the bacon was really good.
Reviewed on May 15, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from May 17 to May 18
$152 total
May 17 - May 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Well, when we pulled in the parking lot, it’s just an absolutely beautiful place really nice. And when I walked inside, I thought a oh boy my husband and I have hit the jackpot. This is absolutely breathtaking. OK the room was nice. It was tiny, but very nice looking the problems I had were. There ...
Reviewed on May 15, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Clean room. Friendly staff. Warm pool. Great hot tub.
Reviewed on May 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
45 properties
Frequently asked questions
Recent Byron hotel reviews by fellow wanderers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
4 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Everyone there is so ice and so helpful. As if they really cared and wanted you there. Love that there were so many ways to get to wherever you parked that it’s never far walk..the breakfast was good the bacon was really good. "
A verified traveler stayed at Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
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