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Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$111 nightly
The price is $128 total per night from Jan 18 to Jan 19
$128 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great
Reviewed on Jan 9, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $158 total per night from Feb 14 to Feb 15
$158 total
Feb 14 - Feb 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Was supposed to have food available and there wasn't due to not having a cook. Nobody said anything at check-in, wasn't listed on their website. Cost extra to have food delivered, which we were trying to avoid.
Reviewed on Jan 12, 2026

Hampton Inn Rochester-South
1755 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $91 total per night from Feb 5 to Feb 6
$91 total
Feb 5 - Feb 6
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. You'll appreciate the free ...
Breakfast was wonderful including items for non milk drinkers. Rooms were clean, WiFi good, and pool being opened 24 hours! The heat between whirlpool and pool got a little messed up, but not a deal breaker.
Reviewed on Jan 13, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$76 nightly
The price is $88 total per night from Jan 30 to Jan 31
$88 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Great stay, convenient and Crave being attached was an added bonus.
Reviewed on Jan 9, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Feb 1 to Feb 2
$149 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Yes, everything was wonderful. Appreciate that it is right across the street from St. Mary’s.
Reviewed on Jan 9, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Jan 16 to Jan 17
$146 total
Jan 16 - Jan 17
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
The employees were very nice and polite.
Reviewed on Jan 14, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $88 total per night from Jan 25 to Jan 26
$88 total
Jan 25 - Jan 26
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
The room was spotless, the staff very friendly, breakfast more than needed, coffee the best of anyplace we've stayed.
Reviewed on Jan 13, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Jan 16 to Jan 17
$152 total
Jan 16 - Jan 17
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
It is great but very noisy next to active construction. Very hard to rest in between appointments. BRING EAR PLUGS.
Reviewed on Jan 15, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE Rochester MN
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $88 total per night from Jan 18 to Jan 19
$88 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the ...
Clean and nice rooms
Reviewed on Jan 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
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3 Star Hotels
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Recent Byron hotel reviews by fellow wanderers

Kahler Inn and Suites - Mayo Clinic Area
5 out of 5
Posted 19 hours ago
Travelocity Verified Review
"It is great but very noisy next to active construction. Very hard to rest in between appointments. BRING EAR PLUGS. "
A verified traveler stayed at Kahler Inn and Suites - Mayo Clinic Area
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