Book Hotels in Byron, MN
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Top Byron hotels

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $79 total per night from Dec 7 to Dec 8
$79 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
Yes the room was clean and the staff was very curious.
Reviewed on Nov 20, 2025

Hampton Inn Rochester-South
1755 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $95 total per night from Dec 12 to Dec 13
$95 total
Dec 12 - Dec 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. You'll appreciate the free ...
The hotel was very nice and clean. The staff was great!
Reviewed on Nov 13, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$79 nightly
The price is $91 total per night from Dec 20 to Dec 21
$91 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
The hotel was clean and nice. We were woken up at 2 am by some loud neighbors but the front desk was receptive to helping with that.
Reviewed on Nov 15, 2025

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $142 total per night from Nov 23 to Nov 24
$142 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
Excellent facility. Wonderful people!
Reviewed on Nov 21, 2025

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Dec 12 to Dec 13
$108 total
Dec 12 - Dec 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
good
Reviewed on Nov 16, 2025

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Nov 26 to Nov 27
$152 total
Nov 26 - Nov 27
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Yes
Reviewed on Nov 20, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Nov 25 to Nov 26
$84 total
Nov 25 - Nov 26
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
nice and quiet, no problems
Reviewed on Nov 20, 2025

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $175 total per night from Nov 23 to Nov 24
$175 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
I stay here everytime I come to Mayo. I love the convenience of it. This
Reviewed on Nov 15, 2025

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $83 total per night from Dec 1 to Dec 2
$83 total
Dec 1 - Dec 2
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
Room was clean, great location, convenient to restaurant.
Reviewed on Nov 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
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3 Star Hotels
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Recent Byron hotel reviews by fellow wanderers

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
5 out of 5
Posted 23 hours ago
Travelocity Verified Review
"Excellent facility. Wonderful people!"
A verified traveler stayed at Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
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