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Top Byron hotels

Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE, Rochester, MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Sep 7 to Sep 8
$84 total
Sep 7 - Sep 8
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
"The only hot food is waffles bed was extremely comfortable staff was amazing kept up with keeping breakfast stocked and clean at all times will stay agin"

Reviewed on Aug 16, 2025

Spark by Hilton Rochester South
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW, Rochester, MN
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $119 total per night from Aug 29 to Aug 30
$119 total
Aug 29 - Aug 30
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Room smelled exceptionally clean upon opening the door! Nothing in the room was dated or worn. We haven’t seen that lately in other stays!"

Reviewed on Aug 17, 2025

Hyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway, Rochester, MN
Fully refundable
$83 nightly
The price is $95 total per night from Sep 12 to Sep 13
$95 total
Sep 12 - Sep 13
Total includes taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Close to clinic easy walk . Good food at hotel. Parking I will say was expensive ."

Reviewed on Aug 14, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Aspen Select

Aspen Select

3.5 out of 5
1215 2nd St SW, Rochester, MN
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Aug 20 to Aug 21
$151 total
Aug 20 - Aug 21
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
"Very affordable The property seems a bit run down and breakfast was not great. The staff was really nice and helpful. The rooms were well maintained."

Reviewed on Aug 16, 2025

Aspen Select
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $140 total per night from Aug 21 to Aug 22
$140 total
Aug 21 - Aug 22
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Great hotel! Directly across from Mayo Clinic."

Reviewed on Aug 16, 2025

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S, Rochester, MN
$74 nightly
The price is $85 total per night from Aug 23 to Aug 24
$85 total
Aug 23 - Aug 24
Total includes taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"Very clean. Good place to stay for a night"

Reviewed on Aug 14, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $140 total per night from Aug 21 to Aug 22
$140 total
Aug 21 - Aug 22
Total includes taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"It’s great because it connects to Mayo in the subway level"

Reviewed on Aug 16, 2025

Kahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Aug 20 to Aug 21
$92 total
Aug 20 - Aug 21
Total includes taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
Ok
"Fine"

Reviewed on Aug 12, 2025

Med City Inn & Suites - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE, Rochester, MN
$72 nightly
The price is $83 total per night from Aug 24 to Aug 25
$83 total
Aug 24 - Aug 25
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the ...
"nice room"

Reviewed on Aug 15, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Byron?
Take some of the worries out of traveling with youngsters by choosing a family-friendly hotel in Byron. From thoughtful amenities to services that bring a smile, these stays offer perks that'll help make your getaway run like a dream: Put your bags down at Luxury Custom Home in Golf Community. It comes with a fireplace, pet-friendly facilities and a flair for making families feel welcome. Also check out the deals at Rochesters Relaxing Ranch - 4 miles from Mayo. It comes with a king bed, free WiFi and ample opportunities for precious family time.
Where can I find cheap hotels in Byron?
At Travelocity you'll find really nice hotels in Byron at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Byron rather than in Byron. We may find you even better rates, too.
How do I find the best Byron hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Byron then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Byron?
The cheapest hotel in Byron is $83. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Byron?
There are 371 hotels in Byron on Travelocity.
What are the best hotels in Byron?
Byron has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Byron for you!
When is the best time to visit Byron?
If you want the joy of a fun-filled trip in peak season, visit Byron during March, May and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Byron?
Based on historic data is usually the cheapest month to visit Byron. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Byron?
There are multiple hotels in Byron that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Byron. We have plenty of kid-friendly hotels in Byron to choose from on Travelocity!
Why book a hotel in Byron through Travelocity?
Because we have the top hotels in Byron! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Byron on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Byron hotel reviews by fellow wanderers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Exceptional Being a Mayo patient, and trying 3 other properties, this by far is the best The Housekeeping far exceed other competitors Our room was vert spacious The bed was comfy as were pillows TJ Maxx is walkable as is the Health Food store Sports Bar is just off hotel parking lot All the staff very helpful and efficient Water Park pool is in hotel There’s an adequate gym "
A verified traveler stayed at Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
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