Book Hotels in Byron, MN
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Top Byron hotels

The Berkman
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $145 total per night from Nov 25 to Nov 26
$145 total
Nov 25 - Nov 26
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
All of the above. Room and staff were great! Never had any issues and will be coming back again and again! Thank you!
Reviewed on Nov 11, 2025

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $79 total per night from Dec 7 to Dec 8
$79 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
Yes the room was clean and the staff was very curious.
Reviewed on Nov 20, 2025

Hampton Inn Rochester-South
1755 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from Dec 22 to Dec 23
$94 total
Dec 22 - Dec 23
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. You'll appreciate the free ...
Very clean room, friendly staff, great breakfast. Felt very safe
Reviewed on Nov 20, 2025

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Nov 25 to Nov 26
$149 total
Nov 25 - Nov 26
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Front desk staff was super friendly and helpful. Easy walk to the Mayo campus was nice. Bathroom had a lingering odor.
Reviewed on Nov 20, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$79 nightly
The price is $91 total per night from Dec 20 to Dec 21
$91 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
The hotel was clean and nice. We were woken up at 2 am by some loud neighbors but the front desk was receptive to helping with that.
Reviewed on Nov 15, 2025

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $102 total per night from Dec 12 to Dec 13
$102 total
Dec 12 - Dec 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Check in was easy. Room was great for me & my sister. All the staff was friendly and helpful. Had a great breakfast buffet. Clean room and great hotel. I would recommend to anyone. You can’t beat the location.
Reviewed on Nov 22, 2025

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Dec 12 to Dec 13
$128 total
Dec 12 - Dec 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Yes
Reviewed on Nov 20, 2025

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $125 total per night from Nov 25 to Nov 26
$125 total
Nov 25 - Nov 26
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Safe and convenient to Mayo clinic
Reviewed on Nov 21, 2025

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Dec 3 to Dec 4
$92 total
Dec 3 - Dec 4
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
Room was clean, great location, convenient to restaurant.
Reviewed on Nov 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
42 properties
Frequently asked questions
Recent Byron hotel reviews by fellow wanderers

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Check in was easy. Room was great for me & my sister. All the staff was friendly and helpful. Had a great breakfast buffet. Clean room and great hotel. I would recommend to anyone. You can’t beat the location."
A verified traveler stayed at SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
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