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Top Byron hotels

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Dec 11 to Dec 12
$128 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Great spot especially for anyone with Mayo appts."
Reviewed on Nov 11, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Nov 14 to Nov 15
$131 total
Nov 14 - Nov 15
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"Wonderful as always!!!!!!"
Reviewed on Nov 11, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $171 total per night from Dec 12 to Dec 13
$171 total
Dec 12 - Dec 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The food at the restaurant and room service were great. Comfortable seating and excellent table service."
Reviewed on Nov 11, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
$137 nightly
The price is $158 total per night from Nov 22 to Nov 23
$158 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"Great location and nice and comfy rooms"
Reviewed on Nov 11, 2026

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Dec 12 to Dec 13
$84 total
Dec 12 - Dec 13
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"The room we were provided was not what we paid for. The overall condition was extremely disappointing and unclean. The carpets were heavily stained, the bathroom was dirty, and the toilet paper was waterlogged. Both the hallways and the room had unpleasant odors. To make matters worse, when we went ..."
Reviewed on Nov 11, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
$73 nightly
The price is $84 total per night from Dec 6 to Dec 7
$84 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

Brentwood Inn & Suites
123 Fourth Ave. NW Rochester MN
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $138 total per night from Nov 12 to Nov 13
$138 total
Nov 12 - Nov 13
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the 24-hour business ...

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$97 nightly
The price is $112 total per night from Nov 28 to Nov 29
$112 total
Nov 28 - Nov 29
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

The Berkman
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $241 total per night from Dec 1 to Dec 2
$241 total
Dec 1 - Dec 2
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

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3 Star Hotels
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Recent Byron hotel reviews by fellow wanderers

Kahler Grand Hotel
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"The food at the restaurant and room service were great. Comfortable seating and excellent table service."
A verified traveler stayed at Kahler Grand Hotel
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