Book Hotels in Byron, MN

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Fully refundable
$126 nightly
The price is $145 total per night from Mar 6 to Mar 7
$145 total
Mar 6 - Mar 7
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean, great staff & close to St Mary’s hospital

Reviewed on Feb 28, 2026

Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Aspen Suites

Aspen Suites

3 out of 5
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Mar 7 to Mar 8
$149 total
Mar 7 - Mar 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Nice amenities, enclosed parking, great staff

Reviewed on Mar 1, 2026

Opens in a new windowAspen Suites
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Mar 14 to Mar 15
$160 total
Mar 14 - Mar 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Staff, location, clean & soup in the evenings.

Reviewed on Feb 25, 2026

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$95 nightly
The price is $109 total per night from Mar 14 to Mar 15
$109 total
Mar 14 - Mar 15
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
The hotel layout and parking are confusing. Our room had a large window opening to a public area so had to keep the curtains drawn for privacy. Room was very clean. The Skywalk to the Civic Center was really nice in the winter weather. Long walk but better than being in the snow and cold. The amount ...

Reviewed on Mar 1, 2026

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

2.5 out of 5
4141 Maine Avenue SE Rochester MN
Fully refundable
$93 nightly
The price is $107 total per night from Mar 9 to Mar 10
$107 total
Mar 9 - Mar 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Room was very clean, staff was friendly and polite, this hotel has a pool and workout room, beds are comfortable, also have a hot breakfast!

Reviewed on Feb 27, 2026

Opens in a new windowHoliday Inn Express Rochester South - Mayo Area by IHG
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Mar 4 to Mar 5
$146 total
Mar 4 - Mar 5
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Room was clean and comfortable

Reviewed on Mar 1, 2026

Opens in a new windowKahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $88 total per night from Mar 20 to Mar 21
$88 total
Mar 20 - Mar 21
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Clean rooms, courteous staff, good location

Reviewed on Mar 1, 2026

Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Mar 3 to Mar 4
$152 total
Mar 3 - Mar 4
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Clean. Courteous staff.

Reviewed on Mar 1, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $173 total per night from Mar 28 to Mar 29
$173 total
Mar 28 - Mar 29
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Opens in a new windowThe Berkman
Don't see what you're looking for?
See all available properties in Byron
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Byron?
Take some of the worries out of traveling with youngsters by choosing a family-friendly hotel in Byron. From thoughtful amenities to services that bring a smile, these stays offer perks that'll help make your getaway run like a dream: Put your bags down at Luxury Custom Home in Golf Community. It comes with a fireplace, pet-friendly facilities and a flair for making families feel welcome. Also check out the deals at Rochesters Relaxing Ranch - 4 miles from Mayo. It comes with a king bed, free WiFi and ample opportunities for precious family time.
Where can I find cheap hotels in Byron?
At Travelocity you'll find really nice hotels in Byron at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Byron rather than in Byron. We may find you even better rates, too.
How do I find the best Byron hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Byron then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Byron?
The cheapest hotel in Byron is $88. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Byron?
There are 394 hotels in Byron on Travelocity.
What are the best hotels in Byron?
Byron has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Byron for you!
When is the best time to visit Byron?
If you want the joy of a fun-filled trip in peak season, visit Byron during March, May and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Byron?
Based on historic data is usually the cheapest month to visit Byron. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Byron?
There are multiple hotels in Byron that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Byron. We have plenty of kid-friendly hotels in Byron to choose from on Travelocity!
Why book a hotel in Byron through Travelocity?
Because we have the top hotels in Byron! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Byron on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Byron hotel reviews by fellow wanderers

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Comfortable, clean room. Perfect location and accessibility."
A verified traveler stayed at Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

Explore More Ways to Travel with Travelocity