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May 22 - May 24
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Top Byron 3 Star hotels

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from May 23 to May 24
$146 total
May 23 - May 24
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.4/10 Very Good! (2,101 reviews)
"The best part of our stay was the staff. Everyone was friendly and helpful. Parking was rough. The garage next to the hotel was full and I did not want to pay $34 for valet parking. The next nearest garage was a couple blocks away. With all the construction, the hotel has provided great unloading ..."

Reviewed on May 20, 2026

Opens in a new windowKahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from May 23 to May 24
$152 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
8/10 Very Good! (1,565 reviews)
"Room was clean, the breakfast was very good, only thing we didn't like was the underground parking."

Reviewed on May 20, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $113 total per night from Jun 12 to Jun 13
$113 total
Jun 12 - Jun 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
8.6/10 Excellent! (1,001 reviews)
"Yes very nice"

Reviewed on May 19, 2026

Opens in a new windowSpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from May 23 to May 24
$131 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
8.6/10 Excellent! (1,002 reviews)
"I will not stay there again."

Reviewed on May 21, 2026

Opens in a new windowCenterstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from May 31 to Jun 1
$160 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
9/10 Wonderful! (1,003 reviews)
"The staff at the Hyatt House in Rochester Minnesota was very friendly. The breakfast was great. They had fresh fruit every morning and plain Greek yogurt. The breakfast area was clean and well stocked. My only issue was in our room that there were stains on the sheets. The mattress was comfy and ..."

Reviewed on May 22, 2026

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
8/10 Very Good! (1,330 reviews)
"Needs work…beds were comfy tho"

Reviewed on May 21, 2026

Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
Marriott Rochester Mayo Clinic

Marriott Rochester Mayo Clinic

3.5 out of 5
101 1st Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $218 total per night from May 23 to May 24
$218 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, ...
8.4/10 Very Good! (553 reviews)
"Very convenient for Mayo appointments"

Reviewed on May 4, 2026

Opens in a new windowMarriott Rochester Mayo Clinic
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$103 nightly
The price is $119 total per night from May 25 to May 26
$119 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
8.8/10 Excellent! (1,002 reviews)
"The room was ok, the beds were comfortable. Housekeeping never came even though we requested them in writing; so a 4 night stay with no housekeeping. The common areas were not well maintained, hallways are dark and common staircases look neglected. Good proximity to Mayo, but we will not stay here ..."

Reviewed on May 22, 2026

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Jun 7 to Jun 8
$89 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
9.4/10 Exceptional! (481 reviews)
"Everything was adequate."

Reviewed on May 19, 2026

Opens in a new windowSpark by Hilton Rochester South
Aspen Select

Aspen Select

3.5 out of 5
1215 2nd St SW Rochester MN
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $130 total per night from May 30 to May 31
$130 total
May 30 - May 31
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
8.4/10 Very Good! (1,002 reviews)
"Clean room and bathroom. Perfect climate control in room. Great on-site free parking. Simple good free breakfast. Nice place to relax and refresh. Very close to a great restaurant. Breakfast, lunch, and dinner or a cocktail."

Reviewed on May 20, 2026

Opens in a new windowAspen Select
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3 Star Hotels Byron

Maybe you’ve got to travel for work, or perhaps you’re finally ready to book that much-deserved vacation—regardless, it’s time for you to get on a plane and you’re going to make the most of it. You’ve traveled enough to know how important a comfy bed and room service can be, so booking a hotel with all the amenities you need is a priority.

You can find 3 star hotels in Byron that keep you close to all the great sightseeing and activities around the area, or even book a place that’s a bit more secluded, if that’s what you prefer. No matter what you’re looking for—whether you’re all about the location or are invested in on-site perks--Travelocity will help you find the accommodation that works best for you.

When it comes to options, you’ll have them. The Byron 3 star hotels give you plenty of choices as far as access to the best areas, and many also offer a breakfast buffet, as well as plenty of other amenities like high-speed Wi-Fi and an on-site pool or spa.

Whatever you’re looking for on your next getaway, browse Travelocity’s big selection of hotels to ensure you get the best possible deal. Book one of the best 3 star hotels in Byron today!

Recent Byron hotel reviews by fellow wanderers

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3 out of 5
Posted 7 hours ago
Travelocity Verified Review
"The room was ok, the beds were comfortable. Housekeeping never came even though we requested them in writing; so a 4 night stay with no housekeeping. The common areas were not well maintained, hallways are dark and common staircases look neglected. Good proximity to Mayo, but we will not stay here again if we have other options."
A verified traveler stayed at Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG

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