Book Hotels in Northeast Missouri, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Northeast Missouri hotels
Drury Plaza Hotel St. Louis Union Station
201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $139 total per night from Nov 1 to Nov 2
$139 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Very nice hotel!"
Reviewed on Oct 3, 2026
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Oct 25 to Oct 26
$110 total
Oct 25 - Oct 26
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"The property is well located, clean and generally well maintained. The shower system is great with the ability to set your own temperature! The breakfasts are included in the room rate and feature both hot and cold items. Parking is easy and at a minimal cost. The property contains a fitness center ..."
Reviewed on Oct 3, 2026
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from Oct 11 to Oct 12
$106 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $138 total per night from Oct 18 to Oct 19
$138 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
Pear Tree Inn St. Louis Near Union Station
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $122 total per night from Oct 11 to Oct 12
$122 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Oct 4 to Oct 5
$144 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $128 total per night from Nov 1 to Nov 2
$128 total
Nov 1 - Nov 2
Total with taxes and fees
A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
Sonesta ES Suites St. Louis - Chesterfield
15431 Conway Rd Chesterfield MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $114 total per night from Nov 1 to Nov 2
$114 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free ...
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from Oct 25 to Oct 26
$173 total
Oct 25 - Oct 26
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Don't see what you're looking for?
See all available properties in Northeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Northeast Missouri hotels
Quality Inn Saint Louis Airport
10232 Natural Bridge Rd St. Louis MO
$59 nightly
The price is $69 total per night from Oct 25 to Oct 26
$69 total
Oct 25 - Oct 26
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Northeast Missouri with star-rating
Check Northeast Missouri Hotels by Star Rating
5 Star Hotels
1 properties
Recent Northeast Missouri hotel reviews by fellow wanderers
Drury Plaza Hotel St. Louis Union Station
4 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Very nice hotel!"
A verified traveler stayed at Drury Plaza Hotel St. Louis Union Station
Explore More Ways to Travel with Travelocity
- Hotels near Long Branch State Park
- Cabins in Macon
- Apartments in Macon
- Hotels in Huntsville
- Lodges in Hurdland
- Hotels in Kirksville
- Hotels in La Grange
- Hotels in Macon
- Privatevacationhomes in Macon
- Hotels near Mark Twain Casino
- Hotels near Mark Twain Lake
- Hotels near Mark Twain State Park
- Hotels in Maywood
- Hotels in Memphis
- Hotels in Mexico
- Hotels in Moberly
- Apartments in Monroe City
- Cabins in Monroe City
- Hotels in Monroe City
- Motels in Monroe City
- Privatevacationhomes in Monroe City
- Agritourism in Northeast Missouri
- Bedandbreakfast in Northeast Missouri
- Cabins in Northeast Missouri
- Aparthotels in Northeast Missouri
- Hostels in Northeast Missouri
- Adults Only in Northeast Missouri
- Arcade in Northeast Missouri
- Romantic in Northeast Missouri
- Winery in Northeast Missouri
- Lodges in Northeast Missouri
- Hotels in Palmyra
- Hotels in Paris
- Hotels in Perry
- Hotels in Rutledge
- Bedandbreakfast in Shelbina
- Cabins in Shelbina
- Hotels in Shelbina
- Agritourism in Shelbyville
- Hotels in Shelbyville
- Cabins in Stoutsville
- Hotels in Stoutsville
- Hotels near Truman State University
- Hotels in Vandalia
- Hotels near A T Still University
- Hotels in Atlanta
- Hotels in Bevier
- Lost Branch Lodge Complete exterior remodel spring 2026
- Oak Hill Inn & Suites
- Hotels in Canton
- Macon County Hotels
- Hotels in Edina
- FairBridge Inn Express Monroe City
- Motel 6 Hannibal MO
- Hotels in Hannibal
- Cabins in Hunnewell
- Travelier Motel
- Simple Rewards Inn Shelbina
- Pet Friendly in Macon
- Indoor Pool in Macon
- Hot Tub in Macon
- Historical in Macon
- Golf in Macon
- Budget in Macon
- Americas Best Value Inn & Suites Macon at Sunset Dr
- Lodges in Macon County
- Cottages in Macon
- Historical in La Plata
- Hotels in La Plata
- Motels in Lewis County
- American Airlines Chicago (ORD) to Kirksville (IRK) flights
- Flights from Kirksville MO
- Flights from St Louis (STL) to Kirksville (IRK)
- Flights from St George (SGU) to Kirksville (IRK)
- Flights from Chicago (ORD) to Kirksville (IRK)
- Flights from Kansas City (MCI) to Kirksville (IRK)
- Flights to Monroe City
- Flights to Northeast Missouri
- Flights to Shelbina
- Flights from Detroit (DTW) to Kirksville (IRK)
- Flights from Columbia (COU) to Kirksville (IRK)
- Flights from South Burlington (BTV) to Kirksville (IRK)
- Delta Air Lines Atlanta (ATL) to Kirksville (IRK) flights
- Cape Air St Louis (STL) to Kirksville (IRK) flights
