Book Hotels in Northeast Missouri, MO

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Northeast Missouri hotels

Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3 out of 5
201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $142 total per night from Dec 11 to Dec 12
$142 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Clean room. Wonderful staff. And great freebies!!!

Reviewed on Nov 30, 2025

Opens in a new windowDrury Inn & Suites St. Louis Union Station
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $153 total per night from Dec 28 to Dec 29
$153 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area.

Reviewed on Dec 2, 2025

Opens in a new window21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Dec 7 to Dec 8
$111 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Love the breakfast buffet! Something for everyone. Staff is always friendly and helpful. I plan to stay at this hotel anytime I’m near it. I always feel so welcome.

Reviewed on Nov 30, 2025

Opens in a new windowClayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Dec 11 to Dec 12
$110 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Our stay was great, minus the fact that the hot tub was out of service. It was one of the reasons we chose this hotel so we (the parents) were disappointed. But the kids loved the pool! There were plenty of breakfast options, though adding one more waffle maker would alleviate the long wait to make ...

Reviewed on Dec 1, 2025

Opens in a new windowPear Tree Inn St. Louis Near Union Station
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $120 total per night from Dec 11 to Dec 12
$120 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
Great

Reviewed on Dec 2, 2025

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
1820 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $169 total per night from Dec 18 to Dec 19
$169 total
Dec 18 - Dec 19
Total with taxes and fees
This historic hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free ...
Great Staff!

Reviewed on Dec 1, 2025

Opens in a new windowSt. Louis Union Station Hotel, Curio Collection by Hilton
Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

3.5 out of 5
1200 S Kirkwood Road Kirkwood MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $115 total per night from Dec 8 to Dec 9
$115 total
Dec 8 - Dec 9
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
The drain in the tub was pulled out and the water didn’t get very hot. Otherwise it was a great place to stay

Reviewed on Dec 4, 2025

Opens in a new windowBest Western St. Louis-Kirkwood Route 66
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $112 total per night from Dec 14 to Dec 15
$112 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the express check-in, express check-out, and free ...
Tesla charger does not agrr

Reviewed on Dec 3, 2025

Opens in a new windowHilton St. Louis Airport
Forest Park Hotel by MDR

Forest Park Hotel by MDR

3 out of 5
5915 Wilson Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $109 total per night from Dec 7 to Dec 8
$109 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling for business? Take advantage of the 24-hour business center, ...
My entire room was clean, the staff are nice, the amenities were efficient…

Reviewed on Nov 28, 2025

Opens in a new windowForest Park Hotel by MDR
Don't see what you're looking for?
See all available properties in Northeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Northeast Missouri hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Northeast Missouri hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity