Explore top 2026 4 Star Hotels in Northeast Missouri

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Top Northeast Missouri 4 Star hotels

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
$152 nightly
The price is $179 total per night from Jul 5 to Jul 6
$179 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (723 reviews)
"Dinning and pool areas were enjoyable."

Reviewed on Jun 2, 2026

Opens in a new windowLe Méridien St. Louis Clayton
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from Jun 21 to Jun 22
$189 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,210 reviews)
"Location and it was really beautiful for the price."

Reviewed on Jun 6, 2026

Opens in a new windowLive by Loews - St.Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
$135 nightly
The price is $158 total per night from Jun 28 to Jun 29
$158 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,093 reviews)
"Everything to do with the Hotel was amazing. Hotels .com not so much."

Reviewed on Jun 5, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $181 total per night from Jun 12 to Jun 13
$181 total
Jun 12 - Jun 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.2/10 Very Good! (1,018 reviews)
"You should never have to pay for parking at the hotel you are staying at. Changing $40 for self parking at their own property garage after paying over $200 for a room will make me never staying there ever again."

Reviewed on Jun 5, 2026

Opens in a new windowMarriott St. Louis Grand
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $183 total per night from Jun 14 to Jun 15
$183 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,887 reviews)
"The room was clean and the bathroom was great! The shower was the absolute best!! The property was very nice, there was plenty to do in the hotel itself and was close by to other activities in St. Louis."

Reviewed on Jun 6, 2026

Opens in a new window21C Museum Hotel St Louis
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
$209 nightly
The price is $246 total per night from Jun 14 to Jun 15
$246 total
Jun 14 - Jun 15
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,010 reviews)
"Nice hotel highly recommended"

Reviewed on Jun 5, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $113 total per night from Jun 30 to Jul 1
$113 total
Jun 30 - Jul 1
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,604 reviews)
"Very nice stay no issues and price was right"

Reviewed on Jun 5, 2026

Opens in a new windowRiver City Casino & Hotel
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4 out of 5
1 S Broadway St. Louis MO
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $204 total per night from Jun 12 to Jun 13
$204 total
Jun 12 - Jun 13
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
7.6/10 Good! (1,158 reviews)
"Staff was excellent and accommodating. Bistro food outstanding. Ideal location."

Reviewed on Jun 5, 2026

Opens in a new windowHilton St. Louis at the Ballpark
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
$114 nightly
The price is $136 total per night from Jun 28 to Jun 29
$136 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,292 reviews)
"Great location, hotel and staff! Food and drinks at the restaurant were exceptional. Everyone was very responsive and friendly. I was pleasantly surprised that the hotel was maintained so well and the rooms were large."

Reviewed on Jun 5, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $226 total per night from Jul 1 to Jul 2
$226 total
Jul 1 - Jul 2
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...
8.6/10 Excellent! (1,006 reviews)
"Room was large with separate sitting area. Shower was fantastic"

Reviewed on Jun 5, 2026

Opens in a new windowAmeristar Casino Resort and Spa
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4 Star Hotels Northeast Missouri

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Northeast Missouri 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Northeast Missouri will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Northeast Missouri, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Northeast Missouri hotel reviews by fellow wanderers

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