Explore top 2026 4 Star Hotels in Northeast Missouri

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Top Northeast Missouri 4 Star hotels

21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $183 total per night from May 3 to May 4
$183 total
May 3 - May 4
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,779 reviews)
Loved this hotel. Staff was amazing. Happy hour and food was very good. Only issue is that there is not much to do directly around hnotel...only a short walk to restaurants and hockey arena..so not awful.. Staff was so nice and hotel is very cool.

Reviewed on Apr 21, 2026

Opens in a new window21C Museum Hotel St Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from May 8 to May 9
$143 total
May 8 - May 9
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
Opens in a new windowRenaissance St. Louis Airport Hotel
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $130 total per night from Apr 22 to Apr 23
$130 total
Apr 22 - Apr 23
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,516 reviews)
Out of the city, clean, comfortable, as described, thanks!

Reviewed on Apr 21, 2026

Opens in a new windowRiver City Casino & Hotel
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $174 total per night from May 10 to May 11
$174 total
May 10 - May 11
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,005 reviews)
There was black long hair in the shower on the wall. There were 2 body was and 1 conditioner but NO shampoo. The lower shower head was facing the door so when I turned on the shower it sprayed me and all my stuff on the bathroom counter. I ordered room service and SPECIFICALLY said I had a gluten ...

Reviewed on Apr 18, 2026

Opens in a new windowThe Westin St. Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
$159 nightly
The price is $189 total per night from May 10 to May 11
$189 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,165 reviews)
Perfectly located

Reviewed on Apr 20, 2026

Opens in a new windowLive by Loews - St.Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $226 total per night from Apr 26 to Apr 27
$226 total
Apr 26 - Apr 27
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...
8.4/10 Very Good! (1,000 reviews)
Room was beautiful. Staff very helpful. Lots of parking.

Reviewed on Apr 21, 2026

Opens in a new windowAmeristar Casino Resort and Spa
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $163 total per night from May 21 to May 22
$163 total
May 21 - May 22
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.2/10 Very Good! (1,000 reviews)
Clean rooms and safe and easy access parking garage.

Reviewed on Apr 16, 2026

Opens in a new windowDoubleTree by Hilton St. Louis Forest Park
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $136 total per night from May 10 to May 11
$136 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,272 reviews)
Great hotel. Staff helped us get parking for our class B camper van so that we didn’t have to go to far to park.

Reviewed on Apr 21, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $210 total per night from May 10 to May 11
$210 total
May 10 - May 11
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,009 reviews)
Nice clean and smooth walk to see other stuff

Reviewed on Apr 19, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4 out of 5
1 S Broadway St. Louis MO
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $204 total per night from May 7 to May 8
$204 total
May 7 - May 8
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
7.6/10 Good! (1,109 reviews)
The 360 bar gives a great option for viewing the city. The hotel is right across the street from the ball park and within walking distance of the Arch

Reviewed on Apr 19, 2026

Opens in a new windowHilton St. Louis at the Ballpark
Don't see what you're looking for?
See all available properties in Northeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Northeast Missouri

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Northeast Missouri 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Northeast Missouri will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Northeast Missouri, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Northeast Missouri hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity