Explore top 2026 4 Star Hotels in Northeast Missouri

Name: Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Price range: $125 total
Rating: 8.8

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Top Northeast Missouri 4 Star hotels

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$197 nightly

$234 total

Jul 29 - Jul 30

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (1,990 reviews)

"Very elegant hotel. Room was clean and spacious. The staff were friendly, and the checkin was fast. On the 8th floor was a beautiful view of the city."

Reviewed on Jul 22, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$177 total

Aug 17 - Aug 18

Total with taxes and fees

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

8.8/10 Excellent! (1,005 reviews)

"Overall room was quiet. Bathroom needed cosmetic help. Damaged wallpaper ,stained floors, chipped mirror, damaged tile work in tub."

Reviewed on Jul 21, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$198 nightly

$234 total

Aug 3 - Aug 4

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$140 nightly

$164 total

Aug 6 - Aug 7

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,006 reviews)

"I booked a deluxe room through Expedia, but the amenities did not match the description of what I paid for. When I went to the front desk, they were very polite but not accommodating. So we get To the room, it is a small room, that looks like it hasn't been dusted in months. Went to fill the Ice ..."

Reviewed on Jul 21, 2026

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$147 nightly

$171 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,000 reviews)

"Our stay was extremely disappointing. Upon arrival, we were assigned a second-floor villa room with no elevator, requiring us to carry all of our luggage up a flight of stairs. The hallways and stairwell were visibly dirty, creating a poor first impression. When we entered our room, we were immediately ..."

Reviewed on Jul 20, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$115 nightly

$135 total

Aug 7 - Aug 8

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,124 reviews)

"I gave this location 4 stars because it looked a little sketchy when we got there. People were sitting outside in lawn chairs around 11:00 p.m. The room was decent; no issues at all. The hallways had an old smell, but overall it was great. Nothing amazing."

Reviewed on Jul 22, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$107 nightly

$126 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

9/10 Wonderful! (1,088 reviews)

"It’s a unique stay. Room was very clean. The rooftop bar is a must."

Reviewed on Jul 21, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

$148 nightly

$173 total

Aug 13 - Aug 14

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$105 nightly

$125 total

Aug 13 - Aug 14

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.8/10 Excellent! (1,335 reviews)

"I would stay at this hotel again. The staff were very nice and accommodating. The room was really clean. That is of utmost importance to me. We went to breakfast in the hotel restaurant. It was super delicious. Parking is a little bit of a problem. The valet is a bit pricey. It's a great location. ..."

Reviewed on Jul 20, 2026

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4 Star Hotels Northeast Missouri

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Northeast Missouri 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Northeast Missouri will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Northeast Missouri, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Northeast Missouri hotel reviews by fellow wanderers

River City Casino & Hotel

4 out of 5

Posted 4 hours ago

Travelocity Verified Review

"We stayed here because it was right on the river, but there wasn't a place to access a river view. Too bad. It also wasn't really close to anything interesting culturally, including great food options. If we were there to gamble, it would have been perfect in every way, though."

A verified traveler stayed at River City Casino & Hotel