Cheap Flights to Santee from $157

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How Much Does it Cost To Fly To Santee?

The cheapest prices found with in the last 7 days for return flights were $249 and $157 for one-way flights to Santee for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel DatesFlights From*
LGAWest ColumbiaMay 8 to May 11$259
DCAWest ColumbiaApril 16 to April 19$260
ORDWest ColumbiaJune 5 to June 7$274
BOSWest ColumbiaMay 28 to May 30$275
EWRWest ColumbiaApril 25 to April 27$280
JFKWest ColumbiaMay 29 to June 1$283
BDLWest ColumbiaJune 5 to June 13$313
LAXWest ColumbiaMay 29 to June 1$389
PHLWest ColumbiaMay 1 to May 2$417
DFWWest ColumbiaApril 27 to April 29$608
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
DFWWest ColumbiaMarch 29 to March 31$607
*Prices include taxes and fees

Santee Flight Information

Traveling to
Santee
Lowest Price
$249
Number of Airlines Serving
Airlines Serving
Delta, United
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Santee Accommodation Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
The price is $89 total per night from Mar 29 to Mar 30
$89 total
per night
Mar 29 - Mar 30
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Opens in a new windowBaymont by Wyndham Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
The price is $70 total per night from Mar 29 to Mar 30
$70 total
per night
Mar 29 - Mar 30
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (710 reviews)
Second time staying here. Adequate for the cost and our needs. Great location; close proximity to amenities. Easy check-in; friendly, courteous employees. Clean, large ground floor room with comfortable bed, small fridge and microwave. Convenient parking right in front of room.

Reviewed on Mar 24, 2026

Opens in a new windowTravelodge by Wyndham Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6 Santee SC
The price is $83 total per night from Mar 29 to Mar 30
$83 total
per night
Mar 29 - Mar 30
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.8/10 (446 reviews)
I originally booked one night, but because the entire staff made me feel relaxed, I decided to stay an additional night. The lady at the check-in desk said they try to get good reviews from guests. I needed to do a Microsoft Teams interview, so I needed a really good internet connection. The pool ...

Reviewed on Mar 11, 2026

Opens in a new windowSuper 8 by Wyndham Santee
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Econo Lodge Santee

Econo Lodge Santee

2 out of 5
9112 Old 6 Highway Santee SC
The price is $66 total per night from Apr 8 to Apr 9
$66 total
per night
Apr 8 - Apr 9
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee National Golf ...
6.4/10 (312 reviews)
Very clean room, fast staff, a lot of food spots nearby!

Reviewed on Mar 24, 2026

Opens in a new windowEcono Lodge Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
$121 nightly
The price is $134 total per night from Apr 13 to Apr 14
$134 total
Apr 13 - Apr 14
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,000 reviews)
We call it the discomfort inn. Never again. I couldn’t book the two places we frequent so we chose here and it’s a no in so many ways. I am now in Savannah for the same price with hotel.com in a beautiful hotel.. Clean your windows, put in room thermostats, add a ceiling fan for air circulation and ...

Reviewed on Mar 23, 2026

Opens in a new windowComfort Inn & Suites Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
$80 nightly
The price is $89 total per night from Mar 31 to Apr 1
$89 total
Mar 31 - Apr 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Opens in a new windowBaymont by Wyndham Santee
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a nightclub. Popular attractions Santee Cooper Country Club and Santee National ...
6.4/10 (553 reviews)
After booking the room and later reading reviews, I was concerned. I met with the desk clerk prior to checking in and asked to see the room first due to the reviews. He was more than happy to allow it, although he stated this is NOT the room i would be staying in, but could expect the same level ...

Reviewed on Mar 13, 2026

Opens in a new windowRamada by Wyndham Santee I-95
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Econo Lodge Santee

Econo Lodge Santee

2 out of 5
9112 Old 6 Highway Santee SC
$59 nightly
The price is $66 total per night from Apr 8 to Apr 9
$66 total
Apr 8 - Apr 9
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee National Golf ...
6.4/10 (312 reviews)
Very clean room, fast staff, a lot of food spots nearby!

Reviewed on Mar 24, 2026

Opens in a new windowEcono Lodge Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
$121 nightly
The price is $134 total per night from Apr 13 to Apr 14
$134 total
Apr 13 - Apr 14
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,000 reviews)
We call it the discomfort inn. Never again. I couldn’t book the two places we frequent so we chose here and it’s a no in so many ways. I am now in Savannah for the same price with hotel.com in a beautiful hotel.. Clean your windows, put in room thermostats, add a ceiling fan for air circulation and ...

Reviewed on Mar 23, 2026

Opens in a new windowComfort Inn & Suites Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
$128 nightly
The price is $142 total per night from Apr 20 to Apr 21
$142 total
Apr 20 - Apr 21
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,000 reviews)
This property is AMAZING!! The rooms are beautiful and well maintained. The breakfast (included) was exceptional as were the ladies preparing it and maintaining the area for cleanliness. The entire staff were helpful, polite and professional. We recommend it highly!!

Reviewed on Mar 22, 2026

Opens in a new windowHampton Inn Santee-I-95
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
$119 nightly
The price is $132 total per night from Apr 12 to Apr 13
$132 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
N/a

Reviewed on Mar 22, 2026

Opens in a new windowBest Western Plus Santee Inn
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Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
$139 nightly
The price is $154 total per night from Apr 13 to Apr 14
$154 total
Apr 13 - Apr 14
Total with taxes and fees
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8.2/10 Very Good! (1,000 reviews)
The property is very nice and convenient for the family to visit with. My only issue was that there wasn’t enough soap in the shower for two people but overall we enjoyed our stay.

Reviewed on Mar 22, 2026

Opens in a new windowHoliday Inn Santee by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Santee Flight and Hotel Packages

Santee flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Holiday Inn & Suites Columbia NE - Ft Jackson Area by IHG
Chesnut Cottage Inn
Hampton Inn Columbia-Downtown Historic District
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Plane Tickets To Santee

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When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Santee to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Santee without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Santee with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Santee today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.