Explore 5 Luxury Hotels in Santee
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Best Luxury Hotels in Santee

Comfort Inn & Suites Santee
Hotel was a little dated but clean.
Reviewed on Mar 3, 2026

Baymont by Wyndham Santee
No hot water for shower, however, oddly the sink did have hot water. Perhaps the shower head was faulty.
Reviewed on Mar 6, 2026

Red Roof Inn Santee
I haven’t be returned my $50 security yet
Reviewed on Mar 3, 2026

Ramada by Wyndham Santee I-95
Clean room and good staff
Reviewed on Mar 1, 2026

Econo Lodge Santee
We first got to the room upon a locking the door and walking in there are stains on the headboard of the bed. The dresser that was in between the two beds and the lamp that was on the dresser were absolutely filthy. The only thing that we’re clean were the microwave in the bed and the sink area. ...
Reviewed on Mar 3, 2026
Santee Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Santee luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Santee to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Santee will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Santee, and plan your next opulent escape.
Santee hotels essential information
Accommodation | 308 hotels |
|---|---|
Lowest Price | $65 |
Highest Price | $115 |
Popular hotels | Red Roof Inn Santee, Comfort Inn & Suites Santee, Baymont by Wyndham Santee, Ramada by Wyndham Santee I-95, Econo Lodge Santee |
Popular Luxury Stays in Santee
Recent Santee Hotel Reviews By Fellow Wanderers

Baymont by Wyndham Santee
Explore More Ways to Travel with Travelocity
- Hotels with Suites in South Carolina
- Hotels with Early Check-in in South Carolina
- Hotels with Pools in South Carolina
- Hotels with Childcare in South Carolina
- Hotels with a Gym in South Carolina
- Hotels with Free Parking in South Carolina
- Hotels with Tennis Courts in South Carolina
- Hotels on the Lake in South Carolina
- Hotels on the River in South Carolina
- Romantic Getaways & Hotels in South Carolina
- Spa Resorts & in South Carolina
- Cottages in Vance
- Vance Hotels
- Apartments in Eutawville
- Cabins in Eutawville
- Condos in Eutawville
- Cottages in Eutawville
- Eutawville Hotels
- Motels in Eutawville
- Vacation Homes in Eutawville
- B&B in Summerton
- Cabins in Summerton
- Condos in Summerton
- Cottages in Summerton
- Extended Stay Hotels in Summerton
- Convention Center Hotels in Summerton
- Pet Friendly Hotels in Summerton
- Red Roof Inn Hotels in Summerton
- Summerton Hotels
- Motels in Summerton
- Vacation Homes in Summerton
- Hotels with Airport Transfers in Myrtle Beach
- Hotels with Pools in Myrtle Beach
- Hotels with Tennis Courts in Myrtle Beach
- Winery Hotels in Columbia
- Hotels near Santee State Park
- All Inclusive Resorts & in French Quarter
- Golf Resorts & in French Quarter
- Hotels with Early Check-in in French Quarter
- Hotels with Air Conditioning in French Quarter
- Spa Resorts & in French Quarter
- Providence Hotels
- Cheap Hotels in St. George
- Hotels with Balconies in St. George
- Luxury Hotels in St. George
- Pet Friendly Hotels in St. George
- 3 Star Hotels in Elloree
- 5 Star Hotels in Elloree
- Elloree Hotels
- Motels in Elloree
- Vacation Homes in Elloree
- Rv Parks in Elloree
- Apartments in Holly Hill
- Holly Hill Hotels
- Vacation Homes in Holly Hill
- Beach Resorts & in Manning
- Cheap Hotels in Manning
- Convention Center Hotels in Manning
- Hotels with Pools in Manning
- Hotels with Bar in Manning
- Pet Friendly Hotels in Manning
- Adults Only Resorts & in Orangeburg
- Beach Resorts & in Orangeburg
- Cheap Hotels in Orangeburg
- Convention Center Hotels in Orangeburg
- Kid Friendly Hotels in Orangeburg
- Golf Resorts & in Orangeburg
- Historic Hotels in Orangeburg
- Hotels with Pools in Orangeburg
- Hotels with Bar in Orangeburg
- Hotels with Hot Tubs in Orangeburg
- Hotels with an Indoor Pool in Orangeburg
- Luxury Hotels in Orangeburg
- Pet Friendly Hotels in Orangeburg
- Romantic Getaways & Hotels in Orangeburg
- Spa Resorts & in Orangeburg
- Hotels with Hot Tubs in Sumter
- Pet Friendly Hotels in Sumter
- Hotels near Santee National Golf Club
- Hotels near Santee Cooper Country Club
- Hotels with a Lazy River in Charleston
- Hotels with a Gym in Charleston
- Hotels with Free Parking in Charleston
- Hotels with Kitchenettes in Charleston
- Winery Hotels in Charleston
- Pet Friendly Hotels in Orangeburg County






