Explore 5 Luxury Hotels in Santee

Name: Red Roof Inn Santee
Price range: $70 total

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Best Luxury Hotels in Santee

Comfort Inn & Suites Santee

221 Britain St Santee SC

Fully refundable

$100 nightly

$111 total

Jun 28 - Jun 29

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...

8/10 Very Good! (1,009 reviews)

"It was good for the night...breakfast was also good"

Reviewed on Jun 4, 2026

Baymont by Wyndham Santee

249 Britain Street Santee SC

Fully refundableReserve now, pay when you stay

$75 nightly

$83 total

Jun 10 - Jun 11

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

8/10 Very Good! (1,471 reviews)

"Staff was very friendly."

Reviewed on Jun 9, 2026

Ramada by Wyndham Santee I-95

123 Mall Street Santee SC

Fully refundableReserve now, pay when you stay

$71 nightly

$78 total

Jul 5 - Jul 6

Total with taxes and fees

A nightclub, a 24-hour gym, and a restaurant are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

6.4/10 (564 reviews)

"The room was very clean, the staff very friendly, and the restaurant/bar had good food and drinks and the pool tables added a unique touch!"

Reviewed on Jun 1, 2026

Econo Lodge Santee

9112 Old 6 Highway Santee SC

Fully refundableReserve now, pay when you stay

$64 nightly

$71 total

Jul 5 - Jul 6

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, luggage storage, and barbecue grills are also on offer.

6.4/10 (314 reviews)

"Expensive for the quality of the place!"

Reviewed on May 3, 2026

Red Roof Inn Santee

9091 Old Hwy 6 Santee SC

Fully refundableReserve now, pay when you stay

$63 nightly

$70 total

Jun 14 - Jun 15

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santee Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Santee luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Santee to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Santee will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Santee, and plan your next opulent escape.

Santee hotels essential information

Accommodation	301 hotels
Lowest Price	$70
Highest Price	$111
Popular hotels	Red Roof Inn Santee, Comfort Inn & Suites Santee, Baymont by Wyndham Santee, Ramada by Wyndham Santee I-95, Econo Lodge Santee