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Top Santee hotels

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
$134 nightly
The price is $149 total per night from May 4 to May 5
$149 total
May 4 - May 5
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Friendly staff, greeted by many. Room was clean and in great shape.

Reviewed on Mar 31, 2026

Opens in a new windowFairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $138 total per night from May 10 to May 11
$138 total
May 10 - May 11
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Guests will appreciate free perks like free self parking and WiFi in public areas. A 24-hour business ...
Propreté

Reviewed on Apr 18, 2026

Opens in a new windowHampton Inn Santee-I-95
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $127 total per night from May 4 to May 5
$127 total
May 4 - May 5
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Very nice Very clean and quie

Reviewed on Apr 20, 2026

Opens in a new windowTru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
$119 nightly
The price is $132 total per night from Apr 29 to Apr 30
$132 total
Apr 29 - Apr 30
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Room was clean, parking was perfect right by our room. Kimberly who checked us in was pleasant, professional & helpful.Breackfast was fresh, hot and tasty. Our cat enjoyed the stay also especially being able to look out of the window. Thank you for a great experience!

Reviewed on Apr 16, 2026

Opens in a new windowBest Western Plus Santee Inn
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Fully refundable
$131 nightly
The price is $145 total per night from May 19 to May 20
$145 total
May 19 - May 20
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
The staff was polite and help.

Reviewed on Apr 11, 2026

Opens in a new windowHoliday Inn Santee by IHG
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Apr 21 to Apr 22
$89 total
Apr 21 - Apr 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
We had our dog with us so I was happy with the outdoor entrances. However, the swimming pool has been filled with concrete so that was disappointing!

Reviewed on Apr 18, 2026

Opens in a new windowBaymont by Wyndham Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Fully refundable
$110 nightly
The price is $122 total per night from May 10 to May 11
$122 total
May 10 - May 11
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Nothings in up to date. Old and run down. Way over price!

Reviewed on Apr 18, 2026

Opens in a new windowComfort Inn & Suites Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $70 total per night from Apr 26 to Apr 27
$70 total
Apr 26 - Apr 27
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
The room was clean. The outside of the property is run down - does not look at all like the pictures on the site. The breakfast is adequate.

Reviewed on Apr 19, 2026

Opens in a new windowTravelodge by Wyndham Santee
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $66 total per night from Apr 27 to Apr 28
$66 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel features 7 restaurants and a seasonal outdoor pool. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink at ...
Opens in a new windowQuality Inn & Suites Santee I-95
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Santee hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santee Hotel & Travel Guide\n

Are you planning to journey to Orangeburg and are eager to find somewhere to rest in between making memories in Santee? Travelocity has a wide range of options. Right now, Travelocity's user-friendly booking portal contains 11 places to base yourself within a 6-mile (10-kilometer) radius of Santee's downtown.

Stay near the heart of Santee. Travelocity-listed rooms found around the area include Holiday Inn Santee and Hampton Inn Santee I-95.

The Super 8 Santee, Red Roof Inn Santee and Rodeway Inn are good accommodation options for travelers who are after budget hotels.

The Hampton Inn Manning is 20 miles (33 kilometers) from the downtown precinct of Santee. Or, alternatively, the Comfort Inn & Suites Santee is located 1 mile (2 kilometers) away. Other hotel options include the Best Western Plus Santee Inn and the Quality Inn And Suites.

Should you have the time, adventurous travelers could see more of South Carolina Midlands. Admire the terrain of South Carolina Midlands's rolling hills. In addition, you should go to its historic mansions and gardens. Outdoor-loving travelers might get involved in hiking here.

Located 20 miles (35 kilometers) west of Santee is Stilton, which is home to a variety of Travelocity-listed hotels. The Comfort Inn & Suites and Holiday Inn Express Hotel & Suites Orangeburg are among the Travelocity-registered options here.

While in town, don't miss out on hanging out with some Orangeburg sports fans at a community game. You can find Colonial Life Arena 50 miles (78 kilometers) to the northwest of Santee. Any sports fans that want to find Travelocity-listed accommodation options in the area around the stadium can choose from the Sheraton Columbia Downtown Hotel or the Hilton Columbia Center.

Located 50 miles (77 kilometers) outside the heart of Santee is Charleston International Airport. Find nearby rooms at Crowne Plaza Charleston Airport - Conv Ctr or Homewood Suites by Hilton Charleston Airport/Conv Center.

Frequently asked questions

What are the top kid-friendly hotels in Santee?
From carefully considered amenities to larger rooms, kid-friendly hotels come with features that can help transform a great family vacation into a sensational one. These Santee options make traveling with little ones child's play: The whole gang will enjoy staying at Wyndham Vacation Resorts Lake Marion. A swimming pool and free WiFi are just a couple of the things that help make this place an appealing option. Holiday Inn Santee, an IHG Hotel is another great choice. After an exciting day of exploring Santee, return to your cozy room and perks like a swimming pool and room service.
Where can I find cheap hotels in Santee?
At Travelocity you'll find really nice hotels in Santee at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Santee rather than in Santee. We may find you even better rates, too.
How do I find the best Santee hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Santee then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Santee?
The cheapest hotel in Santee is $66. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Santee?
There are 309 hotels in Santee on Travelocity.
What are the best hotels in Santee?
Santee has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Santee for you!
When is the best time to visit Santee?
If you want the joy of a fun-filled trip in peak season, visit Santee during March, April and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Santee?
Based on historic data is usually the cheapest month to visit Santee. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Santee?
There are multiple hotels in Santee that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Santee. We have plenty of kid-friendly hotels in Santee to choose from on Travelocity!
Why book a hotel in Santee through Travelocity?
Because we have the top hotels in Santee! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Santee on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

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