Book Hotels in Santee, SC

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Top Santee hotels

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
$125 nightly
The price is $139 total per night from Nov 11 to Nov 12
$139 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"Nice place. Very friendly staff. Clean rooms. Beds were really hard. Breakfast was good."

Reviewed on Oct 14, 2025

Opens in a new windowFairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $132 total per night from Nov 11 to Nov 12
$132 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Guests will appreciate free perks like free self parking and WiFi in public areas. A 24-hour business ...
"Rooms were nice size and very clean. Staff was so nice and helped us find some local spots to eat. Highly recommend"

Reviewed on Oct 16, 2025

Opens in a new windowHampton Inn Santee-I-95
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Nov 2 to Nov 3
$109 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"Room and hotel were very clean!! Staff very helpful… breakfast was great… I would recommend Tru Hilton. Great place to stay!!"

Reviewed on Oct 15, 2025

Opens in a new windowTru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98, Santee, SC
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $132 total per night from Oct 27 to Oct 28
$132 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Cockroach in our bathroom discovered soon upon our entry. The room was located next to the pool area. Furniture is dated, but showed signs of former elegance. Breakfast was excellent. Much broader selection than at most other places. We have seen the woman who oversees the breakfast area on another ..."

Reviewed on Oct 13, 2025

Opens in a new windowBest Western Plus Santee Inn
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St, Santee, SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Nov 2 to Nov 3
$112 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"The room and Hotel was clean."

Reviewed on Oct 12, 2025

Opens in a new windowComfort Inn & Suites Santee
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd, Santee, SC
Fully refundable
$118 nightly
The price is $131 total per night from Nov 18 to Nov 19
$131 total
Nov 18 - Nov 19
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Great hotel w"

Reviewed on Oct 12, 2025

Opens in a new windowHoliday Inn Santee by IHG
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Oct 22 to Oct 23
$83 total
Oct 22 - Oct 23
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
"We liked that we had room to park our truck with small trailer in the lot. Lots of hotels/motels around so felt like a traveling community."

Reviewed on Oct 16, 2025

Opens in a new windowBaymont by Wyndham Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $68 total per night from Nov 3 to Nov 4
$68 total
Nov 3 - Nov 4
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
"The counter tops and appliances needed cleaning, they were greasy. Otherwise the room was okay."

Reviewed on Oct 5, 2025

Opens in a new windowTravelodge by Wyndham Santee
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
8929 Old Number Six Highway, Santee, SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $66 total per night from Oct 27 to Oct 28
$66 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features 7 restaurants and a seasonal outdoor pool. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink at ...
Second time staying here
"The room floor was very dirty the flooring was lamantin and easy to clean I feel that it had not been cleaned in a long time other than this taking into account price and age of the hotel room was good bottoms of my socks were very dirty from walking on this floor I understand how hotels go I worked ..."

Reviewed on Oct 14, 2025

Opens in a new windowQuality Inn & Suites
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Santee hotels

Baymont by Wyndham Santee

Baymont by Wyndham Santee

249 Britain Street, Santee, SC
$75 nightly
The price is $83 total per night from Oct 22 to Oct 23
$83 total
Oct 22 - Oct 23
Total with taxes and fees
7.8/10 Good! (1,365 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santee Hotel & Travel Guide\n

Are you planning to journey to Orangeburg and are eager to find somewhere to rest in between making memories in Santee? Travelocity has a wide range of options. Right now, Travelocity's user-friendly booking portal contains 11 places to base yourself within a 6-mile (10-kilometer) radius of Santee's downtown.

Stay near the heart of Santee. Travelocity-listed rooms found around the area include Holiday Inn Santee and Hampton Inn Santee I-95.

The Super 8 Santee, Red Roof Inn Santee and Rodeway Inn are good accommodation options for travelers who are after budget hotels.

The Hampton Inn Manning is 20 miles (33 kilometers) from the downtown precinct of Santee. Or, alternatively, the Comfort Inn & Suites Santee is located 1 mile (2 kilometers) away. Other hotel options include the Best Western Plus Santee Inn and the Quality Inn And Suites.

Should you have the time, adventurous travelers could see more of South Carolina Midlands. Admire the terrain of South Carolina Midlands's rolling hills. In addition, you should go to its historic mansions and gardens. Outdoor-loving travelers might get involved in hiking here.

Located 20 miles (35 kilometers) west of Santee is Stilton, which is home to a variety of Travelocity-listed hotels. The Comfort Inn & Suites and Holiday Inn Express Hotel & Suites Orangeburg are among the Travelocity-registered options here.

While in town, don't miss out on hanging out with some Orangeburg sports fans at a community game. You can find Colonial Life Arena 50 miles (78 kilometers) to the northwest of Santee. Any sports fans that want to find Travelocity-listed accommodation options in the area around the stadium can choose from the Sheraton Columbia Downtown Hotel or the Hilton Columbia Center.

Located 50 miles (77 kilometers) outside the heart of Santee is Charleston International Airport. Find nearby rooms at Crowne Plaza Charleston Airport - Conv Ctr or Homewood Suites by Hilton Charleston Airport/Conv Center.

Frequently asked questions

What are the top kid-friendly hotels in Santee?
From carefully considered amenities to larger rooms, kid-friendly hotels come with features that can help transform a great family vacation into a sensational one. These Santee options make traveling with little ones child's play: The whole gang will enjoy staying at Wyndham Vacation Resorts Lake Marion. A swimming pool and free WiFi are just a couple of the things that help make this place an appealing option. Holiday Inn Santee, an IHG Hotel is another great choice. After an exciting day of exploring Santee, return to your cozy room and perks like a swimming pool and room service.
Where can I find cheap hotels in Santee?
At Travelocity you'll find really nice hotels in Santee at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Santee rather than in Santee. We may find you even better rates, too.
How do I find the best Santee hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Santee then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Santee?
The cheapest hotel in Santee is $66. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Santee?
There are 290 hotels in Santee on Travelocity.
What are the best hotels in Santee?
Santee has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Santee for you!
When is the best time to visit Santee?
If you want the joy of a fun-filled trip in peak season, visit Santee during March, April and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Santee?
Based on historic data is usually the cheapest month to visit Santee. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Santee?
There are multiple hotels in Santee that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Santee. We have plenty of kid-friendly hotels in Santee to choose from on Travelocity!
Why book a hotel in Santee through Travelocity?
Because we have the top hotels in Santee! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Santee on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Santee hotel reviews by fellow wanderers

Baymont by Wyndham Santee

Baymont by Wyndham Santee

5 out of 5
Posted 5 days ago
Travelocity Verified Review
"We liked that we had room to park our truck with small trailer in the lot. Lots of hotels/motels around so felt like a traveling community. "
A verified traveler stayed at Baymont by Wyndham Santee
Baymont by Wyndham Santee

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