Book Hotels in Santee, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Santee hotels

Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $123 total per night from Sep 20 to Sep 21
$123 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"the room was clean,the breakfest was good all you can eat , the pool was large and clean."

Reviewed on Aug 31, 2026

Opens in a new windowBest Western Plus Santee Inn
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Sep 6 to Sep 7
$89 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
"Very run down hotel. Had multiple issues wrong in the room."

Reviewed on Sep 5, 2026

Opens in a new windowBaymont by Wyndham Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Fully refundable
$102 nightly
The price is $113 total per night from Sep 27 to Sep 28
$113 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"GOOD"

Reviewed on Sep 4, 2026

Opens in a new windowComfort Inn & Suites Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $71 total per night from Sep 6 to Sep 7
$71 total
Sep 6 - Sep 7
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
"The a/c wasn't on when we arrived in about 90 degree weather. The room had a horrific musty smell which didn't clear when we turned the a/c on. We couldn't stay there breathing in that smell. My husband told the person at the front desk we couldn't stay there because of me getting sick from the musty ..."

Reviewed on Sep 4, 2026

Opens in a new windowTravelodge by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $108 total per night from Sep 13 to Sep 14
$108 total
Sep 13 - Sep 14
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Opens in a new windowTru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $144 total per night from Sep 15 to Sep 16
$144 total
Sep 15 - Sep 16
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Opens in a new windowFairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $138 total per night from Sep 13 to Sep 14
$138 total
Sep 13 - Sep 14
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Guests will appreciate free perks like free self parking and WiFi in public areas. A 24-hour business ...
Opens in a new windowHampton Inn Santee-I-95
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Fully refundable
$101 nightly
The price is $112 total per night from Sep 27 to Sep 28
$112 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Opens in a new windowHoliday Inn Santee by IHG
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $77 total per night from Sep 27 to Sep 28
$77 total
Sep 27 - Sep 28
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
Opens in a new windowRamada by Wyndham Santee I-95
Don't see what you're looking for?
See all available properties in Santee
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Santee hotels

Baymont by Wyndham Santee

Baymont by Wyndham Santee

249 Britain Street Santee SC
$80 nightly
The price is $89 total per night from Sep 6 to Sep 7
$89 total
Sep 6 - Sep 7
Total with taxes and fees
8/10 Very Good! (1,486 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santee Hotel & Travel Guide\n

Are you planning to journey to Orangeburg and are eager to find somewhere to rest in between making memories in Santee? Travelocity has a wide range of options. Right now, Travelocity's user-friendly booking portal contains 11 places to base yourself within a 6-mile (10-kilometer) radius of Santee's downtown.

Stay near the heart of Santee. Travelocity-listed rooms found around the area include Holiday Inn Santee and Hampton Inn Santee I-95.

The Super 8 Santee, Red Roof Inn Santee and Rodeway Inn are good accommodation options for travelers who are after budget hotels.

The Hampton Inn Manning is 20 miles (33 kilometers) from the downtown precinct of Santee. Or, alternatively, the Comfort Inn & Suites Santee is located 1 mile (2 kilometers) away. Other hotel options include the Best Western Plus Santee Inn and the Quality Inn And Suites.

Should you have the time, adventurous travelers could see more of South Carolina Midlands. Admire the terrain of South Carolina Midlands's rolling hills. In addition, you should go to its historic mansions and gardens. Outdoor-loving travelers might get involved in hiking here.

Located 20 miles (35 kilometers) west of Santee is Stilton, which is home to a variety of Travelocity-listed hotels. The Comfort Inn & Suites and Holiday Inn Express Hotel & Suites Orangeburg are among the Travelocity-registered options here.

While in town, don't miss out on hanging out with some Orangeburg sports fans at a community game. You can find Colonial Life Arena 50 miles (78 kilometers) to the northwest of Santee. Any sports fans that want to find Travelocity-listed accommodation options in the area around the stadium can choose from the Sheraton Columbia Downtown Hotel or the Hilton Columbia Center.

Located 50 miles (77 kilometers) outside the heart of Santee is Charleston International Airport. Find nearby rooms at Crowne Plaza Charleston Airport - Conv Ctr or Homewood Suites by Hilton Charleston Airport/Conv Center.

Frequently asked questions

What are the top kid-friendly hotels in Santee?
From carefully considered amenities to larger rooms, kid-friendly hotels come with features that can help transform a great family vacation into a sensational one. These Santee options make traveling with little ones child's play: The whole gang will enjoy staying at Wyndham Vacation Resorts Lake Marion. A swimming pool and free WiFi are just a couple of the things that help make this place an appealing option. Holiday Inn Santee, an IHG Hotel is another great choice. After an exciting day of exploring Santee, return to your cozy room and perks like a swimming pool and room service.
Where can I find cheap hotels in Santee?
At Travelocity you'll find really nice hotels in Santee at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Santee rather than in Santee. We may find you even better rates, too.
How do I find the best Santee hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Santee then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Santee?
The cheapest hotel in Santee is $64. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Santee?
There are 343 hotels in Santee on Travelocity.
What are the best hotels in Santee?
Santee has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Santee for you!
When is the best time to visit Santee?
If you want the joy of a fun-filled trip in peak season, visit Santee during March, April and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Santee?
Based on historic data is usually the cheapest month to visit Santee. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Santee?
There are multiple hotels in Santee that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Santee. We have plenty of kid-friendly hotels in Santee to choose from on Travelocity!
Why book a hotel in Santee through Travelocity?
Because we have the top hotels in Santee! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Santee on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Santee hotel reviews by fellow wanderers

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

5 out of 5
Posted 16 hours ago
Travelocity Verified Review
"GOOD"
A verified traveler stayed at Comfort Inn & Suites Santee
Comfort Inn & Suites Santee

Explore More Ways to Travel with Travelocity