Book Hotels in Vance, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Vance hotels

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $138 total per night from May 10 to May 11
$138 total
May 10 - May 11
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Guests will appreciate free perks like free self parking and WiFi in public areas. A 24-hour business ...
Propreté

Reviewed on Apr 18, 2026

Opens in a new windowHampton Inn Santee-I-95
Lake Marion Getaway!

Lake Marion Getaway!

Vance SC
This vacation home features a garden, laundry facilities, and barbecue grills.
Everything was great for the most part, a few dead roaches on the floor, and there was a pair of women’s underwear folded inside one of the dish towels.

Reviewed on Oct 5, 2025

Get rates
Opens in a new windowLake Marion Getaway!
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $128 total per night from May 10 to May 11
$128 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
This place had a great breakfast and the staff was really friendly. Plus the 24 hour coffee was a plus.

Reviewed on Apr 21, 2026

Opens in a new windowTru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
$119 nightly
The price is $132 total per night from May 3 to May 4
$132 total
May 3 - May 4
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Room was clean, parking was perfect right by our room. Kimberly who checked us in was pleasant, professional & helpful.Breackfast was fresh, hot and tasty. Our cat enjoyed the stay also especially being able to look out of the window. Thank you for a great experience!

Reviewed on Apr 16, 2026

Opens in a new windowBest Western Plus Santee Inn
Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg

3 out of 5
663 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $93 total per night from May 17 to May 18
$93 total
May 17 - May 18
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Room quiet and bed comfortable

Reviewed on Apr 20, 2026

Opens in a new windowFairfield Inn by Marriott Orangeburg
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Apr 23 to Apr 24
$83 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
The location of the hotel is a little tricky to get to. It is tucked away behind a few other hotels and business. The actual physical hotel and room were neat, clean and very up to date. I will definitely stay here again. They do not have a business center and they pool is cemented in so there is ...

Reviewed on Apr 21, 2026

Opens in a new windowBaymont by Wyndham Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Fully refundable
$114 nightly
The price is $126 total per night from May 4 to May 5
$126 total
May 4 - May 5
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Nothings in up to date. Old and run down. Way over price!

Reviewed on Apr 18, 2026

Opens in a new windowComfort Inn & Suites Santee
Peach Tree Inn

Peach Tree Inn

2.5 out of 5
111 Conners Dr St. George SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $81 total per night from Apr 23 to Apr 24
$81 total
Apr 23 - Apr 24
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. If you want to take your pet along, this ...
Meubles défraîchis et déjeuner très decevant

Reviewed on Apr 21, 2026

Opens in a new windowPeach Tree Inn
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Fully refundable
$59 nightly
The price is $66 total per night from May 7 to May 8
$66 total
May 7 - May 8
Total with taxes and fees
This hotel features 7 restaurants and a seasonal outdoor pool. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink at ...
Hotel was not busy and breakfast was simple but good and fresh

Reviewed on Apr 22, 2026

Opens in a new windowQuality Inn & Suites Santee I-95
Don't see what you're looking for?
See all available properties in Vance
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vance Hotel & Travel Guide\n

Visiting Orangeburg? Want a place to lay your head? Travelocity's portal contains plenty of hotels and rooms. You can book around 11 modern accommodations within a short drive of of Vance.

Within an easy drive of Vance, are the Holiday Inn Santee and Hampton Inn Santee I-95.

You should investigate the Hampton Inn Manning along with the Comfort Inn & Suites Santee. The Hampton Inn Manning can be found just 20 miles (34 kilometers) away from the city center of Vance. The Comfort Inn & Suites Santee, is only 5 miles (8 kilometers) away. Another option is to book the Best Western Plus Santee Inn or the Quality Inn And Suites.

Why not see the myriad attractions of South Carolina Midlands during your stay in Vance? Familiarize yourself with South Carolina Midlands's historic mansions and gardens and don't forget to enjoy its rolling hills. Wise visitors in this corner of United States of America adore hiking, zip-lining and horse riding.

The nearest accommodation options in Orangeburg include Santee and Santee. Santee is 4 miles (6 kilometers) to the northwest of Vance, while Santee is 4 miles (6 kilometers) to the northwest. Santee Travelocity-registered lodgings include the Super 8 Santee and Red Roof Inn Santee. The Rodeway Inn and Whitten Inn are a number of the Travelocity-registered hotel options in Santee.

Before your Vance trip comes to an end, why not spend an hour or two enjoying the thrills and spills in the company of local spectators at an exciting game. You'll find Colonial Life Arena 50 miles (84 kilometers) to the northwest of Vance. Travelocity customers who are keen on booking a bed not too far away, make a reservation in the Sheraton Columbia Downtown Hotel or Hilton Columbia Center.

Charleston International Airport is a major entry point for those arriving in Vance. It can be found 45 miles (71 kilometers) from the downtown precinct. For modern travelers who would prefer to find a base nearby, read about Crowne Plaza Charleston Airport - Conv Ctr or Homewood Suites by Hilton Charleston Airport/Conv Center.

Frequently asked questions

What are the top kid-friendly hotels in Vance?
Family getaways are where lifelong memories are made, but traveling with children can be demanding. These kid-friendly Vance hotels come with perks that aim to keep young and old alike comfortable and happy: The whole gang will enjoy their time at Beautiful 2 bedroom vacation home, sleeps 6. A fireplace and clothes washing facilities are just a couple of the things that help make this property an attractive option. Also check out the deals at New Lakefront Deck Home with Dock, Views. It comes with a king bed, pet-friendly facilities and ample opportunities to spend time as a family.
Where can I find cheap hotels in Vance?
At Travelocity you'll find really nice hotels in Vance at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Vance rather than in Vance. We may find you even better rates, too.
How do I find the best Vance hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Vance then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Vance?
The cheapest hotel in Vance is $66. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Vance?
There are 272 hotels in Vance on Travelocity.
What are the best hotels in Vance?
Vance has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Vance for you!
When is the best time to visit Vance?
If you want the joy of a fun-filled trip in peak season, visit Vance during March, April and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and December.
When is the cheapest time to stay in Vance?
Based on historic data is usually the cheapest month to visit Vance. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Vance?
There are multiple hotels in Vance that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Vance. We have plenty of kid-friendly hotels in Vance to choose from on Travelocity!
Why book a hotel in Vance through Travelocity?
Because we have the top hotels in Vance! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Vance on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Vance hotel reviews by fellow wanderers

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Hotel was not busy and breakfast was simple but good and fresh"
A verified traveler stayed at Quality Inn & Suites Santee I-95
Quality Inn & Suites Santee I-95

Explore More Ways to Travel with Travelocity