Book Hotels in Santee, SC
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Top Santee hotels

Fairfield Inn & Suites by Marriott Santee
"I’m a picky mom traveler and I give this hotel 2 thumbs up! Hotel staff was pleasant and helpful, hotel was very clean, rooms were enjoyable. Breakfast was good! I traveled with my 3 little kids 7 and younger and we enjoyed the pool on our stop. We were on a road trip and this was a great break."
Reviewed on Jun 6, 2026

Hampton Inn Santee-I-95
"Very clean and quiet. A great place to stop on our way north."
Reviewed on Jun 5, 2026

Tru By Hilton Santee
"The staff was helpful and nice . Unfortunately, could hear the people upstairs very clearly."
Reviewed on Jun 6, 2026

Best Western Plus Santee Inn
"My regular stop driving back to Florida from NYC . Easy access off 95 back ride up to your room. Rooms are spotless very nice restaurant on the property other options nearby Pizza Hut, Waffle House, Starbucks, huddle house and the number of others. Breakfast is excellent coffee 24 hours eggs bacon ..."
Reviewed on May 31, 2026

Holiday Inn Santee by IHG
"Beds & pillows are very comfortable. Amenities needs some upgrading....I brewed a keurig cup coffee & grinds were in the cup. Toilet to upgrade & shower curtain too small. But very clean!"
Reviewed on May 30, 2026

Baymont by Wyndham Santee
"My room was miskeyed and someone walked into my room because they didn’t change the original room in the computer and so I was terrified the rest of the night and I finally fell asleep in at 6:30 AM. The dumpster guy came right outside of my door. Outside entry. It did not go well. Breakfast ..."
Reviewed on Jun 2, 2026

Comfort Inn & Suites Santee
"It was good for the night...breakfast was also good"
Reviewed on Jun 4, 2026

Travelodge by Wyndham Santee
"Room was very worn. Large deposits in corners of bath, tile broken or missing. Could not shower as handicap wouldn’t allow tub use. Had stayed there years back, quite disappointing"
Reviewed on Jun 1, 2026

Quality Inn & Suites Santee I-95
"The towels had dirt stains on them, there was hair everywhere in the bathroom, stuck to shower walls, on floor, etc…The guy that checked me in wasn’t helpful and had an attitude. It looked like dried blood on the stairwell, which was nasty, dirty. I won’t be back, too many better choices less than ..."
Reviewed on Jun 4, 2026
Cheap Santee hotels

Baymont by Wyndham Santee
Hotels in Santee with star-rating
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3 Star Hotels
Santee Hotel & Travel Guide\n
Are you planning to journey to Orangeburg and are eager to find somewhere to rest in between making memories in Santee? Travelocity has a wide range of options. Right now, Travelocity's user-friendly booking portal contains 11 places to base yourself within a 6-mile (10-kilometer) radius of Santee's downtown.
Stay near the heart of Santee. Travelocity-listed rooms found around the area include Holiday Inn Santee and Hampton Inn Santee I-95.
The Super 8 Santee, Red Roof Inn Santee and Rodeway Inn are good accommodation options for travelers who are after budget hotels.
The Hampton Inn Manning is 20 miles (33 kilometers) from the downtown precinct of Santee. Or, alternatively, the Comfort Inn & Suites Santee is located 1 mile (2 kilometers) away. Other hotel options include the Best Western Plus Santee Inn and the Quality Inn And Suites.
Should you have the time, adventurous travelers could see more of South Carolina Midlands. Admire the terrain of South Carolina Midlands's rolling hills. In addition, you should go to its historic mansions and gardens. Outdoor-loving travelers might get involved in hiking here.
Located 20 miles (35 kilometers) west of Santee is Stilton, which is home to a variety of Travelocity-listed hotels. The Comfort Inn & Suites and Holiday Inn Express Hotel & Suites Orangeburg are among the Travelocity-registered options here.
While in town, don't miss out on hanging out with some Orangeburg sports fans at a community game. You can find Colonial Life Arena 50 miles (78 kilometers) to the northwest of Santee. Any sports fans that want to find Travelocity-listed accommodation options in the area around the stadium can choose from the Sheraton Columbia Downtown Hotel or the Hilton Columbia Center.
Located 50 miles (77 kilometers) outside the heart of Santee is Charleston International Airport. Find nearby rooms at Crowne Plaza Charleston Airport - Conv Ctr or Homewood Suites by Hilton Charleston Airport/Conv Center.
Frequently asked questions
Recent Santee hotel reviews by fellow wanderers

Tru By Hilton Santee
"The staff was helpful and nice . Unfortunately, could hear the people upstairs very clearly."
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