Explore top 2026 5 Star Hotels in Panama City

Name: Hilton Panama
Price range: $252 total
Rating: 9

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$147 nightly

$162 total

Jul 26 - Jul 27

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (5,735 reviews)

"I love the breakfast"

Reviewed on Jul 13, 2026

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

Fully refundableReserve now, pay when you stay

$275 nightly

$303 total

Aug 7 - Aug 8

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

9/10 Wonderful! (1,001 reviews)

"Convenient location and a wonderful staff. Very friendly and helpful. The hotel is modern with good amenities."

Reviewed on Jul 8, 2026

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

$289 nightly

$318 total

Jul 17 - Jul 18

Total with taxes and fees

This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...

9/10 Wonderful! (1,009 reviews)

"Vibrant and very nice! Great location, beautiful facility, excellent staff and all the options right at ur fingertips tips! Great choice"

Reviewed on Jul 13, 2026

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

Fully refundableReserve now, pay when you stay

$263 nightly

$290 total

Aug 7 - Aug 8

Total with taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

9/10 Wonderful! (1,007 reviews)

"Everything was excellent service; ms. Elisa (she worked buffets restaurant) she really went above and beyond to make sure we new all the amenities the hotel had to offer. She was a wonderful unofficial concierge.thanks"

Reviewed on Jul 13, 2026

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

Fully refundableReserve now, pay when you stay

$414 nightly

$455 total

Jul 29 - Jul 30

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.8/10 Exceptional! (687 reviews)

"This hotel was absolutely beautiful. The staff were amazing, especially Carlos. He remembered my name and called me by name the entire time I was there. The rooms were beautiful and the area is perfect for sightseeing. 10 out of 10 I will be back."

Reviewed on Jul 13, 2026

Hyatt Regency Panama City

Calle 52 and Ricardo Arias Panama City Panamá Province

Fully refundableReserve now, pay when you stay

$176 nightly

$193 total

Aug 5 - Aug 6

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

9.6/10 Exceptional! (368 reviews)

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Reviewed on Jul 13, 2026

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

$127 nightly

$140 total

Jul 20 - Jul 21

Total with taxes and fees

A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...

8.8/10 Excellent! (250 reviews)

"The hotel was nice and in a good area. Edgar at the front desk was very helpful. This is a good place to stay, my friends and I were there for a week. I will say the pool is a little bit small."

Reviewed on Jul 13, 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

Fully refundableReserve now, pay when you stay

$269 nightly

$296 total

Jul 18 - Jul 19

Total with taxes and fees

This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.6/10 Exceptional! (710 reviews)

"Muy buena estadía el staff estuvo a la altura. Les doy mi recomendación deberían poner un menu Kosher para desayuno y Almuerzos para la gente que tengan dietas especiales se sientan mas a gusto."

Reviewed on Jul 10, 2026

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

$206 nightly

$227 total

Jul 26 - Jul 27

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...

8/10 Very Good! (1,005 reviews)

"Staying at the Westin Playa Bonita was a highlight of our visit to Panama. We LOVED the setting, really enjoyed the many pools, and found that staff so attentive and friendly. The views were amazing and the atmosphere incredibly relaxing. We are already planning our next visit there."

Reviewed on Jul 11, 2026

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

Fully refundableReserve now, pay when you stay

$229 nightly

$252 total

Aug 8 - Aug 9

Total with taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

9/10 Wonderful! (1,013 reviews)

"Everything was clean and excellent . The property was well maintained, the staff was amazing and the best entertainment restaurant located inside the hotel."

Reviewed on Jul 12, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.