Explore top 2025 5 Star Hotels in Panama City

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $115 total per night from Nov 5 to Nov 6
$115 total
Nov 5 - Nov 6
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,369 reviews)
"I haven't been by the pool"

Reviewed on Oct 10, 2025

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street, Panama City, Panama
$188 nightly
The price is $207 total per night from Nov 1 to Nov 2
$207 total
Nov 1 - Nov 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,000 reviews)
"Oliver was a pleasure and very informative on the surrounding areas, include very pleasant attitude with a smile on his face daily !! Thank you Oliver !!"

Reviewed on Sep 29, 2025

Opens in a new windowWaldorf Astoria Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
$237 nightly
The price is $261 total per night from Oct 24 to Oct 25
$261 total
Oct 24 - Oct 25
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,011 reviews)
"Nice property. USA prices but not surprising if you book a mariott in Panama. If I had planned better, I would have stayed in a more unique place. Seems like more of an event hotel. Cava bar had some awesome cocktails and Misi food and wine was great."

Reviewed on Oct 10, 2025

Opens in a new windowJW Marriott Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz, Veracruz, Panama
$166 nightly
The price is $183 total per night from Nov 6 to Nov 7
$183 total
Nov 6 - Nov 7
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,003 reviews)
"Hotel and facilities were outstanding. Staff was helpful and friendly. Food was fresh and delicious!! I will definitely stay again."

Reviewed on Oct 12, 2025

Opens in a new windowThe Westin Playa Bonita Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe, Panama City, Panama
Fully refundableReserve now, pay when you stay
$297 nightly
The price is $327 total per night from Nov 3 to Nov 4
$327 total
Nov 3 - Nov 4
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (514 reviews)
"Impeccable hospitality!"

Reviewed on Oct 3, 2025

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $98 total per night from Oct 26 to Oct 27
$98 total
Oct 26 - Oct 27
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (68 reviews)
"The Room was very clean, all staff were very kind and professional, the breakfast and dinner are so delicious, nothing comparative with other restaurant around."

Reviewed on Sep 22, 2025

Opens in a new windowRenaissance Panama City Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard, Panama City
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $238 total per night from Nov 9 to Nov 10
$238 total
Nov 9 - Nov 10
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (616 reviews)
"Amazing property with top service professionals in all departments across the resort. Enjoyed every single moment of my stay. Recommended to anyone traveling to Panama & wants a bit of luxury with a hint of hospitality."

Reviewed on Oct 12, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $202 total per night from Oct 25 to Oct 26
$202 total
Oct 25 - Oct 26
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
8.8/10 Excellent! (1,002 reviews)
"Nice clean property in a good area"

Reviewed on Oct 1, 2025

Opens in a new windowW Panama
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $202 total per night from Oct 25 to Oct 26
$202 total
Oct 25 - Oct 26
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,005 reviews)
"Excelent atention to detail, recomended stay."

Reviewed on Sep 20, 2025

Opens in a new windowBristol Panama, a Registry Collection Hotel
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
$225 nightly
The price is $248 total per night from Nov 9 to Nov 10
$248 total
Nov 9 - Nov 10
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,001 reviews)
"Amazing stay they accommodated me with looking for a room that i was comfortable with . I saw about 8 rooms till i was content . Amazing service , breakfast was great . Restaurant was amazing . Would definitely return ."

Reviewed on Sep 28, 2025

Opens in a new windowHilton Panama
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity