Explore top 2025 5 Star Hotels in Panama City

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Nov 10 to Nov 11
$131 total
Nov 10 - Nov 11
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,469 reviews)
Great choices of Latin and European food options.

Reviewed on Nov 3, 2025

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $189 total per night from Dec 6 to Dec 7
$189 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,001 reviews)
Upon arrival to the Waldorf, Edgar was right there to assist us with our luggage to the room. It was at that moment I knew the W.A. hospitality was about to be extraordinary.

Reviewed on Oct 22, 2025

Opens in a new windowWaldorf Astoria Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
$197 nightly
The price is $217 total per night from Dec 7 to Dec 8
$217 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,014 reviews)
Yea bar was well stocked

Reviewed on Nov 1, 2025

Opens in a new windowJW Marriott Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $197 total per night from Dec 7 to Dec 8
$197 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
8.8/10 Excellent! (1,002 reviews)
Yes

Reviewed on Nov 2, 2025

Opens in a new windowW Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe, Panama City, Panama
Fully refundableReserve now, pay when you stay
$293 nightly
The price is $322 total per night from Dec 8 to Dec 9
$322 total
Dec 8 - Dec 9
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (524 reviews)
We stayed at Sofitel Legend Casco Viejo for our anniversary, and it was perfect! The staff surprised us with a beautiful anniversary detail that made our stay so special. The hotel is stunning, peaceful, and spotless — everything was perfectly clean and well kept. Everyone was kind and attentive, ...

Reviewed on Oct 19, 2025

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $193 total per night from Dec 6 to Dec 7
$193 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,019 reviews)
Highly recommended for business trips. Very good breakfast with quality food. Nice boutique hotel vibe in the city.

Reviewed on Nov 3, 2025

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $193 total per night from Nov 18 to Nov 19
$193 total
Nov 18 - Nov 19
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,000 reviews)
Staff very friendly, clean room, amazing food&drinks

Reviewed on Nov 5, 2025

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $128 total per night from Nov 14 to Nov 15
$128 total
Nov 14 - Nov 15
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (79 reviews)
N/A

Reviewed on Oct 29, 2025

Opens in a new windowRenaissance Panama City Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard, Panama City
$179 nightly
The price is $197 total per night from Dec 5 to Dec 6
$197 total
Dec 5 - Dec 6
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (622 reviews)
This is a quality hotel with quality service. Recommend it

Reviewed on Oct 30, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $195 total per night from Dec 7 to Dec 8
$195 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,005 reviews)
This hotel is perfection - in every respect. The best location, best amenities, awesome food, great entertainment, excellent service.

Reviewed on Oct 16, 2025

Opens in a new windowHilton Panama
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Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"The rooms have been upgraded and are large, clean, and with a spectacular view of the bay. The location is excellent at the beginning (or end depending on your view point) of the cinta costera. Full breakfast with so many delicious things to choose from, some typical Panamanian food and some American choices. All of them deliciously prepared. "
A verified traveler stayed at Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel

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