Explore top 2026 5 Star Hotels in Panama City
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Panama City 5 Star hotels
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from Sep 28 to Sep 29
$151 total
Sep 28 - Sep 29
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (5,974 reviews)
"I would definitely recommend this hotel to anyone. The hotel is clean, the staff are well trained with excellent customer service skills and the breakfast is excellent. I am definitely going back. The hotel is always in the middle of city which seals the deal"
Reviewed on Sep 26, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $288 total per night from Oct 17 to Oct 18
$288 total
Oct 17 - Oct 18
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,002 reviews)
"The walls are paper thin. We could hear other people in there room doing funky things and the way the doors to the hallway are positioned it makes ever open and closed door a loud slam. We’ve stayed at a lot of 5 star hotels. Never have we not been able to sleep due to the thin walls between rooms. ..."
Reviewed on Sep 26, 2026
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$396 nightly
The price is $436 total per night from Oct 6 to Oct 7
$436 total
Oct 6 - Oct 7
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (751 reviews)
"Sofitel Legend is a wonderful place to stay. The staff are amazing."
Reviewed on Sep 20, 2026
Renaissance Panama City Hotel
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $140 total per night from Oct 9 to Oct 10
$140 total
Oct 9 - Oct 10
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (310 reviews)
"Beautiful property. I enjoyed the courteous nature of the staff."
Reviewed on Sep 24, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$279 nightly
The price is $307 total per night from Oct 24 to Oct 25
$307 total
Oct 24 - Oct 25
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
Hyatt Regency Panama City
Calle 52 and Ricardo Arias Panama City Panamá Province
Fully refundableReserve now, pay when you stay
$187 nightly
The price is $206 total per night from Oct 3 to Oct 4
$206 total
Oct 3 - Oct 4
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $296 total per night from Oct 15 to Oct 16
$296 total
Oct 15 - Oct 16
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (755 reviews)
"Had just a night stay . Wa a good experience"
Reviewed on Sep 24, 2026
W Panama
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $263 total per night from Oct 10 to Oct 11
$263 total
Oct 10 - Oct 11
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,001 reviews)
"5 star!"
Reviewed on Sep 24, 2026
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$253 nightly
The price is $279 total per night from Oct 24 to Oct 25
$279 total
Oct 24 - Oct 25
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
The Westin Playa Bonita Panama
Km 6 Road to Veracruz Veracruz Panama
$206 nightly
The price is $227 total per night from Oct 6 to Oct 7
$227 total
Oct 6 - Oct 7
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Panama City Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Panama City hotel reviews by fellow wanderers
Megapolis Hotel Panamá
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"loved my family suite !!! very spacious and cute ! awesome views… the pool was such a vibe even on the days it did rain the bar was still open. great location in the city"
A verified traveler stayed at Megapolis Hotel Panamá
More ways to wander Panama City
Explore More Ways to Travel with Travelocity
- Waymore Hotel Spa & Casino
- W Panama
- Victoria Hotel and Suites Panama
- TRYP by Wyndham Panamá Centro
- Torres de Alba Hotel & Suites
- The Santa Maria A Luxury Collection Hotel & Golf Resort Panama City
- The Executive Hotel
- Tantalo Hotel
- Spa in Panama City
- Sortis Hotel Spa & Casino Autograph Collection by Marriott
- Sonesta Hotel in Panama City
- Riande Urban Hotel
- Principe Hotel and Suites
- Plaza Paitilla Inn Hotel
- Pet Friendly in Panama City
- Ocean View in Panama City
- Luxury in Panama City
- Las Clementinas
- Las Americas Golden Tower Panama
- Smoking in Panama City
- Room Service in Panama City
- Kitchenette in Panama City
- Indoor Pool in Panama City
- Hot Tub in Panama City
- Free Airport Transportation in Panama City
- Fitness Center in Panama City
- Free Breakfast in Panama City
- Childcare in Panama City
- Balcony in Panama City
- Early Check-in in Panama City
- Airport Transportation in Panama City
- Hotel Terranova
- Hotel San Felipe
- Hotel Riu Plaza Panama
- Hospedium Princess Hotel Panama
- Hotel El Panama by Faranda Grand a member of Radisson Individuals
- Hotel Coral Suites
- Historical in Panama City
- Hilton Panama
- Sustainable in Panama City
- Golf in Panama City
- LGBT Friendly in Panama City
- Decapolis Hotel Panama City
- Business in Panama City
- Budget in Panama City
- Central Hotel Panama Casco Viejo
- Casino in Panama City
- Boutique in Panama City
- Beach in Panama City
- Arcade in Panama City
- American Trade Hotel
- All-Inclusive in Panama City
- Adults Only in Panama City
- Accor Hotels in Panama City
- Hostels in Panama City
- Guesthouses in Panama City
- Aparthotels in Panama City
- Condos in Panama City
- Capsulehotels in Panama City
- Bedandbreakfast in Panama City
- Apartments in Panama City
- Agritourism in Panama City
- El Cangrejo Hotels
- Beach Hotels in El Cangrejo
- Casco Viejo Hotels
- Campo Alegre Hotels
- Adults Only Hotels in Campo Alegre
- Bella Vista Hotels
- Adults Only Hotels in Bella Vista
- Summit Rainforest Golf Resort & All Inclusive
- Radisson Hotel Panama Canal
- MARINN Tropical Vibes Hotel
- 4 Star Hotels in Panama City
- 3 Star Hotels in Panama City
- Treehouses in Panama City
- Hotels near Uruguay Street
- Motels in Panama City
- Privatevacationhomes in Panama City
- Resorts in Panama City
- Houseboats in Panama City
- Hotels in Panama City
- Flights from North Charleston to Panama City
- Flights from Corpus Christi to Panama City
- Flights from Fort Lauderdale to Panama City
- Flights from Myrtle Beach to Panama City
- Flights from Amarillo to Panama City
- Flights from New York to Panama City
- Flights from Memphis to Panama City
- Flights to Panama City