Explore top 2026 5 Star Hotels in Panama City

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from Mar 29 to Mar 30
$151 total
Mar 29 - Mar 30
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (5,027 reviews)
Spotless. Awesome hotel. Food delicious

Reviewed on Feb 27, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$196 nightly
The price is $216 total per night from Mar 28 to Mar 29
$216 total
Mar 28 - Mar 29
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,000 reviews)
The hotel was wonderful. The entire hotel was clean, staff welcoming especially security employee Flash. The breakfast buffet was great and it was so nice that Divney the receptionist remembered our names each day. My overall stay was great and I would highly recommend this hotel to anyone visiting ...

Reviewed on Feb 23, 2026

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $219 total per night from Mar 31 to Apr 1
$219 total
Mar 31 - Apr 1
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,004 reviews)
Had a great time, room service was great as well

Reviewed on Feb 28, 2026

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$279 nightly
The price is $307 total per night from Mar 8 to Mar 9
$307 total
Mar 8 - Mar 9
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,001 reviews)
Great breakfast, service cleanliness.

Reviewed on Feb 21, 2026

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$400 nightly
The price is $439 total per night from Mar 1 to Mar 2
$439 total
Mar 1 - Mar 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (599 reviews)
The hotel was gorgeous - timeless, classy and well appointed. The only disappointment was at the speak easy where I ordered a cocktail and was brought a Taro card. As a Christ follower - it was offensive to me. I asked the waiter to take it back.

Reviewed on Feb 18, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$220 nightly
The price is $242 total per night from Mar 29 to Mar 30
$242 total
Mar 29 - Mar 30
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,001 reviews)
The room was in decent condition. Plumbing issue that took 3 days and 5 visits to fix. Food was old and cold at breakfast buffet. The concierge steered us wrong on multiple occasions when asking for recommendations.

Reviewed on Feb 27, 2026

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
$219 nightly
The price is $241 total per night from Mar 29 to Mar 30
$241 total
Mar 29 - Mar 30
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,002 reviews)
Very excellent service place is beautiful

Reviewed on Feb 27, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $149 total per night from Mar 10 to Mar 11
$149 total
Mar 10 - Mar 11
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (160 reviews)
Everything was perfect ❤️

Reviewed on Feb 28, 2026

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $191 total per night from Mar 29 to Mar 30
$191 total
Mar 29 - Mar 30
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,001 reviews)
The hotel was excellent. Great location and an outstanding staff. If you stay here check out Concolon Panamanian Street Food, just around the corner. Inexpensive and may have been the best food we had in Panama.

Reviewed on Feb 26, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $296 total per night from Mar 6 to Mar 7
$296 total
Mar 6 - Mar 7
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (667 reviews)
Nice hotel and friendly staff

Reviewed on Feb 26, 2026

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers

Principe Hotel and Suites

Principe Hotel and Suites

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Upgraded room was pleasant with good airconditioning and TV with some English channels. WiFi worked okay. Appreciated the coffee maker. Pool on the 3rd floor was small but pleasant to cool off."
A verified traveler stayed at Principe Hotel and Suites
Principe Hotel and Suites

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