Explore top 2025 5 Star Hotels in Panama City

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Nov 29 - Nov 30
Tomorrow
Nov 30 - Dec 1
Next weekend
Dec 5 - Dec 7
In two weeks
Dec 12 - Dec 14

Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $126 total per night from Dec 1 to Dec 2
$126 total
Dec 1 - Dec 2
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,591 reviews)
Todo muy bien, buena ubicado, limpieza y muy buena atencion, buen desayuno, solo los tragos preparados de la piscina de poca calidad. Gracias por todos los dias maravillosos.

Reviewed on Nov 27, 2025

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $189 total per night from Dec 6 to Dec 7
$189 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,004 reviews)
The service was excellent but the installations need a renovation, in my opinion.

Reviewed on Nov 22, 2025

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$186 nightly
The price is $205 total per night from Dec 6 to Dec 7
$205 total
Dec 6 - Dec 7
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
8.8/10 Excellent! (1,005 reviews)
The staff was exceptional, the suite I got was everything plus more of what I expected! 10/10, highly recommend! Loved the panoramic views!

Reviewed on Nov 17, 2025

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$195 nightly
The price is $214 total per night from Dec 7 to Dec 8
$214 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,008 reviews)
Fabulous stay!

Reviewed on Nov 20, 2025

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$423 nightly
The price is $465 total per night from Dec 12 to Dec 13
$465 total
Dec 12 - Dec 13
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (540 reviews)
Precioso, la atención insuperable

Reviewed on Nov 22, 2025

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$186 nightly
The price is $205 total per night from Dec 7 to Dec 8
$205 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,002 reviews)
Great size room, very clean, staff are all friendly. Good choices at the breakfast buffet. I usually stay here for business and it’s always pleasant.

Reviewed on Nov 14, 2025

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $183 total per night from Dec 14 to Dec 15
$183 total
Dec 14 - Dec 15
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,005 reviews)
The rope in the shower was dirty and should be changed.

Reviewed on Nov 22, 2025

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Dec 5 to Dec 6
$121 total
Dec 5 - Dec 6
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (92 reviews)
The staff is always amazing. The breakfast is great and the location is perfect.

Reviewed on Nov 24, 2025

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Dec 6 to Dec 7
$175 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,007 reviews)
The suite was comfortable and roomy with a full kitchen and laindry. The staff in every area of the hotel were superb! We can't say enough good things about the Bristol! Loved it and cannot wait to return!!

Reviewed on Nov 23, 2025

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from Dec 24 to Dec 25
$230 total
Dec 24 - Dec 25
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (633 reviews)
los felicito excelente el servicio y la atencion

Reviewed on Nov 17, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"The room was very clean, we found the staff very polite and accommodating. The breakfast buffet was excellent. Great selection of drinks, also. Great experience in general! "
A verified traveler stayed at Hotel Riu Plaza Panama
Hotel Riu Plaza Panama

Explore More Ways to Travel with Travelocity