Explore top 2025 5 Star Hotels in Panama City

Name: Hilton Panama
Price range: $248 total
Rating: 8.8

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella, Panama City, Panama

Fully refundableReserve now, pay when you stay

$104 nightly

$115 total

Nov 5 - Nov 6

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (4,369 reviews)

"I haven't been by the pool"

Reviewed on Oct 10, 2025

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City, Panama

$188 nightly

$207 total

Nov 1 - Nov 2

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

8.8/10 Excellent! (1,000 reviews)

"Oliver was a pleasure and very informative on the surrounding areas, include very pleasant attitude with a smile on his face daily !! Thank you Oliver !!"

Reviewed on Sep 29, 2025

JW Marriott Panama

Calle Punta Colon, Punta Pacifica, Panama City, Panama

Fully refundableReserve now, pay when you stay

$237 nightly

$261 total

Oct 24 - Oct 25

Total with taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.8/10 Excellent! (1,011 reviews)

"Nice property. USA prices but not surprising if you book a mariott in Panama. If I had planned better, I would have stayed in a more unique place. Seems like more of an event hotel. Cava bar had some awesome cocktails and Misi food and wine was great."

Reviewed on Oct 10, 2025

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Veracruz, Panama

$166 nightly

$183 total

Nov 6 - Nov 7

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...

8/10 Very Good! (1,003 reviews)

"Hotel and facilities were outstanding. Staff was helpful and friendly. Food was fresh and delicious!! I will definitely stay again."

Reviewed on Oct 12, 2025

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe, Panama City, Panama

Fully refundableReserve now, pay when you stay

$297 nightly

$327 total

Nov 3 - Nov 4

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.8/10 Exceptional! (514 reviews)

"Impeccable hospitality!"

Reviewed on Oct 3, 2025

Renaissance Panama City Hotel

Via España & Ricardo Arias Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

$89 nightly

$98 total

Oct 26 - Oct 27

Total with taxes and fees

A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...

8.8/10 Excellent! (68 reviews)

"The Room was very clean, all staff were very kind and professional, the breakfast and dinner are so delicious, nothing comparative with other restaurant around."

Reviewed on Sep 22, 2025

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard, Panama City

Fully refundableReserve now, pay when you stay

$216 nightly

$238 total

Nov 9 - Nov 10

Total with taxes and fees

This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.6/10 Exceptional! (616 reviews)

"Amazing property with top service professionals in all departments across the resort. Enjoyed every single moment of my stay. Recommended to anyone traveling to Panama & wants a bit of luxury with a hint of hospitality."

Reviewed on Oct 12, 2025

W Panama

Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City

Fully refundableReserve now, pay when you stay

$183 nightly

$202 total

Oct 25 - Oct 26

Total with taxes and fees

This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...

8.8/10 Excellent! (1,002 reviews)

"Nice clean property in a good area"

Reviewed on Oct 1, 2025

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

$184 nightly

$202 total

Oct 25 - Oct 26

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,005 reviews)

"Excelent atention to detail, recomended stay."

Reviewed on Sep 20, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City

Fully refundableReserve now, pay when you stay

$225 nightly

$248 total

Nov 9 - Nov 10

Total with taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

8.8/10 Excellent! (1,001 reviews)

"Amazing stay they accommodated me with looking for a room that i was comfortable with . I saw about 8 rooms till i was content . Amazing service , breakfast was great . Restaurant was amazing . Would definitely return ."

Reviewed on Sep 28, 2025

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Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers

Studio Coliving

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"El lugar es buen lugar para hospedarse. Quiero ser muy claro con esto. No es un hotel lujoso no es súper bonito. Es un hotel práctico. Tiene muchas cosas para una buena estadía.Muchas cosas del hotel ya están viejas pero funcionales. Me gustó en cuanto calidad precio lo vale. La ubicación y muchas cosas cerca le ayudan mucho. El personal hace lo que se le pide ni más ni menos. "

A verified traveler stayed at Studio Coliving