Explore top 2026 5 Star Hotels in Panama City

Name: The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Price range: $247 total
Rating: 9.6

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$122 nightly

$135 total

Jan 12 - Jan 13, 2026

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (4,724 reviews)

I will definitely be back !

Reviewed on Dec 27, 2025

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

$221 nightly

$243 total

Jan 10 - Jan 11, 2026

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

8.8/10 Excellent! (1,001 reviews)

Amazing breakfast the 1st day, ok breakfast the 2nd day. Concierge was amazing. Loved the hotel and it's smell. Absolutely recommend! Teenage kids loved it too!

Reviewed on Dec 16, 2025

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

$215 nightly

$237 total

Jan 9 - Jan 10, 2026

Total with taxes and fees

This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...

8.8/10 Excellent! (1,004 reviews)

staff and food are amazing

Reviewed on Dec 25, 2025

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

Fully refundableReserve now, pay when you stay

$329 nightly

$362 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.8/10 Excellent! (1,001 reviews)

Just wonderful hotel

Reviewed on Dec 16, 2025

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

Fully refundableReserve now, pay when you stay

$366 nightly

$402 total

Jan 13 - Jan 14, 2026

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.8/10 Exceptional! (563 reviews)

Amazing hotel , location , staff and amenities . Clean, elegant , great service.

Reviewed on Dec 23, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

Fully refundableReserve now, pay when you stay

$201 nightly

$222 total

Jan 3 - Jan 4, 2026

Total with taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

8.8/10 Excellent! (1,002 reviews)

The restaurant at the pool, Caio Lagazzi, was amazing. The Hilton breakfast was top notch, except that they were a little slow bringing drinks (but to be fair it was Christmas day and they may have been understaffed).

Reviewed on Dec 27, 2025

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

$237 nightly

$260 total

Jan 7 - Jan 8, 2026

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...

8/10 Very Good! (1,005 reviews)

The view was fantastic! The pool was very relaxing and the food was great.

Reviewed on Dec 24, 2025

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

$116 nightly

$128 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...

8.8/10 Excellent! (98 reviews)

I would definitely recommend this hotel. From the front desk staff,to the dining and housekeeping staff Everyone was so efficient.

Reviewed on Dec 27, 2025

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

Fully refundableReserve now, pay when you stay

$201 nightly

$221 total

Jan 14 - Jan 15, 2026

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,000 reviews)

Great staff, super accommodating. Best place to stay in Panama!

Reviewed on Dec 14, 2025

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

Fully refundableReserve now, pay when you stay

$224 nightly

$247 total

Jan 25 - Jan 26, 2026

Total with taxes and fees

This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.6/10 Exceptional! (644 reviews)

this is the best place to stay near the airport. great rooms, fantastic staff. The best breakfast ever! this is not my first time at Santa Maria and definitely not the last!!!

Reviewed on Dec 11, 2025

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Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.