Explore top 2026 5 Star Hotels in Panama City

Name: The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Price range: $296 total
Rating: 9.6

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$132 nightly

$145 total

Mar 10 - Mar 11

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (4,942 reviews)

Room was spotless. Staff very courteous.

Reviewed on Feb 10, 2026

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

Fully refundableReserve now, pay when you stay

$221 nightly

$243 total

Mar 7 - Mar 8

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

8.8/10 Excellent! (1,002 reviews)

Room size

Reviewed on Feb 4, 2026

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

$183 nightly

$202 total

Mar 7 - Mar 8

Total with taxes and fees

This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...

8.8/10 Excellent! (1,002 reviews)

Room

Reviewed on Feb 10, 2026

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

Fully refundableReserve now, pay when you stay

$299 nightly

$329 total

Mar 9 - Mar 10

Total with taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.8/10 Excellent! (1,005 reviews)

Beautiful hotel, great service. Breakfast buffet is amazing.

Reviewed on Jan 29, 2026

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

Fully refundableReserve now, pay when you stay

$370 nightly

$407 total

Feb 17 - Feb 18

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.8/10 Exceptional! (590 reviews)

The hotel was LOVELY and the staff so kind and helpful. Highly, highly recommend! Also-- I highly recommend a higher floor! While they say the 1st is the quietest, the higher floors have beautiful balconies and no problem with noise!

Reviewed on Feb 8, 2026

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

Fully refundableReserve now, pay when you stay

$220 nightly

$242 total

Mar 8 - Mar 9

Total with taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

8.8/10 Excellent! (1,006 reviews)

All good clean, good food, good service. Rooms were clean, friendlt staff

Reviewed on Jan 16, 2026

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

$237 nightly

$260 total

Mar 9 - Mar 10

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...

8/10 Very Good! (1,012 reviews)

Clean rooms

Reviewed on Feb 2, 2026

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

$127 nightly

$139 total

Feb 20 - Feb 21

Total with taxes and fees

A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...

8.8/10 Excellent! (144 reviews)

Comfortable

Reviewed on Feb 7, 2026

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

Fully refundableReserve now, pay when you stay

$177 nightly

$195 total

Mar 15 - Mar 16

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,005 reviews)

Excellent service

Reviewed on Feb 7, 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

Fully refundableReserve now, pay when you stay

$269 nightly

$296 total

Mar 7 - Mar 8

Total with taxes and fees

This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.6/10 Exceptional! (661 reviews)

Visited with friends and had a great stay! The rooms were very clean and comfortable, the staff was very kind, and the buffet breakfast was amazing. Pool was awesome. Highly recommend.

Reviewed on Feb 8, 2026

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Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.