Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$289 nightly
The price is $318 total per night from Aug 18 to Aug 19
$318 total
Aug 18 - Aug 19
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (795 reviews)
"El staff es espectacular. Atentos, gentiles, siempre listos para ayudar. La comida es maravillosa y el hotel es bello, con mucho carácter. Me encantó, volveré sin duda."
Reviewed on Aug 17, 2026
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$224 nightly
The price is $247 total per night from Aug 28 to Aug 29
$247 total
Aug 28 - Aug 29
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,002 reviews)
"Great Hotel!.... Great location!"
Reviewed on Aug 15, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$271 nightly
The price is $298 total per night from Sep 6 to Sep 7
$298 total
Sep 6 - Sep 7
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,004 reviews)
"The employees were friendly and effective. Also, the gym was well equipped. Given my satisfaction, I plan to return. One thing that will make the hotel more family friendly is to have an indoor play area and ball pit for the small children of guests."
Reviewed on Aug 16, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $171 total per night from Aug 18 to Aug 19
$171 total
Aug 18 - Aug 19
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.8/10 Excellent! (1,011 reviews)
"Good location, really nice hotel. 5 stars!!!"
Reviewed on Aug 15, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$266 nightly
The price is $292 total per night from Aug 30 to Aug 31
$292 total
Aug 30 - Aug 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$245 nightly
The price is $270 total per night from Sep 13 to Sep 14
$270 total
Sep 13 - Sep 14
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
$129 nightly
The price is $142 total per night from Sep 17 to Sep 18
$142 total
Sep 17 - Sep 18
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$146 nightly
The price is $160 total per night from Aug 30 to Aug 31
$160 total
Aug 30 - Aug 31
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Decapolis Hotel Panama City
Avenida Balboa Con Multicentro Panama City Panama
$100 nightly
The price is $110 total per night from Sep 17 to Sep 18
$110 total
Sep 17 - Sep 18
Total with taxes and fees
8.6/10 Excellent! (1,716 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
$351 nightly
The price is $386 total per night from Aug 22 to Aug 23
$386 total
Aug 22 - Aug 23
Total with taxes and fees
9.8/10 Exceptional! (718 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,725 hotels |
|---|---|
Lowest Price | $110 |
Highest Price | $386 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Radisson Hotel Panama Canal
5 out of 5
Posted 6 hours ago
Travelocity Verified Review
"The room was clean and the staff was friendly "
A verified traveler stayed at Radisson Hotel Panama Canal
JW Marriott Panama
5 out of 5
Posted 20 hours ago
Travelocity Verified Review
"The employees were friendly and effective. Also, the gym was well equipped. Given my satisfaction, I plan to return. One thing that will make the hotel more family friendly is to have an indoor play area and ball pit for the small children of guests."
A verified traveler stayed at JW Marriott Panama
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