Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$201 nightly
The price is $221 total per night from Jan 14 to Jan 15
$221 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,000 reviews)
Great staff, super accommodating. Best place to stay in Panama!
Reviewed on Dec 14, 2025
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $289 total per night from Jan 5 to Jan 6
$289 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (607 reviews)
From Check in till check-out, how I was welcomed and farwewelled. Amazing. Great staff. Hotel itself is what I visioned. View and character. Comfy room and bedding. Definitely recommended.
Reviewed on Dec 15, 2025
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $129 total per night from Jan 10 to Jan 11
$129 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,007 reviews)
Beautiful hotel. Comfortable and well-appointed room, delicious breakfast, helpful staff. Recommended.
Reviewed on Dec 21, 2025
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$319 nightly
The price is $351 total per night from Jan 3 to Jan 4
$351 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,001 reviews)
Just wonderful hotel
Reviewed on Dec 16, 2025
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $243 total per night from Jan 10 to Jan 11
$243 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,002 reviews)
Amazing breakfast the 1st day, ok breakfast the 2nd day. Concierge was amazing. Loved the hotel and it's smell. Absolutely recommend! Teenage kids loved it too!
Reviewed on Dec 16, 2025
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$201 nightly
The price is $222 total per night from Jan 2 to Jan 3
$222 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,001 reviews)
Nice room! Clean. Nice balcony,
Reviewed on Dec 18, 2025
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Jan 3 to Jan 4
$175 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.6/10 Excellent! (1,001 reviews)
Everything was clean and the staff was very cooperative.
Reviewed on Dec 17, 2025
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
8.4/10 Very Good! (1,000 reviews)
Yes
Reviewed on Nov 7, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo Panama City Panama
$288 nightly
The price is $317 total per night from Dec 25 to Dec 26
$317 total
Dec 25 - Dec 26
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
$383 nightly
The price is $421 total per night from Jan 12 to Jan 13
$421 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
9.8/10 Exceptional! (563 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,648 hotels |
|---|---|
Lowest Price | $93 |
Highest Price | $421 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Hotel Riu Plaza Panama
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Recommend I would stay again "
A verified traveler stayed at Hotel Riu Plaza Panama
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