Explore 48 Luxury Hotels in Panama City
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Best Luxury Hotels in Panama City
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
$191 nightly
The price is $210 total per night from May 15 to May 16
$210 total
May 15 - May 16
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,010 reviews)
Perfect stay.. one of the best hotels we have stayed in ... no complaints
Reviewed on May 8, 2026
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$200 nightly
The price is $222 total per night from Jun 4 to Jun 5
$222 total
Jun 4 - Jun 5
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (727 reviews)
The staff was wondering
Reviewed on May 5, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
$255 nightly
The price is $281 total per night from Jun 6 to Jun 7
$281 total
Jun 6 - Jun 7
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,019 reviews)
Beautiful outdoor pool
Reviewed on May 8, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
$263 nightly
The price is $289 total per night from Jun 5 to Jun 6
$289 total
Jun 5 - Jun 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,004 reviews)
Un poco decepcionado del waldorf la verdad, todo se ve muy antiguo, muebles, facilidades, cuarto, lobby, restaurante. Digamos que uno se siento en un hilton de media gama y bo en la marca mas prestigiosa de hilton. Obviamente es muy barrato comparado con los waldor astoria de otras partes pero ahora ...
Reviewed on May 5, 2026
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $252 total per night from Jun 7 to Jun 8
$252 total
Jun 7 - Jun 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
9/10 Wonderful! (1,006 reviews)
First class hotel in downtown with excellent view from pool and restaurant area on high floor (really pleasant at night). Many dining options and not far from Panama Canal and old city.
Reviewed on Apr 30, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $182 total per night from May 12 to May 13
$182 total
May 12 - May 13
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.8/10 Excellent! (1,002 reviews)
Clean room, awesome front desk staff
Reviewed on May 5, 2026
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
8.4/10 Very Good! (1,000 reviews)
Staff were amazing here! We were totally stressed out after driving from the airport in rush hour traffic. I was almost in tears and the valet parking gentleman was super kind. Then the front desk was fantastic offering us an upgrade to a higher floor. We had dinner in the restaurant and the service ...
Reviewed on Apr 7, 2026
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $143 total per night from May 15 to May 16
$143 total
May 15 - May 16
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo Panama City Panama
$188 nightly
The price is $207 total per night from May 13 to May 14
$207 total
May 13 - May 14
Total with taxes and fees
9.2/10 Wonderful! (1,015 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
$302 nightly
The price is $332 total per night from Jun 5 to Jun 6
$332 total
Jun 5 - Jun 6
Total with taxes and fees
9.8/10 Exceptional! (647 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,632 hotels |
|---|---|
Lowest Price | $101 |
Highest Price | $332 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Hotel Riu Plaza Panama
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Great food, excellent service, overall beautiful hotel."
A verified traveler stayed at Hotel Riu Plaza Panama
More Ways To Wander Panama City
Flights to Panama City
The best fares to get you there
Panama City Hotels
Panama City Vacation Rentals
Great Deals on Alternative Accommodations
Panama City Car Rentals
Affordable cars to get you around town
Panama City Vacations
Save more by combining flights, hotels and cars
Things to do in Panama City
Discover events, experiences & tours
Explore More Ways to Travel with Travelocity
- Adults Only Resorts & in Taboga
- Pet Friendly Hotels in Taboga
- Hotels near Club de Clases y Tropas
- Bethania Hotels
- Hotels near Marcos A. Gelabert Intl.
- Obarrio Hotels
- Hotels near Uruguay Street
- Beach Resorts & in El Cangrejo
- Boutique Hotels in El Cangrejo
- Kid Friendly Hotels in El Cangrejo
- Gay Friendly Hotels in El Cangrejo
- Pet Friendly Hotels in El Cangrejo
- El Cangrejo Hotels
- Hotels with Suites in San Francisco
- Hotels with Hot Tubs in San Francisco
- Luxury Hotels in San Francisco
- San Francisco Hotels
- Santa Ana Hotels
- Adults Only Resorts & in Panamá Province
- All Inclusive Resorts & in Panamá Province
- Gay Friendly Hotels in Panamá Province
- Green Hotels in Panamá Province
- Hotels with a Lazy River in Panamá Province
- Hotels with Free Parking in Panamá Province
- Hotels with Kitchenettes in Panamá Province
- Ski Resorts and in Panamá Province
- Panamá Province Hotels
- Hostels in Panamá Province
- Lodges in Panamá Province
- Hotels near Multiplaza Pacific Mall
- Historic Hotels in Calidonia
- Calidonia Hotels
- Hotels near ATLAPA Conventions Center
- Hotels near El Dorado Mall
- Hostels in Vía Argentina
- Hotels near Omar Torrijos Recreational Park
- Hotels near Cinta Costera
- Barrio Chino Hotels
- Hotels near Multicentro Panama
- Hotels near Bingo 90
- Hotels near National Theater
- Adults Only Resorts & in Bella Vista
- Luxury Hotels in Bella Vista
- Bella Vista Hotels
- Hotels near Hospital Punta Pacífica
- Adults Only Resorts & in Punta Pacifica
- Beach Resorts & in Punta Pacifica
- Pet Friendly Hotels in Punta Pacifica
- Punta Pacifica Hotels
- Boutique Hotels in Marbella
- Casino Resorts & in Marbella
- Cheap Hotels in Marbella
- Hotels with Suites in Marbella
- Luxury Hotels in Marbella
- Curundu Hotels
- Hotels near Pacific Center
- Casco Viejo Hotels
- Hotels near Avenida Balboa
- Gay Friendly Hotels in Punta Paitilla
- Hotels with Free Airport Shuttle in Punta Paitilla
- Punta Paitilla Hotels
- Pueblo Nuevo Hotels
- Hotels near Albrook Shopping Mall
- Adults Only Resorts & in Campo Alegre
- Campo Alegre Hotels
- Flights from Marcos A. Gelabert Intl.
- Apg Distribution System Bocas del Toro (BOC) to Panama City (PAC) flights
- Flights from Austin (AUS) to Panama City (PAC)
- Flights from Bocas del Toro (BOC) to Panama City (PAC)
- Flights from Boise (BOI) to Panama City (PAC)
- Flights from Fort Lauderdale (FLL) to Panama City (PAC)
- Flights from Houston (HOU) to Panama City (PAC)
- Flights from Indianapolis (IND) to Panama City (PAC)
- Flights from Los Angeles (LAX) to Panama City (PAC)
- Flights from Orlando (MCO) to Panama City (PAC)
- Flights from Minneapolis (MSP) to Panama City (PAC)
- Flights from New Orleans (MSY) to Panama City (PAC)
- Flights from West Palm Beach (PBI) to Panama City (PAC)
- Flights from Rockford (RFD) to Panama City (PAC)
- Flights from Louisville (SDF) to Panama City (PAC)
- Flights from Orlando (SFB) to Panama City (PAC)
- Flights from San Francisco (SFO) to Panama City (PAC)
- Flights to Panamá Province