Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$222 nightly
The price is $245 total per night from Jul 17 to Jul 18
$245 total
Jul 17 - Jul 18
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,000 reviews)
"This hotel is beautiful and very clean. The staff are friendly and helpful. The pool is very small and in a strange spot so not that enticing to use. The gym is very well equipped and spacious; but it was under construction partway through our visit which we did not know about ahead of time. The ..."
Reviewed on Jun 15, 2026
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $235 total per night from Jul 14 to Jul 15
$235 total
Jul 14 - Jul 15
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (758 reviews)
"We had a very good experience for our short trip of one night. Excellent breakfast and very great pleasant staff."
Reviewed on Jun 23, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $290 total per night from Jul 31 to Aug 1
$290 total
Jul 31 - Aug 1
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,005 reviews)
"The Marriott was a beautiful hotel. Helpful staff. Recommended"
Reviewed on Jun 29, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$275 nightly
The price is $303 total per night from Aug 1 to Aug 2
$303 total
Aug 1 - Aug 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,002 reviews)
"The staff was amazing, professional, and pleasant. Made us feel important, and welcomed."
Reviewed on Jun 23, 2026
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$247 nightly
The price is $272 total per night from Jul 31 to Aug 1
$272 total
Jul 31 - Aug 1
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
9/10 Wonderful! (1,003 reviews)
"Great staff and location."
Reviewed on Jun 29, 2026
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $143 total per night from Jul 5 to Jul 6
$143 total
Jul 5 - Jul 6
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,049 reviews)
"Comfortable stay"
Reviewed on Jul 1, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $182 total per night from Jul 2 to Jul 3
$182 total
Jul 2 - Jul 3
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.8/10 Excellent! (1,000 reviews)
"Modern. Great staff. Plenty restaurants. Excellent food"
Reviewed on Jun 22, 2026
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
8.4/10 Very Good! (1,000 reviews)
"Staff were amazing here! We were totally stressed out after driving from the airport in rush hour traffic. I was almost in tears and the valet parking gentleman was super kind. Then the front desk was fantastic offering us an upgrade to a higher floor. We had dinner in the restaurant and the service ..."
Reviewed on Apr 7, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Courtyard by Marriott Panama Metromall
Avenida Domingo Diaz via Tocumen San Miguelito Panama
$101 nightly
The price is $111 total per night from Jul 4 to Jul 5
$111 total
Jul 4 - Jul 5
Total with taxes and fees
9/10 Wonderful! (1,004 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
$383 nightly
The price is $421 total per night from Jul 3 to Jul 4
$421 total
Jul 3 - Jul 4
Total with taxes and fees
9.8/10 Exceptional! (676 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,687 hotels |
|---|---|
Lowest Price | $94 |
Highest Price | $421 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Hotel Riu Plaza Panama
4 out of 5
Posted 6 hours ago
Travelocity Verified Review
"For the most part my stay was good. Friendly and helpful staff. I did have to call maintenance twice for toilet issues though, but each time someone came rather quickly and public relations called to follow up - I thought that was nice."
A verified traveler stayed at Hotel Riu Plaza Panama
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