Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $193 total per night from Dec 6 to Dec 7
$193 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,019 reviews)
Highly recommended for business trips. Very good breakfast with quality food. Nice boutique hotel vibe in the city.
Reviewed on Nov 3, 2025
American Trade Hotel
Plaza Herrera Casco Viejo, Panama City, Panama
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $258 total per night from Nov 17 to Nov 18
$258 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (579 reviews)
I had a great time at the American Trade Hotel! The charm of the old-world feel made the experience even more memorable. Beautiful property with so much character — truly a special place to stay.
Reviewed on Nov 2, 2025
JW Marriott Panama
Calle Punta Colon, Punta Pacifica, Panama City, Panama
$197 nightly
The price is $217 total per night from Dec 7 to Dec 8
$217 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,014 reviews)
Yea bar was well stocked
Reviewed on Nov 1, 2025
Waldorf Astoria Panama
47th St. & Uruguay Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $189 total per night from Dec 6 to Dec 7
$189 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,001 reviews)
Upon arrival to the Waldorf, Edgar was right there to assist us with our luggage to the room. It was at that moment I knew the W.A. hospitality was about to be extraordinary.
Reviewed on Oct 22, 2025
Hilton Panama
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $195 total per night from Dec 7 to Dec 8
$195 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,005 reviews)
This hotel is perfection - in every respect. The best location, best amenities, awesome food, great entertainment, excellent service.
Reviewed on Oct 16, 2025
Las Americas Golden Tower Panama
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $136 total per night from Nov 15 to Nov 16
$136 total
Nov 15 - Nov 16
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,028 reviews)
Nice clean spacious room
Reviewed on Nov 1, 2025
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Nov 15 to Nov 16
$175 total
Nov 15 - Nov 16
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.6/10 Excellent! (1,005 reviews)
Amazing stay in amazing staff!
Reviewed on Nov 3, 2025
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63, Panama City, Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
8.4/10 Very Good! (1,001 reviews)
Beautiful views
Reviewed on Oct 25, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco, Panama City, Panama
9.4/10 Exceptional! (1,091 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe, Panama City, Panama
$293 nightly
The price is $322 total per night from Dec 8 to Dec 9
$322 total
Dec 8 - Dec 9
Total with taxes and fees
9.8/10 Exceptional! (524 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,307 hotels |
|---|---|
Lowest Price | $107 |
Highest Price | $322 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Plaza Paitilla Inn Hotel
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"The rooms have been upgraded and are large, clean, and with a spectacular view of the bay. The location is excellent at the beginning (or end depending on your view point) of the cinta costera. Full breakfast with so many delicious things to choose from, some typical Panamanian food and some American choices. All of them deliciously prepared. "
A verified traveler stayed at Plaza Paitilla Inn Hotel
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