Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $185 total per night from Oct 13 to Oct 14
$185 total
Oct 13 - Oct 14
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (817 reviews)
"Beautiful hotel"
Reviewed on Sep 29, 2026
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $233 total per night from Oct 3 to Oct 4
$233 total
Oct 3 - Oct 4
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,000 reviews)
"I love staying at this hotel- it is usually quiet, but there was an event there (on a Tuesday night), and the music lasted until midnight, which made sleeping hard. I was on the 7th floor. Other than that, it was a delightful experience, and the breakfast and staff are amazing."
Reviewed on Sep 23, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$253 nightly
The price is $279 total per night from Oct 31 to Nov 1
$279 total
Oct 31 - Nov 1
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,001 reviews)
"Excelente hotel, muy buena ubicación de la zona financiera"
Reviewed on Oct 1, 2026
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $165 total per night from Nov 1 to Nov 2
$165 total
Nov 1 - Nov 2
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,118 reviews)
"They were repairing the hall and there was a lot of dust and bad smell. They transfer us to another room but after 3 days."
Reviewed on Sep 30, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$309 nightly
The price is $340 total per night from Oct 4 to Oct 5
$340 total
Oct 4 - Oct 5
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.8/10 Excellent! (1,010 reviews)
"Hotel is very clean and great customer service."
Reviewed on Oct 1, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$271 nightly
The price is $298 total per night from Oct 31 to Nov 1
$298 total
Oct 31 - Nov 1
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $274 total per night from Nov 1 to Nov 2
$274 total
Nov 1 - Nov 2
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
$214 nightly
The price is $236 total per night from Oct 25 to Oct 26
$236 total
Oct 25 - Oct 26
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Marriott Panama Hotel
Roosevelt Ave., Allbrook Mall Panama City Panama
$169 nightly
The price is $186 total per night from Oct 10 to Oct 11
$186 total
Oct 10 - Oct 11
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
$396 nightly
The price is $436 total per night from Oct 6 to Oct 7
$436 total
Oct 6 - Oct 7
Total with taxes and fees
9.8/10 Exceptional! (753 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,715 hotels |
|---|---|
Lowest Price | $103 |
Highest Price | $436 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Decapolis Hotel Panama City
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Excellent hotel with a convenient price with the breakfast included."
A verified traveler stayed at Decapolis Hotel Panama City
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