Explore 48 Luxury Hotels in Panama City

Name: Megapolis Hotel Panamá
Rating: 8.4

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Best Luxury Hotels in Panama City

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

$200 nightly

$220 total

Sep 7 - Sep 8

Total includes taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,000 reviews)

"We had an amazing time, great hotel and great breakfast."

Reviewed on Aug 6, 2025

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City, Panama

Fully refundableReserve now, pay when you stay

$204 nightly

$226 total

Sep 8 - Sep 9

Total includes taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.2/10 Wonderful! (546 reviews)

"The American Trade hotel is a spectacular place. Great location; walkable secure area. Lots of shops,restaurants and rooftops. The hotel has a pool on the 3rd floorwit views of the city. Check in and check out smoothas can be."

Reviewed on Jul 29, 2025

JW Marriott Panama

Calle Punta Colon, Punta Pacifica, Panama City, Panama

Fully refundableReserve now, pay when you stay

$220 nightly

$242 total

Aug 23 - Aug 24

Total includes taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.8/10 Excellent! (1,001 reviews)

"-"

Reviewed on Aug 7, 2025

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

$215 nightly

$237 total

Aug 23 - Aug 24

Total includes taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

8.8/10 Excellent! (1,001 reviews)

"Breakfast was excellent! Staff very attentive. Some minor issues with the in-room safe. Clean but somewhat dated hotel decor. Overall, I would recommend."

Reviewed on Jul 23, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City

Fully refundableReserve now, pay when you stay

$212 nightly

$233 total

Aug 30 - Aug 31

Total includes taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

8.8/10 Excellent! (1,000 reviews)

"The hotel was well maintained. The surrounding area has lots to offer in terms of food, entertainment and outdoor activities"

Reviewed on Aug 1, 2025

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Paitilla, Panama City, Panama

Fully refundableReserve now, pay when you stay

$160 nightly

$177 total

Aug 11 - Aug 12

Total includes taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...

8.8/10 Excellent! (1,007 reviews)

"Excellent service! Very friendly and attentive staff Spacious and comfortable room Really good breakfast! We were vacationing for two weeks and had booked two hotels intending to spend one week at each. We were so impressed, we cancelled the second booking and extended our stay at Las Americas Golden ..."

Reviewed on Aug 5, 2025

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

56 y 57 East Street, Obarrio, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

$159 nightly

$175 total

Aug 23 - Aug 24

Total includes taxes and fees

This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...

8.6/10 Excellent! (980 reviews)

"2nd stay at Sortis Hotel in Panama. Never disappoints. Breakfast Buffett incredible and staff pleasant and attentive! Will stay there again!"

Reviewed on Jul 20, 2025

Megapolis Hotel Panamá

Ave. Balboa al lado de Multicentro, 63, Panama City, Panamá Province

This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...

8.4/10 Very Good! (1,000 reviews)

"This is THE place to stay in Panama City... it's location, friendly accommodating staff, and the amenities are fantastic. The rooms were wonderful, clean and bright. We tried Tauro (steakhouse) and the Bazaar - they were both delicious and the service excellent. We literally partied like rock stars ..."

Reviewed on Feb 24, 2021

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More 4 star hotels in Panama City

Marriott Panama Hotel

Roosevelt Ave., Allbrook Mall, Panama City, Panama

$134 nightly

$148 total

Aug 9 - Aug 10

Total includes taxes and fees

9/10 Wonderful! (1,004 reviews)

5 star hotels in Panama City

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe, Panama City, Panama

$293 nightly

$322 total

Sep 7 - Sep 8

Total includes taxes and fees

9.8/10 Exceptional! (486 reviews)

Panama City Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.

Panama City hotels essential information

Accommodation	1,437 hotels
Lowest Price	$105
Highest Price	$322
Popular hotels	JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama