Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from Feb 27 to Feb 28
$230 total
Feb 27 - Feb 28
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,005 reviews)
Excellent service
Reviewed on Feb 7, 2026
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $280 total per night from Mar 9 to Mar 10
$280 total
Mar 9 - Mar 10
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (657 reviews)
Staff was excellent from every transaction we had with them. Very friendly and helpful. Only stayed 2 days yet the staff knew us and greeted us when we saw them. The room was great. A little cold but they helped us regulate the temperature.
Reviewed on Feb 1, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$279 nightly
The price is $307 total per night from Mar 7 to Mar 8
$307 total
Mar 7 - Mar 8
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,004 reviews)
Beautiful hotel, great service. Breakfast buffet is amazing.
Reviewed on Jan 29, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $243 total per night from Mar 7 to Mar 8
$243 total
Mar 7 - Mar 8
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,000 reviews)
Room was great, excellent view, clean and spacious.
Reviewed on Jan 27, 2026
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $232 total per night from Mar 7 to Mar 8
$232 total
Mar 7 - Mar 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,004 reviews)
All good clean, good food, good service. Rooms were clean, friendlt staff
Reviewed on Jan 16, 2026
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $199 total per night from Mar 4 to Mar 5
$199 total
Mar 4 - Mar 5
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
8.8/10 Excellent! (1,005 reviews)
excellent room and location
Reviewed on Jan 31, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Feb 15 to Feb 16
$175 total
Feb 15 - Feb 16
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.6/10 Excellent! (1,003 reviews)
Great hotel with cosy rooms and great staff would definitely recommend staying here.
Reviewed on Feb 2, 2026
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
8.4/10 Very Good! (1,001 reviews)
Check-in at 3:00 pm was a bit inconvenient, and the Sky Bar being closed was a bummer. Aside from those minor issues, the hotel itself is great—stylish, comfortable, and a cool overall experience.
Reviewed on Jan 27, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo Panama City Panama
$303 nightly
The price is $333 total per night from Mar 8 to Mar 9
$333 total
Mar 8 - Mar 9
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
$366 nightly
The price is $402 total per night from Feb 24 to Feb 25
$402 total
Feb 24 - Feb 25
Total with taxes and fees
9.8/10 Exceptional! (586 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,647 hotels |
|---|---|
Lowest Price | $95 |
Highest Price | $402 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Hotel Ojos del Rio
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"The staff, the food and the room and all. "
A verified traveler from Bowmanville stayed at Hotel Ojos del Rio
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