Explore 48 Luxury Hotels in Panama City

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Best Luxury Hotels in Panama City

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $213 total per night from Mar 31 to Apr 1
$213 total
Mar 31 - Apr 1
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,000 reviews)
I received an upgrade to a residential space which was phenomenal - apartment living. The restaurant and spa were wonderful. However, the premises offered very little outdoor space, with a very small lap pool that was underwhelming. On a separate note, housekeeping tossed out food I stored in the ...

Reviewed on Mar 19, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $216 total per night from Apr 6 to Apr 7
$216 total
Apr 6 - Apr 7
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (684 reviews)
Clean Room and friendly staff.

Reviewed on Mar 22, 2026

Opens in a new windowAmerican Trade Hotel
JW Marriott Panama

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $296 total per night from Apr 5 to Apr 6
$296 total
Apr 5 - Apr 6
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,000 reviews)
Fantastic pool. Great food, I'd recommend the fish and chips. Best I've ever had. Great bar. Friendly staff.

Reviewed on Mar 19, 2026

Opens in a new windowJW Marriott Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$251 nightly
The price is $276 total per night from Apr 20 to Apr 21
$276 total
Apr 20 - Apr 21
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,000 reviews)
The BEST!

Reviewed on Mar 22, 2026

Opens in a new windowWaldorf Astoria Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $174 total per night from Apr 24 to Apr 25
$174 total
Apr 24 - Apr 25
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,004 reviews)
Excelente precio -calidad

Reviewed on Mar 25, 2026

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $177 total per night from Apr 10 to Apr 11
$177 total
Apr 10 - Apr 11
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,000 reviews)
Hotel/Conference Center adjacent to a very large Shopping Mall and to the National Bus Terminal. Across the highway from the main Panama Domestic Airport. Not the most attractive environment. Hotel was clean and had limited choice dining options on site or within the Mall. Transport was by taxi or ...

Reviewed on Mar 25, 2026

Opens in a new windowMarriott Panama Hotel
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

56 y 57 East Street, Obarrio Panama City Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Mar 28 to Mar 29
$175 total
Mar 28 - Mar 29
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.8/10 Excellent! (1,001 reviews)
Exceptional in all categories.

Reviewed on Mar 24, 2026

Opens in a new windowSortis Hotel, Spa & Casino, Autograph Collection by Marriott
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
8.4/10 Very Good! (1,000 reviews)
great deal

Reviewed on Feb 20, 2026

Opens in a new windowMegapolis Hotel Panamá
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More 4 star hotels in Panama City

5 star hotels in Panama City

Panama City Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.


Panama City hotels essential information

Accommodation
1,556 hotels
Lowest Price
$108
Highest Price
$316
Popular hotels
JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Megapolis Hotel Panamá, Las Americas Golden Tower Panama, Marriott Panama Hotel

Popular Luxury Stays in Panama City

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