Explore top 2026 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$128 nightly
The price is $141 total per night from May 17 to May 18
$141 total
May 17 - May 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,500 reviews)
Everything is very nice and comfortable at this hotel. We always enjoy staying here when in PC

Reviewed on Apr 23, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $100 total per night from Apr 26 to Apr 27
$100 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (873 reviews)
Everything was amazing!

Reviewed on Apr 24, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
Fully refundable
$74 nightly
The price is $81 total per night from May 10 to May 11
$81 total
May 10 - May 11
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and a gym. Families will appreciate the children's pool and onsite laundry facilities. Unwind ...
8.6/10 Excellent! (1,004 reviews)
The location is the best, calm, quiet and clean environment. The views, scenes without having to actually go pay to view the canal. Restaurants an extra additional convenience.

Reviewed on Apr 24, 2026

Opens in a new windowRadisson Hotel Panama Canal
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from May 1 to May 2
$139 total
May 1 - May 2
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,003 reviews)
Yes

Reviewed on Apr 24, 2026

Opens in a new windowSheraton Grand Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
$110 nightly
The price is $121 total per night from May 2 to May 3
$121 total
May 2 - May 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,006 reviews)
El hotel tiene excelente ubicación, creo que pudieran remodelar los ascensores y otras áreas, el personal es muy amable y atento.

Reviewed on Apr 24, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $225 total per night from May 17 to May 18
$225 total
May 17 - May 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (709 reviews)
Everything was fantastic except the hot water situation. We stayed 5 days and only had hot water for two days. It was due to a broken pipe underneath the building. They worked hard to fix it, but even after the repairs, hot water was limited. Desk staff and especially Porter Angel really worked hard ...

Reviewed on Apr 23, 2026

Opens in a new windowAmerican Trade Hotel
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $112 total per night from May 5 to May 6
$112 total
May 5 - May 6
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,168 reviews)
Friendly staff from the front desk attendants, to the restaurant staff to the housekeeping. Even with the language barriers. Everyone I encountered was pleasant and I appreciate it. Sufficient included breakfast buffet. Nice rooms. Housekeeping was good. Room was clean. Would stay again.

Reviewed on Apr 25, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $123 total per night from May 8 to May 9
$123 total
May 8 - May 9
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,166 reviews)
Muy buen hotel. Excelente el Desayuno y muy atentos los funcionarios. Lo disfrutamos mucho en un país bonito, amable y en franco progreso.

Reviewed on Apr 24, 2026

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (590 reviews)
Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here

Reviewed on Mar 26, 2026

Opens in a new windowStudio Coliving
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $157 total per night from May 9 to May 10
$157 total
May 9 - May 10
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,000 reviews)
Nice

Reviewed on Apr 23, 2026

Opens in a new windowLas Americas Golden Tower Panama
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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