Explore top 2025 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
$124 nightly
The price is $136 total per night from Dec 4 to Dec 5
$136 total
Dec 4 - Dec 5
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.4/10 Very Good! (2,292 reviews)
Everything went smoothly. Room was more than i expected

Reviewed on Nov 3, 2025

Opens in a new windowCrowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Nov 10 to Nov 11
$148 total
Nov 10 - Nov 11
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.4/10 Very Good! (972 reviews)
Excelente atención y servicio La cuna de bebé era de material como fierro, insegura para bebés que ya se paran un poco El área de juegos de niños siempre mojada y no tenía protección solar podría adecuarse mejor

Reviewed on Nov 1, 2025

Opens in a new windowSheraton Grand Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall, Panama City, Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Nov 7 to Nov 8
$148 total
Nov 7 - Nov 8
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,011 reviews)
This property is attached to a mall so for certain many guests are there on shopping junkets. Pretty high turnover I would imagine. Overall, it is operated well and has good management. Everything works, staff are friendly. No complaints.

Reviewed on Nov 3, 2025

Opens in a new windowMarriott Panama Hotel
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama
Fully refundableReserve now, pay when you stay
$44 nightly
The price is $49 total per night from Nov 4 to Nov 5
$49 total
Nov 4 - Nov 5
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (547 reviews)
Room was clean, staff was excellent 👌

Reviewed on Oct 31, 2025

Opens in a new windowStudio Coliving
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo, Panama City, Panama
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $217 total per night from Nov 4 to Nov 5
$217 total
Nov 4 - Nov 5
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in ...
9/10 Wonderful! (1,003 reviews)
Hotel architecture location and friendliness’s of staff

Reviewed on Nov 2, 2025

Opens in a new windowCentral Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $138 total per night from Nov 14 to Nov 15
$138 total
Nov 14 - Nov 15
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,174 reviews)
Room was excellent

Reviewed on Nov 2, 2025

Opens in a new windowMegapolis Hotel Panamá
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Nov 18 to Nov 19
$99 total
Nov 18 - Nov 19
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
9/10 Wonderful! (562 reviews)
Yes

Reviewed on Oct 30, 2025

Opens in a new windowWaymore Hotel Spa & Casino
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $93 total per night from Nov 7 to Nov 8
$93 total
Nov 7 - Nov 8
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,386 reviews)
Everything was seemless

Reviewed on Nov 1, 2025

Opens in a new windowDecapolis Hotel Panama City
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $136 total per night from Nov 7 to Nov 8
$136 total
Nov 7 - Nov 8
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,028 reviews)
Nice clean spacious room

Reviewed on Nov 1, 2025

Opens in a new windowLas Americas Golden Tower Panama
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Nov 19 to Nov 20
$110 total
Nov 19 - Nov 20
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9/10 Wonderful! (1,052 reviews)
We had a great stay and excellent service. Staff was friendly all round, room was clean and fresh, breakfast was really good. highly recommended. Thank you, hope to see you soon.

Reviewed on Nov 3, 2025

Opens in a new windowNovotel Panama City
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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