Explore top 2026 4 Star Hotels in Panama City

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Top Panama City 4 Star hotels

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $172 total per night from Jan 10 to Jan 11
$172 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,015 reviews)
It was a very nice stay. The room is nice, organized and clean with a great view of the city. The blankets are a little too warm and we wished for a lighter blankets. Breakfast buffet was very good with many food choices and best custom eggs cooked tailored to our demands. Uber to Casco Viejo was ...

Reviewed on Dec 15, 2025

Opens in a new windowLas Americas Golden Tower Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Dec 20 to Dec 21
$135 total
Dec 20 - Dec 21
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,269 reviews)
Room was great, the view magnificent

Reviewed on Dec 13, 2025

Opens in a new windowMegapolis Hotel Panamá
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $156 total per night from Dec 20 to Dec 21
$156 total
Dec 20 - Dec 21
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,003 reviews)
Great! Nice restaurant too

Reviewed on Dec 15, 2025

Opens in a new windowMarriott Panama Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from Jan 9 to Jan 10
$139 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.4/10 Very Good! (990 reviews)
Yes

Reviewed on Dec 11, 2025

Opens in a new windowSheraton Grand Panama
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (579 reviews)
Staff very helpful

Reviewed on Dec 11, 2025

Opens in a new windowStudio Coliving
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $114 total per night from Dec 20 to Dec 21
$114 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9/10 Wonderful! (1,022 reviews)
Only 1 staff had an little attitude when i was leaving but the rest was awesome. Food was great hotel is great 👍

Reviewed on Dec 12, 2025

Opens in a new windowNovotel Panama City
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 out of 5
Calle 52 and Ricardo Arias Panama City
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $149 total per night from Dec 20 to Dec 21
$149 total
Dec 20 - Dec 21
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the free WiFi in public areas, ...
9.8/10 Exceptional! (124 reviews)
The hotel was stunning and christmas festive. It smelled great. The room was beautiful, the hospitality was great. I was suprised with a birthday treat to my door and a card which was super sweet and an excellent touch. Everything was clean. Room service made my bed and changed my towels everyday. ...

Reviewed on Dec 6, 2025

Opens in a new windowHyatt Regency Panama City
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Dec 22 to Dec 23
$109 total
Dec 22 - Dec 23
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
9/10 Wonderful! (628 reviews)
Clean room.

Reviewed on Dec 12, 2025

Opens in a new windowWaymore Hotel Spa & Casino
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
$260 nightly
The price is $286 total per night from Dec 23 to Dec 24
$286 total
Dec 23 - Dec 24
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in ...
9/10 Wonderful! (1,005 reviews)
Amazing Location and classy hotel!

Reviewed on Dec 16, 2025

Opens in a new windowCentral Hotel Panama Casco Viejo
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
$109 nightly
The price is $120 total per night from Jan 2 to Jan 3
$120 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.4/10 Exceptional! (1,119 reviews)
Yes and they cleaned and changed towels daiy

Reviewed on Dec 15, 2025

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity