Explore top 2026 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from Apr 28 to Apr 29
$146 total
Apr 28 - Apr 29
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,493 reviews)
Poor at 6am

Reviewed on Apr 4, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from May 1 to May 2
$148 total
May 1 - May 2
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,006 reviews)
The breakfast menu was excellent. It covers ever taste.

Reviewed on Apr 2, 2026

Opens in a new windowSheraton Grand Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $125 total per night from Apr 9 to Apr 10
$125 total
Apr 9 - Apr 10
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
7.8/10 Good! (1,000 reviews)
Was excellent all the staff

Reviewed on Apr 4, 2026

Opens in a new windowHotel El Panama by Faranda Grand, a member of Radisson Individuals
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (829 reviews)
We chose to stay at the Waymore for our honeymoon to Panama. The best thing about this hotel is the location. There were a lot of food options and souvenir shops within walking distance of the hotel. I was sad to find out that the pool was closed for remodeling-they did not inform us of this prior ...

Reviewed on Apr 3, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
$126 nightly
The price is $139 total per night from Apr 27 to Apr 28
$139 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,156 reviews)
Reception desk was very accommodating and helped me check in earlier than 3:00 pm as I was visibly exhausted by the commute from the airport to the hotel. Breakfast was good, byt the yogurt…. (to die for with REAL FRESH strawberries )

Reviewed on Apr 5, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
$110 nightly
The price is $121 total per night from May 2 to May 3
$121 total
May 2 - May 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,008 reviews)
Very clean room, excellent staff, breakfast wonderful and amazing shopping.

Reviewed on Apr 4, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from May 6 to May 7
$117 total
May 6 - May 7
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,150 reviews)
Yes

Reviewed on Apr 3, 2026

Opens in a new windowNovotel Panama City
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $167 total per night from Apr 25 to Apr 26
$167 total
Apr 25 - Apr 26
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,002 reviews)
The main positive is the location with access to the mall.

Reviewed on Apr 3, 2026

Opens in a new windowMarriott Panama Hotel
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $224 total per night from Apr 12 to Apr 13
$224 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (689 reviews)
Staff was very helpful. Wish we had planned to stay longer.

Reviewed on Apr 4, 2026

Opens in a new windowAmerican Trade Hotel
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $142 total per night from May 1 to May 2
$142 total
May 1 - May 2
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.6/10 Excellent! (1,626 reviews)
Good breakfast options. Loved the pool lounge area. The bartender did an excellent job preparing our drinks.

Reviewed on Apr 1, 2026

Opens in a new windowDecapolis Hotel Panama City
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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