Explore top 2025 4 Star Hotels in Panama City

Name: Decapolis Hotel Panama City
Price range: $105 total
Rating: 8.4

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama

Fully refundable

$122 nightly

$134 total

Sep 28 - Sep 29

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...

8.4/10 Very Good! (2,231 reviews)

"I had to spend the night in Panama to continue my trip to South America. Is very convenient I think is the closest hotel to the airport, the shuttle service is a plus. The rides go every hour sharp. Staff is great, food is amazing as well panameño chicken soup was delicious after a long trip I recover ..."

Reviewed on Sep 17, 2025

Sheraton Grand Panama

Via Israel And 77th Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

$134 nightly

$148 total

Oct 4 - Oct 5

Total with taxes and fees

A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...

8.4/10 Very Good! (949 reviews)

"My favorite things were the Bakery, a restaurant and a Casino on property."

Reviewed on Sep 14, 2025

Waymore Hotel Spa & Casino

Calle Augusto Samuel Boyd y Calle Eusebi, Panama City

Fully refundableReserve now, pay when you stay

$87 nightly

$96 total

Sep 26 - Sep 27

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...

9/10 Wonderful! (500 reviews)

"The staff was wonderful"

Reviewed on Sep 24, 2025

Megapolis Hotel Panamá

Avenida Balboa, Panama City

Fully refundableReserve now, pay when you stay

$125 nightly

$138 total

Oct 5 - Oct 6

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.2/10 Very Good! (1,083 reviews)

"The staff were great! Very prompt! Any needs they were right there to attend!"

Reviewed on Sep 16, 2025

Studio Coliving

Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama

Fully refundableReserve now, pay when you stay

$44 nightly

$49 total

Sep 26 - Sep 27

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

7.8/10 Good! (489 reviews)

"Everything was amazing"

Reviewed on Sep 20, 2025

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Via Espana 111, Panama City, Panama

Fully refundableReserve now, pay when you stay

$97 nightly

$107 total

Oct 1 - Oct 2

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...

7.6/10 Good! (1,010 reviews)

"My stay was very enjoyable. The food was great. The city was very accessible. Attractions were all a very short trip away walking or by car. Also pretty close to the airport. The pool was great. Nice gym and sauna. Convention center was very good too. Nearby restaurants."

Reviewed on Sep 18, 2025

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

$100 nightly

$110 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...

9/10 Wonderful! (1,013 reviews)

"Staff was great!"

Reviewed on Sep 18, 2025

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Paitilla, Panama City, Panama

Fully refundableReserve now, pay when you stay

$144 nightly

$159 total

Sep 27 - Sep 28

Total with taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...

8.8/10 Excellent! (1,021 reviews)

"Very friendly staff, room was also very clean"

Reviewed on Sep 21, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica

Via Israel y Calle 71, San Francisco, Panama City, Panama

$124 nightly

$136 total

Sep 28 - Sep 29

Total with taxes and fees

This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

9.4/10 Exceptional! (1,048 reviews)

"Clean room, nice."

Reviewed on Sep 20, 2025

Decapolis Hotel Panama City

Avenida Balboa Con Multicentro, Panama City, Panama

Fully refundableReserve now, pay when you stay

$95 nightly

$105 total

Sep 26 - Sep 27

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.4/10 Very Good! (1,332 reviews)

"The rooms are clean and the staff is very friendly and helpful. The amenities like the hot tub are very good."

Reviewed on Sep 20, 2025

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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.