Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $215 total

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$83 nightly

$99 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$173 nightly

$206 total

Nov 15 - Nov 16

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (4,013 reviews)

"Ok for the location, 65 dollars to park your car per day"

Reviewed on Oct 23, 2026

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

Fully refundableReserve now, pay when you stay

$128 nightly

$152 total

Nov 8 - Nov 9

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

9.4/10 Exceptional! (5,422 reviews)

"close to everything"

Reviewed on Oct 23, 2026

Hotel Valencia Riverwalk

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$139 nightly

$164 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$162 nightly

$192 total

Nov 16 - Nov 17

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$111 nightly

$132 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

$118 nightly

$141 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$216 nightly

$258 total

Oct 28 - Oct 29

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (2,337 reviews)

"The location is amazing. Wonderful staff too."

Reviewed on Oct 22, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

$153 nightly

$183 total

Nov 22 - Nov 23

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

$181 nightly

$215 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

Don't see what you're looking for?

See all available properties in Medical Center District

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Medical Center District hotel reviews by fellow wanderers

Hotel Contessa

4 out of 5

Posted less than an hour ago

Travelocity Verified Review

"Ok for the location, 65 dollars to park your car per day"

A verified traveler stayed at Hotel Contessa

Drury Inn & Suites San Antonio Northwest Medical Center

5 out of 5

Posted 2 hours ago

Travelocity Verified Review

"The rooms were super roomy and the beds were actually queens! Love the breakfast, they had lots of food out not just a small portion. The staff was actually telling us to get more if we like. They had waffles, eggs, potatoes, sausages and tortillas in case you wanted to make tacos. Of course they had hard boiled eggs! I love when they offer that! Different types of juices but that was the only bad part they were all watered down so I got coffee and water. Coffee was very good! I’m a huge coffee drinker so I love that. I love that they had the trolleys for luggage because we were all girls with lots of luggage so that helped us so much! The INDOOR pool was as very nice. They also offered the evening cocktail hour that unfortunately I did not make on time. I’ve never stayed there before but I will from now on! Oh and the front desk girls were all awesome!"

A verified traveler stayed at Drury Inn & Suites San Antonio Northwest Medical Center