Explore top 2026 4 Star Hotels in Medical Center District

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May 12 - May 13
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May 13 - May 14
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May 15 - May 17
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May 22 - May 24

Top Medical Center District 4 Star hotels

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $161 total per night from May 17 to May 18
$161 total
May 17 - May 18
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
9.4/10 Exceptional! (4,599 reviews)
Loved the location

Reviewed on May 12, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $117 total per night from May 13 to May 14
$117 total
May 13 - May 14
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,477 reviews)
Espectacular, excelente lugar, muy lindo y limpio.

Reviewed on May 12, 2026

Opens in a new windowRiverwalk Plaza
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $175 total per night from Jun 2 to Jun 3
$175 total
Jun 2 - Jun 3
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,552 reviews)
The first room had such a strong smell of mold and mildew. The second room had mold surrounding the bathtub. Stained toilet. Old dingy sheets. Housekeeping gets a C- . Parking $65/day plus over $200 in hotel resort fees. Website asserted remodeled rooms, obviously we didn't they failed to say some ...

Reviewed on May 12, 2026

Opens in a new windowHotel Contessa
Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 out of 5
431 South Alamo Street San Antonio TX
Fully refundable
$191 nightly
The price is $226 total per night from May 17 to May 18
$226 total
May 17 - May 18
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (914 reviews)
We love staying here! Unlike the San Antonio Plaza across the way, this hotel has delightful service, pays attention to details, and has been a surprisingly reasonably priced luxury option for our staycations in San Antonio. The service is so great, they are responsive, kind, personable, and never ...

Reviewed on May 12, 2026

Opens in a new windowKimpton Santo San Antonio - Riverwalk by IHG
Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
$405 nightly
The price is $479 total per night from May 14 to May 15
$479 total
May 14 - May 15
Total with taxes and fees
This hotel features a golf course, free water park access, and 5 restaurants. Bring the family and enjoy the lazy river, children's pool, and waterslide. Enjoy ...
8.8/10 Excellent! (1,004 reviews)
Gorgeous place and jacob at the desk sang happy birthday to my wife upon check in! Beautiful stay!

Reviewed on Apr 28, 2026

Opens in a new windowHyatt Regency Hill Country Resort and Villas
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $178 total per night from Jun 6 to Jun 7
$178 total
Jun 6 - Jun 7
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,727 reviews)
Great service, clean room

Reviewed on May 11, 2026

Opens in a new windowHotel Valencia Riverwalk
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$185 nightly
The price is $218 total per night from Jun 1 to Jun 2
$218 total
Jun 1 - Jun 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,941 reviews)
Very good

Reviewed on May 12, 2026

Opens in a new windowOmni La Mansion del Rio
Hilton Palacio Del Rio

Hilton Palacio Del Rio

4 out of 5
200 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $190 total per night from Jun 7 to Jun 8
$190 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,185 reviews)
Recommend adding breakfast to your stay. You can eat the buffet or order off the menu. From the moment we arrive to the moment we left the staff friendly helpful and professional. We stayed in room 1002 beautiful scenery of the Riverwalk. We take binoculars so that we could people watchoff the balcony. ...

Reviewed on May 12, 2026

Opens in a new windowHilton Palacio Del Rio
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

4 out of 5
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $256 total per night from May 30 to May 31
$256 total
May 30 - May 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,130 reviews)
The loud noise from city celebrations until 2:30am over multiple days was terrible.

Reviewed on May 12, 2026

Opens in a new windowHyatt Regency San Antonio Riverwalk
The Westin Riverwalk, San Antonio

The Westin Riverwalk, San Antonio

4 out of 5
420 W Market St San Antonio TX
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $212 total per night from May 31 to Jun 1
$212 total
May 31 - Jun 1
Total with taxes and fees
The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,535 reviews)
Clean and friendly hotel awesome service

Reviewed on Apr 29, 2026

Opens in a new windowThe Westin Riverwalk, San Antonio
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Recent Medical Center District hotel reviews by fellow wanderers

Hotel Contessa

Hotel Contessa

2 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The first room had such a strong smell of mold and mildew. The second room had mold surrounding the bathtub. Stained toilet. Old dingy sheets. Housekeeping gets a C- . Parking $65/day plus over $200 in hotel resort fees. Website asserted remodeled rooms, obviously we didn't they failed to say some remodeled rooms. Very disappointed. Far from a four-star hotel. "
A verified traveler stayed at Hotel Contessa
Hotel Contessa

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