Explore top 2026 4 Star Hotels in Medical Center District

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from May 12 to May 13
$106 total
May 12 - May 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,449 reviews)
Comfortable bed

Reviewed on May 6, 2026

Opens in a new windowRiverwalk Plaza
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $167 total per night from May 17 to May 18
$167 total
May 17 - May 18
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,553 reviews)
Do not listen to the porters about taxi rides back to the airport. They will tell you its $29 but the taxi driver will charge you $39. The taxi driver is trying to charge me twice by double charging my credit card. An uber or lyft will be cheaper. Also the rooms are a little run down. The place needs ...

Reviewed on May 6, 2026

Opens in a new windowHotel Contessa
Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
Fully refundableReserve now, pay when you stay
$405 nightly
The price is $479 total per night from May 11 to May 12
$479 total
May 11 - May 12
Total with taxes and fees
This hotel features a golf course, free water park access, and 5 restaurants. Bring the family and enjoy the lazy river, children's pool, and waterslide. Enjoy ...
8.8/10 Excellent! (1,003 reviews)
Gorgeous place and jacob at the desk sang happy birthday to my wife upon check in! Beautiful stay!

Reviewed on Apr 28, 2026

Opens in a new windowHyatt Regency Hill Country Resort and Villas
Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 out of 5
431 South Alamo Street San Antonio TX
Fully refundable
$181 nightly
The price is $214 total per night from Jun 7 to Jun 8
$214 total
Jun 7 - Jun 8
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (904 reviews)
Very clean hotel. Great breakfast and coffee bar. Nice location, short walk to the Riverwalk. Would stay again.

Reviewed on May 4, 2026

Opens in a new windowKimpton Santo San Antonio - Riverwalk by IHG
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $188 total per night from Jun 6 to Jun 7
$188 total
Jun 6 - Jun 7
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,719 reviews)
Beautiful hotel. Friendly staff from valets to front desk to housekeeping.

Reviewed on May 6, 2026

Opens in a new windowHotel Valencia Riverwalk
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $251 total per night from Jun 1 to Jun 2
$251 total
Jun 1 - Jun 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,927 reviews)
Pool was amazing

Reviewed on May 6, 2026

Opens in a new windowOmni La Mansion del Rio
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

4 out of 5
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $256 total per night from May 30 to May 31
$256 total
May 30 - May 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,137 reviews)
Clean room

Reviewed on May 6, 2026

Opens in a new windowHyatt Regency San Antonio Riverwalk
Plaza San Antonio Hotel & Spa, Autograph Collection

Plaza San Antonio Hotel & Spa, Autograph Collection

4 out of 5
555 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $183 total per night from May 10 to May 11
$183 total
May 10 - May 11
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (797 reviews)
Beautiful hotel, valet is pricey around $70.00 per night, but other than that we had a great stay. Lots to do in the area and staff was very friendly.

Reviewed on May 4, 2026

Opens in a new windowPlaza San Antonio Hotel & Spa, Autograph Collection
Hilton Palacio Del Rio

Hilton Palacio Del Rio

4 out of 5
200 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $196 total per night from Jun 7 to Jun 8
$196 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,173 reviews)
Enjoyed the stay

Reviewed on May 5, 2026

Opens in a new windowHilton Palacio Del Rio
JW Marriott San Antonio Hill Country Resort & Spa

JW Marriott San Antonio Hill Country Resort & Spa

4.5 out of 5
23808 Resort Pkwy San Antonio TX
Fully refundableReserve now, pay when you stay
$443 nightly
The price is $517 total per night from May 26 to May 27
$517 total
May 26 - May 27
Total with taxes and fees
This luxury hotel features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, and ...
9/10 Wonderful! (1,005 reviews)
Everything was amazing and fun. 10/10 will be coming back.

Reviewed on May 3, 2026

Opens in a new windowJW Marriott San Antonio Hill Country Resort & Spa
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