Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $215 total

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$98 nightly

$117 total

Nov 17 - Nov 18

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

8/10 Very Good! (6,523 reviews)

"The room was great. Cleanliness was amazing except for the bath tub. Bath tub needed some work, also the shampoo kept falling off the wall. The adhesive on the shampoo, conditioner and body washed needs to be changed or replaced because it kept falling down. Other than that every else was great. ..."

Reviewed on Oct 27, 2026

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$191 nightly

$228 total

Nov 23 - Nov 24

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (4,022 reviews)

"The room was clean and was in a nice location. The restaurant and bar were very nice. I wish I could have given them 5 stars, but the staff was not very helpful with a problem we had."

Reviewed on Oct 27, 2026

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

Fully refundableReserve now, pay when you stay

$122 nightly

$145 total

Nov 1 - Nov 2

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

9.4/10 Exceptional! (5,443 reviews)

"For the price of this hotel the quality was lacking significantly. Our jacuzzi bathtub was dirty, didn’t look like it had been cleaned the last few guest stays. Both pools were not kept up and dirty. The inside pool on the 9th floor was so bad we just turned around and walked out. The hot tub was ..."

Reviewed on Oct 27, 2026

Hotel Valencia Riverwalk

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$161 nightly

$191 total

Nov 26 - Nov 27

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (3,248 reviews)

"Loved our stay at Hotel Valencia for a conference. It was a nice 11-12 min walk to the conference center and I loved our neighborhood right on the Riverwalk. Hotel staff were incredibly kind and housekeeping was wonderful, with a fresh room every day. I wish there was more dresser space to fully ..."

Reviewed on Oct 27, 2026

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$162 nightly

$192 total

Nov 16 - Nov 17

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$111 nightly

$133 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

Fully refundableReserve now, pay when you stay

$118 nightly

$141 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$216 nightly

$258 total

Nov 22 - Nov 23

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (2,337 reviews)

"Loved the hotel. Would stay here again in a heartbeat"

Reviewed on Oct 27, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$153 nightly

$183 total

Nov 22 - Nov 23

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

8.8/10 Excellent! (1,542 reviews)

"Was a great time. Really recommend."

Reviewed on Oct 27, 2026

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

Fully refundable

$181 nightly

$215 total

Nov 26 - Nov 27

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.