Explore top 2026 4 Star Hotels in Medical Center District

Name: The St. Anthony, A Luxury Collection Hotel, San Antonio
Price range: $188 total
Rating: 8.8

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Top Medical Center District 4 Star hotels

Hotel Valencia Riverwalk

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$142 nightly

$166 total

Jan 25 - Jan 26

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...

9.2/10 Wonderful! (2,402 reviews)

Great old western/Mexican theme. Clean well kept, friendly helpful staff. Perfect location for food, riverwalk, Alamo, everything.

Reviewed on Jan 20, 2026

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$109 nightly

$129 total

Jan 25 - Jan 26

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

8/10 Very Good! (6,323 reviews)

Everything was perfect! Great greetings,super room, great staff….great location

Reviewed on Jan 17, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$195 nightly

$230 total

Feb 8 - Feb 9

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

8.8/10 Excellent! (1,482 reviews)

Great location in a quiet area of the Riverwalk yet walkable to many sites, restaurants, and other entertainment venues.

Reviewed on Jan 18, 2026

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$202 nightly

$239 total

Feb 8 - Feb 9

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

9.2/10 Wonderful! (2,824 reviews)

Double Queen room with balcony was perfect for us to bring our tween. We loved the restaurants around the area.

Reviewed on Jan 20, 2026

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$143 nightly

$168 total

Jan 29 - Jan 30

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (3,446 reviews)

The staff was super helpful and friendly.

Reviewed on Jan 20, 2026

Plaza San Antonio Hotel & Spa, Autograph Collection

555 S Alamo St San Antonio TX

Fully refundableReserve now, pay when you stay

$196 nightly

$231 total

Feb 1 - Feb 2

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.2/10 Wonderful! (711 reviews)

Loved the new renovations!

Reviewed on Jan 14, 2026

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

Fully refundable

$189 nightly

$224 total

Feb 21 - Feb 22

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

9.2/10 Wonderful! (644 reviews)

Nice

Reviewed on Jan 4, 2026

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$215 nightly

$254 total

Feb 8 - Feb 9

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,988 reviews)

Not great. Good.

Reviewed on Jan 19, 2026

Grand Hyatt San Antonio River Walk

600 E Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$214 nightly

$252 total

Feb 16 - Feb 17

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the arcade/game room and onsite laundry facilities. Enjoy the 24-hour ...

9.2/10 Wonderful! (1,344 reviews)

Everything was great!

Reviewed on Jan 17, 2026

The St. Anthony, A Luxury Collection Hotel, San Antonio

300 E Travis St San Antonio TX

Fully refundableReserve now, pay when you stay

$159 nightly

$188 total

Feb 8 - Feb 9

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.8/10 Excellent! (1,002 reviews)

Room was very pleasant. Extremely helpful front desk staff on arrival. Breakfast is a lottery, very few tables, only managed to eat at the hotel one morning out of four.

Reviewed on Jan 10, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.