Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $212 total

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$98 nightly

$117 total

Nov 17 - Nov 18

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$163 nightly

$195 total

Nov 15 - Nov 16

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (4,050 reviews)

"Great hotel location! Staff was amazing and professional."

Reviewed on Nov 7, 2026

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

Fully refundableReserve now, pay when you stay

$128 nightly

$153 total

Nov 15 - Nov 16

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

Hotel Valencia Riverwalk, Valencia Collection

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$161 nightly

$192 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (3,299 reviews)

"The property was extremely close to the Riverwalk and lots of fantastic restaurants"

Reviewed on Nov 6, 2026

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$166 nightly

$198 total

Nov 26 - Nov 27

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

9.4/10 Exceptional! (3,012 reviews)

"Great staff and clean!!!"

Reviewed on Nov 6, 2026

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$96 nightly

$115 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

8.4/10 Very Good! (1,657 reviews)

"very disappointed. looks like they bought and old hotel and never fixed it up. no restaurant to speak of, what food there was is awful. entire floor smelled like smoke. not like someone was just smoking a cig here... but more like everyone was has been smoking here for decades. i doubt i'll go to ..."

Reviewed on Nov 6, 2026

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

Fully refundableReserve now, pay when you stay

$110 nightly

$131 total

Nov 29 - Nov 30

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$188 nightly

$224 total

Nov 22 - Nov 23

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (2,338 reviews)

"Our room was clean and comfortable. Staff was friendly and helpful."

Reviewed on Nov 5, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$153 nightly

$183 total

Nov 22 - Nov 23

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

$177 nightly

$212 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.