Explore top 2026 4 Star Hotels in Medical Center District
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Top Medical Center District 4 Star hotels

Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from May 12 to May 13
$106 total
May 12 - May 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,449 reviews)
Comfortable bed
Reviewed on May 6, 2026

Hotel Contessa
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $167 total per night from May 17 to May 18
$167 total
May 17 - May 18
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,553 reviews)
Do not listen to the porters about taxi rides back to the airport. They will tell you its $29 but the taxi driver will charge you $39. The taxi driver is trying to charge me twice by double charging my credit card. An uber or lyft will be cheaper. Also the rooms are a little run down. The place needs ...
Reviewed on May 6, 2026

Hyatt Regency Hill Country Resort and Villas
9800 Hyatt Resort Dr San Antonio TX
Fully refundableReserve now, pay when you stay
$405 nightly
The price is $479 total per night from May 11 to May 12
$479 total
May 11 - May 12
Total with taxes and fees
This hotel features a golf course, free water park access, and 5 restaurants. Bring the family and enjoy the lazy river, children's pool, and waterslide. Enjoy ...
8.8/10 Excellent! (1,003 reviews)
Gorgeous place and jacob at the desk sang happy birthday to my wife upon check in! Beautiful stay!
Reviewed on Apr 28, 2026

Kimpton Santo San Antonio - Riverwalk by IHG
431 South Alamo Street San Antonio TX
Fully refundable
$181 nightly
The price is $214 total per night from Jun 7 to Jun 8
$214 total
Jun 7 - Jun 8
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (904 reviews)
Very clean hotel. Great breakfast and coffee bar. Nice location, short walk to the Riverwalk. Would stay again.
Reviewed on May 4, 2026

Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $188 total per night from Jun 6 to Jun 7
$188 total
Jun 6 - Jun 7
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,719 reviews)
Beautiful hotel. Friendly staff from valets to front desk to housekeeping.
Reviewed on May 6, 2026

Omni La Mansion del Rio
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $251 total per night from Jun 1 to Jun 2
$251 total
Jun 1 - Jun 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,927 reviews)
Pool was amazing
Reviewed on May 6, 2026

Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $256 total per night from May 30 to May 31
$256 total
May 30 - May 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,137 reviews)
Clean room
Reviewed on May 6, 2026

Plaza San Antonio Hotel & Spa, Autograph Collection
555 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $183 total per night from May 10 to May 11
$183 total
May 10 - May 11
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (797 reviews)
Beautiful hotel, valet is pricey around $70.00 per night, but other than that we had a great stay. Lots to do in the area and staff was very friendly.
Reviewed on May 4, 2026

Hilton Palacio Del Rio
200 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $196 total per night from Jun 7 to Jun 8
$196 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,173 reviews)
Enjoyed the stay
Reviewed on May 5, 2026

JW Marriott San Antonio Hill Country Resort & Spa
23808 Resort Pkwy San Antonio TX
Fully refundableReserve now, pay when you stay
$443 nightly
The price is $517 total per night from May 26 to May 27
$517 total
May 26 - May 27
Total with taxes and fees
This luxury hotel features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, and ...
9/10 Wonderful! (1,005 reviews)
Everything was amazing and fun. 10/10 will be coming back.
Reviewed on May 3, 2026
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Recent Medical Center District hotel reviews by fellow wanderers

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Everything was fine clean quite room."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
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