Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $200 total

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$86 nightly

$103 total

Dec 1 - Dec 2

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

8/10 Very Good! (6,519 reviews)

"This property was NOT ON the Riverwalk like I was told it was. The room was not cleaned throughly, there was dirt on the floor and the table was not clean. The balcony had beer tops left on it. I was VERY disappointed with this property. The staff was not knowledgeable on quite a few things I was ..."

Reviewed on Nov 1, 2026

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$191 nightly

$228 total

Nov 23 - Nov 24

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (4,047 reviews)

"We had high expectations as this hotel had a higher rating and had supposedly been renovated in 2024. Our room certainly was not well renovated. Musty smelling pillows, slightly cooling refrigerator, bedroom TV intermittent, luke warm water, room safe broken, missing knobs on dresser, sofa table ..."

Reviewed on Nov 1, 2026

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

$127 nightly

$152 total

Nov 18 - Nov 19

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

9.4/10 Exceptional! (5,458 reviews)

"Nice hotel and good breakfast and dinner"

Reviewed on Nov 1, 2026

Hotel Valencia Riverwalk, Valencia Collection

150 E Houston St San Antonio TX

$161 nightly

$192 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$162 nightly

$193 total

Nov 24 - Nov 25

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$96 nightly

$115 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

Fully refundableReserve now, pay when you stay

$101 nightly

$121 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

$216 nightly

$258 total

Nov 22 - Nov 23

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (2,344 reviews)

"Check-in was at 4, and the room wasn't ready. We were moved to another room, credited to our account, and then charged right back for “amenity fees,” which were mentioned on the booking. Got a new room, and the TV didn't work, and somehow, when we called the desk to complain, our original room became ..."

Reviewed on Nov 1, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

$153 nightly

$183 total

Nov 22 - Nov 23

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

8.8/10 Excellent! (1,543 reviews)

"Convenient location with direct access to Riverwalk but in the quieter part of the the RW which I liked. Hotel staff and service is great but the age of the hotel shows. The corridors were a bit smelly and of course old (old carpets). Room was alight but we had to call maintenance to fix the bath ..."

Reviewed on Nov 1, 2026

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

Fully refundable

$168 nightly

$200 total

Nov 29 - Nov 30

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.