Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $177 total
Rating: 9.4

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$85 nightly

$102 total

Dec 15 - Dec 16

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

8/10 Very Good! (6,515 reviews)

"Room flooded by the Jacuzzi tub and the Jacuzzi tub didn’t even work. Everything else was beautiful. The scenery was OK or as expected a little down in the dumps."

Reviewed on Nov 14, 2026

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$126 nightly

$150 total

Dec 15 - Dec 16

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

Fully refundableReserve now, pay when you stay

$128 nightly

$153 total

Nov 22 - Nov 23

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

Hotel Valencia Riverwalk, Valencia Collection

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$150 nightly

$178 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$172 nightly

$205 total

Nov 18 - Nov 19

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$96 nightly

$115 total

Nov 30 - Dec 1

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

8.4/10 Very Good! (1,660 reviews)

"Why charge for parking during the week"

Reviewed on Nov 14, 2026

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

Fully refundableReserve now, pay when you stay

$118 nightly

$141 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

9.2/10 Wonderful! (1,471 reviews)

"I would come back again"

Reviewed on Nov 13, 2026

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$188 nightly

$224 total

Nov 22 - Nov 23

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (2,345 reviews)

"Highly recommend..."

Reviewed on Nov 13, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$170 nightly

$203 total

Nov 23 - Nov 24

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

Fully refundable

$148 nightly

$177 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

9.4/10 Exceptional! (810 reviews)

"El mejor hotel. Me encantó la cama y la almohada, súper cómoda, descansé muy bien. La recepción muy amable y atenta. La Limpieza excepcional."

Reviewed on Nov 12, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.