Explore top 2026 4 Star Hotels in Medical Center District

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $141 total per night from Apr 5 to Apr 6
$141 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,389 reviews)
The staff was wonderful. The room was clean. Great hotel.

Reviewed on Mar 15, 2026

Opens in a new windowRiverwalk Plaza
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $176 total per night from Apr 5 to Apr 6
$176 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,540 reviews)
Perfect hotel for a short walk to the Magestic Theater. The walls were a little thin and the beds are tiny (doubles not queens). But, overall, it is a beautiful hotel in an excellent location with kind and helpful staff.

Reviewed on Mar 14, 2026

Opens in a new windowHotel Valencia Riverwalk
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

4 out of 5
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $248 total per night from Apr 5 to Apr 6
$248 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,060 reviews)
Service and staff were great.

Reviewed on Mar 15, 2026

Opens in a new windowHyatt Regency San Antonio Riverwalk
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $234 total per night from Apr 5 to Apr 6
$234 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,839 reviews)
Beautiful balcony with a view of the riverwalk. A short elevator ride down to the river walk with tons of shops and culture. Everything went well, thank you.

Reviewed on Mar 14, 2026

Opens in a new windowOmni La Mansion del Rio
Plaza San Antonio Hotel & Spa, Autograph Collection

Plaza San Antonio Hotel & Spa, Autograph Collection

4 out of 5
555 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$196 nightly
The price is $231 total per night from Apr 5 to Apr 6
$231 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (749 reviews)
👍👍

Reviewed on Mar 15, 2026

Opens in a new windowPlaza San Antonio Hotel & Spa, Autograph Collection
Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 out of 5
431 South Alamo Street San Antonio TX
Fully refundableReserve now, pay when you stay
$201 nightly
The price is $238 total per night from Apr 5 to Apr 6
$238 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (780 reviews)
Very nice modern hotel in walking distance to the Riverwalk and restaurants. Edgy hotel with a phenomoal rooftop bar and pool. The hotel is art deco modern with plenty of places to grab great photos with nature backgrounds

Reviewed on Mar 12, 2026

Opens in a new windowKimpton Santo San Antonio - Riverwalk by IHG
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $176 total per night from Apr 1 to Apr 2
$176 total
Apr 1 - Apr 2
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,485 reviews)
Great remodel! Great hospitality!

Reviewed on Mar 14, 2026

Opens in a new windowHotel Contessa
The Westin San Antonio North

The Westin San Antonio North

4 out of 5
9821 Colonnade Blvd San Antonio TX
Fully refundable
$89 nightly
The price is $106 total per night from Mar 29 to Mar 30
$106 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
8.6/10 Excellent! (1,302 reviews)
Clean rooms

Reviewed on Mar 14, 2026

Opens in a new windowThe Westin San Antonio North
JW Marriott San Antonio Hill Country Resort & Spa

JW Marriott San Antonio Hill Country Resort & Spa

4.5 out of 5
23808 Resort Pkwy San Antonio TX
Fully refundableReserve now, pay when you stay
$489 nightly
The price is $570 total per night from Apr 15 to Apr 16
$570 total
Apr 15 - Apr 16
Total with taxes and fees
This luxury hotel features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, and ...
9/10 Wonderful! (1,003 reviews)
The rooms were cleaned and the staff engages as you pass them. Family friendly with lots of activities for the kids to do on the resort. One of the slides at the waterpark was down so we didnt get to get on it during our stay.

Reviewed on Mar 13, 2026

Opens in a new windowJW Marriott San Antonio Hill Country Resort & Spa
Canopy by Hilton San Antonio Riverwalk

Canopy by Hilton San Antonio Riverwalk

4 out of 5
123 N. Saint Marys St. San Antonio TX
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $206 total per night from Apr 5 to Apr 6
$206 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.4/10 Exceptional! (1,633 reviews)
The room was great and the staff so courteous and helpful. The only issue i had was there wasn't any ice available on my floor, above, and below. However Bill (i think that's his name) at front desk had some ice sent up right away.

Reviewed on Mar 15, 2026

Opens in a new windowCanopy by Hilton San Antonio Riverwalk
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Recent Medical Center District hotel reviews by fellow wanderers

Riverwalk Plaza

Riverwalk Plaza

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The staff was wonderful. The room was clean. Great hotel. "
A verified traveler stayed at Riverwalk Plaza
Riverwalk Plaza

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