Explore top 2026 4 Star Hotels in Medical Center District

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Top Medical Center District 4 Star hotels

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $161 total per night from May 17 to May 18
$161 total
May 17 - May 18
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
9.4/10 Exceptional! (4,616 reviews)
This is probably the best Drury Inn I've stayed at. Great location on Riverwalk and very walkable area. Breakfast was very good and staff was very helpful and friendly.

Reviewed on May 10, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $117 total per night from May 12 to May 13
$117 total
May 12 - May 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,471 reviews)
The stay was suitable and felt safe. The staff was courteous. They obviously didn’t care about people smoking marijuana in the rooms because you could hardly walk down the hallway for the stitch. Definitely needs an update done to the facility. Three star property.

Reviewed on May 10, 2026

Opens in a new windowRiverwalk Plaza
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $155 total per night from Jun 7 to Jun 8
$155 total
Jun 7 - Jun 8
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,570 reviews)
Everything about this hotel is amazing !!!

Reviewed on May 10, 2026

Opens in a new windowHotel Contessa
Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 out of 5
431 South Alamo Street San Antonio TX
Fully refundable
$191 nightly
The price is $226 total per night from May 17 to May 18
$226 total
May 17 - May 18
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (910 reviews)
Loved this hotel! My daughter and I decided to spend an extra night here owing to the excellent front desk, restaurant/bar, gym/pool amenities…highly recommend!

Reviewed on May 10, 2026

Opens in a new windowKimpton Santo San Antonio - Riverwalk by IHG
Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
Fully refundableReserve now, pay when you stay
$405 nightly
The price is $479 total per night from May 17 to May 18
$479 total
May 17 - May 18
Total with taxes and fees
This hotel features a golf course, free water park access, and 5 restaurants. Bring the family and enjoy the lazy river, children's pool, and waterslide. Enjoy ...
8.8/10 Excellent! (1,004 reviews)
Gorgeous place and jacob at the desk sang happy birthday to my wife upon check in! Beautiful stay!

Reviewed on Apr 28, 2026

Opens in a new windowHyatt Regency Hill Country Resort and Villas
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $178 total per night from Jun 6 to Jun 7
$178 total
Jun 6 - Jun 7
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,723 reviews)
Pk

Reviewed on May 11, 2026

Opens in a new windowHotel Valencia Riverwalk
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $251 total per night from Jun 1 to Jun 2
$251 total
Jun 1 - Jun 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,936 reviews)
It's location at the Celena bridge is great!

Reviewed on May 11, 2026

Opens in a new windowOmni La Mansion del Rio
Hilton Palacio Del Rio

Hilton Palacio Del Rio

4 out of 5
200 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $191 total per night from Jun 7 to Jun 8
$191 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,181 reviews)
Significant traffic noise. Lots of noise from weekend parties.

Reviewed on May 10, 2026

Opens in a new windowHilton Palacio Del Rio
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

4 out of 5
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $256 total per night from May 30 to May 31
$256 total
May 30 - May 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,144 reviews)
Property is perfectly situated on Riverwalk. Rooms are modern and comfortable. Breakfast is restaurant was excellent and staff are all very friendly and helpful.

Reviewed on May 8, 2026

Opens in a new windowHyatt Regency San Antonio Riverwalk
The Westin Riverwalk, San Antonio

The Westin Riverwalk, San Antonio

4 out of 5
420 W Market St San Antonio TX
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $212 total per night from May 31 to Jun 1
$212 total
May 31 - Jun 1
Total with taxes and fees
The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,535 reviews)
Clean and friendly hotel awesome service

Reviewed on Apr 29, 2026

Opens in a new windowThe Westin Riverwalk, San Antonio
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