Explore top 2026 4 Star Hotels in Medical Center District
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Top Medical Center District 4 Star hotels
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $161 total per night from May 17 to May 18
$161 total
May 17 - May 18
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
9.4/10 Exceptional! (4,627 reviews)
We had dirty sheets, floors were disgusting in hallways gross. Probably the dirtiest I’ve seen any building. Elevators slow and took forever and would close on you as you entered. Plus was close to everything and they let you check in early. The bed was made but made with dirty bloody sheets. Towels ...
Reviewed on May 11, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $117 total per night from May 13 to May 14
$117 total
May 13 - May 14
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,476 reviews)
L
Reviewed on May 12, 2026
Hotel Contessa
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $155 total per night from Jun 7 to Jun 8
$155 total
Jun 7 - Jun 8
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
Kimpton Santo San Antonio - Riverwalk by IHG
431 South Alamo Street San Antonio TX
Fully refundable
$191 nightly
The price is $226 total per night from May 17 to May 18
$226 total
May 17 - May 18
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (913 reviews)
We love staying here! Unlike the San Antonio Plaza across the way, this hotel has delightful service, pays attention to details, and has been a surprisingly reasonably priced luxury option for our staycations in San Antonio. The service is so great, they are responsive, kind, personable, and never ...
Reviewed on May 12, 2026
Hyatt Regency Hill Country Resort and Villas
9800 Hyatt Resort Dr San Antonio TX
$405 nightly
The price is $479 total per night from May 13 to May 14
$479 total
May 13 - May 14
Total with taxes and fees
This hotel features a golf course, free water park access, and 5 restaurants. Bring the family and enjoy the lazy river, children's pool, and waterslide. Enjoy ...
8.8/10 Excellent! (1,004 reviews)
Gorgeous place and jacob at the desk sang happy birthday to my wife upon check in! Beautiful stay!
Reviewed on Apr 28, 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $178 total per night from Jun 6 to Jun 7
$178 total
Jun 6 - Jun 7
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,726 reviews)
Great service, clean room
Reviewed on May 11, 2026
Omni La Mansion del Rio
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $239 total per night from May 31 to Jun 1
$239 total
May 31 - Jun 1
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,938 reviews)
Staff was super friendly and very professional. We were given a larger room with a private balcony after the person at the front desk learned we were there to celebrate our wedding anniversary. Room had a refrigerator but no Microwave, so something to keep in mind when bringing leftovers to the room ...
Reviewed on May 11, 2026
Hilton Palacio Del Rio
200 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $190 total per night from Jun 7 to Jun 8
$190 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,182 reviews)
Significant traffic noise. Lots of noise from weekend parties.
Reviewed on May 10, 2026
Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $256 total per night from May 30 to May 31
$256 total
May 30 - May 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,145 reviews)
Clean room
Reviewed on May 12, 2026
The Westin Riverwalk, San Antonio
420 W Market St San Antonio TX
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $212 total per night from May 31 to Jun 1
$212 total
May 31 - Jun 1
Total with taxes and fees
The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,535 reviews)
Clean and friendly hotel awesome service
Reviewed on Apr 29, 2026
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Recent Medical Center District hotel reviews by fellow wanderers
Riverwalk Plaza
4 out of 5
Posted 7 hours ago
Travelocity Verified Review
"L"
A verified traveler stayed at Riverwalk Plaza
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