Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $220 total

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$86 nightly

$102 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$173 nightly

$206 total

Nov 15 - Nov 16

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

Fully refundableReserve now, pay when you stay

$128 nightly

$152 total

Nov 8 - Nov 9

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

Hotel Valencia Riverwalk

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$139 nightly

$164 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$162 nightly

$192 total

Nov 16 - Nov 17

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

9.4/10 Exceptional! (3,004 reviews)

"Perfect location"

Reviewed on Oct 23, 2026

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$111 nightly

$132 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

$118 nightly

$141 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$216 nightly

$258 total

Oct 28 - Oct 29

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (2,338 reviews)

"Everything was great… the only issue was the pillows were flat… other than that it was a great hotel!!!"

Reviewed on Oct 23, 2026

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$153 nightly

$183 total

Nov 22 - Nov 23

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

8.8/10 Excellent! (1,539 reviews)

"Great hotel, location on the riverwalk. Check in and out was a breeze. A lot of space but its location gives one the ability to walk around a lot but be close to get back to the hotel. Highly recommend."

Reviewed on Oct 24, 2026

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

Fully refundable

$185 nightly

$220 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Medical Center District hotel reviews by fellow wanderers

Drury Inn & Suites San Antonio Northwest Medical Center

5 out of 5

Posted 15 hours ago

Travelocity Verified Review

"Great service!!!!!!!"

A verified traveler stayed at Drury Inn & Suites San Antonio Northwest Medical Center

Courtyard by Marriott Medical Center San Antonio

4 out of 5

Posted 2 days ago

Travelocity Verified Review

"The hotel was very nice. It obviously had been updated recently. The room was well maintained and very clean. My husband liked the big TV and sofa. The hotel has a small restaurant in house, The Bistro. It was pricey so be prepared to pay out for this convenience. There are restaurants within walking distance. Be sure to bring your own water, snacks, napkins and if needed a blanket. The only amenity is the coffee bags in the rooms. Also you might want to ask for trash can bags especially if you eat in the room like we did. We didn’t have any bags to throw out this trash. The cans are very small."

A verified traveler stayed at Courtyard by Marriott Medical Center San Antonio