Explore top 2026 4 Star Hotels in Medical Center District

Name: InterContinental San Antonio Riverwalk by IHG
Price range: $200 total

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

100 Villita Street San Antonio TX

Fully refundableReserve now, pay when you stay

$98 nightly

$117 total

Nov 17 - Nov 18

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...

8/10 Very Good! (6,498 reviews)

Reviewed on Oct 29, 2026

Hotel Contessa

306 W Market Street San Antonio TX

Fully refundableReserve now, pay when you stay

$191 nightly

$228 total

Nov 23 - Nov 24

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (4,033 reviews)

"The suites are spacious and offer a very practical layout, which is a definite plus. Unfortunately, the property feels dated and poorly maintained. There was a strong musty odor, visible mold, and a bathroom door that wouldn’t close properly due to warped, deteriorating wood. Additionally, the $70 ..."

Reviewed on Oct 29, 2026

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX

Fully refundableReserve now, pay when you stay

$128 nightly

$152 total

Nov 8 - Nov 9

Total with taxes and fees

2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...

Hotel Valencia Riverwalk, Valencia Collection

150 E Houston St San Antonio TX

Fully refundableReserve now, pay when you stay

$161 nightly

$191 total

Nov 19 - Nov 20

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Omni La Mansion del Rio

112 College St San Antonio TX

Fully refundableReserve now, pay when you stay

$162 nightly

$192 total

Nov 24 - Nov 25

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

9.4/10 Exceptional! (3,010 reviews)

"We loved this hotel. It is very conveniently located on the Riverwalk with lots of dining options nearby. We had breakfast at the hotel one morning and at the sister hotel across the river one morning, but were great. The property is clean, beautiful and well maintained. The staff is very friendly ..."

Reviewed on Oct 29, 2026

The Westin San Antonio North

9821 Colonnade Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$96 nightly

$115 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...

Element by Marriott San Antonio Riverwalk

111 Soledad Street San Antonio TX

Fully refundableReserve now, pay when you stay

$118 nightly

$141 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. Valet parking, ...

Hyatt Regency San Antonio Riverwalk

123 Losoya St San Antonio TX

Fully refundableReserve now, pay when you stay

$216 nightly

$258 total

Nov 22 - Nov 23

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

The Westin Riverwalk, San Antonio

420 W Market St San Antonio TX

Fully refundableReserve now, pay when you stay

$153 nightly

$183 total

Nov 22 - Nov 23

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...

InterContinental San Antonio Riverwalk by IHG

111 East Pecan Street San Antonio TX

Fully refundable

$168 nightly

$200 total

Nov 29 - Nov 30

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Medical Center District hotel reviews by fellow wanderers

Drury Inn & Suites San Antonio Northwest Medical Center

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"Staff was great, friendly, and kind. I cant complain. And to my surprise, they had fountain drinks and popcorn, which was perfect. Enjoyed complimentary breakfast annnnnd dinner. That in itself deserves 5 stars. Overall, great stay. I would return back."

A verified traveler stayed at Drury Inn & Suites San Antonio Northwest Medical Center

Riverwalk Plaza

4 out of 5

Posted 4 hours ago

Travelocity Verified Review

"The location was conveniently located with the Riverwalk close by and major attractions were within walking distance. The staff was very friendly and helpful. the valet parking was a little confusing at first. Our room was clean and air conditioner worked well. Problems were obvious in bathroom. Tub spigot ran constantly at a slight stream and the toilet rocked when you sat on it. All in all I would probably stay there if I am in the city again. Price was right."

A verified traveler stayed at Riverwalk Plaza

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

4 out of 5

Posted 2 days ago

Travelocity Verified Review

"We stayed at Wild Oak Ranch for four days in late October whilst visiting rour son at Trinity University about 25 mins away. It was a nice change from a standard hotel. The villa was excellent, very clean, well equipped and the washer & tumble dryer were useful. Nice spa bath and big bathroom. We used the pool, lazy river, gym and played pickle ball, all great and never too busy. We didn’t use the fire pits or bbqs, but seemed like a nice touch. Perhaps the only disappointing thing was the bar/restaurant. It would have been nice to have a more relaxing f&b offering, more in keeping with the lobby feel. It was great for a short stay and as it wasn’t the main focus of our vacation we really enjoyed our visit."

A verified traveler stayed at Hyatt Vacation Club at Wild Oak Ranch, San Antonio