Find a Hotel in Medical Center District

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Top hotels in Medical Center District

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St, San Antonio, TX
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $177 total per night from Oct 2 to Oct 3
$177 total
Oct 2 - Oct 3
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Nice hotel and staff missing parking
"Very polite staff. Up scale hotel on the river walk. For parking they only offer very expensive valet. Late check in time."

Reviewed on Sep 16, 2025

Opens in a new windowHotel Valencia Riverwalk
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $142 total per night from Sep 30 to Oct 1
$142 total
Sep 30 - Oct 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Great service and location
"Always an amazing stay. The location was perfect great price for all the amenities the hotel offers."

Reviewed on Sep 18, 2025

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $103 total per night from Oct 19 to Oct 20
$103 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features free self parking and free WiFi in public areas. Free buffet breakfast is served. A computer station and luggage storage are also ...
"Great location and facilities, people at the front desk super nice"

Reviewed on Sep 19, 2025

Opens in a new windowFairfield Inn & Suites by Marriott San Antonio Medical Center
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive, San Antonio, TX
Fully refundable
$140 nightly
The price is $166 total per night from Oct 8 to Oct 9
$166 total
Oct 8 - Oct 9
Total with taxes and fees
This hotel features an outdoor pool, an indoor pool, and a restaurant. Bring the family and enjoy the lazy river, mini golf, and waterslide. Enjoy the 24-hour ...
"Good service"

Reviewed on Sep 22, 2025

Opens in a new windowHyatt Vacation Club at Wild Oak Ranch, San Antonio
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Oct 3 to Oct 4
$105 total
Oct 3 - Oct 4
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"The room"

Reviewed on Sep 20, 2025

Opens in a new windowCourtyard by Marriott Medical Center San Antonio
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Sep 26 to Sep 27
$105 total
Sep 26 - Sep 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference center. ...
"The pool was very nice and the rooms were very clean"

Reviewed on Sep 23, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from Oct 3 to Oct 4
$113 total
Oct 3 - Oct 4
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and WiFi in public ...
"Clean , Friendly staff , room clean"

Reviewed on Sep 20, 2025

Opens in a new windowSan Antonio Marriott Northwest Medical Center
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $99 total per night from Sep 28 to Sep 29
$99 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...
"Maria was so amazing."

Reviewed on Sep 23, 2025

Opens in a new windowSonesta ES Suites San Antonio Downtown Alamo Plaza
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $116 total per night from Oct 2 to Oct 3
$116 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
"Staff waa very friendly."

Reviewed on Sep 17, 2025

Opens in a new windowRiverwalk Plaza
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Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers