Find a Hotel in Medical Center District

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Top hotels in Medical Center District

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St, San Antonio, TX
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $175 total per night from Nov 11 to Nov 12
$175 total
Nov 11 - Nov 12
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Nice place

Reviewed on Nov 8, 2025

Opens in a new windowHotel Valencia Riverwalk
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $142 total per night from Nov 16 to Nov 17
$142 total
Nov 16 - Nov 17
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
Room was clean and housekeeping was on point!

Reviewed on Nov 6, 2025

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $93 total per night from Nov 17 to Nov 18
$93 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel features free self parking and free WiFi in public areas. Free buffet breakfast is served. A computer station and luggage storage are also ...
Staff was helpful! Everything super clean and free breakfast was good

Reviewed on Nov 2, 2025

Opens in a new windowFairfield Inn & Suites by Marriott San Antonio Medical Center
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $106 total per night from Nov 14 to Nov 15
$106 total
Nov 14 - Nov 15
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the laundry service and WiFi in public areas. Enjoy ...
Nice views

Reviewed on Nov 1, 2025

Opens in a new windowSan Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $99 total per night from Nov 16 to Nov 17
$99 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Over all very quiet peaceful stay

Reviewed on Oct 19, 2025

Opens in a new windowCourtyard by Marriott Medical Center San Antonio
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Nov 10 to Nov 11
$105 total
Nov 10 - Nov 11
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference center. ...
Staff was amazing.

Reviewed on Nov 7, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $103 total per night from Nov 16 to Nov 17
$103 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...
Friendly staff, clean rooms, everything worked!

Reviewed on Nov 6, 2025

Opens in a new windowSonesta ES Suites San Antonio Downtown Alamo Plaza
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $116 total per night from Nov 11 to Nov 12
$116 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
It’s ok

Reviewed on Nov 8, 2025

Opens in a new windowRiverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $102 total per night from Nov 16 to Nov 17
$102 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
1 night stay did use these services. Wall electric plug next to A/C did not work. Hair dryer in bathroom did not work. Chair in room showed a lot of wear on the seat. Not a deal breaker.

Reviewed on Nov 3, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers

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