Find a Hotel in Medical Center District

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top hotels in Medical Center District

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
$128 nightly
The price is $153 total per night from Nov 22 to Nov 23
$153 total
Nov 22 - Nov 23
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
"👍🏾"

Reviewed on Nov 14, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
$90 nightly
The price is $107 total per night from Nov 22 to Nov 23
$107 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Rooms were clean, beds were comfortable, Breakfast and Dinner were awesom"

Reviewed on Nov 13, 2026

Opens in a new windowDrury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
$89 nightly
The price is $106 total per night from Nov 26 to Nov 27
$106 total
Nov 26 - Nov 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Enjoy ourselves while staying at the hotel. Good location, clean room, and friendly staff."

Reviewed on Nov 13, 2026

Opens in a new windowCourtyard by Marriott Medical Center San Antonio
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
$85 nightly
The price is $102 total per night from Dec 15 to Dec 16
$102 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
"Room flooded by the Jacuzzi tub and the Jacuzzi tub didn’t even work. Everything else was beautiful. The scenery was OK or as expected a little down in the dumps."

Reviewed on Nov 14, 2026

Opens in a new windowRiverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
$89 nightly
The price is $106 total per night from Nov 15 to Nov 16
$106 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference center. ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
$94 nightly
The price is $112 total per night from Dec 15 to Dec 16
$112 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the laundry service and WiFi in public areas. There's ...
Opens in a new windowSan Antonio Marriott Northwest Medical Center
Hotel Valencia Riverwalk, Valencia Collection

Hotel Valencia Riverwalk, Valencia Collection

4.5 out of 5
150 E Houston St San Antonio TX
$150 nightly
The price is $178 total per night from Nov 22 to Nov 23
$178 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Opens in a new windowHotel Valencia Riverwalk, Valencia Collection
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
$76 nightly
The price is $91 total per night from Nov 15 to Nov 16
$91 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. WiFi in public areas is free. Valet parking, a business center, and a coffee shop are also ...
Opens in a new windowCrockett Hotel
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
$93 nightly
The price is $111 total per night from Nov 18 to Nov 19
$111 total
Nov 18 - Nov 19
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Don't see what you're looking for?
See all available properties in Medical Center District
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity