Cheap Flights to Santee from $166

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How Much Does it Cost To Fly To Santee?

The cheapest prices found with in the last 7 days for return flights were $222 and $166 for one-way flights to Santee for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel DatesFlights From*
DCAWest ColumbiaDecember 2 to December 9$259
BOSWest ColumbiaSeptember 26 to October 3$265
ORDWest ColumbiaNovember 6 to November 8$279
EWRWest ColumbiaOctober 7 to October 13$293
EWRWest ColumbiaOctober 7 to October 13$293
BDLWest ColumbiaSeptember 11 to September 12$307
JFKWest ColumbiaOctober 7 to October 13$365
LAXWest ColumbiaSeptember 18 to September 21$379
PHLWest ColumbiaOctober 28 to October 31$391
DALWest ColumbiaOctober 21 to October 24$445
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
DCAWest ColumbiaSeptember 5 to September 8$316
ORDWest ColumbiaSeptember 6 to September 7$333
LGAWest ColumbiaSeptember 5 to September 6$376
JFKWest ColumbiaSeptember 5 to September 6$396
TTNWest ColumbiaSeptember 5 to September 8$427
BDLWest ColumbiaSeptember 4 to September 6$439
DFWWest ColumbiaSeptember 4 to September 7$665
EWRWest ColumbiaSeptember 4 to September 7$667
LAXWest ColumbiaSeptember 5 to September 12$758
*Prices include taxes and fees

Santee Flight Information

Traveling to
Santee
Lowest Price
$222
Number of Airlines Serving
Airlines Serving
American Airlines, Delta
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Santee Accommodation Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
$75 nightly
The price is $83 total per night from Aug 30 to Aug 31
$83 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,481 reviews)
"The room was clean but dated. The door was loose and had visible damage that it had been kicked in and not replaced. The staff was great. It was a last-minute choice as my husband got sick while driving back home."

Reviewed on Aug 27, 2026

Opens in a new windowBaymont by Wyndham Santee
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
$63 nightly
The price is $70 total per night from Aug 31 to Sep 1
$70 total
Aug 31 - Sep 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
Opens in a new windowRed Roof Inn Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
$64 nightly
The price is $71 total per night from Aug 30 to Aug 31
$71 total
Aug 30 - Aug 31
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (770 reviews)
"0"

Reviewed on Aug 27, 2026

Opens in a new windowTravelodge by Wyndham Santee
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Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95

2 out of 5
9125 Old Highway 6 Santee SC
$64 nightly
The price is $71 total per night from Sep 3 to Sep 4
$71 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.8/10 (473 reviews)
"The bathroom in the room was very small. The tub would not drain properly. There was a piece on the tub that was broke. There was no shampoo in the bathroom and the piece of soap that we did have was very small. The very small pool that they had the water was green. The parking was very limited and ..."

Reviewed on Aug 7, 2026

Opens in a new windowSuper 8 by Wyndham Santee/I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Santee

Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
$63 nightly
The price is $70 total per night from Aug 31 to Sep 1
$70 total
Aug 31 - Sep 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
Opens in a new windowRed Roof Inn Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
$101 nightly
The price is $112 total per night from Sep 20 to Sep 21
$112 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,000 reviews)
"Clean room"

Reviewed on Aug 26, 2026

Opens in a new windowComfort Inn & Suites Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
$75 nightly
The price is $83 total per night from Aug 30 to Aug 31
$83 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,481 reviews)
"The room was clean but dated. The door was loose and had visible damage that it had been kicked in and not replaced. The staff was great. It was a last-minute choice as my husband got sick while driving back home."

Reviewed on Aug 27, 2026

Opens in a new windowBaymont by Wyndham Santee
Save an average of 15% on thousands of hotels when you're signed in
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
$69 nightly
The price is $76 total per night from Sep 8 to Sep 9
$76 total
Sep 8 - Sep 9
Total with taxes and fees
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a nightclub. Popular attractions Santee Cooper Country Club and Santee National ...
Opens in a new windowRamada by Wyndham Santee I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
$101 nightly
The price is $112 total per night from Sep 20 to Sep 21
$112 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,000 reviews)
"Clean room"

Reviewed on Aug 26, 2026

Opens in a new windowComfort Inn & Suites Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
$123 nightly
The price is $137 total per night from Sep 7 to Sep 8
$137 total
Sep 7 - Sep 8
Total with taxes and fees
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,000 reviews)
"Room was dirty."

Reviewed on Aug 23, 2026

Opens in a new windowHampton Inn Santee-I-95
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
$111 nightly
The price is $123 total per night from Sep 6 to Sep 7
$123 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Opens in a new windowBest Western Plus Santee Inn
Save an average of 15% on thousands of hotels when you're signed in
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
$103 nightly
The price is $114 total per night from Sep 27 to Sep 28
$114 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
Opens in a new windowHoliday Inn Santee by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Santee Flight and Hotel Packages

Santee flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Fairfield Inn & Suites by Marriott Columbia Downtown
Lexington Expo Hotel by IHG
Sheraton Columbia Downtown Hotel
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Need a Car For After Your Flight?

Plane Tickets To Santee

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Santee. Browse through our inventory to explore a wide range of cheap flights to Santee to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Santee as you anxiously await to exit the plane and explore what Santee has to offer. Considering all the amazing local food and culture in Santee, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Santee to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Santee without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Santee with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Santee today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.