Book Hotels in Southeast Minnesota, MN

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Dec 10 - Dec 11
Tomorrow
Dec 11 - Dec 12
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Southeast Minnesota hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Fully refundable
$103 nightly
The price is $118 total per night from Dec 12 to Dec 13
$118 total
Dec 12 - Dec 13
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
The room was great! Will stay again

Reviewed on Dec 8, 2025

Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $79 total per night from Dec 21 to Dec 22
$79 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
Hotels was very clean and staff was very friendly.

Reviewed on Dec 9, 2025

Opens in a new windowSpark by Hilton Rochester South
Hampton Inn Rochester-South

Hampton Inn Rochester-South

2.5 out of 5
1755 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $95 total per night from Jan 4 to Jan 5
$95 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. You'll appreciate the free ...
The hotel had a choice among eggs, breakfast meats and potatoes, as well as two flavors of waffle batter. There were oatmeal and cereal options.

Reviewed on Dec 10, 2025

Opens in a new windowHampton Inn Rochester-South
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Dec 20 to Dec 21
$149 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Great location. Friendly staff. Easy access to Mayo Clinic’s via shuttle. Rooms were comfortable and spacious.

Reviewed on Dec 6, 2025

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$69 nightly
The price is $79 total per night from Dec 26 to Dec 27
$79 total
Dec 26 - Dec 27
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Clean, quiet room and comfortable bed

Reviewed on Dec 7, 2025

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $172 total per night from Dec 12 to Dec 13
$172 total
Dec 12 - Dec 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Staff was friendly and helpful! Will continue to stay here while at the Mayo,

Reviewed on Dec 8, 2025

Opens in a new windowKahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Dec 26 to Dec 27
$84 total
Dec 26 - Dec 27
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Clean room and great staff

Reviewed on Dec 8, 2025

Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $153 total per night from Jan 10 to Jan 11
$153 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Our room was clean. We attempted to stream a movie on TV but could not do so! There was lots of construction noise throughout our overnight stay.

Reviewed on Dec 10, 2025

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $83 total per night from Dec 26 to Dec 27
$83 total
Dec 26 - Dec 27
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
I arrived late at night and the young man checking me in was most helpful and friendly (don't always see this at 11 pm!) Very clean and comfortable room, even including a selection of different thicknesses of pillows! (A bonus for those of us who don't like sleeping with our head a foot up in the ...

Reviewed on Dec 7, 2025

Opens in a new windowMed City Inn & Suites - Mayo Clinic Area
Don't see what you're looking for?
See all available properties in Southeast Minnesota
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Southeast Minnesota hotels

Red Carpet Inn Rochester

Red Carpet Inn Rochester

2214 South Broadway Rochester MN
$60 nightly
The price is $69 total per night from Dec 12 to Dec 13
$69 total
Dec 12 - Dec 13
Total with taxes and fees
7.6/10 Good! (530 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Southeast Minnesota hotel reviews by fellow wanderers

Hampton Inn Rochester-South

Hampton Inn Rochester-South

5 out of 5
Posted 18 hours ago
Travelocity Verified Review
"The hotel had a choice among eggs, breakfast meats and potatoes, as well as two flavors of waffle batter. There were oatmeal and cereal options."
A verified traveler stayed at Hampton Inn Rochester-South
Hampton Inn Rochester-South

Explore More Ways to Travel with Travelocity