Explore 9 Luxury Hotels in West Main Historic District

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Best Luxury Hotels in West Main Historic District

21c Museum Hotel Louisville

21c Museum Hotel Louisville

700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $180 total per night from Jan 30 to Jan 31
$180 total
Jan 30 - Jan 31
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,003 reviews)
Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.

Reviewed on Jan 25, 2026

Opens in a new window21c Museum Hotel Louisville
Louisville Marriott Downtown

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$180 nightly
The price is $211 total per night from Feb 8 to Feb 9
$211 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,001 reviews)
Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again!

Reviewed on Jan 16, 2026

Opens in a new windowLouisville Marriott Downtown
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Feb 3 to Feb 4
$159 total
Feb 3 - Feb 4
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (3,999 reviews)
The breakfast was delicious, the staff was amazing to be with and supper attended.

Reviewed on Jan 20, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $150 total per night from Feb 8 to Feb 9
$150 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
8.8/10 Excellent! (1,144 reviews)
Room was spotless

Reviewed on Jan 23, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

500 S 4th St Louisville KY
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Feb 2 to Feb 3
$155 total
Feb 2 - Feb 3
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
8.6/10 Excellent! (1,000 reviews)
The area was congested but the motel was good.

Reviewed on Jan 14, 2026

Opens in a new windowSeelbach Hilton Louisville Downtown
Hyatt Regency Louisville

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $184 total per night from Feb 5 to Feb 6
$184 total
Feb 5 - Feb 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (1,004 reviews)
Excellent

Reviewed on Jan 21, 2026

Opens in a new windowHyatt Regency Louisville
Hampton Inn Louisville Downtown

Hampton Inn Louisville Downtown

101 E Jefferson St Louisville KY
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Feb 8 to Feb 9
$105 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Relax ...
8.4/10 Very Good! (1,004 reviews)
Great staff and wonderful location. Thank you!!

Reviewed on Jan 25, 2026

Opens in a new windowHampton Inn Louisville Downtown
Econo Lodge Louisville Downtown

Econo Lodge Louisville Downtown

401 S 2nd St Louisville KY
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $74 total per night from Feb 9 to Feb 10
$74 total
Feb 9 - Feb 10
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...
7/10 Good! (1,000 reviews)
Nice hotel with a great location near Whiskey Row. This is my 3rd stay at this hotel and will definitely come back again

Reviewed on Dec 11, 2025

Opens in a new windowEcono Lodge Louisville Downtown
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in West Main Historic District

5 star hotels in West Main Historic District

Louisville Bourbon Inn

Louisville Bourbon Inn

1332 S 4th St Louisville KY
$265 nightly
The price is $308 total per night from Jan 28 to Jan 29
$308 total
Jan 28 - Jan 29
Total with taxes and fees
10/10 Exceptional! (21 reviews)

West Main Historic District Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the West Main Historic District luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in West Main Historic District to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in West Main Historic District will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in West Main Historic District, and plan your next opulent escape.


West Main Historic District hotels essential information

Accommodation
2,101 hotels
Lowest Price
$74
Highest Price
$308
Popular hotels
21c Museum Hotel Louisville, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Louisville Marriott Downtown, Hyatt Regency Louisville, Hampton Inn Louisville Downtown

Popular Luxury Stays in West Main Historic District

Recent West Main Historic District Hotel Reviews By Fellow Wanderers

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