Book Hotels in Byron, MN
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Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$117 nightly
The price is $134 total per night from Apr 11 to Apr 12
$134 total
Apr 11 - Apr 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean room and the staff was amazing.
Reviewed on Apr 4, 2026

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $81 total per night from Apr 12 to Apr 13
$81 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
The breakfast was very limited and no hot food. The coffee was terrible. The staff was nice and answered all questions. Housekeeping was nice as well. Big TV in the room was a nice addition.
Reviewed on Apr 3, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $167 total per night from Apr 12 to Apr 13
$167 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Good location
Reviewed on Apr 5, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Apr 9 to Apr 10
$146 total
Apr 9 - Apr 10
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
Clean room, staff was kind and extremely helpful as always, shuttle service was excellent!
Reviewed on Apr 4, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $121 total per night from Apr 11 to Apr 12
$121 total
Apr 11 - Apr 12
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Mark the magician at gust services waa excellent!! He really went above amd beyond!
Reviewed on Apr 5, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $172 total per night from Apr 10 to Apr 11
$172 total
Apr 10 - Apr 11
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Room was nice and big. Convenient to everything downtown.
Reviewed on Apr 5, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Apr 14 to Apr 15
$108 total
Apr 14 - Apr 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
Overall great stay. Pool had a slide which my son enjoyed but water had too much bleach.
Reviewed on Apr 6, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $178 total per night from Apr 7 to Apr 8
$178 total
Apr 7 - Apr 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
The keys would stop working frequently. This caused us not to get in our room and frequent visits to the front desk. The pool area is very small and the gym had water standing in the floor.
Reviewed on Apr 3, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$105 nightly
The price is $121 total per night from May 7 to May 8
$121 total
May 7 - May 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
45 properties
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Recent Byron hotel reviews by fellow wanderers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
4 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Overall great stay. Pool had a slide which my son enjoyed but water had too much bleach. "
A verified traveler stayed at Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
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