Book Hotels in Byron, MN
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Top Byron hotels

Spark by Hilton Rochester South
4165 Maine Ave SE, Rochester, MN
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $90 total per night from Aug 3 to Aug 4
$90 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
"The painting on the property looked like they went with the cheapest bid, but overall it was an ok motel for the money. Staff was very nice. Good coffee. Very quiet. I do think when someone books a room there with kids they should be on the 1st floor for obvious reasons."
Reviewed on Jul 26, 2025

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW, Rochester, MN
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $137 total per night from Aug 24 to Aug 25
$137 total
Aug 24 - Aug 25
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"everything is fine except the shower pressure is terribly low"
Reviewed on Jul 23, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway, Rochester, MN
Fully refundable
$114 nightly
The price is $131 total per night from Aug 23 to Aug 24
$131 total
Aug 23 - Aug 24
Total includes taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"This is a pleasant place to stay if you’re being seen at the Mayo Clinic. It’s a 5 minute walk to the subway level, via the skyway. There are numerous restaurants nearby. The restaurant in the hotel, Crave, is convenient and very good. Disappointed that the hotel did not provide bottled water in ..."
Reviewed on Jul 17, 2025

Aspen Select
1215 2nd St SW, Rochester, MN
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Jul 29 to Jul 30
$151 total
Jul 29 - Jul 30
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
"This hotel was an interesting find. The room was nice and had the basic amenities, but since it didn't have an outside window, it had big windows to the hallway, which allowed sunlight to come through from the hallway windows. Breakfast was OK but didn't have the waffle options that many places have. ..."
Reviewed on Jul 22, 2025

Kahler Grand Hotel
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $134 total per night from Aug 2 to Aug 3
$134 total
Aug 2 - Aug 3
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Location!!"
Reviewed on Jul 24, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S, Rochester, MN
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $90 total per night from Aug 3 to Aug 4
$90 total
Aug 3 - Aug 4
Total includes taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"Nice large rooms, good dining options on site"
Reviewed on Jul 21, 2025

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Aug 8 to Aug 9
$92 total
Aug 8 - Aug 9
Total includes taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"Nice place!"
Reviewed on Jul 24, 2025

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $136 total per night from Aug 2 to Aug 3
$136 total
Aug 2 - Aug 3
Total includes taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"Nothing"
Reviewed on Jul 23, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE, Rochester, MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $83 total per night from Jul 30 to Jul 31
$83 total
Jul 30 - Jul 31
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the ...
"Clean room, hot breakfast, cordial staff. Would stay again."
Reviewed on Jul 27, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
41 properties
Frequently asked questions
Recent Byron hotel reviews by fellow wanderers

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Clean room, hot breakfast, cordial staff.
Would stay again."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
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