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Top Byron hotels

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
$118 nightly
The price is $136 total per night from Oct 17 to Oct 18
$136 total
Oct 17 - Oct 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"I was there for 3 days. Housekeeping came by once. And even with asking multiple times I never got any towels. I had to go to the front desk to get fresh towels. Like bro that’s literally the bare minimum. Also the shower has so partition and no gradient in the floor to help drain so every shower ..."

Reviewed on Oct 3, 2026

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
Brentwood Inn & Suites

Brentwood Inn & Suites

2.5 out of 5
123 Fourth Ave. NW Rochester MN
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $122 total per night from Oct 29 to Oct 30
$122 total
Oct 29 - Oct 30
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the 24-hour business ...
"Staff was very helpful and kind. Desk chair worn and could use a replacement-normally would not care but was working remote while there. Wi-Fi great"

Reviewed on Oct 1, 2026

Opens in a new windowBrentwood Inn & Suites
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $157 total per night from Nov 4 to Nov 5
$157 total
Nov 4 - Nov 5
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"The location connected to Mayo and the underground parking for only $15/night can not be beat. So convenient. The room itself was good, roomy, comfy bed. It is an older hotel with older decor but I’m not here for an extravagant vacation I need convenience. And the staff was helpful with needing a ..."

Reviewed on Oct 6, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $82 total per night from Oct 7 to Oct 8
$82 total
Oct 7 - Oct 8
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
Opens in a new windowMed City Inn & Suites - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $169 total per night from Oct 28 to Oct 29
$169 total
Oct 28 - Oct 29
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Opens in a new windowKahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Oct 25 to Oct 26
$84 total
Oct 25 - Oct 26
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $118 total per night from Oct 19 to Oct 20
$118 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
Opens in a new windowCenterstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $114 total per night from Oct 11 to Oct 12
$114 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
Opens in a new windowBest Western Rochester Hotel Mayo Clinic Area/St. Mary's
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$190 nightly
The price is $219 total per night from Nov 1 to Nov 2
$219 total
Nov 1 - Nov 2
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Opens in a new windowThe Berkman
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Byron?
Take some of the worries out of traveling with youngsters by choosing a family-friendly hotel in Byron. From thoughtful amenities to services that bring a smile, these stays offer perks that'll help make your getaway run like a dream: Put your bags down at Luxury Custom Home in Golf Community. It comes with a fireplace, pet-friendly facilities and a flair for making families feel welcome. Also check out the deals at Rochesters Relaxing Ranch - 4 miles from Mayo. It comes with a king bed, free WiFi and ample opportunities for precious family time.
Where can I find cheap hotels in Byron?
At Travelocity you'll find really nice hotels in Byron at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Byron rather than in Byron. We may find you even better rates, too.
How do I find the best Byron hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Byron then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Byron?
The cheapest hotel in Byron is $82. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Byron?
There are 383 hotels in Byron on Travelocity.
What are the best hotels in Byron?
Byron has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Byron for you!
When is the best time to visit Byron?
If you want the joy of a fun-filled trip in peak season, visit Byron during March, May and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Byron?
Based on historic data is usually the cheapest month to visit Byron. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Byron?
There are multiple hotels in Byron that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Byron. We have plenty of kid-friendly hotels in Byron to choose from on Travelocity!
Why book a hotel in Byron through Travelocity?
Because we have the top hotels in Byron! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Byron on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Byron hotel reviews by fellow wanderers

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"The location connected to Mayo and the underground parking for only $15/night can not be beat. So convenient. The room itself was good, roomy, comfy bed. It is an older hotel with older decor but I’m not here for an extravagant vacation I need convenience. And the staff was helpful with needing a late checkout and extending our time in their parking garage since we had a late appointment. Oh and the attached Chinese restaurant is Amazing!!"
A verified traveler stayed at Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

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