Book Hotels in Byron, MN
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Top Byron hotels

The Berkman
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Feb 20 to Feb 21
$151 total
Feb 20 - Feb 21
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Everything was excellent, second time staying there.
Reviewed on Jan 25, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$121 nightly
The price is $139 total per night from Feb 20 to Feb 21
$139 total
Feb 20 - Feb 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Friendly atmosphere & great service in the lobby restaurant/bar
Reviewed on Feb 12, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Feb 19 to Feb 20
$149 total
Feb 19 - Feb 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
It was a very nice stay, everyone was very nice helpful, and on their game. Definitely will be staying again. Great thanks to all. Keep up the great work. Love the location in regards to the hospital. Made our visit to a loved one extremely convenient. I can’t think of anything that needed improvement ...
Reviewed on Feb 12, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $161 total per night from Feb 21 to Feb 22
$161 total
Feb 21 - Feb 22
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
The room was clean the staff was friendly and the breakfast was very good. We are all ready planning to go back.
Reviewed on Feb 9, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$106 nightly
The price is $122 total per night from Mar 5 to Mar 6
$122 total
Mar 5 - Mar 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Excellent service, above and beyond. Very nice hotel and rooms were perfect. Convenient access to Mayo. My only complaints would be no microwave in rooms and no help with luggage. Just had my leg amputated.
Reviewed on Feb 14, 2026

Holiday Inn Express Rochester South - Mayo Area by IHG
4141 Maine Avenue SE Rochester MN
Fully refundable
$89 nightly
The price is $102 total per night from Feb 22 to Feb 23
$102 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Staff was very friendly, facilities were clean, nice breakfast area, pool area was clean. Room was very nice and large. We had no issues and will stay again at our next Mayo visit!
Reviewed on Jan 30, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Feb 19 to Feb 20
$146 total
Feb 19 - Feb 20
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Excellent staff. Very helpful!
Reviewed on Feb 12, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $86 total per night from Feb 19 to Feb 20
$86 total
Feb 19 - Feb 20
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Staff, able to eat to the bar and grill connecting to the motel
Reviewed on Feb 11, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Feb 17 to Feb 18
$152 total
Feb 17 - Feb 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Clean room but missing hair sryer
Reviewed on Feb 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Byron with star-rating
Check Byron Hotels by Star Rating

4 Star Hotels
2 properties

3 Star Hotels
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Recent Byron hotel reviews by fellow wanderers

Hotel Indigo Rochester – Mayo Clinic Area by IHG
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Excellent service, above and beyond. Very nice hotel and rooms were perfect. Convenient access to Mayo.
My only complaints would be no microwave in rooms and no help with luggage. Just had my leg amputated. "
A verified traveler stayed at Hotel Indigo Rochester – Mayo Clinic Area by IHG
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