Explore top 2026 4 Star Hotels in Medical Center District
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Top Medical Center District 4 Star hotels

Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Feb 1 to Feb 2
$159 total
Feb 1 - Feb 2
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
9.2/10 Wonderful! (2,424 reviews)
Very nice staff, very clean room, great location near riverwalk, shops and restaurants. We liked that you have to have your room key to go on the elevator - it felt safer! Our city view was nice, but we did have to move a night stand table to be able to open the window cover, and look out. I brought ...
Reviewed on Jan 25, 2026

Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $129 total per night from Feb 1 to Feb 2
$129 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,340 reviews)
It was nice
Reviewed on Jan 25, 2026

The Westin Riverwalk, San Antonio
420 W Market St San Antonio TX
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $199 total per night from Feb 15 to Feb 16
$199 total
Feb 15 - Feb 16
Total with taxes and fees
The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,489 reviews)
It was a busy day so we got our room late. Elevator situation was terrible but it was NYE so I can understand. Everything else was good. We really enjoyed seeing the NYE fireworks from our room’s balcony.
Reviewed on Jan 23, 2026

Omni La Mansion del Rio
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $212 total per night from Feb 8 to Feb 9
$212 total
Feb 8 - Feb 9
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.2/10 Wonderful! (2,827 reviews)
The room had a great view
Reviewed on Jan 26, 2026

Hotel Contessa
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $208 total per night from Feb 8 to Feb 9
$208 total
Feb 8 - Feb 9
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
8.8/10 Excellent! (3,452 reviews)
We always the love the hotel location and friendly staff
Reviewed on Jan 25, 2026

Plaza San Antonio Hotel & Spa, Autograph Collection
555 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$196 nightly
The price is $231 total per night from Feb 8 to Feb 9
$231 total
Feb 8 - Feb 9
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (717 reviews)
The room was great and staff was very helpful and kind.
Reviewed on Jan 25, 2026

InterContinental San Antonio Riverwalk by IHG
111 East Pecan Street San Antonio TX
Fully refundable
$231 nightly
The price is $273 total per night from Feb 1 to Feb 2
$273 total
Feb 1 - Feb 2
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9.2/10 Wonderful! (646 reviews)
Nice
Reviewed on Jan 4, 2026

Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $254 total per night from Feb 8 to Feb 9
$254 total
Feb 8 - Feb 9
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (2,001 reviews)
Clean
Reviewed on Jan 28, 2026

Grand Hyatt San Antonio River Walk
600 E Market St San Antonio TX
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $254 total per night from Feb 16 to Feb 17
$254 total
Feb 16 - Feb 17
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the arcade/game room and onsite laundry facilities. Enjoy the 24-hour ...
9.2/10 Wonderful! (1,356 reviews)
Everything was great!
Reviewed on Jan 17, 2026

The St. Anthony, A Luxury Collection Hotel, San Antonio
300 E Travis St San Antonio TX
$167 nightly
The price is $198 total per night from Mar 1 to Mar 2
$198 total
Mar 1 - Mar 2
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.8/10 Excellent! (1,005 reviews)
Room was very pleasant. Extremely helpful front desk staff on arrival. Breakfast is a lottery, very few tables, only managed to eat at the hotel one morning out of four.
Reviewed on Jan 10, 2026
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Recent Medical Center District hotel reviews by fellow wanderers

Crockett Hotel
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Clearn room, excellent staff, superb location, walkable to all the major sites."
A verified traveler stayed at Crockett Hotel
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