Explore top 2026 4 Star Hotels in Medical Center District
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Top Medical Center District 4 Star hotels
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $118 total per night from Apr 5 to Apr 6
$118 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
8/10 Very Good! (6,401 reviews)
Very friendly staff and clean hotel. I really enjoyed my stay. When I come back to San Antonio I’m staying here again!
Reviewed on Mar 21, 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $194 total per night from Mar 22 to Mar 23
$194 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (2,558 reviews)
Beautiful hotel. Rooms did not have fridge or microwave. Parking was expensive. Bar service was nice. Property was in perfect location
Reviewed on Mar 20, 2026
Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $248 total per night from Apr 5 to Apr 6
$248 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (2,059 reviews)
Clean room , friendly
Reviewed on Mar 21, 2026
Omni La Mansion del Rio
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
$200 nightly
The price is $236 total per night from Apr 5 to Apr 6
$236 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.4/10 Exceptional! (2,850 reviews)
Clean room and great location
Reviewed on Mar 21, 2026
Plaza San Antonio Hotel & Spa, Autograph Collection
555 S Alamo St San Antonio TX
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $222 total per night from Apr 5 to Apr 6
$222 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (757 reviews)
The staff was extremely helpful and friendly.
Reviewed on Mar 16, 2026
Kimpton Santo San Antonio - Riverwalk by IHG
431 South Alamo Street San Antonio TX
Fully refundable
$200 nightly
The price is $236 total per night from Mar 26 to Mar 27
$236 total
Mar 26 - Mar 27
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at one of the 2 bars/lounges and get perks ...
9.4/10 Exceptional! (792 reviews)
Very nice hotel excellent for families
Reviewed on Mar 21, 2026
Hotel Contessa
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $173 total per night from Apr 1 to Apr 2
$173 total
Apr 1 - Apr 2
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,488 reviews)
This hotel consistently delivers an amazing experience. Everything is always spotless—the cleanliness throughout the property really stands out. The front desk staff are always friendly and welcoming, making you feel right at home from the moment you arrive. The hotel itself smells incredible, which ...
Reviewed on Mar 21, 2026
The Westin San Antonio North
9821 Colonnade Blvd San Antonio TX
Fully refundable
$92 nightly
The price is $109 total per night from Apr 5 to Apr 6
$109 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
8.6/10 Excellent! (1,299 reviews)
Pool n hot tub where great for da kids!!
Reviewed on Mar 18, 2026
JW Marriott San Antonio Hill Country Resort & Spa
23808 Resort Pkwy San Antonio TX
Fully refundableReserve now, pay when you stay
$448 nightly
The price is $522 total per night from Apr 19 to Apr 20
$522 total
Apr 19 - Apr 20
Total with taxes and fees
This luxury hotel features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, and ...
9/10 Wonderful! (1,005 reviews)
For the price we paid, the experience didn’t feel worth it. The staff were not very friendly, and overall it didn’t meet our expectations. I wouldn’t go back, it felt quite overrated
Reviewed on Mar 21, 2026
Canopy by Hilton San Antonio Riverwalk
123 N. Saint Marys St. San Antonio TX
Fully refundableReserve now, pay when you stay
$190 nightly
The price is $225 total per night from Apr 5 to Apr 6
$225 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.4/10 Exceptional! (1,637 reviews)
Had a great weekend there and it was really easy to check in and out. Everyone was very polite.
Reviewed on Mar 21, 2026
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Medical Center District hotel reviews by fellow wanderers
Riverwalk Plaza
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Very friendly staff and clean hotel. I really enjoyed my stay. When I come back to San Antonio I’m staying here again!"
A verified traveler stayed at Riverwalk Plaza
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