Explore top 2026 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Dec 23 to Dec 24
$121 total
Dec 23 - Dec 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.4/10 Very Good! (2,307 reviews)
Had a short overnight stop in our way back to the US. Rooms were clean and quiet. Staff was very helpful.

Reviewed on Dec 9, 2025

Opens in a new windowCrowne Plaza Panama Airport by IHG
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $144 total per night from Dec 18 to Dec 19
$144 total
Dec 18 - Dec 19
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,258 reviews)
Front desk people and their Amenities are amazing!

Reviewed on Dec 7, 2025

Opens in a new windowMegapolis Hotel Panamá
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $175 total per night from Jan 9 to Jan 10
$175 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,004 reviews)
clean and new rooms, the customer service was perfect.

Reviewed on Dec 9, 2025

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $156 total per night from Dec 12 to Dec 13
$156 total
Dec 12 - Dec 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,002 reviews)
This hotel accommodated my husband and I at the last minute. Due to the prior booking we had to relocate. The staff was friendly and helpful. The location was a bit further from Panama City then we would like. But we were grateful to find somewhere to stay due to it being a 3-day holiday. Would definitely ...

Reviewed on Dec 9, 2025

Opens in a new windowMarriott Panama Hotel
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from Dec 13 to Dec 14
$117 total
Dec 13 - Dec 14
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9/10 Wonderful! (1,016 reviews)
Good staff and food

Reviewed on Dec 8, 2025

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
$44 nightly
The price is $49 total per night from Dec 11 to Dec 12
$49 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (576 reviews)
Not much different than a basic hotel

Reviewed on Dec 6, 2025

Opens in a new windowStudio Coliving
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $123 total per night from Dec 11 to Dec 12
$123 total
Dec 11 - Dec 12
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,435 reviews)
Todo bien

Reviewed on Dec 8, 2025

Opens in a new windowDecapolis Hotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Dec 24 to Dec 25
$131 total
Dec 24 - Dec 25
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.4/10 Exceptional! (1,103 reviews)
The only issue was the walkability from the hotel to the mall. The sidewalks were not user friendly for pedestrians.

Reviewed on Dec 6, 2025

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
$262 nightly
The price is $289 total per night from Jan 4 to Jan 5
$289 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (601 reviews)
Perfect location, friendly and attentive staff, plenty of character.

Reviewed on Dec 7, 2025

Opens in a new windowAmerican Trade Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Jan 9 to Jan 10
$148 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.4/10 Very Good! (989 reviews)
A nice hotel in the midst of renovations which will hopefully return it to its former glory. The spa staff were lovely.

Reviewed on Dec 8, 2025

Opens in a new windowSheraton Grand Panama
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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