Explore top 2026 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$123 nightly
The price is $136 total per night from Mar 3 to Mar 4
$136 total
Mar 3 - Mar 4
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,424 reviews)
Room musty , one small Bottle of water in the room for 2 people . We would have had to wait 40 min at 8:30pm for " free shuttle" On departure day, Hotel shuttle only runs 1 each hiur even in morning when many people trying to catch flights .

Reviewed on Feb 17, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $243 total per night from Feb 24 to Feb 25
$243 total
Feb 24 - Feb 25
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,419 reviews)
My only problem is there was barely bilingual staff. I had to use my app most of the time to communicate.

Reviewed on Feb 17, 2026

Opens in a new windowMegapolis Hotel Panamá
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $190 total per night from Feb 25 to Feb 26
$190 total
Feb 25 - Feb 26
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,037 reviews)
Tremendous views of the city from our 21st floor hotel room. Huge breakfast with large selection. The room was super comfortable and spacious. Loved the layout. The beds super comfortable The staff was excellent.

Reviewed on Feb 18, 2026

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $177 total per night from Mar 15 to Mar 16
$177 total
Mar 15 - Mar 16
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,003 reviews)
The room is comfortable & clean. Staff was helpful and courteous. Having the mall next door is invaluable!

Reviewed on Feb 16, 2026

Opens in a new windowMarriott Panama Hotel
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $122 total per night from Mar 15 to Mar 16
$122 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,109 reviews)
Clean room

Reviewed on Feb 16, 2026

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowStudio Coliving
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $128 total per night from Feb 19 to Feb 20
$128 total
Feb 19 - Feb 20
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.6/10 Excellent! (1,558 reviews)
Yes staff not supportive

Reviewed on Feb 10, 2026

Opens in a new windowDecapolis Hotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $115 total per night from Feb 28 to Mar 1
$115 total
Feb 28 - Mar 1
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,154 reviews)
Stayed for six days and loved it. Most major tourist attractions were within a US$10 Uber ride, although traffic can be an issue. There are plenty of good restaurants within walking distance, including two ranked among the Top 50 in Latin America in 2025. The staff were friendly and knowledgeable, ...

Reviewed on Feb 16, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
$254 nightly
The price is $280 total per night from Mar 8 to Mar 9
$280 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (659 reviews)
Hotel muy céntrico y bien cuidado, con vistas increíbles a la plaza y las iglesias. El servicio es muy cordial y acogedor.

Reviewed on Feb 16, 2026

Opens in a new windowAmerican Trade Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Mar 8 to Mar 9
$148 total
Mar 8 - Mar 9
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,001 reviews)
The bed was comfortable and the room quiet. We stayed 4 nights so it would have been nice if the tea and coffee had been replenished during our stay. Also some towels were not always provided ( bath mats, face cloths)

Reviewed on Feb 17, 2026

Opens in a new windowSheraton Grand Panama
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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