Find a Hotel in South Main

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Top hotels in South Main

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $149 total per night from Oct 2 to Oct 3
$149 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
"Staff was great! Everyone was pleasant and friendly with us during our stay and we’d recommend this hotel to everyone. We will definitely stay there again when we’re in Houston."

Reviewed on Sep 20, 2026

Opens in a new windowThe Royal Sonesta Houston Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $104 total per night from Sep 29 to Sep 30
$104 total
Sep 29 - Sep 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Always have a great time at club quarters. The location is perfect. The staff is super friendly. The room is not huge, but it is perfect for a couple. The price and value are excellent. Didn’t have a chance to use the bar or restaurant, but I heard everything was great there valet was very easy. ..."

Reviewed on Sep 21, 2026

Opens in a new windowClub Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $144 total per night from Sep 27 to Sep 28
$144 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
"Ok ok ok ok ok ok ok ok ok ok ok Expedia App review process is very hard to deal with"

Reviewed on Sep 21, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Sep 27 to Sep 28
$110 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowWyndham Houston at Reliant Park & Medical Center
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$264 nightly
The price is $307 total per night from Sep 25 to Sep 26
$307 total
Sep 25 - Sep 26
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
Opens in a new windowHotel Zaza Houston Museum District
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $140 total per night from Oct 21 to Oct 22
$140 total
Oct 21 - Oct 22
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Opens in a new windowThe Whitehall Houston
Hyatt Regency Houston West

Hyatt Regency Houston West

3.5 out of 5
13210 Katy Fwy Houston TX
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Sep 25 to Sep 26
$111 total
Sep 25 - Sep 26
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Opens in a new windowHyatt Regency Houston West
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $124 total per night from Sep 22 to Sep 23
$124 total
Sep 22 - Sep 23
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...
Opens in a new windowGrand Tuscany Hotel
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $125 total per night from Oct 11 to Oct 12
$125 total
Oct 11 - Oct 12
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Opens in a new windowHilton Houston Plaza/Medical Center
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See all available properties in South Main
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Main Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Main area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Main to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Main are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Main hotel reviews by fellow wanderers

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Always have a great time at club quarters. The location is perfect. The staff is super friendly. The room is not huge, but it is perfect for a couple. The price and value are excellent. Didn’t have a chance to use the bar or restaurant, but I heard everything was great there valet was very easy. Parking was not as easy, but it was manageable."
A verified traveler stayed at Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston

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