Find a Hotel in South Central Houston

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Top hotels in South Central Houston

InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$216 nightly
The price is $253 total per night from Mar 23 to Mar 24
$253 total
Mar 23 - Mar 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Top Tier visit. Enjoyed the stay everyone who helped was very nice. Loved the view we had. An overall 10/10 experience. Cant wait for my next visit.

Reviewed on Feb 15, 2026

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$278 nightly
The price is $322 total per night from Mar 22 to Mar 23
$322 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Very nice place . I will give them 9/10

Reviewed on Feb 17, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$243 nightly
The price is $285 total per night from Mar 23 to Mar 24
$285 total
Mar 23 - Mar 24
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Everything has been wonderful! Ashlee at the front desk went above and beyond more than once in helping me out with a couple of different needs! I am extremely thankful and grateful!

Reviewed on Feb 17, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$283 nightly
The price is $331 total per night from Feb 25 to Feb 26
$331 total
Feb 25 - Feb 26
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...
Thoughtfully designed property with perks like complimentary shuttle to/from the hotel in 3 mile radius, proximity to great museums, and little amenities like chocolates or prosecco in the room for Valentine’s Day. :)

Reviewed on Feb 16, 2026

Opens in a new windowHotel Zaza Houston Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $144 total per night from Mar 23 to Mar 24
$144 total
Mar 23 - Mar 24
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Staff members are excellent.

Reviewed on Feb 18, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$146 nightly
The price is $171 total per night from Mar 23 to Mar 24
$171 total
Mar 23 - Mar 24
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great service

Reviewed on Feb 17, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $107 total per night from Mar 2 to Mar 3
$107 total
Mar 2 - Mar 3
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
Good

Reviewed on Feb 14, 2026

Opens in a new windowDowntowner Inns - Houston Downtown
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr Houston TX
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $97 total per night from Feb 24 to Feb 25
$97 total
Feb 24 - Feb 25
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
Great host, very flexible and accommodating! Also walkable to a massive supermarket which is super convenient. Room has fridge and everything!!

Reviewed on Feb 20, 2026

Opens in a new windowAmericas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $96 total per night from Mar 23 to Mar 24
$96 total
Mar 23 - Mar 24
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
The proximity to md anderson. The staff was very nice. Rooms very clean

Reviewed on Feb 17, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

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