Find a Hotel in South Central Houston

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Top hotels in South Central Houston

Sentral Forme Houston

Sentral Forme Houston

4.5 out of 5
5501 La Branch Street Houston TX
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $197 total per night from Apr 26 to Apr 27
$197 total
Apr 26 - Apr 27
Total with taxes and fees
This aparthotel features an outdoor pool and a 24-hour gym. Enjoy the hot tub and perks like free WiFi. Self parking and express check-in are also offered on ...
Verry nice and staff was very helpful. Will stay again

Reviewed on Apr 20, 2026

Opens in a new windowSentral Forme Houston
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$180 nightly
The price is $211 total per night from Apr 25 to Apr 26
$211 total
Apr 25 - Apr 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
This is a mediocre property who is selling $8 for bottle water. Not worthy of price. Rooms are cheap quality and boring.

Reviewed on Apr 20, 2026

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $212 total per night from May 17 to May 18
$212 total
May 17 - May 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
The staff was very delightful, room was exactly what I expected plus more. Clean room, bed was so comfortable. Valet top tier!

Reviewed on Apr 17, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$228 nightly
The price is $266 total per night from Apr 26 to Apr 27
$266 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
Breakfast was excellent but expensive. Our room was too dimly lit and darkly furnished, but the bed was comfortable.

Reviewed on Apr 21, 2026

Opens in a new windowHotel Zaza Houston Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $242 total per night from May 22 to May 23
$242 total
May 22 - May 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
The hotel is very well-maintained and our room was clean and comfortable. The valet service for the shuttle was excellent with everyone involved giving special consideration to the passengers, most of whom were in Houston for medical reasons and were being transported to the various hospitals within ...

Reviewed on Apr 13, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from May 10 to May 11
$117 total
May 10 - May 11
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Room needs fixtures replaced. Towel holder not in good condition and bath tub spigot needs to be worked on. The door security latch is broken and the mattress is way too soft. Staff was very helpful.

Reviewed on Apr 21, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $123 total per night from Apr 25 to Apr 26
$123 total
Apr 25 - Apr 26
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Not as updated as other double tree hotels I feel I was mislead

Reviewed on Apr 16, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr Houston TX
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $97 total per night from Apr 24 to Apr 25
$97 total
Apr 24 - Apr 25
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
Room was dirty and smelled of mold

Reviewed on Apr 20, 2026

Opens in a new windowAmericas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $91 total per night from Apr 26 to Apr 27
$91 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
Parking was easy and free. Walked to MD Anderson from room. It was great

Reviewed on Apr 21, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Breakfast basic. The owners were great. Rooms very clean "
A verified traveler stayed at Downtowner Inns - Houston Downtown
Downtowner Inns - Houston Downtown

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