Find a Hotel in South Central Houston

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top hotels in South Central Houston

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel

2 out of 5
520 Sampson St, Houston, TX
Fully refundable
$123 nightly
The price is $145 total per night from Sep 30 to Oct 1
$145 total
Sep 30 - Oct 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A communal living room, express check-in, and express check-out are also ...
"Staff was very friendly and professional. Rooms clean and comfortable. All good, I’d stay again and recommend to others."

Reviewed on Sep 20, 2025

Opens in a new windowWanderstay Boutique Hotel
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Fully refundable
$172 nightly
The price is $201 total per night from Sep 28 to Sep 29
$201 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Very nice hotel, workers very friendly. Food good. I will return to this hotel."

Reviewed on Sep 20, 2025

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
$181 nightly
The price is $212 total per night from Sep 27 to Sep 28
$212 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Clean, comfortable and great service all around."

Reviewed on Sep 21, 2025

Opens in a new windowThe Westin Houston Medical Center/Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street, Houston, TX
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $242 total per night from Sep 27 to Sep 28
$242 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"Our stay was for medical reasons at Methodist -"

Reviewed on Sep 15, 2025

Opens in a new windowHouston Marriott Medical Center/Museum District
Mint House Houston – Medical Center

Mint House Houston – Medical Center

4 out of 5
1911 Holcombe Boulevard, Houston, TX
This apartment features an outdoor pool and a 24-hour gym. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Great experience
"Beautiful property and way better than a traditional hotel. I had to be on a special diet for my stay so being able to cook was so nice."

Reviewed on Sep 12, 2025

Opens in a new windowMint House Houston – Medical Center
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
$278 nightly
The price is $326 total per night from Sep 28 to Sep 29
$326 total
Sep 28 - Sep 29
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...
"Great stay at Hotel Zaza. The staff is amazing, accommodating, friendly, helpful!"

Reviewed on Sep 15, 2025

Opens in a new windowHotel Zaza Houston Museum District
Hilton University of Houston

Hilton University of Houston

3.5 out of 5
4450 University Drive, Houston, TX
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $208 total per night from Oct 24 to Oct 25
$208 total
Oct 24 - Oct 25
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
"This hotel will be rated even higher once UH completes this massive construction project (in 2027) - the front entrance is completely blocked, and it’s confusing to know where to be dropped off due to detours and one-way streets. However, once you enter the hotel, it’s quite nice here, and the front ..."

Reviewed on Sep 20, 2025

Opens in a new windowHilton University of Houston
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Oct 12 to Oct 13
$109 total
Oct 12 - Oct 13
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Easy acce to facility. “ hospital”"

Reviewed on Sep 22, 2025

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $160 total per night from Oct 5 to Oct 6
$160 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Fhjgg"

Reviewed on Sep 22, 2025

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Don't see what you're looking for?
See all available properties in South Central Houston
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers