Find a Hotel in South Central Houston

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Top hotels in South Central Houston

InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$180 nightly
The price is $211 total per night from May 29 to May 30
$211 total
May 29 - May 30
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Excellent Hotel! Great price and beautiful and clean , 5 star hotel

Reviewed on Apr 26, 2026

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $212 total per night from May 17 to May 18
$212 total
May 17 - May 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
The staff at the restaurant was very nice and the food was very good.

Reviewed on Apr 29, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
Sentral Forme Houston

Sentral Forme Houston

4.5 out of 5
5501 La Branch Street Houston TX
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $227 total per night from May 25 to May 26
$227 total
May 25 - May 26
Total with taxes and fees
This aparthotel features an outdoor pool and a 24-hour gym. Enjoy the hot tub and perks like free WiFi. Self parking and express check-in are also offered on ...
The check in was awesome. We got there a little early and were able to find the front easily due to the addition info provided. It made finding everything super simple. We were greeted by David and Tiffany. They were so sweet and helpful. Tiffany definitely went above and beyond helping us and showing ...

Reviewed on Apr 26, 2026

Opens in a new windowSentral Forme Houston
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$246 nightly
The price is $288 total per night from May 26 to May 27
$288 total
May 26 - May 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
Great location to the Metrorail to take us to the rodeo with no hassles. Also wonderful location to walk around the neighborhood/park. Beds were comfortable. However, staff in restaurant and bar were lacking. Extremely rude when we asked for coffee or latte or even an extra set of silverware :( decor ...

Reviewed on Apr 28, 2026

Opens in a new windowHotel Zaza Houston Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $242 total per night from May 22 to May 23
$242 total
May 22 - May 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
We were there for my wife’s annual cardiology check up. We ran into a problem that resulted in her hospitalization and an unplanned extension. I contacted the staff and they were very supportive and proactive in setting an additional stay at reasonable rates.

Reviewed on Apr 25, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from May 10 to May 11
$117 total
May 10 - May 11
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
We were in town for my daughter’s medical procedure so we spent most of the time at the hospital. But the room was very nice, beds were comfortable, staff was helpful. My wife and I are already talking about going back to enjoy the rest of the amenities. Overall, great place to stay.

Reviewed on Apr 29, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from May 29 to May 30
$113 total
May 29 - May 30
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
I had a good stay, although there was a college team there it was still very quiet. Only issue I had was there was communication issue between the front desk and the restaurant regarding breakfast. Be sure that you have that cleared and paid for at check-in.

Reviewed on Apr 27, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr Houston TX
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $98 total per night from Apr 30 to May 1
$98 total
Apr 30 - May 1
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
The Clerk at the front desk was very RUDE . When he spoke to me. I ask for assistance making a phone call and the clerk said the call would not go through. The room was clean, how I could tell was when I took my shoes off and walked to the bathroom. Before putting on my flip flops my socks were still ...

Reviewed on Apr 27, 2026

Opens in a new windowAmericas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $93 total per night from May 11 to May 12
$93 total
May 11 - May 12
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
Breakfast is incorrect or rather not what I assumed. It consisted of coffee, bagged oatmeal and small muffins.

Reviewed on Apr 29, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"The staff at the restaurant was very nice and the food was very good."
A verified traveler stayed at The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District

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