Find a Hotel in South Central Houston

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Top hotels in South Central Houston

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel

2 out of 5
520 Sampson St, Houston, TX
$118 nightly
The price is $139 total per night from Nov 3 to Nov 4
$139 total
Nov 3 - Nov 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A communal living room, express check-in, and express check-out are also ...
Great Stay and the Staff was wonderful

Reviewed on Oct 15, 2025

Opens in a new windowWanderstay Boutique Hotel
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Fully refundable
$160 nightly
The price is $187 total per night from Nov 23 to Nov 24
$187 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
The restaurant is wonderful, as is the bar. The rooms are nice, clean and comfortable. The staff is very helpful.

Reviewed on Oct 21, 2025

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $179 total per night from Nov 2 to Nov 3
$179 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Joy checked us in took great care of all the details. Thank you!

Reviewed on Oct 21, 2025

Opens in a new windowThe Westin Houston Medical Center/Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street, Houston, TX
Fully refundableReserve now, pay when you stay
$187 nightly
The price is $219 total per night from Nov 22 to Nov 23
$219 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Property was very clean and safe was very friendly.

Reviewed on Oct 10, 2025

Opens in a new windowHouston Marriott Medical Center/Museum District
Mint House Houston – Medical Center

Mint House Houston – Medical Center

4 out of 5
1911 Holcombe Boulevard, Houston, TX
This apartment features an outdoor pool and a 24-hour gym. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Kitchen and laundry were nice. There was slight damage to a wall. Also, check-in instructions were incomplete, leaving out the code to access the building and elevator key. That was resolved easily through a call.

Reviewed on Oct 20, 2025

Opens in a new windowMint House Houston – Medical Center
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
$282 nightly
The price is $329 total per night from Nov 3 to Nov 4
$329 total
Nov 3 - Nov 4
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...
Great location, wonderful staff, and always down to accommodate

Reviewed on Oct 25, 2025

Opens in a new windowHotel Zaza Houston Museum District
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St, Houston, TX
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from Oct 29 to Oct 30
$106 total
Oct 29 - Oct 30
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
Good

Reviewed on Oct 19, 2025

Opens in a new windowDowntowner Inns - Houston Downtown
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $116 total per night from Oct 31 to Nov 1
$116 total
Oct 31 - Nov 1
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Great service. Good hotel for staying in the medical district

Reviewed on Oct 21, 2025

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $125 total per night from Nov 27 to Nov 28
$125 total
Nov 27 - Nov 28
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Staff welcoming.

Reviewed on Oct 20, 2025

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

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