Find a Hotel in South Central Houston

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Top hotels in South Central Houston

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$214 nightly
The price is $248 total per night from Mar 29 to Mar 30
$248 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Wonderful!

Reviewed on Mar 1, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$190 nightly
The price is $222 total per night from Mar 29 to Mar 30
$222 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Spotless, smells good, friendly staff.

Reviewed on Feb 28, 2026

Opens in a new windowInterContinental Houston by IHG
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$288 nightly
The price is $337 total per night from Mar 15 to Mar 16
$337 total
Mar 15 - Mar 16
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...
Fantastic all around

Reviewed on Feb 27, 2026

Opens in a new windowHotel Zaza Houston Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $274 total per night from Mar 29 to Mar 30
$274 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Nice and helpful staff, clean rooms, nice amenities

Reviewed on Mar 2, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Mar 29 to Mar 30
$117 total
Mar 29 - Mar 30
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Outdated hotel. Otherwise fine

Reviewed on Feb 27, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $107 total per night from Mar 15 to Mar 16
$107 total
Mar 15 - Mar 16
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
I will say I was very impressed with this inn. King size bed , and very spacious roomish vibe. The staff was great and very accommodating, and its legit right off the highway, and very close to downtown. If you coming down as a pair or even alone, i would reccomend this spot to you. Definitely will ...

Reviewed on Feb 24, 2026

Opens in a new windowDowntowner Inns - Houston Downtown
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
$119 nightly
The price is $139 total per night from Mar 30 to Mar 31
$139 total
Mar 30 - Mar 31
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
The room was gorgeous and I even got warm cookies upon check in!

Reviewed on Mar 1, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr Houston TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $116 total per night from Mar 23 to Mar 24
$116 total
Mar 23 - Mar 24
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
Coffee pot in room, no dogs in room , more quieter at night

Reviewed on Feb 27, 2026

Opens in a new windowAmericas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $96 total per night from Mar 29 to Mar 30
$96 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
Good room.

Reviewed on Mar 1, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

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