Find a Hotel in South Central Houston

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Top hotels in South Central Houston

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$241 nightly
The price is $282 total per night from Jul 11 to Jul 12
$282 total
Jul 11 - Jul 12
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
"We really enjoyed our stay! Room was very clean and staff super friendly and helpful."

Reviewed on Jun 11, 2026

Opens in a new windowHotel Zaza Houston Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
$183 nightly
The price is $214 total per night from Jul 5 to Jul 6
$214 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"NICE HOTEL IN THE NICE ARE, CLOSE TO THE PARKS AND THE TRAIN TO MOVE ARROUND. ALL MUSEUM ARE REALLY CLOSE."

Reviewed on Jun 8, 2026

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $186 total per night from Jul 12 to Jul 13
$186 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"The room was very clean somewhat there was hai inside the bathtub so I wasn’t able to use it. Air conditioner didn’t get cold it took 1 hour before we feel the coldness. It was hard to find the parking we found the easiest parking valet when we were about to leave. But overall it was very neat and ..."

Reviewed on Jun 9, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $103 total per night from Jul 6 to Jul 7
$103 total
Jul 6 - Jul 7
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
"Great staff. Great value."

Reviewed on Jun 7, 2026

Opens in a new windowDowntowner Inns - Houston Downtown
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $221 total per night from Jul 10 to Jul 11
$221 total
Jul 10 - Jul 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
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Reviewed on Jun 11, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Sentral Forme Houston

Sentral Forme Houston

4.5 out of 5
5501 La Branch Street Houston TX
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $227 total per night from Jul 12 to Jul 13
$227 total
Jul 12 - Jul 13
Total with taxes and fees
This aparthotel features an outdoor pool and a 24-hour gym. Enjoy the hot tub and perks like free WiFi. Self parking and express check-in are also offered on ...
"We had a great stay loved the view and the spot it's self."

Reviewed on Jun 6, 2026

Opens in a new windowSentral Forme Houston
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Jul 5 to Jul 6
$117 total
Jul 5 - Jul 6
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Pros: Nice clean property, great location, garage parking good. Pool and rooftop view great. Check in easy and elevators work fast. Cons: No ironing board, had to iron on bed. No ice machines, had to call front desk and request ice be brought. Depending on time, it can come fast or take very ..."

Reviewed on Jun 12, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from Jul 5 to Jul 6
$143 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Not enough electrical outlets at the head of the bed In room coffee lack there of Carpets stained Limited parking Delicious cookies Scarce luggage carriages Nice lobby but wish for higher seating"

Reviewed on Jun 9, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Jul 10 to Jul 11
$117 total
Jul 10 - Jul 11
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
"We had two rooms in the 3 days we were there. Both rooms were disgusting. The worst was room 341. The walls were dirty. We could not use the couch or chairs because they were so dirty. The bathtub leaked and got the floor soaked. The caulking job was terrible. The bathtub felt like you could fall ..."

Reviewed on Jun 10, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

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