Explore 35 Luxury Hotels in Key West Historic District

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Best Luxury Hotels in Key West Historic District

H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street Key West FL
$789 nightly
The price is $888 total per night from Mar 22 to Mar 23
$888 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (587 reviews)
Wow. Great experience. Great location. Didn’t really use the pool or (practically) day-long happy hour at the pool but nice touch. Would stay again.

Reviewed on Mar 2, 2026

Opens in a new windowH2O Suites - Adults Only
The Gardens Hotel

The Gardens Hotel

526 Angela Street Key West FL
$530 nightly
The price is $596 total per night from Mar 23 to Mar 24
$596 total
Mar 23 - Mar 24
Total with taxes and fees
2 outdoor pools, 2 bars/lounges, and a restaurant are among this bed & breakfast's featured amenities. Business travelers can take advantage of the free WiFi ...
9.8/10 Exceptional! (1,002 reviews)
The pool in front of our cottage was pure perfection, clean and warm!

Reviewed on Mar 2, 2026

Opens in a new windowThe Gardens Hotel
The Marquesa Hotel

The Marquesa Hotel

600 Fleming Street Key West FL
$619 nightly
The price is $696 total per night from Mar 31 to Apr 1
$696 total
Mar 31 - Apr 1
Total with taxes and fees
This hotel features 3 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the laundry service. Self parking, a terrace, and ...
9.8/10 Exceptional! (1,000 reviews)
Great accommodations and great staff

Reviewed on Feb 3, 2026

Opens in a new windowThe Marquesa Hotel
The Marker Key West Harbor Resort

The Marker Key West Harbor Resort

200 William Street Key West FL
Fully refundableReserve now, pay when you stay
$616 nightly
The price is $692 total per night from Mar 4 to Mar 5
$692 total
Mar 4 - Mar 5
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9.2/10 Wonderful! (1,004 reviews)
Enjoyed our stay here! Staff was kind- room was clean and beautiful!

Reviewed on Mar 2, 2026

Opens in a new windowThe Marker Key West Harbor Resort
Silver Palms Inn

Silver Palms Inn

830 Truman Ave Key West FL
Fully refundableReserve now, pay when you stay
$383 nightly
The price is $431 total per night from Apr 1 to Apr 2
$431 total
Apr 1 - Apr 2
Total with taxes and fees
An outdoor pool is featured at this hotel, along with free WiFi in public areas and luggage storage. Enjoy the free continental breakfast each morning. There's ...
9.2/10 Wonderful! (1,017 reviews)
Clean Good location

Reviewed on Mar 1, 2026

Opens in a new windowSilver Palms Inn
La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

430 Duval St Key West FL
Fully refundableReserve now, pay when you stay
$582 nightly
The price is $655 total per night from Mar 30 to Mar 31
$655 total
Mar 30 - Mar 31
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (348 reviews)
I never received a call about room being ready, our TV didn’t work day one and our shower didn’t drain properly day two

Reviewed on Feb 27, 2026

Opens in a new windowLa Concha Key West, Autograph Collection
The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

413 Applerouth Lane Key West FL
$379 nightly
The price is $427 total per night from Mar 31 to Apr 1
$427 total
Mar 31 - Apr 1
Total with taxes and fees
This guesthouse features an outdoor pool and a hot tub. Enjoy the free continental breakfast each morning. Self parking, a terrace, and a garden are also ...
8.8/10 Excellent! (1,010 reviews)
Really clean. Great breakfast. Easy walk to Duval Street

Reviewed on Mar 3, 2026

Opens in a new windowThe Cabana Inn Key West - Adults Only
Duval House

Duval House

815 Duval St Key West FL
$380 nightly
The price is $424 total per night from Mar 8 to Mar 9
$424 total
Mar 8 - Mar 9
Total with taxes and fees
This bed & breakfast features a terrace, concierge services, and self parking. A garden, a picnic area, and express check-in are also on offer.
Opens in a new windowDuval House
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More 4 star hotels in Key West Historic District

Key West Historic District Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Key West Historic District luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Key West Historic District to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Key West Historic District will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Key West Historic District, and plan your next opulent escape.


Key West Historic District hotels essential information

Accommodation
1,702 hotels
Lowest Price
$409
Highest Price
$888
Popular hotels
The Marker Key West Harbor Resort, H2O Suites - Adults Only, La Concha Key West, Autograph Collection, Silver Palms Inn, Duval House, The Cabana Inn Key West - Adults Only, The Gardens Hotel, The Marquesa Hotel

Popular Luxury Stays in Key West Historic District

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