The much-loved Union Square will be easy to get to for those wandering through Tenderloin.
The Exploratorium is a great Tenderloin place of interest for groups or for those traveling solo. You'll be well located to head over and see it from a great variety of nearby lodgings, such as the Fairmont Heritage Place, Ghirardelli Square, The St. Regis San Francisco, Loews Regency San Francisco, Four Seasons Hotel San Francisco and The Ritz-Carlton, San Francisco.
In Tenderloin, you and your fellow travelers have the choice of spending your vacation within a few blocks of the Ghirardelli Square at the Hotel Zetta San Francisco and Fairmont San Francisco, or if you'd prefer, you can book a hotel near to the Aquarium of the Bay at the The Scarlet Huntington Hotel and San Francisco Marriott Union Square.
If you're thinking about heading to Tenderloin and after somewhere to rest your head, it's also worth thinking about booking a room in one of the nearby destinations, Embarcadero Plaza and Haight-Ashbury.
Vacationers vacationing in San Francisco will be pleased to know that Travelocity's booking portal boasts a range of hotel options.