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Top St. Charles hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Great
Reviewed on Jan 9, 2026

Aspen Suites
I stayed here for 2+ months this past summer when my daughter had her heart transplant and they became like family to me and they helped me get through it. We were back this past week for my daughters check up and as usual everything and everyone was wonderful. The breakfast food was fresh and delicious. ...
Reviewed on Jan 16, 2026

Hyatt House Rochester/Mayo Clinic Area
Was supposed to have food available and there wasn't due to not having a cook. Nobody said anything at check-in, wasn't listed on their website. Cost extra to have food delivered, which we were trying to avoid.
Reviewed on Jan 12, 2026

Hampton Inn Rochester-South
Breakfast was wonderful including items for non milk drinkers. Rooms were clean, WiFi good, and pool being opened 24 hours! The heat between whirlpool and pool got a little messed up, but not a deal breaker.
Reviewed on Jan 13, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Need to change up the beding. Not the best. Comforter to hold.
Reviewed on Jan 14, 2026

Kahler Grand Hotel
The employees were very nice and polite.
Reviewed on Jan 14, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
The room was spotless, the staff very friendly, breakfast more than needed, coffee the best of anyplace we've stayed.
Reviewed on Jan 13, 2026

Kahler Inn and Suites - Mayo Clinic Area
It is great but very noisy next to active construction. Very hard to rest in between appointments. BRING EAR PLUGS.
Reviewed on Jan 15, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Clean and nice rooms
Reviewed on Jan 12, 2026
St. Charles Hotel & Travel Guide\n
There are less than a handful of hotels within a short drive of St. Charles. We recommend all visitors book early if you'd like to stay central.
The White Valley Motel is the closest accommodation to the center of St. Charles and the only Travelocity-listed hotel within a quick drive.
For those who are in the heart of St. Charles, it is around 13 miles (20 kilometers) to the Oakenwald Terrace.
Planning on seeing more of the forests and lakes this part of the country offers? How about you spend some extra nights in some of the other destinations in Southern Minnesota? Spend your time ice skating and quad biking or make a trip to the area's diverse places of interest. Suitable Travelocity-listed establishments will be your home away from home.
The closest hotels in Rochester are Austin and Austin. Austin is 50 miles (83 kilometers) to the southwest of St. Charles, while Austin is 50 miles (83 kilometers) to the southwest. Travelocity-registered hotel options in Austin include the Holiday Inn Austin and AmericInn Austin. The Days Inn Austin and Econo Lodge are some of the places to stay in Austin.
Make sure you spend a few hours hanging out with some Rochester lovers of sports at a community game. La Crosse Center is 40 miles (67 kilometers) to the east of St. Charles. Sports fans wanting to find hotels nearby can take their choice from the Courtyard by Marriott La Crosse or the Holiday Inn Hotel & Suites La Crosse.
If you're flying to St. Charles, a logical gateway is Rochester International Airport. The closest accommodation option is AmericInn Hotel & Suites Rochester Airport.
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