Explore top 2026 5 Star Hotels in Brookline

Name: Mandarin Oriental, Boston
Price range: $885 total
Rating: 9.4

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Top Brookline 5 Star hotels

Encore Boston Harbor

1 Broadway Everett MA

Fully refundableReserve now, pay when you stay

$328 nightly

$367 total

Oct 4 - Oct 5

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and a nightclub. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, ...

Omni Boston Hotel at the Seaport

450 Summer Street Boston MA

Fully refundableReserve now, pay when you stay

$235 nightly

$274 total

Sep 6 - Sep 7

Total with taxes and fees

A full-service spa, 4 restaurants, and an outdoor pool are all featured at this luxury hotel. Relax with a drink at one of the 2 bars/lounges and get perks like ...

The Langham, Boston

250 Franklin St Boston MA

Fully refundableReserve now, pay when you stay

$525 nightly

$611 total

Sep 7 - Sep 8

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Families will appreciate the onsite laundry facilities, kid-friendly dining, and babysitting. ...

9.8/10 Exceptional! (1,001 reviews)

"The rooms were clean, staff were polite and friendly, and location was perfect for our trip. More kid friendly that I was expecting with our 2 year old."

Reviewed on Sep 3, 2026

Boston Harbor Hotel

70 Rowes Wharf Boston MA

Fully refundableReserve now, pay when you stay

$731 nightly

$851 total

Sep 6 - Sep 7

Total with taxes and fees

A marina, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly dining, ...

9.8/10 Exceptional! (1,001 reviews)

"Wow. Just wow. What a stay. Fantastic hotel well looked after. Amazing staff so friendly and welcoming. Great location. A fabulous stay couldn’t recommend more."

Reviewed on Sep 2, 2026

The Charles Hotel

One Bennett Street Cambridge MA

Fully refundableReserve now, pay when you stay

$386 nightly

$448 total

Sep 12 - Sep 13

Total with taxes and fees

A full-service spa, 3 restaurants, and a 24-hour gym are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

The Newbury Boston

15 Arlington St Boston MA

Fully refundableReserve now, pay when you stay

$809 nightly

$942 total

Sep 5 - Sep 6

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Families will appreciate the picnic area and in-room childcare. If you want to take your pet ...

Four Seasons Hotel One Dalton Street, Boston

One Dalton Street Boston MA

Fully refundableReserve now, pay when you stay

$705 nightly

$821 total

Sep 20 - Sep 21

Total with taxes and fees

A full-service spa, 3 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.6/10 Exceptional! (438 reviews)

"Had to ask to clean my room three time"

Reviewed on Sep 3, 2026

Raffles Boston

40 Trinity Place Boston MA

Fully refundableReserve now, pay when you stay

$784 nightly

$913 total

Sep 6 - Sep 7

Total with taxes and fees

A full-service spa, 3 restaurants, and an indoor pool are all featured at this luxury hotel. Traveling on business? Take advantage of the free WiFi in public ...

InterContinental Boston by IHG

510 Atlantic Ave Boston MA

Fully refundable

$333 nightly

$388 total

Sep 7 - Sep 8

Total with taxes and fees

A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,164 reviews)

"Excellent hotel in downtown Boston. Convenient to South Station, shopping and restaurants. Staff is friendly and welcoming. Rooms are exceptionally clean. The hotel bar and patio are great for relaxing after a long day sightseeing. Wouldn’t stay anywhere else."

Reviewed on Sep 2, 2026

Mandarin Oriental, Boston

776 Boylston St Boston MA

Fully refundableReserve now, pay when you stay

$760 nightly

$885 total

Sep 6 - Sep 7

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Families will appreciate the onsite laundry facilities and babysitting. ...

9.4/10 Exceptional! (451 reviews)

"Over the top nice hotel and room was amazing!"

Reviewed on Aug 31, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Brookline Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Brookline to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Brookline 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Brookline before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.