Explore top 2026 5 Star Hotels in Brookline

Name: Mandarin Oriental, Boston
Price range: $769 total

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Top Brookline 5 Star hotels

Omni Boston Hotel at the Seaport

450 Summer Street Boston MA

Fully refundableReserve now, pay when you stay

$302 nightly

$352 total

Oct 30 - Oct 31

Total with taxes and fees

A full-service spa, 4 restaurants, and an outdoor pool are all featured at this luxury hotel. Relax with a drink at one of the 2 bars/lounges and get perks like ...

9.2/10 Wonderful! (4,906 reviews)

"The room was clean and had a good view of the city . We were on the 16th floor. The room was very small and not worth the $499 per night . I was expecting higher end sheets , comforter etc for this price ."

Reviewed on Oct 18, 2026

Encore Boston Harbor

1 Broadway Everett MA

Fully refundableReserve now, pay when you stay

$279 nightly

$312 total

Nov 11 - Nov 12

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and a nightclub. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, ...

9.6/10 Exceptional! (4,269 reviews)

"Gorgeous hotel. Roommate huge. Very clean. Only issue was strike and certain restaurants closed but otherwise incredible experience. Would definitely go back."

Reviewed on Oct 18, 2026

The Langham, Boston

250 Franklin St Boston MA

Fully refundableReserve now, pay when you stay

$518 nightly

$603 total

Oct 31 - Nov 1

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Families will appreciate the onsite laundry facilities, kid-friendly dining, and babysitting. ...

Four Seasons Hotel Boston

200 Boylston St Boston MA

$825 nightly

$961 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

9.4/10 Exceptional! (490 reviews)

"Your staff is Five star! Hotel needs updating badly. My far the worst Four Seasons we have stayed in. On the day of check-in, our flight was delayed and we got in at 2:30 in the morning had room service and it was an edible. Your staff indicated they would remove the charges, but I see we were still ..."

Reviewed on Oct 6, 2026

The Charles Hotel

One Bennett Street Cambridge MA

Fully refundableReserve now, pay when you stay

$304 nightly

$352 total

Nov 17 - Nov 18

Total with taxes and fees

A full-service spa, 3 restaurants, and a 24-hour gym are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

Boston Harbor Hotel

70 Rowes Wharf Boston MA

Fully refundableReserve now, pay when you stay

$680 nightly

$792 total

Nov 13 - Nov 14

Total with taxes and fees

A marina, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly dining, ...

The Newbury Boston

One Newbury Street Boston MA

$683 nightly

$795 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Families will appreciate the picnic area and in-room childcare. If you want to take your pet ...

9.4/10 Exceptional! (741 reviews)

"Incredible hospitality"

Reviewed on Oct 13, 2026

InterContinental Boston by IHG

510 Atlantic Ave Boston MA

$336 nightly

$391 total

Nov 15 - Nov 16

Total with taxes and fees

A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

Four Seasons Hotel One Dalton Street, Boston

One Dalton Street Boston MA

Fully refundableReserve now, pay when you stay

$645 nightly

$751 total

Nov 1 - Nov 2

Total with taxes and fees

A full-service spa, 3 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.6/10 Exceptional! (454 reviews)

"Clean room"

Reviewed on Oct 14, 2026

Mandarin Oriental, Boston

776 Boylston St Boston MA

Fully refundableReserve now, pay when you stay

$660 nightly

$769 total

Nov 8 - Nov 9

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Families will appreciate the onsite laundry facilities and babysitting. ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Brookline

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Brookline to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Brookline 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Brookline before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.