Explore top 2026 4 Star Hotels in O'Fallon

Name: The Cheshire
Price range: $177 total
Rating: 8.8

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Top O'Fallon 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$113 nightly

$133 total

Nov 27 - Nov 28

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,400 reviews)

"Ruth’s Chris on site was a nice touch and the staff at this Hyatt are top notch"

Reviewed on Nov 8, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$147 nightly

$172 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$149 nightly

$177 total

Nov 18 - Nov 19

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$139 nightly

$165 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,365 reviews)

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Reviewed on Nov 9, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$174 nightly

$205 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,007 reviews)

"Great atmosphere with different dining experiences available on site. Staff was friendly and helpful. And the hotel halls were quiet allowing for a restful stay."

Reviewed on Nov 9, 2026

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$122 nightly

$143 total

Nov 15 - Nov 16

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.8/10 Excellent! (1,004 reviews)

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Reviewed on Nov 8, 2026

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$87 nightly

$102 total

Dec 10 - Dec 11

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...

Marriott St. Louis Grand

800 Washington Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$127 nightly

$151 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.4/10 Very Good! (1,007 reviews)

"The stay was great. The valet parking was terrible. I realize it was a lot of people in town; however, it took 2 hours for us to get our car. If we needed to catch a flight, we would have missed it. The customer service for the valet was very unprofessional. I witnessed the young man speak very rudely ..."

Reviewed on Nov 9, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$95 nightly

$113 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

The Cheshire

6300 Clayton Rd Richmond Heights MO

Fully refundableReserve now, pay when you stay

$149 nightly

$177 total

Nov 29 - Nov 30

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8.8/10 Excellent! (1,006 reviews)

"A wonderful break from boring hotels! My kids loved all the artwork and the scavenger hunt. The pub food and drinks were fantastic, as was the hotel breakfast each morning. We will definitely plan to return."

Reviewed on Nov 9, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels O'Fallon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in O'Fallon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in O'Fallon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in O'Fallon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.