Explore top 2026 4 Star Hotels in Roxana

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Oct 30 - Nov 1
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Top Roxana 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
$134 nightly
The price is $158 total per night from Oct 30 to Oct 31
$158 total
Oct 30 - Oct 31
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
Opens in a new windowHyatt Regency St. Louis at The Arch
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from Nov 15 to Nov 16
$173 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (2,139 reviews)
"Had a great time from Valet to the front desk and housekeepers everyone was nice and attentive the room was excellent. The museum with the art was amazing a lot of places to take pictures and take everything in. Great downtown location as well. 10/10 would recommend"

Reviewed on Oct 24, 2026

Opens in a new window21C Museum Hotel St Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $130 total per night from Nov 20 to Nov 21
$130 total
Nov 20 - Nov 21
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,185 reviews)
"The stay was good."

Reviewed on Oct 24, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $180 total per night from Nov 22 to Nov 23
$180 total
Nov 22 - Nov 23
Total with taxes and fees
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (2,053 reviews)
"Great location."

Reviewed on Oct 24, 2026

Opens in a new windowMoonrise Hotel
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $165 total per night from Nov 15 to Nov 16
$165 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Opens in a new windowLive by Loews - St.Louis
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
$159 nightly
The price is $188 total per night from Nov 22 to Nov 23
$188 total
Nov 22 - Nov 23
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Nov 1 to Nov 2
$179 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Opens in a new windowLe Méridien St. Louis Clayton
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
$131 nightly
The price is $153 total per night from Nov 15 to Nov 16
$153 total
Nov 15 - Nov 16
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
Opens in a new windowThe Westin St. Louis
Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
10700 Pear Tree Lane St. Louis MO
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $172 total per night from Nov 13 to Nov 14
$172 total
Nov 13 - Nov 14
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center, express check-in, and free airport ...
8/10 Very Good! (1,002 reviews)
"Good food an"

Reviewed on Oct 24, 2026

Opens in a new windowMarriott St. Louis Airport
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $151 total per night from Nov 22 to Nov 23
$151 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.4/10 Very Good! (1,003 reviews)
"Overall a good experience, hot water was non existent however which was the only disappointment"

Reviewed on Oct 22, 2026

Opens in a new windowMarriott St. Louis Grand
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4 Star Hotels Roxana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Roxana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Roxana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Roxana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Roxana hotel reviews by fellow wanderers

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Large room. Very clean and comfortable. Quiet. negatives are no breakfast, no coffee except a tiny maker in room, and $40 parking fee for self-part and $48 for valet."
A verified traveler stayed at Courtyard by Marriott St. Louis Downtown/Convention Center
Courtyard by Marriott St. Louis Downtown/Convention Center

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