Explore top 2026 4 Star Hotels in Roxana

Name: Moonrise Hotel
Price range: $196 total
Rating: 9

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Top Roxana 4 Star hotels

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$123 nightly

$144 total

Oct 2 - Oct 3

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,173 reviews)

"The rooms and hotel were nice."

Reviewed on Sep 9, 2026

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Oct 4 - Oct 5

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,214 reviews)

"The property was located near the Dome Of America where we attended a concert. Restaurants were handy. Property clean and staff was excellent."

Reviewed on Sep 9, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (2,103 reviews)

"It was quiet and sleep well We had a problem with lights not turning on. and the coffee maker on dresser we could see was pulled out from plug just enough to cause the appliance not to operate couldn’t move the dresser (very heavy!) to plug it in Otherwise fine"

Reviewed on Sep 9, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

$169 nightly

$201 total

Sep 10 - Sep 11

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,333 reviews)

"Everything was wonderful!"

Reviewed on Sep 9, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$126 nightly

$149 total

Oct 2 - Oct 3

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$186 nightly

$219 total

Oct 4 - Oct 5

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,021 reviews)

"Staff was friendly, building and rooms are amazing"

Reviewed on Sep 8, 2026

The Westin St. Louis

811 Spruce St St. Louis MO

$136 nightly

$158 total

Sep 27 - Sep 28

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,016 reviews)

"Top notch property from super clean and comfortable room to great breakfast. Staff excelled at enjoying their jobs and being friendly and personable. Cant rate them higher! Thank you."

Reviewed on Sep 7, 2026

Marriott St. Louis Grand

800 Washington Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$181 total

Sep 20 - Sep 21

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.2/10 Very Good! (1,011 reviews)

"Excellent Staff, one of the friendliest helpful place we have been. Clean, great location for Sites in downtown."

Reviewed on Sep 9, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$108 nightly

$128 total

Sep 13 - Sep 14

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.6/10 Excellent! (1,356 reviews)

"The hotel was nice and the staff was helpful. Only problem was trying to get room service. I would call and call with no answer. I finally went down and they were not busy at all. Not sure what the problem was."

Reviewed on Sep 9, 2026

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

$165 nightly

$196 total

Sep 20 - Sep 21

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (2,011 reviews)

"The hotel was great except for the fitness room. It needs some attention. Sanitizer dispensers were empty and wet wipes were all dried out. Also, the roof top bar on inside could use some love. Small glass of wine was $14!"

Reviewed on Sep 9, 2026

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4 Star Hotels Roxana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Roxana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Roxana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Roxana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.