Explore top 2026 4 Star Hotels in Roxana

Name: Moonrise Hotel
Price range: $208 total
Rating: 9

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Top Roxana 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Jun 14 - Jun 15

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,116 reviews)

"🔝"

Reviewed on Jun 9, 2026

Le Méridien St. Louis Clayton

7730 Bonhomme Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Jul 5 - Jul 6

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (723 reviews)

"Dinning and pool areas were enjoyable."

Reviewed on Jun 2, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Jun 21 - Jun 22

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,217 reviews)

"Good hotel but found the neighborhood inconvenient for a business traveler"

Reviewed on Jun 9, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$135 nightly

$158 total

Jun 28 - Jun 29

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,103 reviews)

"Location was not good. Clean rooms, nice staff and good breakfast."

Reviewed on Jun 8, 2026

Marriott St. Louis Grand

800 Washington Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$181 total

Jun 18 - Jun 19

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.2/10 Very Good! (1,020 reviews)

"The hallway wreaked of marijuana. Our room didn’t have a bar of soap upon checking. Upon requesting feather free pillows the staff brought us feather pillows. Lack of attention to detail."

Reviewed on Jun 7, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$165 nightly

$193 total

Jun 21 - Jun 22

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,898 reviews)

"I loved my stay, but evidently this is in a relatively rough part of town. I didn’t realise that when I booked it so it’s probably not very good in terms of walking around, but I was just there for one quick overnight stay so it was lovely. In addition the restaurant was absolutely fantastic and ..."

Reviewed on Jun 9, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$211 nightly

$249 total

Jun 14 - Jun 15

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9/10 Wonderful! (1,012 reviews)

"Nice old school hotel. Great gym !!! Nice pool, not sure why they don’t have a jacuzzi . All in all very nice and old school and right next to the park."

Reviewed on Jun 8, 2026

Hilton St. Louis at the Ballpark

1 S Broadway St. Louis MO

Fully refundableReserve now, pay when you stay

$171 nightly

$204 total

Jun 18 - Jun 19

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

7.6/10 Good! (1,162 reviews)

"Huge place! For the price rooms were nothing special, small. The shower was scalding hot very hard to get it to a temperature that didn’t leave burns! Valet and bellman were very nice and very helpful. Room temperature was hard to keep cool."

Reviewed on Jun 8, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$114 nightly

$136 total

Jun 28 - Jun 29

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.8/10 Excellent! (1,297 reviews)

"Old style"

Reviewed on Jun 9, 2026

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$175 nightly

$208 total

Jun 21 - Jun 22

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (1,967 reviews)

"The staff were so sweet! Check in was quick and easy. They knew the area really well and gave great food recommendations for places to eat in the area, which is all walking distance. The room was very clean and the bed was very comfortable. The restaurant connected to the hotel was decent. You will ..."

Reviewed on Jun 8, 2026

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4 Star Hotels Roxana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Roxana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Roxana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Roxana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.