Find and compare 2 Star hotels in Southeast Missouri

Name: Holiday Inn Express & Suites Perryville by IHG
Price range: $127 total
Rating: 9.2

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Top Southeast Missouri 2 Star hotels

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Fully refundableReserve now, pay when you stay

$56 nightly

$64 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

8/10 Very Good! (1,001 reviews)

Great over all. Just the door wouldnt open right for the carpet.

Reviewed on Oct 21, 2025

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO

Fully refundableReserve now, pay when you stay

$63 nightly

$72 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,000 reviews)

The staff was very professional, kind and accommodating.

Reviewed on Oct 12, 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Fully refundableReserve now, pay when you stay

$79 nightly

$83 total

Oct 27 - Oct 28

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...

7.8/10 Good! (1,000 reviews)

Everything we needed

Reviewed on Oct 19, 2025

The Farmstead Hotel

778 E 3rd St, Caruthersville, MO

Fully refundableReserve now, pay when you stay

$89 nightly

$102 total

Nov 24 - Nov 25

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

8.6/10 Excellent! (432 reviews)

We enjoyed our stay . It was only for one night but we would go back again . The only thing the place there where they had to get drinks was pretty empty . Would Suggest filling it up more often . Overall very nice stay !

Reviewed on Oct 22, 2025

Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove, Poplar Bluff, MO

Fully refundableReserve now, pay when you stay

$102 nightly

$115 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...

9.4/10 Exceptional! (826 reviews)

Everything was very good and clean and fresh we will be back

Reviewed on Oct 19, 2025

Comfort Inn Festus - St Louis South

1303 Veterans Blvd, Festus, MO

Fully refundableReserve now, pay when you stay

$82 nightly

$93 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...

7.8/10 Good! (895 reviews)

Mika went above and beyond even getting us ice when we checked in. As I was checking out Gary fell out used.Mika got him up and inside. Got ice and bandages. We were soon on our way.

Reviewed on Oct 17, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$70 nightly

$79 total

Oct 26 - Oct 27

Total with taxes and fees

Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.

8.8/10 Excellent! (1,012 reviews)

Always enjoy our stay. Staff is very friendly, especially at breakfast!

Reviewed on Oct 22, 2025

Hampton Inn Sikeston

1240 Commerce Drive, Sikeston, MO

Fully refundableReserve now, pay when you stay

$98 nightly

$110 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...

8.8/10 Excellent! (409 reviews)

Clean property

Reviewed on Oct 15, 2025

Hampton Inn Poplar Bluff

2420 Crestwood Dr, Poplar Bluff, MO

Fully refundableReserve now, pay when you stay

$96 nightly

$107 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business ...

9.2/10 Wonderful! (772 reviews)

Weekend giveaway

Very friendly staff

Reviewed on Oct 14, 2025

Holiday Inn Express & Suites Perryville by IHG

2020 Jefferson St, Perryville, MO

Fully refundable

$111 nightly

$127 total

Nov 9 - Nov 10

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...

9.2/10 Wonderful! (522 reviews)

Reviewed on Oct 22, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

2 Star Hotels Southeast Missouri

Looking to break out of your routine for some much needed rest and relaxation? Or maybe you’ve already decided it’s time for a trip and are trying to find affordable hotels in Southeast Missouri that won’t bust your travel budget?

Southeast Missouri 2 star hotels will give you everything you need to enjoy the city like a local, saving a ton of money so you can hit all the hot spots in town.

Have a delicious breakfast at your hotel to fuel up for your day of sightseeing, then enjoy amenities like fresh towels and linens, as well as a nice hot shower to unwind after a busy day of experiencing everything the city has to offer.

As you explore a new locale, or one you love to visit over and over, you can rest easy knowing you’re staying in a great hotel that lets you discover Southeast Missouri and welcomes you back to a clean, comfortable room at night.

Browse Travelocity’s wide selection of 2 star hotels in Southeast Missouri and find one that’s perfectly priced and places you next to all the best activities and sights. The town is your oyster, and we can help you seek out its secrets while sticking to your budget.