Find and compare 2 Star hotels in Southeast Missouri

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Top Southeast Missouri 2 Star hotels

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $62 total per night from Dec 17 to Dec 18
$62 total
Dec 17 - Dec 18
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
7.8/10 Good! (1,000 reviews)
The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe.

Reviewed on Dec 7, 2025

Opens in a new windowBaymont Inn and Suites by Wyndham Farmington, MO
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $80 total per night from Dec 11 to Dec 12
$80 total
Dec 11 - Dec 12
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
7.8/10 Good! (1,000 reviews)
Love the updated rooms and the vending area.

Reviewed on Dec 6, 2025

Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Dec 14 to Dec 15
$72 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,001 reviews)
Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms.

Reviewed on Dec 7, 2025

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Dec 14 to Dec 15
$79 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
9/10 Wonderful! (1,000 reviews)
Staff are very pleasant. Room is clean and well-maintained. Good value for the money. Appreciate they are pet-friendly. I stay there monthly. Don't consider other options.

Reviewed on Dec 4, 2025

Opens in a new windowPear Tree Inn Cape Girardeau West
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
Fully refundable
$95 nightly
The price is $107 total per night from Dec 18 to Dec 19
$107 total
Dec 18 - Dec 19
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
9.4/10 Exceptional! (1,002 reviews)
We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly.

Reviewed on Dec 3, 2025

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 out of 5
3109 Oak Grove Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $118 total per night from Jan 4 to Jan 5
$118 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
9.4/10 Exceptional! (846 reviews)
Very nice

Reviewed on Dec 3, 2025

Opens in a new windowFairfield Inn & Suites by Marriott Poplar Bluff
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $97 total per night from Dec 11 to Dec 12
$97 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
8.6/10 Excellent! (461 reviews)
Clean, quiet and friendly staff.

Reviewed on Dec 1, 2025

Opens in a new windowThe Farmstead Hotel
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Dec 14 to Dec 15
$79 total
Dec 14 - Dec 15
Total with taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,005 reviews)
Room could have been cleaner and no cups for coffee. Staff at front desk OUTSTANDING.

Reviewed on Dec 6, 2025

Opens in a new windowPear Tree Inn Cape Girardeau Near the Medical Center
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Dec 21 to Dec 22
$108 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
8.8/10 Excellent! (442 reviews)
Yes

Reviewed on Dec 10, 2025

Opens in a new windowHampton Inn Sikeston
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
Fully refundable
$70 nightly
The price is $84 total per night from Dec 14 to Dec 15
$84 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, ...
8/10 Very Good! (876 reviews)
Clean room, low noise and very comfortable!

Reviewed on Dec 4, 2025

Opens in a new windowCandlewood Suites Cape Girardeau by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

2 Star Hotels Southeast Missouri

Looking to break out of your routine for some much needed rest and relaxation? Or maybe you’ve already decided it’s time for a trip and are trying to find affordable hotels in Southeast Missouri that won’t bust your travel budget?

Southeast Missouri 2 star hotels will give you everything you need to enjoy the city like a local, saving a ton of money so you can hit all the hot spots in town.

Have a delicious breakfast at your hotel to fuel up for your day of sightseeing, then enjoy amenities like fresh towels and linens, as well as a nice hot shower to unwind after a busy day of experiencing everything the city has to offer.

As you explore a new locale, or one you love to visit over and over, you can rest easy knowing you’re staying in a great hotel that lets you discover Southeast Missouri and welcomes you back to a clean, comfortable room at night.

Browse Travelocity’s wide selection of 2 star hotels in Southeast Missouri and find one that’s perfectly priced and places you next to all the best activities and sights. The town is your oyster, and we can help you seek out its secrets while sticking to your budget.

Recent Southeast Missouri hotel reviews by fellow wanderers

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