Find and compare 2 Star hotels in Southeast Missouri

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Top Southeast Missouri 2 Star hotels

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $64 total per night from Jul 5 to Jul 6
$64 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
8/10 Very Good! (1,018 reviews)
"Amazing"

Reviewed on Jun 14, 2026

Opens in a new windowBaymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jun 17 to Jun 18
$79 total
Jun 17 - Jun 18
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,008 reviews)
"Lobby reeked like pot and cigarettes, room was not the cleanest and smelled like wet dog, water only got lukewarm, and milk for breakfast was days expired. Pics on Expedia definitely don’t look like the room we had."

Reviewed on Jun 8, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
Fully refundable
$76 nightly
The price is $91 total per night from Jul 5 to Jul 6
$91 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, ...
8/10 Very Good! (962 reviews)
"Overbooked my stay didn't have a room"

Reviewed on Jun 8, 2026

Opens in a new windowCandlewood Suites Cape Girardeau by IHG
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Jul 12 to Jul 13
$105 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business ...
9.4/10 Exceptional! (875 reviews)
"It was really noisy. We were on the 2nd floor and there was a baby shower taking place in one of the meeting rooms. The bass on the music was extremely loud it was vibrating our room. Also the lady in the room next to us was talking so loud we could hear every word she said and she was in the room ..."

Reviewed on Jun 14, 2026

Opens in a new windowHampton Inn Poplar Bluff
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $84 total per night from Jun 16 to Jun 17
$84 total
Jun 16 - Jun 17
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
8/10 Very Good! (1,005 reviews)
"The motel was great, however, they did not have blankets for the beds and the shower head left a lot to be desired. We would stay here again."

Reviewed on Jun 15, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $78 total per night from Jun 21 to Jun 22
$78 total
Jun 21 - Jun 22
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like on-the-go breakfast and WiFi in ...
7/10 Good! (645 reviews)
"ac worked sometimes, made it uncomfortable at times."

Reviewed on Jun 11, 2026

Opens in a new windowSuper 8 by Wyndham Sikeston/Miner Area
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from Jul 12 to Jul 13
$115 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
9/10 Wonderful! (577 reviews)
"Staff were great at Check in, room was clean, breakfast was good."

Reviewed on Jun 14, 2026

Opens in a new windowHampton Inn Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $81 total per night from Jun 21 to Jun 22
$81 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
9/10 Wonderful! (1,013 reviews)
"Staff was friendly and helpful"

Reviewed on Jun 12, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $82 total per night from Jun 16 to Jun 17
$82 total
Jun 16 - Jun 17
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
6.8/10 (439 reviews)
"The first room we were given had not been cleaned; dirty towels on the floor, unmade bed. The 2nd room we were given had dirty sheets. The front desk gave us new sheets which when we went to put them on the bed were stained and when removing the dirty sheets, the mattress topper had blood on it. ..."

Reviewed on Jun 1, 2026

Opens in a new windowDays Inn by Wyndham Perryville
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
Fully refundable
$110 nightly
The price is $124 total per night from Jun 28 to Jun 29
$124 total
Jun 28 - Jun 29
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
9.4/10 Exceptional! (1,004 reviews)
"Staff and breakfast were excellent."

Reviewed on Jun 14, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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2 Star Hotels Southeast Missouri

Looking to break out of your routine for some much needed rest and relaxation? Or maybe you’ve already decided it’s time for a trip and are trying to find affordable hotels in Southeast Missouri that won’t bust your travel budget?

Southeast Missouri 2 star hotels will give you everything you need to enjoy the city like a local, saving a ton of money so you can hit all the hot spots in town.

Have a delicious breakfast at your hotel to fuel up for your day of sightseeing, then enjoy amenities like fresh towels and linens, as well as a nice hot shower to unwind after a busy day of experiencing everything the city has to offer.

As you explore a new locale, or one you love to visit over and over, you can rest easy knowing you’re staying in a great hotel that lets you discover Southeast Missouri and welcomes you back to a clean, comfortable room at night.

Browse Travelocity’s wide selection of 2 star hotels in Southeast Missouri and find one that’s perfectly priced and places you next to all the best activities and sights. The town is your oyster, and we can help you seek out its secrets while sticking to your budget.

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