Southeast Missouri , MO Pet Friendly Hotels

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Top Southeast Missouri Pet Friendly Hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $117 total per night from Jul 27 to Jul 28
$117 total
Jul 27 - Jul 28
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,002 reviews)
"Staff was kind and accommodating."

Reviewed on Jul 16, 2025

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Jul 20 to Jul 21
$92 total
Jul 20 - Jul 21
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (1,000 reviews)
"Would have appreciated a way to charge our phone. We had our cord but nowhere to put it. Maybe a clock with the port for charging? The faucet leaked in the sink. Everything else was great."

Reviewed on Jul 15, 2025

Pear Tree Inn Sikeston
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

2220 N Westwood Blvd, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $107 total per night from Aug 3 to Aug 4
$107 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (884 reviews)
"All the staff was absolutely WONDERFUL!!!!"

Reviewed on Jul 7, 2025

Drury Inn & Suites Poplar Bluff
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jul 21 to Jul 22
$79 total
Jul 21 - Jul 22
Total includes taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,002 reviews)
Nice One-Night Stay
"Stopped in in late June. One night stay. Rooms was fine. Bed was comfy and pillows were good. The 'continental' breakfast was severely lacking."

Reviewed on Jul 6, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32, Ste Genevieve, MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Aug 17 to Aug 18
$100 total
Aug 17 - Aug 18
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
8.6/10 Excellent! (580 reviews)
Gross cleaning service in front of guests at bkfst
"The first morning we ate breakfast (24th) as we were in the breakfast room I witnessed a female cleaning the area. She used a rag to scrub at the floor in front of the coffee machine. Nothing unusual, but I kept watching. She then stood up, rinsed out the rag then immediately started to wipe down ..."

Reviewed on Jun 27, 2025

Microtel Inn & Suites by Wyndham Sainte Genevieve
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $83 total per night from Jul 20 to Jul 21
$83 total
Jul 20 - Jul 21
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
7.8/10 Good! (1,004 reviews)
"Good"

Reviewed on Jul 16, 2025

Motel 6 Poplar Bluff, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd, Festus, MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $126 total per night from Aug 17 to Aug 18
$126 total
Aug 17 - Aug 18
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
7.8/10 Good! (820 reviews)
"It was nice and clean."

Reviewed on Jul 17, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $82 total per night from Jul 21 to Jul 22
$82 total
Jul 21 - Jul 22
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,001 reviews)
Keep up the renovations
"This hotel looked like an old apartment building renovation into a hotel with much wrk in progress. Decent stay. Spacious. Very minimal breakfast offerings. The geese outside sure left messes everywhere but the greeting cat was a nice touch"

Reviewed on Jun 28, 2025

Days Inn and Suites by Wyndham Sikeston
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

It’s hard to leave for a trip when the last image you have is of your four-legged best friend staring out the living-room window with those sad eyes as you drive away. You don’t have to leave Spot behind any longer, he can finally join you on your adventures.

Turn your trip into a family getaway by booking a stay at one of the pet-friendly hotels in Southeast Missouri for you and your furry kids. No more sending them to pet hotels or leaving them home alone to run amok in the house. Southeast Missouri pet-friendly hotels are perfect for weekend escapes with your pooch, kitty, bird, or fish. These accommodations not only welcome your pets, but they offer many services to help make your stay more relaxing. Things like on-site grooming and complimentary dog walking are some of the amenities provided. In most cases, you’ll also be near outdoor spaces like dog parks if you both need some exercise, as well as pet-friendly restaurants.

Don’t ever feel guilty about leaving your beloved Maximus behind on a trip again. Travelocity wants to help the both of you enjoy a wonderful vacation together. Search our extensive inventory of the best pet-friendly hotels in Southeast Missouri and book your stay now.

Southeast Missouri hotels essential information

Accommodation
582 hotels
Lowest Price
$79
Highest Price
$126
Popular hotels
Motel 6 Poplar Bluff, MO, Microtel Inn & Suites by Wyndham Sainte Genevieve, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Drury Inn & Suites Sikeston, MO, Pear Tree Inn Sikeston, Drury Inn & Suites Poplar Bluff, Days Inn and Suites by Wyndham Sikeston, Pear Tree Inn Cape Girardeau Near the Medical Center

Recent Southeast Missouri hotel reviews by fellow wanderers

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