Southeast Missouri , MO Pet Friendly Hotels
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Top Southeast Missouri Pet Friendly Hotels

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $117 total per night from May 4 to May 5
$117 total
May 4 - May 5
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.6/10 Exceptional! (1,001 reviews)
Manager’s reception is a hit!
Reviewed on Apr 29, 2026

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from May 31 to Jun 1
$102 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (1,000 reviews)
Friendly staff. Good food.
Reviewed on Apr 26, 2026

Drury Inn & Suites Hayti Caruthersville
1317 E Highway 84 Hayti MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $112 total per night from May 10 to May 11
$112 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (1,000 reviews)
Clean facility, great staff friendly and helpful. Great breakfast and good coffee. If I am by that way again, I plan to stay there,
Reviewed on Apr 29, 2026

Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from May 31 to Jun 1
$106 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (1,000 reviews)
Especially liked the "Managers Welcome" event.
Reviewed on Apr 29, 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve
21958 Hwy 32 Ste Genevieve MO
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $92 total per night from May 3 to May 4
$92 total
May 3 - May 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
8.8/10 Excellent! (630 reviews)
Staff was very nice. Decent overall experience.
Reviewed on Apr 19, 2026

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $82 total per night from May 1 to May 2
$82 total
May 1 - May 2
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
8/10 Very Good! (1,000 reviews)
Floors and windows in room were dirty.. terrible lighting TERRIBLE!!!
Reviewed on Apr 27, 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from May 3 to May 4
$106 total
May 3 - May 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
8/10 Very Good! (972 reviews)
It was a nice weekend stay. Great location
Reviewed on Apr 27, 2026

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $75 total per night from May 2 to May 3
$75 total
May 2 - May 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
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See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Pet Friendly Hotel in Southeast Missouri
Southeast Missouri hotels essential information
Accommodation | 663 hotels |
|---|---|
Lowest Price | $75 |
Highest Price | $117 |
Popular hotels | Motel 6 Poplar Bluff, MO, Microtel Inn & Suites by Wyndham Sainte Genevieve, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Poplar Bluff, Days Inn and Suites by Wyndham Sikeston, Drury Inn & Suites Cape Girardeau, Drury Inn & Suites Hayti Caruthersville |
Recent Southeast Missouri hotel reviews by fellow wanderers

Drury Plaza Hotel Cape Girardeau Conference Center
5 out of 5
Posted 10 hours ago
Travelocity Verified Review
"The dinners and drinks were great every night. The breakfast was good too. Rooms are clean. Great place to stay!"
A verified traveler stayed at Drury Plaza Hotel Cape Girardeau Conference Center
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