Southeast Missouri , MO Pet Friendly Hotels

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Top Southeast Missouri Pet Friendly Hotels

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Nov 9 to Nov 10
$102 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,003 reviews)
"Absolutely the friendliest front desk staff I have ever experienced! Such a delight! They have a quick bite for supper available as well as popcorn and soda in the evening. Breakfast was great. It was Halloween and the hotel was packed with college ball players but the staff kept Bfast stocked and ..."

Reviewed on Nov 4, 2026

Opens in a new windowDrury Inn & Suites Poplar Bluff
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Nov 12 to Nov 13
$102 total
Nov 12 - Nov 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (1,004 reviews)
"Always stay at a Drury"

Reviewed on Nov 4, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32 Ste Genevieve MO
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $102 total per night from Nov 15 to Nov 16
$102 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
8.8/10 Excellent! (681 reviews)
"Refrigerator in the room did was not cold. Did not get cold all night TV in the room. Had to call maintenance to fix it. Overall it was a good stay. Just need to fix the fridge"

Reviewed on Nov 1, 2026

Opens in a new windowMicrotel Inn & Suites by Wyndham Sainte Genevieve
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $88 total per night from Nov 6 to Nov 7
$88 total
Nov 6 - Nov 7
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
8/10 Very Good! (1,000 reviews)
"The hallways reeked of marijuana smoke. Changed hotels the second night."

Reviewed on Nov 2, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $96 total per night from Nov 8 to Nov 9
$96 total
Nov 8 - Nov 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
7.8/10 Good! (1,004 reviews)
"it's nice to see familiar faces's. Daniella, the tiny girl with the great short hair and your breakfast server. Good luck and we'll be back. Thanks"

Reviewed on Nov 2, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Nov 15 to Nov 16
$108 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Opens in a new windowDrury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $76 total per night from Nov 8 to Nov 9
$76 total
Nov 8 - Nov 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

1317 E Highway 84 Hayti MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $112 total per night from Nov 15 to Nov 16
$112 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Opens in a new windowDrury Inn & Suites Hayti Caruthersville
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri hotels essential information

Accommodation
695 hotels
Lowest Price
$76
Highest Price
$112
Popular hotels
Motel 6 Poplar Bluff, MO, Microtel Inn & Suites by Wyndham Sainte Genevieve, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Poplar Bluff, Days Inn and Suites by Wyndham Sikeston, Drury Inn & Suites Cape Girardeau, Drury Inn & Suites Hayti Caruthersville

Recent Southeast Missouri hotel reviews by fellow wanderers