Cheap Flights to Southeast Missouri from $39

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How Much Does it Cost To Fly To Southeast Missouri?

The cheapest prices found with in the last 7 days for return flights were $144 and $39 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel DatesFlights From*
EWRSt. LouisMay 2 to May 6$174
DCASt. LouisMay 8 to May 11$183
LAXSt. LouisMay 3 to May 9$190
MCISt. LouisMay 1 to May 4$255
CMHSt. LouisMay 1 to May 3$270
SATWest PaducahMay 17 to May 23$326
MCIScott CityMay 3 to May 6$511
EWRMarionJuly 1 to July 5$562
EWRScott CityJuly 11 to July 19$606
MCIWest PaducahApril 26 to April 30$635
LAXScott CityApril 30 to May 3$641
CMHScott CityApril 23 to April 28$666
MSYScott CityApril 24 to April 26$799
LAXMarionMay 15 to May 20$879
BWIScott CityMay 7 to May 10$1,603
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
BWISt. LouisApril 19 to April 29$230
SATSt. LouisApril 18 to April 23$299
DCASt. LouisApril 18 to April 19$305
EWRSt. LouisApril 19 to April 23$312
LAXSt. LouisApril 18 to May 24$352
MSYSt. LouisApril 19 to April 20$358
CMHSt. LouisApril 18 to April 19$367
MSPSt. LouisApril 18 to April 20$515
MSPScott CityApril 19 to April 24$953
*Prices include taxes and fees

Southeast Missouri Flight Information

Traveling to
Southeast Missouri
Lowest Price
$144
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Southeast Missouri Accommodation Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$65 nightly
The price is $69 total per night from Apr 26 to Apr 27
$69 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,002 reviews)
Clean rooms, and they leave the light on for you…

Reviewed on Apr 9, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $65 total per night from May 3 to May 4
$65 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (638 reviews)
Breakfast menu was a little limited. Clean room. Staff great! Air condition and heat perfect. Better than what I consider it's price competitors to be. In today's high tech age, a few more electrical receptacles would be nice, but that's the case in most hotel/motels in this price range.

Reviewed on Mar 31, 2026

Opens in a new windowSuper 8 by Wyndham Farmington
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
$79 nightly
The price is $91 total per night from Apr 19 to Apr 20
$91 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (845 reviews)
Horrible dirty needs cleaned everywhere smells like mold and staff is rude

Reviewed on Apr 13, 2026

Opens in a new windowSuper 8 by Wyndham Pevely
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Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Apr 20 to Apr 21
$81 total
Apr 20 - Apr 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
Breakfast was hot and manned by a friendly staff member. Room was clean and met my needs.

Reviewed on Apr 9, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
$79 nightly
The price is $91 total per night from Apr 19 to Apr 20
$91 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (845 reviews)
Horrible dirty needs cleaned everywhere smells like mold and staff is rude

Reviewed on Apr 13, 2026

Opens in a new windowSuper 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$65 nightly
The price is $69 total per night from Apr 26 to Apr 27
$69 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,002 reviews)
Clean rooms, and they leave the light on for you…

Reviewed on Apr 9, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$68 nightly
The price is $78 total per night from Apr 19 to Apr 20
$78 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
It had a clean room. Better than most hotels like this. The bathroom smelled like mold or mildew. And the lobby smelled of moth balls. Some of the sheets had black stuff on them. Not sure what it was. Air conditioning was cold.

Reviewed on Apr 12, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on Dec 15, 2025

Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$98 nightly
The price is $113 total per night from Apr 21 to Apr 22
$113 total
Apr 21 - Apr 22
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Amazingly they had dinner and breakfast. For a family this would be great savings. But be parpared for a crowd.

Reviewed on Apr 15, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$76 nightly
The price is $87 total per night from Apr 26 to Apr 27
$87 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
Everything went perfect.

Reviewed on Apr 13, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from May 3 to May 4
$102 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,003 reviews)
This is a wonderful property. The hotel itself has had upgrades. The staff is wonderful! The rooms are clean and quiet. The food service was fresh and delicious. We stay here every time we're on I-55

Reviewed on Apr 16, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from Apr 23 to Apr 24
$100 total
Apr 23 - Apr 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (760 reviews)
Rooms were clean, AC worked great and the staff was friendly

Reviewed on Apr 3, 2026

Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Southeast Missouri Flight and Hotel Packages

Southeast Missouri flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Hampton Inn By Hilton St Louis Airport
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Frequently asked questions

How much is the cheapest flight to Southeast Missouri?
A roundtrip flight to Southeast Missouri cost as little as $144 over the last seven days. Once you've chosen your travel dates, we'll help you find an amazing deal. This price was available on Travelocity for flights to Southeast Missouri departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly to Southeast Missouri?
Be sure to leave May empty in your calendar, because it's the most affordable month to travel to Southeast Missouri. That's based on Travelocity's direct flight demand from January to December last year. With the cash you save, you can go on a spending spree, go for a fancy dinner or whatever makes you happy.
How can I check my flight status to Southeast Missouri?
Make the most of Travelocity's handy portal, Trips. You'll find just about everything related to your flight to Southeast Missouri here, including details about flight status, gate numbers and more. Look for Trips at the top of the Travelocity homepage. Create your free account and get the answers you need. Or you can access your itinerary while you're on the go and get real-time travel updates through the Travelocity app. You'll find all your itineraries in one place, making it a cinch to share details with any members of your family flying with you.
How do I find the best deals on flights to Southeast Missouri?
Being flexible with your dates is one of the best ways to snag an awesome deal. Travelocity makes it a cinch to find your perfect fare through the "Flexible dates" feature. First, search for your Southeast Missouri flight, then compare prices for surrounding dates by hitting the Flexible dates box above. Booking in advance and avoiding peak travel periods are other steps you can take. In the last seven days, the lowest price for a return flight to Southeast Missouri was $144. This price was available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Why should I book my flight to Southeast Missouri with Travelocity?
If you're looking for cheap flights to Southeast Missouri, you'll discover some tempting deals with Travelocity. From cheap family flights with low-cost airlines to flexible tickets, we can help you. Enjoy a worry-free trip with our 24/7 customer support, Price Match Guarantee and free cancellations with most hotels. Start packing your bags and get ready to jump on a plane to this interesting destination.
How much is a flight to Southeast Missouri on average?
Airfares for roundtrip flights to Southeast Missouri were priced between $144 and $1,603 in the last seven days. The minute you spot a good deal, snap it up and get ready for your dream getaway with Travelocity. These prices were available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What can I expect on a flight to Southeast Missouri?
Factors like who you're flying with and where you're departing from will mostly determine what you'll be offered on your trip. Chances are you'll find all kinds of flights to Southeast Missouri, from cheap flights for family vacations to premium fares. Warm meals, entertainment and games for the little ones are usually what most airlines offer on long-haul flights.

Plane Tickets To Southeast Missouri

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.