Cheap Flights to Southeast Missouri from $45
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How Much Does it Cost To Fly To Southeast Missouri?
The cheapest prices found with in the last 7 days for return flights were $86 and $45 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$86 Roundtrip, found 2 hours ago
$86
Roundtrip
found 2 hours ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| BWI | St. Louis | April 21 to April 22 | $144 |
| EWR | St. Louis | April 28 to May 5 | $150 |
| LAX | St. Louis | April 25 to May 9 | $176 |
| DCA | St. Louis | May 31 to June 8 | $181 |
| CMH | St. Louis | May 6 to May 9 | $203 |
| MCI | St. Louis | April 25 to April 28 | $259 |
| DCA | West Paducah | May 8 to May 10 | $328 |
| SAT | West Paducah | June 9 to June 14 | $338 |
| MSY | West Paducah | April 10 to April 12 | $338 |
| STL | Marion | June 4 to June 8 | $427 |
| EWR | Scott City | April 23 to April 26 | $474 |
| MCI | Marion | April 23 to April 27 | $480 |
| LAX | Marion | April 20 to April 24 | $559 |
| SAT | Marion | June 24 to June 27 | $598 |
| EWR | Marion | July 1 to July 5 | $987 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| BWI | St. Louis | April 5 to April 9 | $246 |
| EWR | St. Louis | April 5 to April 9 | $255 |
| MSY | St. Louis | April 3 to April 4 | $308 |
| LAX | St. Louis | April 4 to April 8 | $390 |
| MSP | St. Louis | April 3 to April 6 | $408 |
| MCI | St. Louis | April 3 to April 5 | $653 |
| SAT | St. Louis | April 5 to April 9 | $763 |
| DCA | St. Louis | April 3 to April 6 | $854 |
Southeast Missouri Flight Information
Traveling to | Southeast Missouri |
|---|---|
Lowest Price | $86 |
Number of Airlines Serving | |
Airlines Serving | Frontier Airlines |
Number of Daily Flights | |
Airlines with Direct Flights |
Find The Perfect Hotel For After Your Flight
Amazing Southeast Missouri Accommodation Deals
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$73 nightly
The price is $77 total per night from Apr 1 to Apr 2
$77 total
Apr 1 - Apr 2
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,006 reviews)
Very basic. No shampoo or facial tissue. Seemed unusual, but it was clean and in good condition.
Reviewed on Mar 29, 2026
Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $68 total per night from Apr 6 to Apr 7
$68 total
Apr 6 - Apr 7
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (630 reviews)
Room was clean. Bed was comfy. Water was hot and the AC was cold.... Only 2 things that were keeping it from 5 stars. 1. The towels and wash clothes were old, gray and rough instead of white and soft. And the breakfast. The dining area is super small and the food options are seriously limited. Waffle ...
Reviewed on Mar 23, 2026
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$79 nightly
The price is $91 total per night from Apr 1 to Apr 2
$91 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (841 reviews)
The staff was great. When we checked in the clerk was very helpful. She told us that room 116 had to be aired out because the former guest had to be asked to leave because he was using a deep fryer in the room and it was a fire hazzard and was stinking up the whole hotel. In that same room Timothy ...
Reviewed on Mar 24, 2026
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Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Apr 5 to Apr 6
$81 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,004 reviews)
Very decent hotel, Affordable, free pop corn abd soda, nice touch, good breakfast.
Reviewed on Mar 29, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Luxury Hotels in Southeast Missouri
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$79 nightly
The price is $91 total per night from Apr 1 to Apr 2
$91 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (841 reviews)
The staff was great. When we checked in the clerk was very helpful. She told us that room 116 had to be aired out because the former guest had to be asked to leave because he was using a deep fryer in the room and it was a fire hazzard and was stinking up the whole hotel. In that same room Timothy ...
Reviewed on Mar 24, 2026
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$73 nightly
The price is $77 total per night from Apr 1 to Apr 2
$77 total
Apr 1 - Apr 2
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,006 reviews)
Very basic. No shampoo or facial tissue. Seemed unusual, but it was clean and in good condition.
Reviewed on Mar 29, 2026
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$68 nightly
The price is $78 total per night from Apr 2 to Apr 3
$78 total
Apr 2 - Apr 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
The floor in the room was dirty. It needed sweeping. There was a large ball of human hair on the floor near the bed. The bed spread had 2 red stains on the cover. The sink in the bathroom had a defective stopper. The cover control rod was not working. To flush the toilet, you had to continuously ...
Reviewed on Mar 30, 2026
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!
Reviewed on Dec 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Southeast Missouri
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Apr 5 to Apr 6
$108 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,007 reviews)
Our first visit to a Drury Inn — what an amazing place. Not only was there an excellent breakfast with many choices, but there was also a light dinner served. This was all included for a very reasonable price. Our room was very clean and comfortable. We will definitely be looking for more Drury Inns ...
Reviewed on Mar 30, 2026
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
$73 nightly
The price is $83 total per night from Apr 5 to Apr 6
$83 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
The bed and chair was hard. Will not go back
Reviewed on Mar 30, 2026
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$94 nightly
The price is $106 total per night from Apr 7 to Apr 8
$106 total
Apr 7 - Apr 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,002 reviews)
Clean room, friendly staff, great breakfast.
Reviewed on Mar 28, 2026
Save an average of 15% on thousands of hotels when you're signed in
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from Apr 5 to Apr 6
$100 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (755 reviews)
There was no water pressure, luke warm water both nights. The breakfast was subpar & with an hour left with breakfast the workers refused to refill empty items. Several people complained to no avail. Breakfast area was dirty & two people sitting upfront playing on their phones. We made our first ...
Reviewed on Mar 22, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Southeast Missouri Flight and Hotel Packages
Southeast Missouri flight + hotel packages - economy flights
Price found within the past 48 hours. Click for updated prices.
Don't see what you're looking for?
See all available trips from Dallas to Southeast Missouri
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Economy
Chevrolet Spark or similar
Compact
Ford Focus or similar
Midsize
Toyota Corolla or similar
SUV
Jeep Compass or similar
Frequently asked questions
Plane Tickets To Southeast Missouri
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When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!
More Ways To Wander
Southeast Missouri Hotels
Find the perfect hotel after your flight
Southeast Missouri Vacation Rentals
Great Deals on alternative accommodations
Southeast Missouri Car Rentals
Affordable cars to get you around town
Southeast Missouri Vacations
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Things to do in Southeast Missouri
Activities, attractions and tours
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