Cheap Flights to Southeast Missouri from $20

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How Much Does it Cost To Fly To Southeast Missouri?

The cheapest prices found with in the last 7 days for return flights were $44 and $20 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply

Wed, Nov 4 - Mon, Nov 9
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$44 Roundtrip, found 21 hours ago
$44
Roundtrip
found 21 hours ago
Select Frontier Airlines flight, departing Wed, Nov 4 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Nov 9, priced at $44 found 21 hours ago
Fri, Oct 2 - Sat, Oct 10
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 6 days ago
$88
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Oct 2 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 10, priced at $88 found 6 days ago
OriginDestinationTravel DatesFlights From*
BWISt. LouisOctober 28 to November 2$124
CMHSt. LouisNovember 16 to November 18$213
LAXSt. LouisOctober 31 to November 14$242
MCIWest PaducahNovember 11 to November 14$308
MCISt. LouisOctober 14 to October 15$329
MSPWest PaducahOctober 1 to October 12$429
MSPScott CityDecember 22 to December 29$478
LAXScott CityDecember 15 to January 5$514
STLWest PaducahSeptember 29 to October 6$551
DCAWest PaducahOctober 14 to October 16$560
MCIScott CityOctober 25 to October 29$605
STLScott CityOctober 25 to October 29$657
LAXWest PaducahNovember 15 to November 20$1,091
DCAScott CityOctober 12 to October 18$1,268
CMHWest PaducahSeptember 24 to September 25$1,431
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
DCASt. LouisSeptember 19 to September 23$386
LAXSt. LouisSeptember 19 to September 22$436
MSYSt. LouisSeptember 19 to September 21$439
CMHSt. LouisSeptember 19 to September 21$467
MSPSt. LouisSeptember 19 to September 20$611
MCISt. LouisSeptember 19 to September 21$943
BWISt. LouisSeptember 19 to September 21$984
EWRSt. LouisSeptember 19 to September 21$1,277
*Prices include taxes and fees

Southeast Missouri Flight Information

Traveling to
Southeast Missouri
Lowest Price
$44
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Southeast Missouri Accommodation Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$74 nightly
The price is $83 total per night from Sep 18 to Sep 19
$83 total
Sep 18 - Sep 19
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
"Nice"

Reviewed on Sep 8, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $65 total per night from Sep 28 to Sep 29
$65 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (677 reviews)
"Very nice for the price everything was good plenty of restaurants nearby and grocery across street"

Reviewed on Sep 15, 2026

Opens in a new windowSuper 8 by Wyndham Farmington
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
$69 nightly
The price is $80 total per night from Oct 18 to Oct 19
$80 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.8/10 (877 reviews)
"It was an awesome stay. Very nice. Only downside was you have to pay for parking"

Reviewed on Sep 8, 2026

Opens in a new windowSuper 8 by Wyndham Pevely
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Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Sep 27 to Sep 28
$81 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,004 reviews)
"I was there overnight while I visited a family member. Everything was fine. People were friendly."

Reviewed on Sep 17, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
$69 nightly
The price is $80 total per night from Oct 18 to Oct 19
$80 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.8/10 (877 reviews)
"It was an awesome stay. Very nice. Only downside was you have to pay for parking"

Reviewed on Sep 8, 2026

Opens in a new windowSuper 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$74 nightly
The price is $83 total per night from Sep 18 to Sep 19
$83 total
Sep 18 - Sep 19
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
"Nice"

Reviewed on Sep 8, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$66 nightly
The price is $76 total per night from Sep 20 to Sep 21
$76 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
"Staff was prompt and helpful in getting us set up in a new room. Only because the outlet for the blowdryer wasn't working. The facilities were kinda updated. There could have been additional attention paid to light switch covers being VERY outdated and furniture being worn and tattered."

Reviewed on Sep 17, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (228 reviews)
"Very nice hospitality and accommodations ComfortableGreat location"

Reviewed on Jul 5, 2026

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Sep 27 to Sep 28
$108 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"Our stay was comfortable and the room was nice. The staff was very kind and helpful. Complimentary dinner was a great surprise and very tasty. I've never stayed at a Drury Inn before and am very satisfied. I will look for availability from now on when we travel."

Reviewed on Sep 17, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$87 nightly
The price is $99 total per night from Sep 20 to Sep 21
$99 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,005 reviews)
"Bathroom was not cleaned properly and there was no shower floor mat."

Reviewed on Sep 17, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from Sep 24 to Sep 25
$102 total
Sep 24 - Sep 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
$76 nightly
The price is $82 total per night from Oct 11 to Oct 12
$82 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Southeast Missouri Flight and Hotel Packages

Southeast Missouri flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG

3.5 out of 5
Price was $538, price is now $459 per person
$459
per person
Oct 29 - Oct 31
found 10 hours ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $1,257, price is now $737 per person
$737
per person
Nov 5 - Nov 8
found 17 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
Moonrise Hotel

Moonrise Hotel

4 out of 5
Price was $618, price is now $494 per person
$494
per person
Oct 29 - Oct 31
found 10 hours ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
Don't see what you're looking for?
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Need a Car For After Your Flight?

Economy

  • 4 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$81

$287 total
found 3 days ago
Economy undefined

Midsize

  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$81

$287 total
found 3 days ago
Midsize undefined

Compact

  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$81

$287 total
found 3 days ago
Compact undefined

Standard

  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$95

$335 total
found 3 days ago
Standard undefined
Lowest prices found within the past 3 days. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much is the cheapest flight to Southeast Missouri?
A roundtrip flight to Southeast Missouri cost as little as $44 over the last seven days. Once you've chosen your travel dates, we'll help you find an amazing deal. This price was available on Travelocity for flights to Southeast Missouri departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly to Southeast Missouri?
Be sure to leave November empty in your calendar, because it's the most affordable month to travel to Southeast Missouri. That's based on Travelocity's direct flight demand from January to December last year. With the cash you save, you can go on a spending spree, go for a fancy dinner or whatever makes you happy.
How can I check my flight status to Southeast Missouri?
Make the most of Travelocity's handy portal, Trips. You'll find just about everything related to your flight to Southeast Missouri here, including details about flight status, gate numbers and more. Look for Trips at the top of the Travelocity homepage. Create your free account and get the answers you need. Or you can access your itinerary while you're on the go and get real-time travel updates through the Travelocity app. You'll find all your itineraries in one place, making it a cinch to share details with any members of your family flying with you.
How do I find the best deals on flights to Southeast Missouri?
Being flexible with your dates is one of the best ways to snag an awesome deal. Travelocity makes it a cinch to find your perfect fare through the "Flexible dates" feature. First, search for your Southeast Missouri flight, then compare prices for surrounding dates by hitting the Flexible dates box above. Booking in advance and avoiding peak travel periods are other steps you can take. In the last seven days, the lowest price for a return flight to Southeast Missouri was $44. This price was available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Why should I book my flight to Southeast Missouri with Travelocity?
If you're looking for cheap flights to Southeast Missouri, you'll discover some tempting deals with Travelocity. From cheap family flights with low-cost airlines to flexible tickets, we can help you. Enjoy a worry-free trip with our 24/7 customer support, Price Match Guarantee and free cancellations with most hotels. Start packing your bags and get ready to jump on a plane to this interesting destination.
How much is a flight to Southeast Missouri on average?
Airfares for roundtrip flights to Southeast Missouri were priced between $44 and $1,431 in the last seven days. The minute you spot a good deal, snap it up and get ready for your dream getaway with Travelocity. These prices were available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What can I expect on a flight to Southeast Missouri?
Factors like who you're flying with and where you're departing from will mostly determine what you'll be offered on your trip. Chances are you'll find all kinds of flights to Southeast Missouri, from cheap flights for family vacations to premium fares. Warm meals, entertainment and games for the little ones are usually what most airlines offer on long-haul flights.

Plane Tickets To Southeast Missouri

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!

Explore More Ways to Travel with Travelocity

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.