Cheap Flights to Southeast Missouri from $24

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How Much Does it Cost To Fly To Southeast Missouri?

The cheapest prices found with in the last 7 days for return flights were $56 and $24 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply

Thu, Oct 15 - Thu, Oct 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, found 1 hour ago
$56
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Thu, Oct 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Oct 22, priced at $56 found 1 hour ago
Thu, Sep 17 - Sat, Sep 19
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$130 Roundtrip, found 5 days ago
$130
Roundtrip
found 5 days ago
Select United flight, departing Thu, Sep 17 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Sep 19, priced at $130 found 5 days ago
OriginDestinationTravel DatesFlights From*
CMHSt. LouisOctober 10 to October 11$192
DCASt. LouisSeptember 10 to September 14$200
MCISt. LouisOctober 12 to October 14$208
BWISt. LouisSeptember 3 to September 7$226
EWRSt. LouisSeptember 21 to September 23$228
LAXSt. LouisOctober 3 to October 5$278
MSPWest PaducahNovember 5 to November 7$324
LAXWest PaducahSeptember 10 to September 13$353
EWRWest PaducahAugust 15 to August 19$366
SATWest PaducahOctober 8 to October 12$372
MSPScott CityOctober 31 to November 7$415
BWIScott CityOctober 16 to October 19$544
LAXScott CitySeptember 3 to September 6$569
DCAScott CityOctober 16 to October 18$595
SATScott CityAugust 13 to August 17$804
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
BWISt. LouisAugust 7 to August 10$349
EWRSt. LouisAugust 7 to August 11$358
LAXSt. LouisAugust 8 to August 9$380
DCASt. LouisAugust 7 to August 9$387
CMHSt. LouisAugust 7 to August 10$392
MSPSt. LouisAugust 7 to August 9$493
MSPMarionAugust 9 to August 12$668
MSYWest PaducahAugust 9 to August 12$691
MSYSt. LouisAugust 9 to August 11$752
LAXScott CityAugust 7 to August 9$803
MCISt. LouisAugust 8 to August 10$899
SATSt. LouisAugust 8 to August 11$927
*Prices include taxes and fees

Southeast Missouri Flight Information

Traveling to
Southeast Missouri
Lowest Price
$56
Number of Airlines Serving
Airlines Serving
Frontier Airlines, American Airlines, United
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Southeast Missouri Accommodation Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$79 nightly
The price is $88 total per night from Aug 4 to Aug 5
$88 total
Aug 4 - Aug 5
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,006 reviews)
"Traveling with dog, so I appreciate the pet-friendly approach. This is a newer Motel 6 which is more like a "hotel" than a "motel." Easy access, clean and comfortable."

Reviewed on Aug 2, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $65 total per night from Aug 9 to Aug 10
$65 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (664 reviews)
"The check-in was smooth and professional. The room was great - very clean, even the carpet. Only negative was there was no closet. But the set up of the room was great. I was a little disappointed in the breakfast. It’s just a continental breakfast, it I’ve had better continental breakfasts at other ..."

Reviewed on Aug 2, 2026

Opens in a new windowSuper 8 by Wyndham Farmington
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
$56 nightly
The price is $65 total per night from Sep 1 to Sep 2
$65 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
Opens in a new windowSuper 8 by Wyndham Pevely
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Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Aug 9 to Aug 10
$81 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,006 reviews)
"Courteous friendly staff. Quick check in. Excellent breakfast."

Reviewed on Aug 2, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
$56 nightly
The price is $65 total per night from Sep 1 to Sep 2
$65 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
Opens in a new windowSuper 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$79 nightly
The price is $88 total per night from Aug 4 to Aug 5
$88 total
Aug 4 - Aug 5
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,006 reviews)
"Traveling with dog, so I appreciate the pet-friendly approach. This is a newer Motel 6 which is more like a "hotel" than a "motel." Easy access, clean and comfortable."

Reviewed on Aug 2, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$64 nightly
The price is $73 total per night from Sep 1 to Sep 2
$73 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (228 reviews)
"Very nice hospitality and accommodations ComfortableGreat location"

Reviewed on Jul 5, 2026

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from Aug 9 to Aug 10
$128 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,005 reviews)
"The parking lot and the whole hotel, including halls and elevators was over ran with loitering. People were even sitting in lawn chairs blocking parking spots."

Reviewed on Aug 2, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$93 nightly
The price is $106 total per night from Aug 9 to Aug 10
$106 total
Aug 9 - Aug 10
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"The hotels.com app advertises that it has a hot tub but it does not. The pool is heated. The staff was great. The grass was way too high, wet due to the weather but so high the dogs didn't want to use the bathroom. The breakfast was ok. The luggage carts were rough and difficult to use. Its a little ..."

Reviewed on Aug 1, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from Aug 9 to Aug 10
$102 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
$89 nightly
The price is $97 total per night from Sep 1 to Sep 2
$97 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Southeast Missouri Flight and Hotel Packages

Southeast Missouri flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Lodge Of Four Seasons Golf Resort, Marina & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

4 out of 5
Save 100% on your flight
Price was $720, price is now $493 per person
$493
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $794, price is now $506 per person
$506
per person
Sep 10 - Sep 14
found 17 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
Price was $776, price is now $545 per person
$545
per person
Sep 10 - Sep 14
found 17 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
Don't see what you're looking for?
See all available trips from Detroit to Southeast Missouri
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Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Frequently asked questions

How much is the cheapest flight to Southeast Missouri?
A roundtrip flight to Southeast Missouri cost as little as $56 over the last seven days. Once you've chosen your travel dates, we'll help you find an amazing deal. This price was available on Travelocity for flights to Southeast Missouri departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly to Southeast Missouri?
Be sure to leave October empty in your calendar, because it's the most affordable month to travel to Southeast Missouri. That's based on Travelocity's direct flight demand from January to December last year. With the cash you save, you can go on a spending spree, go for a fancy dinner or whatever makes you happy.
How can I check my flight status to Southeast Missouri?
Make the most of Travelocity's handy portal, Trips. You'll find just about everything related to your flight to Southeast Missouri here, including details about flight status, gate numbers and more. Look for Trips at the top of the Travelocity homepage. Create your free account and get the answers you need. Or you can access your itinerary while you're on the go and get real-time travel updates through the Travelocity app. You'll find all your itineraries in one place, making it a cinch to share details with any members of your family flying with you.
How do I find the best deals on flights to Southeast Missouri?
Being flexible with your dates is one of the best ways to snag an awesome deal. Travelocity makes it a cinch to find your perfect fare through the "Flexible dates" feature. First, search for your Southeast Missouri flight, then compare prices for surrounding dates by hitting the Flexible dates box above. Booking in advance and avoiding peak travel periods are other steps you can take. In the last seven days, the lowest price for a return flight to Southeast Missouri was $56. This price was available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Why should I book my flight to Southeast Missouri with Travelocity?
If you're looking for cheap flights to Southeast Missouri, you'll discover some tempting deals with Travelocity. From cheap family flights with low-cost airlines to flexible tickets, we can help you. Enjoy a worry-free trip with our 24/7 customer support, Price Match Guarantee and free cancellations with most hotels. Start packing your bags and get ready to jump on a plane to this interesting destination.
How much is a flight to Southeast Missouri on average?
Airfares for roundtrip flights to Southeast Missouri were priced between $56 and $927 in the last seven days. The minute you spot a good deal, snap it up and get ready for your dream getaway with Travelocity. These prices were available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What can I expect on a flight to Southeast Missouri?
Factors like who you're flying with and where you're departing from will mostly determine what you'll be offered on your trip. Chances are you'll find all kinds of flights to Southeast Missouri, from cheap flights for family vacations to premium fares. Warm meals, entertainment and games for the little ones are usually what most airlines offer on long-haul flights.

Plane Tickets To Southeast Missouri

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!

Explore More Ways to Travel with Travelocity

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.