Cheap Flights to Southeast Missouri from $39
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How Much Does it Cost To Fly To Southeast Missouri?
The cheapest prices found with in the last 7 days for return flights were $144 and $39 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 1 day ago
$144
Roundtrip
found 1 day ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| EWR | St. Louis | May 2 to May 6 | $174 |
| DCA | St. Louis | May 8 to May 11 | $183 |
| LAX | St. Louis | May 3 to May 9 | $190 |
| MCI | St. Louis | May 1 to May 4 | $255 |
| CMH | St. Louis | May 1 to May 3 | $270 |
| SAT | West Paducah | May 17 to May 23 | $326 |
| MCI | Scott City | May 3 to May 6 | $511 |
| EWR | Marion | July 1 to July 5 | $562 |
| EWR | Scott City | July 11 to July 19 | $606 |
| MCI | West Paducah | April 26 to April 30 | $635 |
| LAX | Scott City | April 30 to May 3 | $641 |
| CMH | Scott City | April 23 to April 28 | $666 |
| MSY | Scott City | April 24 to April 26 | $799 |
| LAX | Marion | May 15 to May 20 | $879 |
| BWI | Scott City | May 7 to May 10 | $1,603 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| BWI | St. Louis | April 19 to April 29 | $230 |
| SAT | St. Louis | April 18 to April 23 | $299 |
| DCA | St. Louis | April 18 to April 19 | $305 |
| EWR | St. Louis | April 19 to April 23 | $312 |
| LAX | St. Louis | April 18 to May 24 | $352 |
| MSY | St. Louis | April 19 to April 20 | $358 |
| CMH | St. Louis | April 18 to April 19 | $367 |
| MSP | St. Louis | April 18 to April 20 | $515 |
| MSP | Scott City | April 19 to April 24 | $953 |
Southeast Missouri Flight Information
Traveling to | Southeast Missouri |
|---|---|
Lowest Price | $144 |
Number of Airlines Serving | |
Airlines Serving | Frontier Airlines |
Number of Daily Flights | |
Airlines with Direct Flights |
Find The Perfect Hotel For After Your Flight
Amazing Southeast Missouri Accommodation Deals
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$65 nightly
The price is $69 total per night from Apr 26 to Apr 27
$69 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,002 reviews)
Clean rooms, and they leave the light on for you…
Reviewed on Apr 9, 2026
Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $65 total per night from May 3 to May 4
$65 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (638 reviews)
Breakfast menu was a little limited. Clean room. Staff great! Air condition and heat perfect. Better than what I consider it's price competitors to be. In today's high tech age, a few more electrical receptacles would be nice, but that's the case in most hotel/motels in this price range.
Reviewed on Mar 31, 2026
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$79 nightly
The price is $91 total per night from Apr 19 to Apr 20
$91 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (845 reviews)
Horrible dirty needs cleaned everywhere smells like mold and staff is rude
Reviewed on Apr 13, 2026
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Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Apr 20 to Apr 21
$81 total
Apr 20 - Apr 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
Breakfast was hot and manned by a friendly staff member. Room was clean and met my needs.
Reviewed on Apr 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Luxury Hotels in Southeast Missouri
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$79 nightly
The price is $91 total per night from Apr 19 to Apr 20
$91 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (845 reviews)
Horrible dirty needs cleaned everywhere smells like mold and staff is rude
Reviewed on Apr 13, 2026
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$65 nightly
The price is $69 total per night from Apr 26 to Apr 27
$69 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,002 reviews)
Clean rooms, and they leave the light on for you…
Reviewed on Apr 9, 2026
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$68 nightly
The price is $78 total per night from Apr 19 to Apr 20
$78 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
It had a clean room. Better than most hotels like this. The bathroom smelled like mold or mildew. And the lobby smelled of moth balls. Some of the sheets had black stuff on them. Not sure what it was. Air conditioning was cold.
Reviewed on Apr 12, 2026
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!
Reviewed on Dec 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Southeast Missouri
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$98 nightly
The price is $113 total per night from Apr 21 to Apr 22
$113 total
Apr 21 - Apr 22
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Amazingly they had dinner and breakfast. For a family this would be great savings. But be parpared for a crowd.
Reviewed on Apr 15, 2026
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
$76 nightly
The price is $87 total per night from Apr 26 to Apr 27
$87 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
Everything went perfect.
Reviewed on Apr 13, 2026
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from May 3 to May 4
$102 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,003 reviews)
This is a wonderful property. The hotel itself has had upgrades. The staff is wonderful! The rooms are clean and quiet. The food service was fresh and delicious. We stay here every time we're on I-55
Reviewed on Apr 16, 2026
Save an average of 15% on thousands of hotels when you're signed in
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from Apr 23 to Apr 24
$100 total
Apr 23 - Apr 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (760 reviews)
Rooms were clean, AC worked great and the staff was friendly
Reviewed on Apr 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Southeast Missouri Flight and Hotel Packages
Southeast Missouri flight + hotel packages - economy flights
Price found within the past 48 hours. Click for updated prices.
Don't see what you're looking for?
See all available trips from Atlanta to Southeast Missouri
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Economy
Chevrolet Spark or similar
Compact
Ford Focus or similar
Midsize
Toyota Corolla or similar
SUV
Jeep Compass or similar
Frequently asked questions
Plane Tickets To Southeast Missouri
Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.
When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!
More Ways To Wander
Southeast Missouri Hotels
Find the perfect hotel after your flight
Southeast Missouri Vacation Rentals
Great Deals on alternative accommodations
Southeast Missouri Car Rentals
Affordable cars to get you around town
Southeast Missouri Vacations
Save more by combining flights, hotels and cars
Things to do in Southeast Missouri
Activities, attractions and tours
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