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Top Southeast Missouri hotels

Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
$327 nightly
The price is $349 total per night from Apr 27 to Apr 28
$349 total
Apr 27 - Apr 28
Total with taxes and fees
This farm stay features laundry facilities.
We had an amazing time! Great property and cozy. We had a few dead flies in the bed but otherwise perfect stay!

Reviewed on Mar 29, 2026

Opens in a new windowSilo Farm Haus- located in the heart of wine country!
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $108 total per night from May 3 to May 4
$108 total
May 3 - May 4
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
This is my home away from home place! You get free dinner and the BEST breakfast buffet ever with your stay! Plus the indoor pool and hot tub! There is a thermostat in every room to control requirement. It’s just simply the best hotel ever seriously I absolutely love staying here!!!

Reviewed on Apr 18, 2026

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $117 total per night from Apr 29 to Apr 30
$117 total
Apr 29 - Apr 30
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
👍

Reviewed on Apr 19, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $140 total per night from May 7 to May 8
$140 total
May 7 - May 8
Total with taxes and fees
This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. ...
Quite and clean

Reviewed on Apr 24, 2026

Opens in a new windowThe Riverview
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from May 3 to May 4
$115 total
May 3 - May 4
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
Property was pet friendly. They have nice dog park in the back of the building.

Reviewed on Apr 24, 2026

Opens in a new windowHampton Inn Sikeston
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $96 total per night from Apr 26 to Apr 27
$96 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Basic breakfast the juice machine was down so that was a bummer

Reviewed on Apr 21, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $81 total per night from May 17 to May 18
$81 total
May 17 - May 18
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
Breakfast was hot and manned by a friendly staff member. Room was clean and met my needs.

Reviewed on Apr 9, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $65 total per night from May 17 to May 18
$65 total
May 17 - May 18
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Overall ok. Ceiling had peeling paint and 1 of the bath towels had holes

Reviewed on Apr 24, 2026

Opens in a new windowBaymont Inn and Suites by Wyndham Farmington, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Apr 27 to Apr 28
$106 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Close to stores and our final destination.

Reviewed on Apr 21, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Southeast Missouri hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top reasons for your vacation to Southeast Missouri

  • Outdoor Activities: Southeast Missouri offers a range of outdoor activities, including boating, fishing, and scenic river cruises along the picturesque Mississippi River.
  • Delicious Cuisine: Explore the friendly cafes and dining spots in Southeast Missouri to savor delicious meals and local cuisine.
  • Family-friendly Entertainment: The Isle Casino Cape Girardeau provides adult entertainment options, while the area offers numerous attractions and recreational activities for kids.
  • Charming Cape Girardeau: Start your adventure in this charming area known for its friendly people, delicious dining options, beautiful trails, and scenic views at nearby state parks.
  • Wineries and Wine Country: Don't miss the chance to visit the wineries in Southeast Missouri's wine country, where you can sample exquisite wines amidst picturesque surroundings.

Find your favorite hotels in Southeast Missouri

If you're planning an outdoor vacation in Southeast Missouri, you'll find a variety of hotel accommodations to choose from. Located in or near Cape Girardeau, there are hotels that range from budget-friendly to high-end options. Whether you prefer a cozy inn or a modern hotel, you'll have plenty of lodging options to suit your needs. Most hotels in the area offer comfortable rooms and convenient amenities, making them a great choice for families visiting the region.

Hotel nameTypeStarsDescription
Baymont Inn and Suites by Wyndham Farmington, MOHotel2.5This 2.5-star rated hotel is a great option for your outdoor vacation in Southeast Missouri. It is located 29.2 miles away from the area and offers a range of amenities including an outdoor pool, arcade, friendly staff, golf, connecting rooms, a bar, transportation services, and a budget-friendly option.
Quality Inn FarmingtonHotel2.5With its 2.5-star rating, this hotel is another excellent choice for your outdoor getaway. It is situated 29.5 miles from Southeast Missouri and provides easy access to an indoor and outdoor pool, friendly staff, urban surroundings, a poolside bar, breakfast options, a business center, and swimming facilities.
Holiday Inn Express & Suites Farmington, an IHG HotelHotel2.5This 2.5-star rated hotel is located 30.4 miles away from Southeast Missouri and offers various amenities suitable for your family vacation. These include an indoor pool, fitness center, sports facilities, free breakfast, business services, friendly staff, laundry facilities, and a family-friendly environment.

Explore the best activities and sights in Southeast Missouri

Southeast Missouri offers a range of activities for a fun-filled outdoor vacation with your family. Explore the local attractions, such as the picturesque Mississippi River, where you can enjoy boating, fishing, and scenic river cruises. Take a stroll through the friendly cafes and dining spots to savor delicious meals and local cuisine. Visit the Isle Casino Cape Girardeau for some adult entertainment, while the kids can enjoy the many attractions and recreational activities available. With its beautiful flowers, welcoming people, and proximity to a university and business centers, Southeast Missouri is the perfect destination for a family-friendly outdoor vacation.

  1. Six Flags St. Louis: Six Flags St. Louis is an exhilarating theme park that offers a thrilling and memorable experience. Get your adrenaline pumping as you enjoy the exciting rides and attractions. The park is surrounded by beautiful nature, providing a scenic backdrop for your adventures. Whether you're looking for a romantic date or a fun family outing, Six Flags St. Louis has something for everyone. Don't forget to indulge in the delicious dining options available throughout the park.
  2. Mississippi River: The Mississippi River is a majestic river that offers a picturesque and serene experience. Immerse yourself in the beauty of the river as you stroll along its banks. The vibrant flowers and lush greenery create a stunning natural setting. Sports enthusiasts can enjoy watching baseball games or even join in on the action. Take a leisurely walk through the nearby university campus and admire the stunning architecture. In the evenings, enjoy live music performances that add to the vibrant atmosphere. For those feeling lucky, try your hand at the nearby casino and experience the excitement of the riverfront.
  3. The Fugitive Beach: The Fugitive Beach is an exciting waterpark that promises a day of adventure and entertainment. The friendly atmosphere welcomes visitors of all ages, making it perfect for families. Explore the thrilling rides and water attractions that cater to both the young and the young at heart. After a day of excitement, relax with a cup of coffee or visit the trendy winery for a unique experience. The secluded location adds an element of tranquility, allowing you to escape the hustle and bustle of everyday life. Whether you're looking for a budget-friendly outing or simply want to have a memorable time, The Fugitive Beach is the place to be.

Where to stay in Southeast Missouri

Get ready for an unforgettable outdoor vacation in Southeast Missouri! Start your adventure in the charming Cape Girardeau area, known for its friendly people and delicious dining options. Explore the beautiful trails and scenic views at the nearby state park, perfect for hiking and picnicking. For a taste of local culture, visit downtown Cape Girardeau, where you can stroll through the historic streets and enjoy the vibrant atmosphere. And don't miss the chance to visit the wineries in the area, where you can sample exquisite wines while taking in the picturesque surroundings of Missouri's wine country. Get ready to create amazing memories with your family in Southeast Missouri!

  1. Farmington: Farmington is a charming city located 29.7 miles away from Southeast Missouri. It is a perfect destination for an outdoor vacation with your family. The city is known for its family-friendly atmosphere, beautiful churches, and vibrant cathedral. You can also explore the stunning flowers in the local gardens and enjoy dining at the various cafes and restaurants. For a unique experience, take a tour of the local winery and indulge in some shopping. Farmington also offers activities like rollerskating, making it a fun-filled destination for everyone.
  2. Lesterville: Lesterville is a popular city situated just 22.8 miles away from Southeast Missouri. While it may be lesser-known, Lesterville offers a unique outdoor experience for families. The city is surrounded by beautiful natural parks and offers opportunities for adventure and relaxation. You can enjoy activities like hiking, fishing, and camping. Lesterville is known for its friendly people and peaceful atmosphere, making it an ideal destination to connect with nature and create lasting memories with your family.
  3. Ironton: Located only 19.6 miles away from Southeast Missouri, Ironton is a must-visit destination for an outdoor vacation with your family. The city offers a range of activities suitable for all ages, including shopping, dining, and golfing. You can also explore the rich history of Ironton through its historical sites and visit the local university. The friendly people and relaxing atmosphere make it a perfect place to unwind and enjoy the natural beauty of the region.

Best times to go to Southeast Missouri

Southeast Missouri has something in store for you whenever you visit. January is the coldest month of the year, while July is hottest, with average temperatures up to 79.2 degrees Fahrenheit. The wettest month in Southeast Missouri is April, so pack accordingly.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationcloud iconCloudiness
January34.9°F (1.6°C)Light RainMostly Sunny
February38.1°F (3.4°C)Light RainMostly Sunny
March48.0°F (8.9°C)Light RainMostly Sunny
April57.6°F (14.2°C)Light RainMostly Sunny
May67.3°F (19.6°C)Light RainMostly Sunny
June76.5°F (24.7°C)Light RainMostly Sunny
July79.2°F (26.2°C)Light RainMostly Sunny
August77.2°F (25.1°C)Light RainMostly Sunny
September71.6°F (22.0°C)Light RainMostly Sunny
October59.9°F (15.5°C)Light RainMostly Sunny
November47.5°F (8.6°C)Light RainMostly Sunny
December40.1°F (4.5°C)Light RainMostly Sunny

Food and dining in Southeast Missouri

When visiting Southeast Missouri, you'll find a variety of popular restaurants to satisfy your taste buds. One of the highly rated and popular options is Wally's, a buffet-style restaurant that offers a wide selection of dishes. If you're in the mood for classic American fast food, Sonic Drive-In is a great choice, known for its burgers, fries, and milkshakes. Another popular spot is Culver's, which specializes in North American cuisine. These restaurants are just a few of the many options available in the area, ensuring that you and your family can enjoy a delicious meal during your vacation.

How do I find a great hotel with Travelocity?

Ensure that your entire crew enjoys a memorable vacation by finding the ideal accommodations. Utilize our family-friendly badge to explore hotels that offer additional amenities for children. Moreover, our tailored filters assist you in narrowing down hotels that are conveniently located near popular attractions, feature enhanced cleanliness measures, and fall within your budget range.

Why should I book with Travelocity?

Conference calls, to-do lists, and, of course, football training. Busy lives and packed schedules require trips that are hassle-free. Our aim is to provide worry-free travel every time you and your family book with us, so you can spend less time fretting and more time creating cherished memories. For this purpose, we will assist you in finding and planning your ideal trip, offering transparent pricing, trustworthy reviews, and 24/7 customer support guaranteed before, during, and after your vacation.

How can I save money on my trip to Southeast Missouri?

Save money on your trip to Southeast Missouri by bundling your flights, hotel, and car rental together for a discounted price. When exploring locally, take advantage of the inexpensive attractions such as family-friendly cafes, affordable dining options, and visiting the beautiful wineries in the area. Enjoy the friendly people, stunning river views, and vibrant flowers while engaging in recreational activities. Southeast Missouri is also home to a university and offers great business opportunities. Take advantage of these affordable affinities to make the most of your family trip.

Recent Southeast Missouri hotel reviews by fellow wanderers

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