Find and compare 2 Star hotels in Southeast Missouri

Name: Holiday Inn Express & Suites Perryville by IHG
Price range: $109 total
Rating: 9.2

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Top Southeast Missouri 2 Star hotels

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$92 nightly

$104 total

Apr 12 - Apr 13

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...

9/10 Wonderful! (498 reviews)

East, friendly check in. Beautiful, large room.

Reviewed on Mar 9, 2026

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$70 nightly

$74 total

Mar 14 - Mar 15

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...

8/10 Very Good! (1,000 reviews)

This was our third stay at this Motel 6. It’s a great hotel with friendly staff, clean rooms and good location. Pets stay free!

Reviewed on Mar 9, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$57 nightly

$65 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

8/10 Very Good! (1,003 reviews)

The breakfast was delicious. Fresh and hot.

Reviewed on Mar 11, 2026

The Farmstead Hotel

778 E 3rd St Caruthersville MO

Fully refundableReserve now, pay when you stay

$76 nightly

$86 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

8.6/10 Excellent! (509 reviews)

Had problems with the tv and air controllers

Reviewed on Mar 12, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

Fully refundable

$99 nightly

$112 total

Mar 29 - Mar 30

Total with taxes and fees

A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...

9.4/10 Exceptional! (1,000 reviews)

Clean room staff is very nice parking it great

Reviewed on Mar 6, 2026

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$72 nightly

$81 total

Mar 17 - Mar 18

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...

9/10 Wonderful! (1,001 reviews)

Yes

Reviewed on Mar 10, 2026

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

Fully refundableReserve now, pay when you stay

$73 nightly

$83 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...

7.8/10 Good! (921 reviews)

Badly in need of an update. Missing electric plates. Broken cord on clock radio. Rust on bedside lamps. Musty smell. Not up to Comfort Inn standards! Would not stay here again.

Reviewed on Mar 7, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

Fully refundableReserve now, pay when you stay

$60 nightly

$69 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...

8.4/10 Very Good! (749 reviews)

Very clean but sometimes noisy from outside traffic

Reviewed on Mar 6, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Fully refundableReserve now, pay when you stay

$68 nightly

$78 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,003 reviews)

Close access to I-55.

Reviewed on Mar 11, 2026

Holiday Inn Express & Suites Perryville by IHG

2020 Jefferson St Perryville MO

Fully refundable

$95 nightly

$109 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...

9.2/10 Wonderful! (564 reviews)

Room was great, front desk was professional but friendly. Breakfast was excellent. Spotless — both room and lobby.

Reviewed on Feb 24, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

2 Star Hotels Southeast Missouri

Looking to break out of your routine for some much needed rest and relaxation? Or maybe you’ve already decided it’s time for a trip and are trying to find affordable hotels in Southeast Missouri that won’t bust your travel budget?

Southeast Missouri 2 star hotels will give you everything you need to enjoy the city like a local, saving a ton of money so you can hit all the hot spots in town.

Have a delicious breakfast at your hotel to fuel up for your day of sightseeing, then enjoy amenities like fresh towels and linens, as well as a nice hot shower to unwind after a busy day of experiencing everything the city has to offer.

As you explore a new locale, or one you love to visit over and over, you can rest easy knowing you’re staying in a great hotel that lets you discover Southeast Missouri and welcomes you back to a clean, comfortable room at night.

Browse Travelocity’s wide selection of 2 star hotels in Southeast Missouri and find one that’s perfectly priced and places you next to all the best activities and sights. The town is your oyster, and we can help you seek out its secrets while sticking to your budget.