Find and compare 3 Star hotels in Cape Girardeau

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Top Cape Girardeau 3 Star hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Jun 14 to Jun 15
$113 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.6/10 Exceptional! (1,002 reviews)
"Very clean, helpful staff"

Reviewed on Jun 2, 2026

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $87 total per night from Jun 21 to Jun 22
$87 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.6/10 Exceptional! (1,011 reviews)
"Lived this hotel offered great evening snacks and drinks and a great continental breakfast."

Reviewed on Jun 4, 2026

Opens in a new windowDrury Inn & Suites Jackson MO
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Jun 14 to Jun 15
$105 total
Jun 14 - Jun 15
Total with taxes and fees
An indoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi in ...
9.4/10 Exceptional! (195 reviews)
"The staff were excellent! Front desk and Breakfast staff were very friendly and attentive."

Reviewed on Jun 3, 2026

Opens in a new windowFairfield Inn & Suites by Marriott Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $100 total per night from Jun 7 to Jun 8
$100 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
9/10 Wonderful! (777 reviews)
"Beautiful hotel at a very good price."

Reviewed on Jun 5, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $142 total per night from Jul 3 to Jul 4
$142 total
Jul 3 - Jul 4
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.6/10 Exceptional! (514 reviews)
"Beautiful and comfortable room in a vibrant small downtown setting."

Reviewed on May 31, 2026

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Jun 21 to Jun 22
$102 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (1,008 reviews)
"The staff at this Drury are always super friendly and helpful. It's nice to have breakfast and an evening meal in the cost of the stay. The rooms are very spacious and the bed is very comfortable. I love the pictures of Cape Girardeau worked into the decorating."

Reviewed on Jun 4, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
301 1st St Marble Hill MO
$95 nightly
The price is $103 total per night from Jun 13 to Jun 14
$103 total
Jun 13 - Jun 14
Total with taxes and fees
The hotel doesn't skimp on freebies - guests receive free continental breakfast and free self parking. If you want to take your pet along, this pet-friendly ...
9.6/10 Exceptional! (95 reviews)
"We didn’t see any staff and everything was out and waiting for us. The property is very well maintained and quaint. There is coffee, water, and snacks for the continental breakfast. The hours of the Mercantile were limited."

Reviewed on May 29, 2026

Opens in a new windowEC Reed's Mercantile and Hotel
Makanda Inn

Makanda Inn

3.5 out of 5
855 Old Lower Cobden Road Makanda IL
$255 nightly
The price is $282 total per night from Jun 7 to Jun 8
$282 total
Jun 7 - Jun 8
Total with taxes and fees
A restaurant and a bar/lounge are featured at this bed & breakfast. Guests will appreciate free perks like free self parking and WiFi in public areas. A coffee ...
10/10 Exceptional! (37 reviews)
"Jackie was amazing. She was very informative and helpful. Great communication. The room was really comfortable. And breakfast was great."

Reviewed on May 10, 2026

Opens in a new windowMakanda Inn
Cozy Anna Home Near Southern Illinois Attractions!

Cozy Anna Home Near Southern Illinois Attractions!

3 out of 5
Anna IL
Free WiFi in public areas is available at this cottage. Take advantage of the free self parking.
10/10 Exceptional! (1 review)
"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Reviewed on Feb 3, 2025

Opens in a new windowCozy Anna Home Near Southern Illinois Attractions!
Deck & Large Yard! Family Haven in Cape Girardeau

Deck & Large Yard! Family Haven in Cape Girardeau

3 out of 5
Cape Girardeau MO
This cottage doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.
Opens in a new windowDeck & Large Yard! Family Haven in Cape Girardeau
Don't see what you're looking for?
See all available properties in Cape Girardeau
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

3 Star Hotels Cape Girardeau

Maybe you’ve got to travel for work, or perhaps you’re finally ready to book that much-deserved vacation—regardless, it’s time for you to get on a plane and you’re going to make the most of it. You’ve traveled enough to know how important a comfy bed and room service can be, so booking a hotel with all the amenities you need is a priority.

You can find 3 star hotels in Cape Girardeau that keep you close to all the great sightseeing and activities around the area, or even book a place that’s a bit more secluded, if that’s what you prefer. No matter what you’re looking for—whether you’re all about the location or are invested in on-site perks--Travelocity will help you find the accommodation that works best for you.

When it comes to options, you’ll have them. The Cape Girardeau 3 star hotels give you plenty of choices as far as access to the best areas, and many also offer a breakfast buffet, as well as plenty of other amenities like high-speed Wi-Fi and an on-site pool or spa.

Whatever you’re looking for on your next getaway, browse Travelocity’s big selection of hotels to ensure you get the best possible deal. Book one of the best 3 star hotels in Cape Girardeau today!

Recent Cape Girardeau hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity