Explore 4 Luxury Hotels in Cape Girardeau

Name: Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Address: Cape Girardeau

Best Luxury Hotels in Cape Girardeau

Drury Inn & Suites Cape Girardeau

3303 Campster Drive, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$94 nightly

$107 total

Jun 8 - Jun 9

Total includes taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.2/10 Wonderful! (934 reviews)

"Front desk staff was so helpful and friendly. We didnt know there was complimentary dinner and drinks, in addition to a fabulcius and tasty breakfast. We will stay here again"

Reviewed on May 31, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$58 nightly

$66 total

Jun 8 - Jun 9

Total includes taxes and fees

A seasonal outdoor pool is featured at this hotel, along with free WiFi in public areas and express check-out. Staff at the 24-hour front desk can provide around-the-clock ...

8.8/10 Excellent! (1,001 reviews)

"Good"

Reviewed on Jun 2, 2025

Quality Inn

2011 North Kingshighway, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$64 nightly

$72 total

Jun 4 - Jun 5

Total includes taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7/10 Good! (587 reviews)

"Great room, great experience"

Reviewed on May 27, 2025

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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau

This apartment features a water park, laundry facilities, and barbecue grills.

Perfect stay!!

"We enjoyed this property so much!! The location was perfect, it was so clean, very accommodating, perfect amount of space, and awesome host! We were in town for AAU basketball and this rental gave us the comfort of being at home. The washer/dryer availability was a plus after sweaty ballgames! We ..."

Reviewed on May 4, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Cape Girardeau luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Cape Girardeau to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Cape Girardeau will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Cape Girardeau, and plan your next opulent escape.

Cape Girardeau hotels essential information

Accommodation	164 hotels
Lowest Price	$66
Highest Price	$107
Popular hotels	Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Cape Girardeau

Popular Luxury Stays in Cape Girardeau

Top landmarks in Cape Girardeau

Southeast Missouri State University

4.5/5(76 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.