Explore 4 Luxury Hotels in Cape Girardeau

Name: Quality Inn
Price range: $65 total
Rating: 7

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Best Luxury Hotels in Cape Girardeau

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

This apartment features a water park, laundry facilities, and barbecue grills.

9.8/10 Exceptional! (170 reviews)

Great place! It was exactly as advertised. We were so close to shops and restaurants. We will definitely be back!

Reviewed on Oct 12, 2025

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Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Dec 8 - Dec 9

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (999 reviews)

I do love this hotel chain. Another great visit!

Reviewed on Dec 2, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$70 nightly

$79 total

Dec 8 - Dec 9

Total with taxes and fees

Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.

8.8/10 Excellent! (1,010 reviews)

Welcoming staff, clean room, good breakfast, great location to the medical center.

Reviewed on Dec 2, 2025

Quality Inn

2011 North Kingshighway Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$58 nightly

$65 total

Dec 10 - Dec 11

Total with taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7/10 Good! (678 reviews)

very clean

Reviewed on Nov 29, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Cape Girardeau luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Cape Girardeau to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Cape Girardeau will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Cape Girardeau, and plan your next opulent escape.

Cape Girardeau hotels essential information

Accommodation	172 hotels
Lowest Price	$65
Highest Price	$102
Popular hotels	Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Cape Girardeau