Explore 4 Luxury Hotels in Cape Girardeau

Name: Quality Inn Cape Girardeau North
Price range: $68 total
Rating: 7.2

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Cape Girardeau

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

This apartment featured laundry facilities and barbecue grills.

10/10 Exceptional! (224 reviews)

Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on Dec 15, 2025

Get rates

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Mar 10 - Mar 11

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (1,006 reviews)

Great as all Drury’s

Reviewed on Mar 4, 2026

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$60 nightly

$68 total

Mar 11 - Mar 12

Total with taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7.2/10 Good! (706 reviews)

Noisy. Could hear noise from parking lot and from upstairs. Did not like required refundable $50 deposit. After hearing a shower running from another room, our shower leaked from the wall connection. Staff said there was no one available to fix. Staff offered to move us. but we were unpacked ready ...

Reviewed on Mar 4, 2026

Don't see what you're looking for?

See all available properties in Cape Girardeau

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Cape Girardeau luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Cape Girardeau to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Cape Girardeau will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Cape Girardeau, and plan your next opulent escape.

Cape Girardeau hotels essential information

Accommodation	169 hotels
Lowest Price	$68
Highest Price	$102
Popular hotels	Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Quality Inn Cape Girardeau North, Drury Inn & Suites Cape Girardeau