Explore 4 Luxury Hotels in Cape Girardeau
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Best Luxury Hotels in Cape Girardeau
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau
This apartment features a water park, laundry facilities, and barbecue grills.
9.8/10 Exceptional! (166 reviews)
"As always the Kage House is always above par. Keith is such a delightful host and this is my umpteenth time staying here. No matter the occasion we never leave without having a great time"
Reviewed on Jun 15, 2025
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Jul 25 to Jul 26
$102 total
Jul 25 - Jul 26
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (956 reviews)
Great stay.
"I put a couple of my guys up for a short stay, they were very pleased with the service and hotel in general."
Reviewed on Jul 16, 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jul 21 to Jul 22
$79 total
Jul 21 - Jul 22
Total includes taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,002 reviews)
Nice One-Night Stay
"Stopped in in late June. One night stay. Rooms was fine. Bed was comfy and pillows were good. The 'continental' breakfast was severely lacking."
Reviewed on Jul 6, 2025
Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Jul 20 to Jul 21
$76 total
Jul 20 - Jul 21
Total includes taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...
7/10 Good! (611 reviews)
"This was the second stay in a weeks time. Different room but the bed still squeaked, same as the room across the hall. My husband thinks it is the bedframe when you sit on the bed or stand from it. Otherwise quite comfortable"
Reviewed on Jul 17, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cape Girardeau Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Cape Girardeau luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Cape Girardeau to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Cape Girardeau will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Cape Girardeau, and plan your next opulent escape.
Cape Girardeau hotels essential information
Accommodation | 160 hotels |
|---|---|
Lowest Price | $76 |
Highest Price | $102 |
Popular hotels | Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Cape Girardeau |
Popular Luxury Stays in Cape Girardeau
Recent Cape Girardeau Hotel Reviews By Fellow Wanderers
Drury Inn & Suites Cape Girardeau
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"I put a couple of my guys up for a short stay, they were very pleased with the service and hotel in general. "
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
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