Book Hotels in Cape Girardeau, MO

Hotels in Cape Girardeau start at $65 per night. Prices and availability subject to change. Additional terms may apply.

As Mark Helprin once wrote, “A good river is nature’s life work in song.” Balmy, sunshine-filled days on the Mississippi River will redefine your ideas of a weekend “at the Cape.” Follow the strong currents and the sweet scent of pecan pie to the waterside city of Cape Girardeau. Known by many as mighty, the Mississippi is an exquisite river, and down in Southeast Missouri it sings a relaxing tune. Relax in Cape Girardeau hotels, just 120 miles south of St. Louis, and revel in small-town history and the beauty of the Ozarks.

Visiting Cape Girardeau

Don’t be fooled by the sleepy, small-town vibes that warmly welcome you to Cape Girardeau. Peruse the murals on the Missouri Wall of Fame and take in the visages of hometown heroes and heroines, like astronaut Linda M. Goodwin and other hometown heroes. Perhaps the greatest heroine here may be Mother Nature herself. Take a cue from the Mighty Mississippi and roll through the lush landscape in one of our classic Cape Girardeau rental cars.

Sway with the unique melody of herons in the sprawling serenity of the Cape Girardeau Conservation Nature Center. Take a walk around the pond or while away the hours with your favorite book of poems by Missouri’s own Maya Angelou, who described your getaway when she said, “This is a wonderful day, I have never seen this one before.” Find extraordinary treasures tucked away in the corners of antique shops downtown and crunch into the time-tested and local-approved flavor of St. Louis-style pizza. Snooze away the tasty food coma in one of the quiet hotels in Cape Girardeau or follow up your savory slice with the region’s signature “gooey buttery cake.”

Whether you want to hide away in Cape Girardeau motels or rest up in cheap hotels in St. Louis, Travelocity has the best deals to show you the best of “the Show-Me State.”