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Top Cape Girardeau hotels

Drury Plaza Hotel Cape Girardeau Conference Center
"The evening manager’s reception is awesome. There are several things available, which saved me having to eat out. This saves me money on dinners, especially since 3 small alcohol beverages are included too. Of course, the breakfast is pretty great too!"
Reviewed on Jul 27, 2026

Courtyard by Marriott Cape Girardeau Downtown
"The property was a converted bank and was interesting to walk around. Bank walk-in safe is still there with marble stair cases. Staff was very accommodating and the room was spacious and quiet."
Reviewed on Jul 25, 2026

The Riverview
"The staff and room was awesome! Very clean"
Reviewed on Jul 26, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
"This place was super clean! Only complaint I have, and it's not just this hotel. The pool area smells so strong of chlorine, it burns your eyes, and lungs. Literally. I took my grandsons so we could swim, and couldn't even be in the pool are for more than 10 minutes. Others were in there also complaining ..."
Reviewed on Jul 27, 2026

Drury Inn & Suites Cape Girardeau
"We have a wonderful stay. Very clean facility, very nice staff, and the meals are bad either!"
Reviewed on Jul 26, 2026

Pear Tree Inn Cape Girardeau West
"While the staff was helpful for check-in, the room smelled like marijuana and there was what appeared to be mold on the walls. I do not know that the room had been thoroughly cleaned, given the odor. Other guests on the hall were extremely loud and obnoxious late into the night, knocking on doors ..."
Reviewed on Jul 27, 2026

Quality Inn Cape Girardeau North
"I have nothing to say"
Reviewed on Jul 27, 2026

Candlewood Suites Cape Girardeau by IHG

Fairfield Inn & Suites by Marriott Cape Girardeau
Cheap Cape Girardeau hotels

Pear Tree Inn Cape Girardeau West
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Cape Girardeau Hotel & Travel Guide\n
As Mark Helprin once wrote, “A good river is nature’s life work in song.” Balmy, sunshine-filled days on the Mississippi River will redefine your ideas of a weekend “at the Cape.” Follow the strong currents and the sweet scent of pecan pie to the waterside city of Cape Girardeau. Known by many as mighty, the Mississippi is an exquisite river, and down in Southeast Missouri it sings a relaxing tune. Relax in Cape Girardeau hotels, just 120 miles south of St. Louis, and revel in small-town history and the beauty of the Ozarks.
Visiting Cape Girardeau
Don’t be fooled by the sleepy, small-town vibes that warmly welcome you to Cape Girardeau. Peruse the murals on the Missouri Wall of Fame and take in the visages of hometown heroes and heroines, like astronaut Linda M. Goodwin and other hometown heroes. Perhaps the greatest heroine here may be Mother Nature herself. Take a cue from the Mighty Mississippi and roll through the lush landscape in one of our classic Cape Girardeau rental cars.
Sway with the unique melody of herons in the sprawling serenity of the Cape Girardeau Conservation Nature Center. Take a walk around the pond or while away the hours with your favorite book of poems by Missouri’s own Maya Angelou, who described your getaway when she said, “This is a wonderful day, I have never seen this one before.” Find extraordinary treasures tucked away in the corners of antique shops downtown and crunch into the time-tested and local-approved flavor of St. Louis-style pizza. Snooze away the tasty food coma in one of the quiet hotels in Cape Girardeau or follow up your savory slice with the region’s signature “gooey buttery cake.”
Whether you want to hide away in Cape Girardeau motels or rest up in cheap hotels in St. Louis, Travelocity has the best deals to show you the best of “the Show-Me State.”
Frequently asked questions
Recent Cape Girardeau hotel reviews by fellow wanderers

Drury Plaza Hotel Cape Girardeau Conference Center
"The evening manager’s reception is awesome. There are several things available, which saved me having to eat out. This saves me money on dinners, especially since 3 small alcohol beverages are included too. Of course, the breakfast is pretty great too!"
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