Book Hotels in Cape Girardeau, MO

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Top Cape Girardeau hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Oct 6 to Oct 7
$102 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"This is a beautiful, up-to-date facility. The room was spacious with very comfortable beds. Our favorite part of our stay was the food and drinks provided. We took advantage of the free snacks and drinks on the main level in the evening. They also provide dinner, but we chose to eat at the onsite ..."

Reviewed on Sep 26, 2025

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $115 total per night from Oct 12 to Oct 13
$115 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Guests will appreciate freebies like daily breakfast and free self parking. Staff at the 24-hour front desk can ...
"Checking in was great lady was very helpful in all ways possible. Thank you!"

Reviewed on Sep 28, 2025

Opens in a new windowTru By Hilton Cape Girardeau
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St., Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $142 total per night from Oct 12 to Oct 13
$142 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Very nice hotel within walking distance to many good restaurants"

Reviewed on Sep 28, 2025

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street, Cape Girardeau, MO
Fully refundable
$95 nightly
The price is $107 total per night from Oct 19 to Oct 20
$107 total
Oct 19 - Oct 20
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
"The beds were so uncomfortable and the pillows were worse. I did not sleep well. The breakfast buffet was nice, but the sausage was served cold and it gave us all a stomach ache. The whole hotel was very clean and the staff were all very nice. They even gave me a free tooth rush because I had forgotten ..."

Reviewed on Sep 28, 2025

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $149 total per night from Nov 2 to Nov 3
$149 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. ...
"Hotel was very close to the Show Me Center. Very clean, quiet and comfortable room."

Reviewed on Sep 30, 2025

Opens in a new windowThe Riverview
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Oct 5 to Oct 6
$79 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
"Everything was clean and looked newly renovated. Staff was friendly. Parking was convenient and the area seemed safe."

Reviewed on Sep 26, 2025

Opens in a new windowPear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Oct 6 to Oct 7
$79 total
Oct 6 - Oct 7
Total with taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
"Staff was friendly, room was clean, good location, good rate."

Reviewed on Sep 22, 2025

Opens in a new windowPear Tree Inn Cape Girardeau Near the Medical Center
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
Fully refundable
$78 nightly
The price is $93 total per night from Oct 12 to Oct 13
$93 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, ...
"clean rooms and nice staff"

Reviewed on Sep 27, 2025

Opens in a new windowCandlewood Suites Cape Girardeau by IHG
Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $65 total per night from Oct 8 to Oct 9
$65 total
Oct 8 - Oct 9
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...
"clean and comfortab;le. Highway is close."

Reviewed on Sep 22, 2025

Opens in a new windowQuality Inn
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Cape Girardeau hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Hotel & Travel Guide\n

As Mark Helprin once wrote, “A good river is nature’s life work in song.” Balmy, sunshine-filled days on the Mississippi River will redefine your ideas of a weekend “at the Cape.” Follow the strong currents and the sweet scent of pecan pie to the waterside city of Cape Girardeau. Known by many as mighty, the Mississippi is an exquisite river, and down in Southeast Missouri it sings a relaxing tune. Relax in Cape Girardeau hotels, just 120 miles south of St. Louis, and revel in small-town history and the beauty of the Ozarks.

Visiting Cape Girardeau

Don’t be fooled by the sleepy, small-town vibes that warmly welcome you to Cape Girardeau. Peruse the murals on the Missouri Wall of Fame and take in the visages of hometown heroes and heroines, like astronaut Linda M. Goodwin and other hometown heroes. Perhaps the greatest heroine here may be Mother Nature herself. Take a cue from the Mighty Mississippi and roll through the lush landscape in one of our classic Cape Girardeau rental cars.

Sway with the unique melody of herons in the sprawling serenity of the Cape Girardeau Conservation Nature Center. Take a walk around the pond or while away the hours with your favorite book of poems by Missouri’s own Maya Angelou, who described your getaway when she said, “This is a wonderful day, I have never seen this one before.” Find extraordinary treasures tucked away in the corners of antique shops downtown and crunch into the time-tested and local-approved flavor of St. Louis-style pizza. Snooze away the tasty food coma in one of the quiet hotels in Cape Girardeau or follow up your savory slice with the region’s signature “gooey buttery cake.”

Whether you want to hide away in Cape Girardeau motels or rest up in cheap hotels in St. Louis, Travelocity has the best deals to show you the best of “the Show-Me State.”

Frequently asked questions

What are the top kid-friendly hotels in Cape Girardeau?
Family trips are where you make the best memories, but it's no secret that traveling with young ones can be challenging. These kid-friendly Cape Girardeau hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy their time at Newly re-listed downtown historic apartment. A fireplace and internet access are a few of the things that help make this property an appealing option. Also consider Courtyard by Marriott Cape Girardeau Downtown. It offers a cafe, front desk services and ample opportunities for precious family time.
Where can I find cheap hotels in Cape Girardeau?
At Travelocity you'll find really nice hotels in Cape Girardeau at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Cape Girardeau rather than in Cape Girardeau. We may find you even better rates, too.
How do I find the best Cape Girardeau hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Cape Girardeau then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Cape Girardeau?
The cheapest hotel in Cape Girardeau is $65. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Cape Girardeau?
There are 168 hotels in Cape Girardeau on Travelocity.
What are the best hotels in Cape Girardeau?
Cape Girardeau has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Cape Girardeau for you!
When is the best time to visit Cape Girardeau?
If you want the joy of a fun-filled trip in peak season, visit Cape Girardeau during January, May and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as March, September and November.
When is the cheapest time to stay in Cape Girardeau?
Based on historic data is usually the cheapest month to visit Cape Girardeau. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Cape Girardeau?
There are multiple hotels in Cape Girardeau that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Cape Girardeau. We have plenty of kid-friendly hotels in Cape Girardeau to choose from on Travelocity!
Why book a hotel in Cape Girardeau through Travelocity?
Because we have the top hotels in Cape Girardeau! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Cape Girardeau on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

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