Book Hotels in Puxico, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Puxico hotels

Hampton Inn By Hilton Dexter
2179 Gill Plaza Drive Dexter MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Mar 15 to Mar 16
$110 total
Mar 15 - Mar 16
Total with taxes and fees
Stay at this hotel in Dexter. Popular attractions The Heritage House and Keller Veteran Memorial are located nearby.
Very pleasant experience
Reviewed on Mar 6, 2026

Lake Wappapello
8005 Missouri 172 Williamsville MO
$85 nightly
The price is $90 total per night from Apr 1 to Apr 2
$90 total
Apr 1 - Apr 2
Total with taxes and fees
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went.
Reviewed on Sep 28, 2025

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Greenville MO
A hot tub is featured at this cabin, along with a living plant wall and barbecue grills.
What a magical, romantic cabin, we loved it. Everything in the cabin was well thought of. We recommend it strongly for a relaxing vacation. Thank you, Kim
Reviewed on Jan 2, 2026

Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $124 total per night from Mar 15 to Mar 16
$124 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Staff is Great , Room very clean and well stocked .
Reviewed on Mar 2, 2026

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Mar 15 to Mar 16
$105 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business ...
Overcrowded parkinh.
Reviewed on Mar 4, 2026

Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Mar 15 to Mar 16
$106 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Clean, comfortable room and great staff!
Reviewed on Mar 5, 2026

Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$93 nightly
The price is $105 total per night from Mar 15 to Mar 16
$105 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Everything was great
Reviewed on Mar 1, 2026

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $74 total per night from Mar 8 to Mar 9
$74 total
Mar 8 - Mar 9
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
Staff was nice, room subpar. Uncomfortable bed, very noisy hotel and zero amenities.
Reviewed on Mar 2, 2026

Travelodge by Wyndham Dexter
1608 E Business US 60 Dexter MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Mar 8 to Mar 9
$106 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the business center. A restaurant, ...
Clean and quiet
Reviewed on Feb 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Puxico hotel reviews by fellow wanderers

Hampton Inn By Hilton Dexter
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Very pleasant experience "
A verified traveler stayed at Hampton Inn By Hilton Dexter
Explore More Ways to Travel with Travelocity
- Sikeston Hotels
- Ellsinore Hotels
- Hotels near Black River Coliseum
- Piedmont Hotels
- Cabins in Bernie
- Bernie Hotels
- Cabins in Dexter
- Cheap Hotels in Dexter
- Historic Hotels in Dexter
- Hotels with Pools in Dexter
- Hotels with Free Breakfast in Dexter
- Dexter Hotels
- Motels in Dexter
- Vacation Homes in Dexter
- Hotels near Sikeston Depot Museum
- Hotels near Poplar Bluff Municipal
- Oran Hotels
- Hotels near Dexter Welcome Center Depot and Museum
- Cabins in Marble Hill
- Marble Hill Hotels
- Campbell Hotels
- Cabins in Wappapello
- Cheap Hotels in Wappapello
- Wappapello Hotels
- Motels in Wappapello
- Vacation Homes in Wappapello
- Chaffee Hotels
- Hotels near Central Park
- Hotels near Sikeston Memorial Municipal
- Greenville Hotels
- Allenville Hotels
- Malden Hotels
- Apartments in Poplar Bluff Station
- Lodges in Poplar Bluff Station
- 3 Star Hotels in Poplar Bluff
- Apartments in Poplar Bluff
- Cabins in Poplar Bluff
- Arcade Hotels in Poplar Bluff
- Convention Center Hotels in Poplar Bluff
- Drury Inn & Suites Hotels in Poplar Bluff
- Gay Friendly Hotels in Poplar Bluff
- Golf Resorts & in Poplar Bluff
- Hotels with Pools in Poplar Bluff
- Hotels with Bar in Poplar Bluff
- Hotels with Hot Tubs in Poplar Bluff
- Hotels with an Indoor Pool in Poplar Bluff
- Hotels with Restaurants in Poplar Bluff
- Luxury Hotels in Poplar Bluff
- Pet Friendly Hotels in Poplar Bluff
- Romantic Getaways & Hotels in Poplar Bluff
- Spa Resorts & in Poplar Bluff
- Poplar Bluff Hotels
- Motels in Poplar Bluff
- Vacation Homes in Poplar Bluff
- Zalma Hotels
- Hotels near Stoddard County Civil War Memorial Cemetery
- Hotels near Lake Wappapello
- Dutchtown Hotels
- Cabins in Qulin
- Qulin Hotels
- Hotels near Margaret Harwell Art Museum
- Southeast Missouri Hotels
- Parma Hotels
- Cabins in Bloomfield
- Bloomfield Hotels
- Motels in Bloomfield
- Catron Hotels
- Flights to Dexter
- Flights from Chicago to Dexter
- Flights from Houston to Dexter
- Flights from Miami to Dexter
- Flights from Washington to Dexter
- Flights from Poplar Bluff Municipal
- Flights from Malden Regional
- Flights to Poplar Bluff
- Flights from Atlanta to Poplar Bluff
- Flights from Denver to Poplar Bluff
- Flights from Indianapolis to Poplar Bluff
- Flights from Kansas City to Poplar Bluff
- Flights from Orlando to Poplar Bluff
- Flights from Phoenix to Poplar Bluff
- Flights from Portland to Poplar Bluff
- Flights from San Antonio to Poplar Bluff
- Flights from Pittsburgh to Poplar Bluff
- Flights from Reno to Poplar Bluff
- Car rental Bernie
- Car rental Dexter
- Luxury Car Rentals in Dexter
- Premium Car Rentals in Dexter
- Van Car Rentals in Dexter
- Car rental Marble Hill
- Car rental Poplar Bluff
- Convertible Car Rentals in Poplar Bluff
- Pickup Car Rentals in Poplar Bluff
- Suv Car Rentals in Poplar Bluff
- Van Car Rentals in Poplar Bluff






