Book Hotels in Puxico, MO
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Top Puxico hotels

Lake Wappapello
8005 Missouri 172 Williamsville MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $90 total per night from Apr 24 to Apr 25
$90 total
Apr 24 - Apr 25
Total with taxes and fees
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
Pet friendly. Family-friendly
Reviewed on Apr 12, 2026

Hampton Inn By Hilton Dexter
2179 Gill Plaza Drive Dexter MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from May 3 to May 4
$110 total
May 3 - May 4
Total with taxes and fees
Stay at this hotel in Dexter. Popular attractions The Heritage House and Keller Veteran Memorial are located nearby.
Beautiful new location, excellent staff and amenities
Reviewed on Apr 17, 2026

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from May 3 to May 4
$105 total
May 3 - May 4
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business ...
Great breakfast and friendly staff. Very pet friendly.
Reviewed on Apr 21, 2026

Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $114 total per night from Apr 26 to Apr 27
$114 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Very clean Great staff
Reviewed on Apr 12, 2026

Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $108 total per night from May 3 to May 4
$108 total
May 3 - May 4
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
I love the beds, the employees are all amazing
Reviewed on Apr 10, 2026

Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$87 nightly
The price is $98 total per night from May 23 to May 24
$98 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
The staff was friendly
Reviewed on Apr 20, 2026

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $69 total per night from Apr 24 to Apr 25
$69 total
Apr 24 - Apr 25
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
Clean room
Reviewed on Apr 21, 2026

Dexter Inn
1807 W Business US Highway 60 Dexter MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $61 total per night from May 17 to May 18
$61 total
May 17 - May 18
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk ...
Room was clean but had a musty smell. Not unbearable but annoying. Air and heat worked ok. Just need to air out the rooms and not cover up the musty smell with deodorizer. Price was reasonable.
Reviewed on Apr 12, 2026

Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $62 total per night from May 8 to May 9
$62 total
May 8 - May 9
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Yes pet friendly
Reviewed on Apr 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Puxico hotel reviews by fellow wanderers

Motel 6 Poplar Bluff, MO
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Clean room"
A verified traveler stayed at Motel 6 Poplar Bluff, MO
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