Book Hotels in Sikeston, MO

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Sikeston hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $103 total per night from Oct 5 to Oct 6
$103 total
per night
Oct 5 - Oct 6
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Everything was extremely nice"

Reviewed on Sep 22, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $114 total per night from Oct 5 to Oct 6
$114 total
per night
Oct 5 - Oct 6
This hotel features a restaurant, an indoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate ...
"The stars tell it all😉"

Reviewed on Sep 22, 2025

Opens in a new windowFairfield Inn & Suites by Marriott Sikeston
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $89 total per night from Oct 3 to Oct 4
$89 total
per night
Oct 3 - Oct 4
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Very comfortable bed for people with back issues"

Reviewed on Sep 20, 2025

Opens in a new windowPear Tree Inn Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive, Sikeston, MO
The price is $107 total per night from Oct 19 to Oct 20
$107 total
per night
Oct 19 - Oct 20
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
"Nice property and friendly staff."

Reviewed on Sep 22, 2025

Opens in a new windowHampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr, Sikeston, MO
Fully refundable
The price is $119 total per night from Oct 17 to Oct 18
$119 total
per night
Oct 17 - Oct 18
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Clean and nice facilities. All the staff we met were friendly and helpful. Breakfast was great."

Reviewed on Sep 20, 2025

Opens in a new windowHoliday Inn Express & Suites Sikeston Southwest by IHG
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $66 total per night from Oct 5 to Oct 6
$66 total
per night
Oct 5 - Oct 6
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
"This is a great place to stay and the staff are super friendly. The manager helped me with a double booking issue and was able to get me a refund which is amazing! Good clean place to stay."

Reviewed on Sep 18, 2025

Opens in a new windowTravel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $93 total per night from Oct 12 to Oct 13
$93 total
per night
Oct 12 - Oct 13
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...
"This is such a nice clean place to stay. Breakfast was really good and the staff so nice and helpful."

Reviewed on Sep 16, 2025

Opens in a new windowBest Western Plus Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $72 total per night from Sep 30 to Oct 1
$72 total
per night
Sep 30 - Oct 1
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
"Spacious room"

Reviewed on Sep 13, 2025

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Country Yard Inn and Suite

Country Yard Inn and Suite

2 out of 5
110 South Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $67 total per night from Sep 29 to Sep 30
$67 total
per night
Sep 29 - Sep 30
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
"The property was well kept but lacked convenience of food and computer."

Reviewed on Aug 11, 2025

Opens in a new windowCountry Yard Inn and Suite
Don't see what you're looking for?
See all available properties in Sikeston
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Sikeston hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sikeston Hotel & Travel Guide\n

Spending several days in Southeast Missouri? With Travelocity, you'll unearth a select number of places to base your adventure in Sikeston. Within 6 miles (10 kilometers) of Sikeston, there are 9 suitable long and short-stay accommodation options.

People watch right by the downtown area of Sikeston. Travelocity-listed rooms here include Days Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest.

If you're heading to the Dexter area in Sikeston, your hotel options include the Hickory House Inn and Dexter Inn. Dexter is 20 miles (34 kilometers) from downtown Sikeston. Another suburb to stay in is Cape Girardeau, 30 miles (50 kilometers) from the center of Sikeston, where you can find the Pear Tree Inn Cape Girardeau West and Holiday Inn Express Hotel & Suites Cape Girardeau I-55.

If you're traveling on a tight budget, you'll be happy to learn that there's a nice selection of mid to low-budget rooms and apartments in Sikeston. Different lower-cost accommodation options are the Super 8 - Sikeston/Miner Area and the Super 8 Cape Girardeau.

The Comfort Inn And Suites is situated 3 miles (5 kilometers) from the heart of Sikeston. If you would prefer another option, the Quality Inn Charleston can be found approximately 13 miles (21 kilometers) away. Some other places to rest your head include the Super 8 Charleston MO and the Pear Tree Inn - Sikeston.

Hayti is 45 miles (73 kilometers) to the south of Sikeston and is where you'll find Hayti Pentecostal Holiness Church and Hayti Park. The Comfort Inn Hayti and Drury Inn & Suites Hayti Caruthersville are just a handful of the comfortable short and long-stay options in Hayti. 60 miles (97 kilometers) to the north of Sikeston, you will find Perryville, which features the Super 8 Perryville and Days Inn Perryville. The National Shrine of Our Lady of the Miraculous Medal and Perryville Country Club are other frequented points of interest to discover in Perryville.

If sport is never far from your mind, put aside some time for a trip to Players Bluegrass Downs, situated 55 miles (87 kilometers) to the east of Sikeston. Book accommodation right by the action at the Holiday Inn Express Hotel & Suites Paducah West or the Residence Inn by Marriott Paducah.

Before you and your traveling partner head out the door to Sikeston, take the time to look through Travelocity's Sikeston city page where you can get the inside scoop on all the attractions to be found here.

Frequently asked questions

What are the top kid-friendly hotels in Sikeston?
Take some of the hassles out of traveling with little ones by staying in a family-friendly hotel in Sikeston. From fun amenities to innovative services, these stays feature perks that'll help make your getaway smooth sailing: You'll be well looked after at Modern and Cozy Apartment with large windows and sunlight.. It comes with pet-friendly facilities, internet access and a knack for making families feel welcome. Otherwise, spend your evenings in Sikeston at Lambert's Homestead. Very Cozy & Clean 5 bed home.. Take advantage of a fireplace, a barbecue grill and more here.
Where can I find cheap hotels in Sikeston?
At Travelocity you'll find really nice hotels in Sikeston at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Sikeston rather than in Sikeston. We may find you even better rates, too.
How do I find the best Sikeston hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Sikeston then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Sikeston?
The cheapest hotel in Sikeston is $61. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Sikeston?
There are 276 hotels in Sikeston on Travelocity.
What are the best hotels in Sikeston?
Sikeston has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Sikeston for you!
When is the best time to visit Sikeston?
If you want the joy of a fun-filled trip in peak season, visit Sikeston during May, June and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Sikeston?
Based on historic data is usually the cheapest month to visit Sikeston. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Sikeston?
There are multiple hotels in Sikeston that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Sikeston. We have plenty of kid-friendly hotels in Sikeston to choose from on Travelocity!
Why book a hotel in Sikeston through Travelocity?
Because we have the top hotels in Sikeston! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Sikeston on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Sikeston hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity

Explore More Ways to Travel with Travelocity