Cheap Flights to Southeast Missouri from $64
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How Much Does it Cost To Fly To Southeast Missouri?
The cheapest prices found with in the last 7 days for return flights were $129 and $64 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply
CLT
Charlotte-Douglas Intl.
STL
Lambert-St. Louis Intl.
$163 Roundtrip, found 5 days ago
$163
Roundtrip
found 5 days ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| BWI | St. Louis | January 31 to February 7 | $129 |
| CMH | St. Louis | February 7 to February 24 | $141 |
| SAT | St. Louis | February 21 to February 23 | $147 |
| MSY | St. Louis | January 15 to January 21 | $159 |
| LAX | St. Louis | January 31 to February 4 | $162 |
| EWR | St. Louis | March 3 to March 9 | $174 |
| DCA | St. Louis | February 18 to March 2 | $176 |
| MSP | St. Louis | January 30 to February 2 | $210 |
| BWI | Marion | February 20 to February 28 | $317 |
| STL | Scott City | January 30 to February 2 | $413 |
| MCI | St. Louis | January 10 to January 16 | $448 |
| MCI | Scott City | January 30 to February 2 | $465 |
| STL | Marion | January 16 to January 23 | $501 |
| LAX | Scott City | March 28 to April 1 | $504 |
| MSP | Scott City | January 9 to January 11 | $611 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| CMH | St. Louis | January 4 to January 21 | $215 |
| EWR | St. Louis | January 4 to January 17 | $355 |
| BWI | St. Louis | January 2 to January 13 | $382 |
| MSY | St. Louis | January 2 to January 10 | $422 |
| MCI | St. Louis | January 3 to January 7 | $554 |
| DCA | St. Louis | January 2 to January 10 | $572 |
| MSP | St. Louis | January 4 to January 5 | $641 |
| LAX | St. Louis | January 2 to January 4 | $755 |
| SAT | St. Louis | January 4 to January 7 | $1,186 |
Southeast Missouri Flight Information
Traveling to | Southeast Missouri |
|---|---|
Lowest Price | $129 |
Number of Airlines Serving | |
Airlines Serving | Frontier Airlines, Contour Airlines |
Number of Daily Flights | |
Airlines with Direct Flights |
Find The Perfect Hotel For After Your Flight
Amazing Southeast Missouri Accommodation Deals
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$76 nightly
The price is $83 total per night from Dec 31 to Jan 1
$83 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,000 reviews)
It was a nice stay.
Reviewed on Dec 22, 2025
Pear Tree Inn Sikeston
2602 E Malone Avenue Sikeston MO
$75 nightly
The price is $86 total per night from Jan 4 to Jan 5
$86 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,005 reviews)
Very clean, very friendly! We will be staying again.
Reviewed on Dec 28, 2025
Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$53 nightly
The price is $60 total per night from Jan 6 to Jan 7
$60 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (612 reviews)
The room was excellent and the staff was extremely nice
Reviewed on Nov 25, 2025
Save an average of 15% on thousands of hotels when you're signed in
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (831 reviews)
Awesome
Reviewed on Nov 11, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Luxury Hotels in Southeast Missouri
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (831 reviews)
Awesome
Reviewed on Nov 11, 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$76 nightly
The price is $83 total per night from Dec 31 to Jan 1
$83 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,000 reviews)
It was a nice stay.
Reviewed on Dec 22, 2025
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$63 nightly
The price is $72 total per night from Jan 4 to Jan 5
$72 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
Staff was very nice. Room layout with two separate rooms was appreciated, especially at this price point. Good bed and bedding. Not super high end or careful about the rehab, and the breakfast was a carb fest, but overall we still felt it was a very good value
Reviewed on Dec 26, 2025
Save an average of 15% on thousands of hotels when you're signed in
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, a water park, and laundry facilities. Popular attractions Riverfront Park and eDen Spa & Salon are ...
9.8/10 Exceptional! (172 reviews)
Great place! It was exactly as advertised. We were so close to shops and restaurants. We will definitely be back!
Reviewed on Oct 12, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Southeast Missouri
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$90 nightly
The price is $103 total per night from Jan 4 to Jan 5
$103 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
Everything was great
Reviewed on Dec 29, 2025
Pear Tree Inn Sikeston
2602 E Malone Avenue Sikeston MO
$75 nightly
The price is $86 total per night from Jan 4 to Jan 5
$86 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,005 reviews)
Very clean, very friendly! We will be staying again.
Reviewed on Dec 28, 2025
Best Western Plus Sikeston
120 S Interstate Drive Sikeston MO
$80 nightly
The price is $91 total per night from Jan 4 to Jan 5
$91 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,000 reviews)
Great place to stay to stop over for the night. Very clean. Great value.
Reviewed on Dec 25, 2025
Save an average of 15% on thousands of hotels when you're signed in
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from Jan 4 to Jan 5
$102 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (999 reviews)
Clean and very nice room
Reviewed on Dec 24, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Southeast Missouri Flight and Hotel Packages
Southeast Missouri flight + hotel packages - economy flights
Price found within the past 48 hours. Click for updated prices.
Don't see what you're looking for?
See all available trips from Newark Liberty Intl. Airport to Southeast Missouri
View all tripsNeed a Car For After Your Flight?
Economy
Chevrolet Spark or similar
Compact
Ford Focus or similar
Midsize
Toyota Corolla or similar
SUV
Jeep Compass or similar
Frequently asked questions
Plane Tickets To Southeast Missouri
Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.
When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!
More Ways To Wander
Southeast Missouri Hotels
Find the perfect hotel after your flight
Southeast Missouri Vacation Rentals
Great Deals on alternative accommodations
Southeast Missouri Car Rentals
Affordable cars to get you around town
Southeast Missouri Vacations
Save more by combining flights, hotels and cars
Things to do in Southeast Missouri
Activities, attractions and tours
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