Cheap Flights to Southeast Missouri from $35
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How Much Does it Cost To Fly To Southeast Missouri?
The cheapest prices found with in the last 7 days for return flights were $77 and $35 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$77 Roundtrip, found 17 hours ago
$77
Roundtrip
found 17 hours ago
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$81 Roundtrip, found 15 hours ago
$81
Roundtrip
found 15 hours ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| BWI | St. Louis | April 7 to April 22 | $182 |
| DCA | St. Louis | May 8 to May 11 | $182 |
| EWR | St. Louis | May 3 to May 14 | $197 |
| LAX | St. Louis | May 9 to May 9 | $223 |
| CMH | St. Louis | April 14 to April 17 | $270 |
| DCA | West Paducah | May 21 to May 24 | $306 |
| MCI | St. Louis | April 15 to April 22 | $346 |
| MSP | Marion | May 27 to June 2 | $362 |
| LAX | West Paducah | April 16 to April 19 | $383 |
| DCA | Scott City | April 22 to May 4 | $432 |
| BWI | Scott City | March 31 to April 1 | $575 |
| MCI | Scott City | March 31 to April 1 | $594 |
| LAX | Marion | May 8 to May 10 | $811 |
| LAX | Scott City | March 31 to April 3 | $951 |
| MSP | Scott City | April 12 to April 19 | $7,163 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| BWI | St. Louis | March 22 to March 24 | $281 |
| SAT | St. Louis | March 21 to March 25 | $291 |
| MSP | St. Louis | March 21 to March 25 | $298 |
| CMH | St. Louis | March 21 to March 23 | $415 |
| LAX | St. Louis | March 22 to March 24 | $500 |
| EWR | St. Louis | March 21 to March 23 | $638 |
| MCI | St. Louis | March 21 to March 22 | $662 |
| MSY | St. Louis | March 22 to March 25 | $788 |
| DCA | St. Louis | March 22 to March 24 | $867 |
| STL | Scott City | March 21 to March 23 | $942 |
| STL | Marion | March 21 to March 23 | $1,032 |
Southeast Missouri Flight Information
Traveling to | Southeast Missouri |
|---|---|
Lowest Price | $77 |
Number of Airlines Serving | |
Airlines Serving | Frontier Airlines |
Number of Daily Flights | |
Airlines with Direct Flights |
Find The Perfect Hotel For After Your Flight
Amazing Southeast Missouri Accommodation Deals
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$73 nightly
The price is $77 total per night from Mar 20 to Mar 21
$77 total
Mar 20 - Mar 21
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
Bed was worn out felt like I was sleeping on a pile of rocks. Had 2 towels when made a reservation for 5. Glad I only made a 1 night reservation. This one ruined it for all the rest
Reviewed on Mar 17, 2026
Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $68 total per night from Mar 25 to Mar 26
$68 total
Mar 25 - Mar 26
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (629 reviews)
Parking was easy. The property is in the process of being updated, so the rooms, carpet, paint are all new. Looks good. Breakfast is ok, but there are no protein items (eggs, bacon/sausage).
Reviewed on Mar 12, 2026
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$82 nightly
The price is $94 total per night from Apr 19 to Apr 20
$94 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (837 reviews)
Mold in room, hole in wall, dirty sheets, smelt musty. Breakfast server cold biscuits and watered down meatless gravy, warm milk and a broken juice machine. Save the suffering and sleep in you car or keep driving
Reviewed on Mar 15, 2026
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Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Mar 29 to Mar 30
$81 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
Clean room, great breakfast. The lady that worked breakfast was very nice and worked hard. I gave her a tip. You dont see that much at hotels
Reviewed on Mar 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Luxury Hotels in Southeast Missouri
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$82 nightly
The price is $94 total per night from Apr 19 to Apr 20
$94 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (837 reviews)
Mold in room, hole in wall, dirty sheets, smelt musty. Breakfast server cold biscuits and watered down meatless gravy, warm milk and a broken juice machine. Save the suffering and sleep in you car or keep driving
Reviewed on Mar 15, 2026
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$73 nightly
The price is $77 total per night from Mar 20 to Mar 21
$77 total
Mar 20 - Mar 21
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
Bed was worn out felt like I was sleeping on a pile of rocks. Had 2 towels when made a reservation for 5. Glad I only made a 1 night reservation. This one ruined it for all the rest
Reviewed on Mar 17, 2026
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$68 nightly
The price is $78 total per night from Mar 22 to Mar 23
$78 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,001 reviews)
Business friendly, clean room staff very friendly, accommodating.
Reviewed on Mar 19, 2026
Save an average of 15% on thousands of hotels when you're signed in
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!
Reviewed on Dec 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Southeast Missouri
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Mar 26 to Mar 27
$108 total
Mar 26 - Mar 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
Pool not too cold and it was even snowing at one point. Staff was very friendly and helpful. Never had to wait for elevator. Breakfast waffles were excellent. Room was spacious. I’ve stayed in a lot of hotels, and this is one of the best. They get a 100/10 for amenities!
Reviewed on Mar 18, 2026
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
$87 nightly
The price is $99 total per night from Mar 26 to Mar 27
$99 total
Mar 26 - Mar 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,006 reviews)
Room was clean, the bathroom had a good vent and nice lighting which we've had a problem with with other hotels. Very satisfied with our stay and breakfast was gold.
Reviewed on Mar 19, 2026
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$91 nightly
The price is $103 total per night from Mar 29 to Mar 30
$103 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,001 reviews)
Can’t beat a Drury Hotel! Kind, attentive staff, spic and span room, excellent cocktails and food. Breakfast was hardy and had many choices. We love Drury!
Reviewed on Mar 19, 2026
Save an average of 15% on thousands of hotels when you're signed in
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from Mar 23 to Mar 24
$100 total
Mar 23 - Mar 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (752 reviews)
Hotel was ok, not terribly dirty, but not very clean. Chose for the jetted tub in the photo. Come to find out there was no jetted tub in the rooms, it was a regular very old tub that wasn’t quite clean looking, so definitely false advertising. I would absolutely not have chosen this hotel otherwise. ...
Reviewed on Mar 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Southeast Missouri Flight and Hotel Packages
Southeast Missouri flight + hotel packages - economy flights
Price found within the past 48 hours. Click for updated prices.
Don't see what you're looking for?
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Economy
Chevrolet Spark or similar
Compact
Ford Focus or similar
Midsize
Toyota Corolla or similar
SUV
Jeep Compass or similar
Frequently asked questions
Plane Tickets To Southeast Missouri
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When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!
More Ways To Wander
Southeast Missouri Hotels
Find the perfect hotel after your flight
Southeast Missouri Vacation Rentals
Great Deals on alternative accommodations
Southeast Missouri Car Rentals
Affordable cars to get you around town
Southeast Missouri Vacations
Save more by combining flights, hotels and cars
Things to do in Southeast Missouri
Activities, attractions and tours
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