Cheap Flights to Sikeston from $35
Wander Wisely with exceptional service, 24/7 supportOpens in a new window
Feel at ease with free flight cancellations within 24 hours of booking
Change your flight without a fee on select flights
How Much Does it Cost To Fly To Sikeston?
The cheapest prices found with in the last 7 days for return flights were $58 and $35 for one-way flights to Sikeston for the period specified. Prices and availability are subject to change. Additional terms apply
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 11 hours ago
$58
Roundtrip
found 11 hours ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| ATL | St. Louis | May 27 to June 3 | $107 |
| EWR | St. Louis | May 12 to May 13 | $154 |
| LGA | St. Louis | May 12 to May 15 | $164 |
| DFW | Scott City | June 5 to June 12 | $178 |
| LAX | St. Louis | May 8 to May 10 | $205 |
| ATL | West Paducah | May 14 to May 17 | $299 |
| TPA | West Paducah | May 1 to May 5 | $332 |
| LAX | West Paducah | June 1 to June 8 | $362 |
| SEA | West Paducah | May 5 to May 19 | $481 |
| EWR | Scott City | July 11 to July 19 | $606 |
| SEA | Scott City | May 10 to May 14 | $687 |
| PHL | West Paducah | May 4 to May 8 | $729 |
| LAX | Scott City | April 30 to May 3 | $774 |
| DEN | West Paducah | May 14 to May 17 | $784 |
| FCO | St. Louis | May 6 to May 10 | $978 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| EWR | St. Louis | April 24 to May 6 | $230 |
| LGA | St. Louis | April 24 to April 30 | $238 |
| TTN | St. Louis | April 26 to April 28 | $241 |
| DFW | St. Louis | April 25 to April 30 | $251 |
| DEN | St. Louis | April 24 to April 26 | $291 |
| LAX | St. Louis | April 26 to May 4 | $296 |
| TPA | St. Louis | April 26 to May 2 | $307 |
| ATL | St. Louis | April 25 to April 27 | $315 |
| SEA | St. Louis | April 24 to April 26 | $522 |
Sikeston Flight Information
Traveling to | Sikeston |
|---|---|
Lowest Price | $58 |
Number of Airlines Serving | |
Airlines Serving | Frontier Airlines |
Number of Daily Flights | |
Airlines with Direct Flights |
Find The Perfect Hotel For After Your Flight
Amazing Sikeston Accommodation Deals
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from May 17 to May 18
$81 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,002 reviews)
Breakfast was hot and manned by a friendly staff member. Room was clean and met my needs.
Reviewed on Apr 9, 2026
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$61 nightly
The price is $70 total per night from Apr 26 to Apr 27
$70 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
It had a clean room. Better than most hotels like this. The bathroom smelled like mold or mildew. And the lobby smelled of moth balls. Some of the sheets had black stuff on them. Not sure what it was. Air conditioning was cold.
Reviewed on Apr 12, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
$105 nightly
The price is $118 total per night from Apr 26 to Apr 27
$118 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,004 reviews)
Yes
Reviewed on Apr 20, 2026
Save an average of 15% on thousands of hotels when you're signed in
Eagle Inn Charleston
2811 East Marshall Street Charleston MO
$55 nightly
The price is $61 total per night from May 2 to May 3
$61 total
May 2 - May 3
Total with taxes and fees
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (106 reviews)
Great
Reviewed on Apr 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Luxury Hotels in Sikeston
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$61 nightly
The price is $70 total per night from Apr 26 to Apr 27
$70 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
It had a clean room. Better than most hotels like this. The bathroom smelled like mold or mildew. And the lobby smelled of moth balls. Some of the sheets had black stuff on them. Not sure what it was. Air conditioning was cold.
Reviewed on Apr 12, 2026
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!
Reviewed on Dec 15, 2025
Quality Inn Cape Girardeau North
2011 North Kingshighway Cape Girardeau MO
$67 nightly
The price is $75 total per night from Apr 23 to Apr 24
$75 total
Apr 23 - Apr 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7.2/10 Good! (730 reviews)
It was good, but a noticeable hole in the wall above the toilet paper.
Reviewed on Apr 17, 2026
Save an average of 15% on thousands of hotels when you're signed in
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$97 nightly
The price is $112 total per night from Apr 27 to Apr 28
$112 total
Apr 27 - Apr 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
👍
Reviewed on Apr 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Sikeston
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$97 nightly
The price is $112 total per night from Apr 27 to Apr 28
$112 total
Apr 27 - Apr 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
👍
Reviewed on Apr 19, 2026
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
$77 nightly
The price is $88 total per night from Apr 26 to Apr 27
$88 total
Apr 26 - Apr 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
The staff were all wonderful and the breakfast was good. Our room door was propped open when we arrived, which was kind of off-putting. Also, the property could use some upgrades. I think the bathtub was clean, just old so kind of dingy looking. The elevator was out of order.
Reviewed on Apr 20, 2026
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$94 nightly
The price is $106 total per night from May 17 to May 18
$106 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,006 reviews)
Wonderful stay, very spacious room, clean, super comfortable beds, breakfast was delicious!
Reviewed on Apr 20, 2026
Save an average of 15% on thousands of hotels when you're signed in
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from May 3 to May 4
$100 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (762 reviews)
It was way below average and was not a cheap property to stay at. Very dirty room, bathroom was disgusting. Breakfast was mediocre. Pool area was even dirty. Front desk clerk was also doing the breakfast area. Wore the same gloves from food area, to front desk, back to food area.
Reviewed on Apr 18, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Sikeston Flight and Hotel Packages
Sikeston flight + hotel packages - economy flights
Price found within the past 48 hours. Click for updated prices.
Need a Car For After Your Flight?
Special
Saint Ann, Missouri, USA
$47
$128 total
found 1 day ago
Midsize
St Louis, Missouri, USA
$48
$124 total
found 11 hours ago
Compact
St Louis, Missouri, USA
$48
$124 total
found 11 hours ago
Economy
St Louis, Missouri, USA
$48
$124 total
found 11 hours ago
Frequently asked questions
Plane Tickets To Sikeston
Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Sikeston. Browse through our inventory to explore a wide range of cheap flights to Sikeston to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Sikeston as you anxiously await to exit the plane and explore what Sikeston has to offer. Considering all the amazing local food and culture in Sikeston, we won't hold this against you.
When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Sikeston to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Sikeston without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Sikeston with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Sikeston today!
Explore More Ways to Travel with Travelocity
- Hotels near Sikeston Depot Museum
- Hotels near New Madrid Historical Museum
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Stoddard County Civil War Memorial Cemetery
- Lodges in Benton
- Hotels near Hunter-Dawson State Historic Site
- Bertrand Hotels
- Blodgett Hotels
- Cabins in Dexter
- Cheap Hotels in Dexter
- Historic Hotels in Dexter
- Hotels with Pools in Dexter
- Hotels with Free Breakfast in Dexter
- Dexter Hotels
- Motels in Dexter
- Vacation Homes in Dexter
- Chaffee Hotels
- Hotels near Central Park
- Cabins in Scott City
- Parma Hotels
- Cabins in Bloomfield
- Bloomfield Hotels
- Motels in Bloomfield
- Catron Hotels
- East Prairie Hotels
- Motels in East Prairie
- Vacation Homes in East Prairie
- Hotels with smoking rooms in Charleston
- Pet Friendly Hotels in Charleston
- Spa Resorts & in Charleston
- Charleston Hotels
- Motels in Charleston
- New Madrid Hotels
- Houseboats in New Madrid
- Motels in New Madrid
- Vacation Homes in New Madrid
- Hotels near River Ridge Winery
- Hotels near Sikeston Memorial Municipal
- Hotels near Big Oak Tree State Park
- 3 Star Hotels in Oran
- Apartments in Oran
- Oran Hotels
- Motels in Oran
- Hotels near Front Street Studio & Art Gallery
- Flights to Flat River
- Flights to Southeast Missouri
- Flights to Poplar Bluff
- Flights to Eminence
- Flights to Alton
- Flights to Cape Girardeau
- Flights to Jackson
- Flights from Cape Girardeau Municipal
- United Chicago (ORD) to Cape Girardeau (CGI) flights
- Flights from Atlanta (ATL) to Cape Girardeau (CGI)
- Flights from Nashville (BNA) to Cape Girardeau (CGI)
- Flights from Columbia (COU) to Cape Girardeau (CGI)
- Flights from Dallas (DFW) to Cape Girardeau (CGI)
- Flights from Kansas City (MCI) to Cape Girardeau (CGI)
- Flights from Chicago (ORD) to Cape Girardeau (CGI)
- Flights from St. Louis (STL) to Cape Girardeau (CGI)
- Flights to Farmington
- Flights to Bertrand
- Flights to Dexter
- Flights from Chicago to Dexter
- Flights from Houston to Dexter
- Flights from Miami to Dexter
- Flights from Washington to Dexter
- Flights to Malden
- Flights to East Prairie
- Flights from Boston to Charleston
- Flights to Ste Genevieve
- Flights to Doniphan
- Flights to New Madrid
- Flights to Fredericktown
- Flights to Ellington
- Flights to Kennett
- Flights from Sikeston Memorial Municipal
- Flights to Caruthersville
- Flights to Annapolis
- Flights to Hayti
- Flights to Steele
- Flights to Festus
- Flights to Couch
- Flights to Perryville
- Flights to Potosi
- Avis Rental Cars in Cape Girardeau Municipal
- Budget Rental Cars in Cape Girardeau Municipal
- Enterprise Rental Cars in Cape Girardeau Municipal
- Thrifty Car Rental Rental Cars in Cape Girardeau Municipal
- Car rental Dexter
- Luxury Car Rentals in Dexter
- Premium Car Rentals in Dexter
- Van Car Rentals in Dexter
- Car rental Catron
- Car rental East Prairie
- Car rental Charleston
- Fullsize Car Rentals in Charleston
- Premium Car Rentals in New Madrid