Cheap Flights to Sikeston from $20

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How Much Does it Cost To Fly To Sikeston?

The cheapest prices found with in the last 7 days for return flights were $43 and $20 for one-way flights to Sikeston for the period specified. Prices and availability are subject to change. Additional terms apply

Wed, Oct 14 - Mon, Oct 19
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$43 Roundtrip, found 3 days ago
$43
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Oct 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Oct 19, priced at $43 found 3 days ago
OriginDestinationTravel DatesFlights From*
DFWSt. LouisOctober 4 to October 9$74
PHLSt. LouisOctober 7 to October 12$111
TPASt. LouisOctober 7 to October 9$133
LAXSt. LouisOctober 31 to November 7$208
SEASt. LouisOctober 17 to October 23$222
LGASt. LouisSeptember 23 to September 23$222
LGASt. LouisSeptember 23 to September 23$222
DFWScott CityNovember 5 to November 12$238
DFWWest PaducahOctober 29 to October 31$308
DENWest PaducahOctober 18 to October 24$308
SEAWest PaducahSeptember 30 to October 3$353
ATLScott CitySeptember 25 to September 27$523
SEAScott CityOctober 12 to October 26$668
FCOSt. LouisSeptember 16 to September 21$871
LGAScott CityOctober 5 to October 13$1,153
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
TPASt. LouisSeptember 11 to October 5$293
DENSt. LouisSeptember 13 to September 19$294
PHLSt. LouisSeptember 13 to September 18$294
ATLSt. LouisSeptember 11 to September 14$304
LGASt. LouisSeptember 11 to September 14$304
LGASt. LouisSeptember 11 to September 14$304
DFWSt. LouisSeptember 12 to September 14$305
DFWScott CitySeptember 11 to September 18$358
LAXSt. LouisSeptember 11 to October 17$367
SEASt. LouisSeptember 12 to September 16$458
*Prices include taxes and fees

Sikeston Flight Information

Traveling to
Sikeston
Lowest Price
$43
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Sikeston Accommodation Deals

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Sep 13 to Sep 14
$81 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,002 reviews)
"Clean room friendly staff"

Reviewed on Sep 3, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$66 nightly
The price is $76 total per night from Sep 7 to Sep 8
$76 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"Front desk was welcoming and nice. Room was cleaned, beds were comfy. Very spacious. Quiet as well."

Reviewed on Sep 1, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
$101 nightly
The price is $115 total per night from Sep 7 to Sep 8
$115 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,001 reviews)
"This location is a must stay any time I am traveling in the area. The staff are helpful. There are lots of dinning options near by. I can always count on a peaceful night sleep at this location."

Reviewed on Sep 2, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Eagle Inn Charleston

Eagle Inn Charleston

2 out of 5
2811 East Marshall Street Charleston MO
$77 nightly
The price is $85 total per night from Sep 8 to Sep 9
$85 total
Sep 8 - Sep 9
Total with taxes and fees
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (107 reviews)
"Don’t go here if you’re a single woman traveling alone. I did not feel save even with my dog."

Reviewed on Aug 27, 2026

Opens in a new windowEagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$66 nightly
The price is $76 total per night from Sep 7 to Sep 8
$76 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"Front desk was welcoming and nice. Room was cleaned, beds were comfy. Very spacious. Quiet as well."

Reviewed on Sep 1, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (228 reviews)
"Very nice hospitality and accommodations ComfortableGreat location"

Reviewed on Jul 5, 2026

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
$61 nightly
The price is $69 total per night from Oct 4 to Oct 5
$69 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
Opens in a new windowQuality Inn Cape Girardeau North
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Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Sep 14 to Sep 15
$108 total
Sep 14 - Sep 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"Very nice and clean property."

Reviewed on Sep 3, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Sep 14 to Sep 15
$108 total
Sep 14 - Sep 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"Very nice and clean property."

Reviewed on Sep 3, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$87 nightly
The price is $99 total per night from Sep 20 to Sep 21
$99 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,006 reviews)
"We were greeted with a warm smile from a really nice gentleman that checked us in. He chatted with us the entire time we checked in. He gave us ideas where to eat and Lamberts won. The hotel and room was very clean. Breakfast was great. They serve something hot everyday like biscuits and gravy, eggs, ..."

Reviewed on Sep 3, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from Sep 13 to Sep 14
$102 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
$80 nightly
The price is $86 total per night from Oct 4 to Oct 5
$86 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Sikeston Flight and Hotel Packages

Sikeston flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
Price was $522, price is now $390 per person
$390
per person
Oct 22 - Oct 26
found 1 day ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Alhonna Resort LLC

Alhonna Resort LLC

3 out of 5
Price was $506, price is now $402 per person
$402
per person
Oct 21 - Oct 24
found 1 day ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $820, price is now $507 per person
$507
per person
Oct 22 - Oct 26
found 1 day ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
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Need a Car For After Your Flight?

Economy

  • 4 people
  • Unlimited mileage
Sikeston, Missouri, USA

$40

$94 total
found 2 days ago
Economy undefined

Compact

  • 5 people
  • Unlimited mileage
Sikeston, Missouri, USA

$40

$94 total
found 2 days ago
Compact undefined

Midsize

  • 5 people
  • Unlimited mileage
SIKESTON, USA

$42

$98 total
found 2 days ago
Midsize undefined

Standard

  • 5 people
  • Unlimited mileage
SIKESTON, USA

$45

$105 total
found 2 days ago
Standard undefined
Lowest prices found within the past 2 days. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Which airlines fly to Sikeston?
You won't find many airlines that service Sikeston. So, if you're planning to embark on your long-anticipated adventure from here, book a seat with Cape Air as soon as you can.
Where to stay in Sikeston
Lock in your Sikeston accommodations through Travelocity and then turn your attention to what really matters — creating remarkable travel memories. Pick from 12 lodgings from which you can explore this enticing destination.If you're on the hunt for the top accommodation options in Sikeston, we suggest the Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel and the Hampton Inn Sikeston. Reserve a room and then start booking all your exciting getaway activities.
Places to visit in Sikeston
Every visitor will hear talk of The Book Bug at least once. It's a well-known local store. Like some more ideas? Lovers of painting should plan to pay a visit to Sikeston Depot Museum where they'll certainly be impressed. But that's not all there is. Central Park is an urban sanctuary. It is a beautiful place to go for a jog and enjoy the outdoors.
How to get through airport security fast when traveling to Sikeston
Your adventure to Sikeston starts as soon as you've finished all the security checks. Here are some tips and pointers to help you get through quickly:

  • Security personnel will ask to see your travel ID and boarding pass as part of their checks. Tuck them away in a convenient place, so they're all ready for inspection.
  • Remove your shoes and belt before arriving at the airport security checkpoint. Items like these are not permitted to pass through the body scanner.
  • Make sure your phone, laptop and other electronic devices are easily accessible. These items need to be sent through the X-ray machine separately.
  • When you approach the security checkpoint, you'll be asked to place all creams, gels and liquids in a separate tray for scanning. Make sure they're all packed in containers smaller than 3.4 ounces (100 milliliters) and sealed in a clear zip-lock bag.
  • Security personnel will likely tell you to take off your shoes for the body scanner. Choose a pair that you can slip off easily. There's nothing more irritating than having to do your laces up over and over again.
  • Pocketknives and corkscrews are not permitted on board the aircraft. Tuck them away in your checked luggage to avoid them being confiscated at the airport security checkpoint.

Plane Tickets To Sikeston

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Sikeston. Browse through our inventory to explore a wide range of cheap flights to Sikeston to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Sikeston as you anxiously await to exit the plane and explore what Sikeston has to offer. Considering all the amazing local food and culture in Sikeston, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Sikeston to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Sikeston without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Sikeston with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Sikeston today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.