Explore 7 Luxury Hotels in Sikeston

Name: Days Inn and Suites by Wyndham Sikeston
Price range: $73 total

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Best Luxury Hotels in Sikeston

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

This apartment featured laundry facilities and barbecue grills.

10/10 Exceptional! (225 reviews)

Amazing place to stay at the Cape!

Reviewed on Apr 12, 2026

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Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$111 nightly

$128 total

May 16 - May 17

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...

9.6/10 Exceptional! (1,014 reviews)

I loved everything. Was surprised of the amenities that they offered that evening drinks and food. For FREE

Reviewed on May 10, 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

May 17 - May 18

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (1,008 reviews)

Clean and comfortable room for a good price.

Reviewed on May 11, 2026

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$67 nightly

$75 total

May 17 - May 18

Total with taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7.2/10 Good! (739 reviews)

The place was not good at all. If it wasn't for it being so late at night when we arrived, I would have left and demanded a refund. Room was as if someone before me had just left 5 minutes prior to me going in. Not clean at all!!

Reviewed on May 6, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

$64 nightly

$73 total

May 17 - May 18

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sikeston Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.

Sikeston hotels essential information

Accommodation	303 hotels
Lowest Price	$73
Highest Price	$128
Popular hotels	Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Quality Inn Cape Girardeau North, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau