Explore 7 Luxury Hotels in Sikeston

Name: Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Address: Cape Girardeau

Best Luxury Hotels in Sikeston

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO

Fully refundableReserve now, pay when you stay

$99 nightly

$114 total

Jun 8 - Jun 9

Total includes taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...

9.4/10 Exceptional! (1,001 reviews)

"The bed was so comfortable. The front desk service was outstanding. I had my dog with me. Very accommodating."

Reviewed on May 29, 2025

Drury Inn & Suites Cape Girardeau

3303 Campster Drive, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$94 nightly

$107 total

Jun 8 - Jun 9

Total includes taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.2/10 Wonderful! (933 reviews)

"Room was very clean and staff was excellent!"

Reviewed on May 25, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$58 nightly

$66 total

Jun 5 - Jun 6

Total includes taxes and fees

A seasonal outdoor pool is featured at this hotel, along with free WiFi in public areas and express check-out. Staff at the 24-hour front desk can provide around-the-clock ...

8.8/10 Excellent! (1,000 reviews)

"Clean and comfortable"

Reviewed on May 26, 2025

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Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO

Fully refundableReserve now, pay when you stay

$81 nightly

$92 total

Jun 3 - Jun 4

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,000 reviews)

"Nice and clean"

Reviewed on Apr 14, 2025

Quality Inn

2011 North Kingshighway, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$64 nightly

$72 total

Jun 2 - Jun 3

Total includes taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7/10 Good! (587 reviews)

"Great room, great experience"

Reviewed on May 27, 2025

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau

This apartment features a water park, laundry facilities, and barbecue grills.

Perfect stay!!

"We enjoyed this property so much!! The location was perfect, it was so clean, very accommodating, perfect amount of space, and awesome host! We were in town for AAU basketball and this rental gave us the comfort of being at home. The washer/dryer availability was a plus after sweaty ballgames! We ..."

Reviewed on May 4, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sikeston Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.

Sikeston hotels essential information

Accommodation	267 hotels
Lowest Price	$66
Highest Price	$114
Popular hotels	Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau