Explore 7 Luxury Hotels in Sikeston
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Best Luxury Hotels in Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau
This apartment features a water park, laundry facilities, and barbecue grills.
9.8/10 Exceptional! (168 reviews)
"Property location was perfect.Deck view was great.Very clean and comfortable place."
Reviewed on Jul 21, 2025
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Oct 2 to Oct 3
$103 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,012 reviews)
"Everything was extremely nice"
Reviewed on Sep 22, 2025
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Oct 2 to Oct 3
$102 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (998 reviews)
"I like the 5:30 kickback of snacks and drinks at no cost"
Reviewed on Sep 15, 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Oct 5 to Oct 6
$79 total
Oct 5 - Oct 6
Total with taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,006 reviews)
"Quiet sleep. No microwave in the room. Very inconvenient to have to go back and forth with food."
Reviewed on Sep 11, 2025
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Sep 28 to Sep 29
$72 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,003 reviews)
"Spacious room"
Reviewed on Sep 13, 2025
Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $65 total per night from Oct 2 to Oct 3
$65 total
Oct 2 - Oct 3
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...
7/10 Good! (643 reviews)
"clean and comfortab;le. Highway is close."
Reviewed on Sep 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Sikeston Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.
Sikeston hotels essential information
Accommodation | 277 hotels |
|---|---|
Lowest Price | $65 |
Highest Price | $103 |
Popular hotels | Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau |
Popular Luxury Stays in Sikeston
Recent Sikeston Hotel Reviews By Fellow Wanderers
Drury Inn & Suites Sikeston, MO
5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Everything was extremely nice"
A verified traveler stayed at Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston
5 out of 5
Posted 12 days ago
Travelocity Verified Review
"Spacious room "
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston
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