Explore 7 Luxury Hotels in Sikeston

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Best Luxury Hotels in Sikeston

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau
This apartment features a water park, laundry facilities, and barbecue grills.
9.8/10 Exceptional! (166 reviews)
"As always the Kage House is always above par. Keith is such a delightful host and this is my umpteenth time staying here. No matter the occasion we never leave without having a great time"

Reviewed on Jun 15, 2025

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $117 total per night from Jul 20 to Jul 21
$117 total
Jul 20 - Jul 21
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,003 reviews)
"The staff here from check in to the morning breakfast were welcoming and friendly. Cost was reasonable. I loved seeing the dogs and that it is pet friendly. Everything was clean. The location was close to places to eat - we even walked to El Bracero for dinner. I would highly recommend"

Reviewed on Jul 11, 2025

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Jul 16 to Jul 17
$102 total
Jul 16 - Jul 17
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (954 reviews)
"The hotel workers were very pleasant and helpful. The hotel was clean and very attractive. It was such a wonderful weekend with my family. Thank you so much."

Reviewed on Jul 7, 2025

Drury Inn & Suites Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Jul 16 to Jul 17
$76 total
Jul 16 - Jul 17
Total includes taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,007 reviews)
Nice One-Night Stay
"Stopped in in late June. One night stay. Rooms was fine. Bed was comfy and pillows were good. The 'continental' breakfast was severely lacking."

Reviewed on Jul 6, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $92 total per night from Jul 14 to Jul 15
$92 total
Jul 14 - Jul 15
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,000 reviews)
Keep up the renovations
"This hotel looked like an old apartment building renovation into a hotel with much wrk in progress. Decent stay. Spacious. Very minimal breakfast offerings. The geese outside sure left messes everywhere but the greeting cat was a nice touch"

Reviewed on Jun 28, 2025

Days Inn and Suites by Wyndham Sikeston
Quality Inn

Quality Inn

2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Jul 13 to Jul 14
$76 total
Jul 13 - Jul 14
Total includes taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...
7/10 Good! (602 reviews)
"The hospitality team members were warm and helpful. The amenities were a bit basic. When I asked for half-and-half to be added to the options on the coffee set-up, they explained that that chain did not allow them to offer that. The water in the pool looked an odd shade of green. We'd picked the ..."

Reviewed on Jul 5, 2025

Quality Inn
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Sikeston Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.


Sikeston hotels essential information

Accommodation
262 hotels
Lowest Price
$76
Highest Price
$117
Popular hotels
Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau

Popular Luxury Stays in Sikeston

Recent Sikeston Hotel Reviews By Fellow Wanderers

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