Explore 7 Luxury Hotels in Sikeston
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Best Luxury Hotels in Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau
This apartment features a water park, laundry facilities, and barbecue grills.
9.8/10 Exceptional! (166 reviews)
"As always the Kage House is always above par. Keith is such a delightful host and this is my umpteenth time staying here. No matter the occasion we never leave without having a great time"
Reviewed on Jun 15, 2025
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $117 total per night from Jul 20 to Jul 21
$117 total
Jul 20 - Jul 21
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,003 reviews)
"The staff here from check in to the morning breakfast were welcoming and friendly. Cost was reasonable. I loved seeing the dogs and that it is pet friendly. Everything was clean. The location was close to places to eat - we even walked to El Bracero for dinner. I would highly recommend"
Reviewed on Jul 11, 2025
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Jul 16 to Jul 17
$102 total
Jul 16 - Jul 17
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (954 reviews)
"The hotel workers were very pleasant and helpful. The hotel was clean and very attractive. It was such a wonderful weekend with my family. Thank you so much."
Reviewed on Jul 7, 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Jul 16 to Jul 17
$76 total
Jul 16 - Jul 17
Total includes taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,007 reviews)
Nice One-Night Stay
"Stopped in in late June. One night stay. Rooms was fine. Bed was comfy and pillows were good. The 'continental' breakfast was severely lacking."
Reviewed on Jul 6, 2025
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $92 total per night from Jul 14 to Jul 15
$92 total
Jul 14 - Jul 15
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,000 reviews)
Keep up the renovations
"This hotel looked like an old apartment building renovation into a hotel with much wrk in progress. Decent stay. Spacious. Very minimal breakfast offerings. The geese outside sure left messes everywhere but the greeting cat was a nice touch"
Reviewed on Jun 28, 2025
Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Jul 13 to Jul 14
$76 total
Jul 13 - Jul 14
Total includes taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...
7/10 Good! (602 reviews)
"The hospitality team members were warm and helpful. The amenities were a bit basic. When I asked for half-and-half to be added to the options on the coffee set-up, they explained that that chain did not allow them to offer that. The water in the pool looked an odd shade of green. We'd picked the ..."
Reviewed on Jul 5, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Sikeston Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.
Sikeston hotels essential information
Accommodation | 262 hotels |
|---|---|
Lowest Price | $76 |
Highest Price | $117 |
Popular hotels | Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau |
Popular Luxury Stays in Sikeston
Recent Sikeston Hotel Reviews By Fellow Wanderers
Drury Inn & Suites Sikeston, MO
5 out of 5
Posted 20 hours ago
Travelocity Verified Review
"The staff here from check in to the morning breakfast were welcoming and friendly. Cost was reasonable. I loved seeing the dogs and that it is pet friendly. Everything was clean. The location was close to places to eat - we even walked to El Bracero for dinner. I would highly recommend "
A verified traveler from Rolling Prairie stayed at Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston
5 out of 5
Posted 3 weeks ago
Travelocity Verified Review
"This property is updated, fresh paint in the halls and alot of work has gone into this location. The bed is comfortable and there are plenty of pillows (4). "
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston
Explore More Ways to Travel with Travelocity
Explore More Ways to Travel with Travelocity
- Explore More
- Other Hotel Types
- Other Accommodation Types
- Explore Neighborhoods in Sikeston
- Luxury hotels in other cities
- Book on Expedia
An attraction
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Riverfront Bridge Park
- Hotels near Big Oak Tree State Park
- Hotels near Marston Community Center
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Mound City National Cemetery
- Hotels near River Ridge Winery
- Hotels near New Madrid Historical Museum
- Hotels near Stoddard County Civil War Memorial Cemetery
- Hotels near Hunter-Dawson State Historic Site
- Hotels near Front Street Studio & Art Gallery
Types of Hotels
- Hotels with Restaurants in Sikeston
- Kid Friendly Hotels in Sikeston
- Pet Friendly Hotels in Sikeston
- Hotels with Free Breakfast in Sikeston
- Hotels with Pools in Sikeston
- Convention Center Hotels in Sikeston
- Cheap Hotels in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Hotels with Hot Tubs in Sikeston
- Hotels with Bar in Sikeston
- Casino Resorts & Hotels in Sikeston
- Hotels with Suites in Sikeston
- Hotel Wedding Venues in Sikeston
- Adventure Hotels in Sikeston
- Historic Hotels in Sikeston
- Spa Resorts & Hotels in Sikeston
- Hotels with smoking rooms in Sikeston
- Hotels with Balconies in Sikeston
- Adults Only Resorts & Hotels in Sikeston
- Romantic Getaways & Hotels in Sikeston
- Hotels with Kitchenettes in Sikeston
Areas of Sikeston
- Cape Girardeau Hotels
- Ozarks Hotels
- Southern Illinois Hotels
- Southeastern United States Hotels
- Dexter Hotels
- Cairo Hotels
- Tiptonville Hotels
- Charleston Hotels
- Marston Hotels
- Western Kentucky Hotels
- Portageville Hotels
- Western Tennessee Hotels
- Southeast Missouri Hotels
- Malden Hotels
- New Madrid Hotels
- Benton Hotels
- Scott City Hotels
- Miner Hotels
- The South Hotels
- Wickliffe Hotels
- East Prairie Hotels
- Central United States Hotels
- Hickman Hotels
- Bloomfield Hotels
- Puxico Hotels
- Advance Hotels
- Mounds Hotels
- Ullin Hotels
- Tamms Hotels
- Great River Road Hotels
- Chaffee Hotels
- Bertrand Hotels
- Thebes Hotels
- Bernie Hotels
- Mound City Hotels
- Oran Hotels
- Gideon Hotels
- New York City Luxury Hotels
- London Luxury Hotels
- Cabo San Lucas Luxury Hotels
- Los Angeles Luxury Hotels
- Las Vegas Luxury Hotels
- New Orleans Luxury Hotels
- Orlando Luxury Hotels
- Palm Springs Luxury Hotels
- Philadelphia Luxury Hotels
- Miami Luxury Hotels
- Atlanta Luxury Hotels
- Rome Luxury Hotels
- Sedona Luxury Hotels
- South Beach Luxury Hotels
- Bali Luxury Hotels
- Charleston Luxury Hotels
- Cancun Luxury Hotels
- Punta Cana Luxury Hotels
- Dallas Luxury Hotels
- Naples Luxury Hotels
Most Popular
Hotels
- Hotels in Joplin
- Hotels in Jefferson City
- Pet Friendly Hotels in Branson
- Hotels in Fulton
- Hotels in Lebanon
- Hotels in Springfield
- Kid Friendly Hotels in Branson
- Hotels in St. Joseph
- Hotels in Clinton
- Hotels in Camdenton
- Hotels with an Indoor Pool in Branson
- Hotels with Hot Tubs in Branson
- Hotels in Lake Ozark
- Hotels in Poplar Bluff
- Hotels in Farmington
- Hotels in Rolla
- Hotels in Washington
- Hotels in Columbia
- Hotels in Sedalia
- Hotels in Cape Girardeau
- Hotels in Branson
- Hotels in Osage Beach
- Hotels in Hannibal
Activities
Packages