Explore 7 Luxury Hotels in Sikeston

Name: Quality Inn
Price range: $72 total
Rating: 7

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Best Luxury Hotels in Sikeston

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau

This apartment features a water park, laundry facilities, and barbecue grills.

9.8/10 Exceptional! (170 reviews)

Great place! It was exactly as advertised. We were so close to shops and restaurants. We will definitely be back!

Reviewed on Oct 12, 2025

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Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO

Fully refundableReserve now, pay when you stay

$94 nightly

$108 total

Nov 18 - Nov 19

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...

9.4/10 Exceptional! (1,002 reviews)

Clean rooms. Great staff

Reviewed on Nov 5, 2025

Drury Inn & Suites Cape Girardeau

3303 Campster Drive, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Nov 16 - Nov 17

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (1,002 reviews)

Clean and friendly staff!!!

Reviewed on Nov 9, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$70 nightly

$79 total

Nov 16 - Nov 17

Total with taxes and fees

Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.

8.8/10 Excellent! (1,003 reviews)

Nice place for a stay at a reasonable price.

Reviewed on Nov 9, 2025

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO

Fully refundableReserve now, pay when you stay

$63 nightly

$72 total

Nov 16 - Nov 17

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,002 reviews)

Large property, great for dogs.

Reviewed on Nov 7, 2025

Quality Inn

2011 North Kingshighway, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$64 nightly

$72 total

Nov 20 - Nov 21

Total with taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7/10 Good! (666 reviews)

Great place with great employees

Reviewed on Oct 20, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sikeston Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.

Sikeston hotels essential information

Accommodation	277 hotels
Lowest Price	$72
Highest Price	$108
Popular hotels	Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau