Sikeston Vacation Packages 2026 from $339

Sikeston flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$339

per person

Sep 24 - Sep 28

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Remodeled and Inviting Free EV

Save 100% on your flight

$535

per person

Sep 27 - Oct 2

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This vacation home doesn't skimp on freebies - guests receive free WiFi and free self parking. A virtual front desk are provided for your convenience.

The Cheshire

Save 100% on your flight

$455

per person

Sep 27 - Oct 2

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.

Moonrise Hotel

Delmar Loop

Save 100% on your flight

$478

per person

Sep 27 - Oct 2

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy a meal from the a restaurant and perks like free self parking.

Top Sikeston hotels deals

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$94 nightly

$108 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$64 nightly

$73 total

Sep 13 - Sep 14

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$95 nightly

$108 total

Aug 19 - Aug 20

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Free Cancellation

$97 nightly

$110 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$98 nightly

$110 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A 24-hour business center, a snack bar/deli, and express check-out are also on offer.

Country Yard Inn and Suite

110 South Interstate Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$59 nightly

$67 total

Sep 5 - Sep 6

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)

You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this relaxing area, you can savor the top-notch restaurants.

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Frequently asked questions

How much are vacation packages to Sikeston?

Starting from as little as $339, flight and hotel packages are a fabulous way to make your travel budget stretch further. Sikeston, here you come!

How long should my Sikeston vacation be?

Generally, visitors stay 2 nights in Sikeston. Although, that might not be enough time for you. If you aim to explore some of the region's hidden treasures, why not add another few nights to your travel schedule?

Where can I get the best vacation package deals for Sikeston?

With around 400 airlines and 1,000,000 hotels across the world, it's hard to beat Travelocity. Make the most of our impressive range and create your dream Sikeston vacation package. Don't you love it when planning a trip is that easy?

Why should I purchase my Sikeston vacation bundle via Travelocity?

You'll not only enjoy big savings, but you can also access our 24/7 customer support, high-quality service and a Price Match Guarantee. Journey across the globe, discover hidden gems and make lifelong memories — we'll take care of the important details.

Can I save money on my Sikeston car rental if I book it with my hotel or flight?

Absolutely — combine your flight, hotel and car into a Sikeston vacation package and you can save a tidy sum. With so much to see and do in the Sikeston area, that rental car will come in handy. Once you've buckled yourself in, turn up the stereo and make your way to Orpheum Theatre, a famous sight roughly 120 mi from Sikeston.

Which airport is best for Sikeston?

Many vacationers arrive at Cape Girardeau Municipal Airport (CGI). After you've landed and grabbed your luggage, you'll need to head 25 mi south to reach downtown Sikeston. Barkley Regional Airport (PAH) is another option, 45 mi from the center of the city.

What is there to do in Sikeston?

There's an undeniable magic as you wander the streets of Sikeston. The Book Bug and Central Park are just a couple of famous sights that make this city such a sought-after destination, so put them at the top of your travel itinerary.

Where should I stay when visiting Sikeston?

The Pear Tree Inn Sikeston is recommended by many visitors. Book as soon as possible to avoid missing out.

Where to stay in Sikeston: Best areas for travelers

Miner: If you're in the mood for some sightseeing in this neighborhood, head straight for The Book Bug. It's just one reason many visitors stay here. We suggest checking out the rates and reviews of the Drury Inn & Suites Sikeston, MO, the Motel 6 Sikeston MO and the Pear Tree Inn Sikeston.
Charleston: This is a great neighborhood for your next getaway — not the busiest place around, but still highly rated by many travelers. For an enjoyable stay, make a reservation at the Quality Inn Charleston I-57 or the Super 8 by Wyndham Charleston MO.